{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:27:37Z","timestamp":1787761657671,"version":"build-2784847793"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      McArdle\u2019s disease, known as blockage of muscle glycogen metabolism, is characterized by glycogen accumulation of chains in skeletal striated muscles. One of the typical symptoms of the disease is the feeling of intolerance to exercise. Severe muscle cram and contracture, which often cause stiffness, occur due to a lack of muscle energy substrate during the exercise. These factors can lead to muscle damage, myoglobinuria, and, in severe cases, renal failure and rhabdomyolysis. Rhabdomyolysis is a syndrome that presents injury and necrosis of muscle cells leading to the release of intracellular material to the circulatory system. The present study aimed to report rhabdomyolysis in an individual with McArdle\u2019s disease after exercise of walking with low intensity. Patient, aged 33 years, was treated in the emergency room of a hospital located in the State of Rio de Janeiro, Brazil. After performing a full lap on the block of home (~500 m in ~4 min 37 s), walking at a moderate speed (~6.5 km\/h), the individual felt sick and was rescued, later being hospitalized. The examinations collected presented hematocrit (HCT) compatible with chronic disease anemia and myoglobinuria. The patient was discharged from the intensive care center on the 3\n                      <jats:sup>rd<\/jats:sup>\n                      day, after a 45% drop in creatine kinase. The patient described in the present study achieved full recovery. Attention to symptoms, early diagnosis, and immediate treatment made it possible to interrupt the development of complications caused by rhabdomyolysis, not allowing progression to acute renal failure.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/1319-2442.374387","type":"journal-article","created":{"date-parts":[[2023,4,19]],"date-time":"2023-04-19T11:42:43Z","timestamp":1681904563000},"page":"S91-S99","source":"Crossref","is-referenced-by-count":2,"title":["Rhabdomyolysis Episode in an Individual with McArdle\u2019s Disease after Low Aerobic Exercise"],"prefix":"10.4103","volume":"33","author":[{"given":"Guilherme Henrique Mattos","family":"Dantas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artur Lu\u00eds Bessa","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo Jorge","family":"Marcos-Pardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa Franco Ferreira","family":"Coutinho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe Cassau","family":"de S\u00e1 Freire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana Brand\u00e3o Pinto","family":"de Castro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo Gomes","family":"de Souza Vale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-12-20230924","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1126\/science.6587566","article-title":"High-resolution chromosome sorting and DNA spot-blot analysis assign McArdle\u2019s syndrome to chromosome 11","volume":"225","author":"Lebo","year":"1984","journal-title":"Science"},{"key":"R2-12-20230924","first-page":"13","article-title":"Myopathy due to a defect in muscle glycogen breakdown","volume":"10","author":"McArdle","year":"1951","journal-title":"Clin Sci"},{"key":"R3-12-20230924","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s10545-014-9743-2","article-title":"The pathogenomics of McArdle disease genes, enzymes, models, and therapeutic implications","volume":"38","author":"Nogales-Gadea","year":"2015","journal-title":"J Inherit Metab Dis"},{"key":"R4-12-20230924","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/j.nmd.2017.09.002","article-title":"211th ENMC International Workshop: Development of diagnostic criteria and management strategies for McArdle disease and related rare glycogenolytic disorders to improve standards of care. 17-19 April 2015, Naarden, the Netherlands","volume":"27","author":"Quinlivan","year":"2017","journal-title":"Neuromuscul Disord"},{"key":"R5-12-20230924","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1038\/ncpneuro0913","article-title":"McArdle disease: What do neurologists need to know?","volume":"4","author":"Lucia","year":"2008","journal-title":"Nat Clin Pract Neurol"},{"key":"R6-12-20230924","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1136\/jnnp-2011-301593","article-title":"Genotypic and phenotypic features of McArdle disease: Insights from the Spanish national registry","volume":"83","author":"Lucia","year":"2012","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"R7-12-20230924","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1136\/jnnp.2009.195040","article-title":"McArdle disease: A clinical review","volume":"81","author":"Quinlivan","year":"2010","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"R8-12-20230924","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1007\/s12017-013-8233-2","article-title":"Clinical and molecular characterization of McArdle\u2019s disease in Brazilian patients","volume":"15","author":"Gurgel-Giannetti","year":"2013","journal-title":"Neuromolecular Med"},{"key":"R9-12-20230924","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1590\/0004-282X20140062","article-title":"From exercise intolerance to functional improvement: The second wind phenomenon in the identification of McArdle disease","volume":"72","author":"Scalco","year":"2014","journal-title":"Arq Neuropsiquiatr"},{"key":"R10-12-20230924","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1249\/MSS.0000000000000458","article-title":"Cardiorespiratory fitness, physical activity, and quality of life in patients with McArdle disease","volume":"47","author":"Mungu\u00eda-Izquierdo","year":"2015","journal-title":"Med Sci Sports Exerc"},{"key":"R11-12-20230924","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.ejim.2006.09.020","article-title":"The syndrome of rhabdomyolysis: Pathophysiology and diagnosis","volume":"18","author":"Giannoglou","year":"2007","journal-title":"Eur J Intern Med"},{"key":"R12-12-20230924","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ramd.2015.09.002","article-title":"Rhabdomyolysis after spinning: A peculiar association","volume":"9","author":"Torres-Le\u00f3n","year":"2016","journal-title":"Rev Andal Med Deport"},{"key":"R14-12-20230924","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1590\/S0004-282X2007000500020","article-title":"McArdle disease with rhabdomyolysis induced by rosuvastatin: Case report","volume":"65","author":"Lorenzoni","year":"2007","journal-title":"Arq Neuropsiquiatr"},{"key":"R17-12-20230924","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1590\/S0004-282X2005000500031","article-title":"Motor nerve conduction study in McArdle disease: Case report","volume":"63","author":"Lorenzoni","year":"2005","journal-title":"Arq Neuropsiquiatr"},{"key":"R18-12-20230924","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/j.jocn.2010.12.033","article-title":"Clinical and laboratory features of patients with myophosphorylase deficiency (McArdle disease)","volume":"18","author":"Miteff","year":"2011","journal-title":"J Clin Neurosci"},{"key":"R19-12-20230924","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.ando.2009.08.005","article-title":"McArdle disease revealed by exercise intolerance associated with severe rhabdomyolysis","volume":"70","author":"Amezyane","year":"2009","journal-title":"Ann Endocrinol (Paris"},{"key":"R20-12-20230924","first-page":"157","article-title":"McArdle disease and exercise physiology","volume":"3","author":"Kitaoka","year":"2014","journal-title":"Biology (Basel"},{"key":"R21-12-20230924","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1016\/j.neurol.2008.03.020","article-title":"McArdle disease (gycogenosis type V): Analysis of clinical, biological and genetic features of five French patients","volume":"164","author":"Delmont","year":"2008","journal-title":"Rev Neurol (Paris"},{"key":"R22-12-20230924","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1038\/gim.2015.9","article-title":"Determining the prevalence of McArdle disease from gene frequency by analysis of next-generation sequencing data","volume":"17","author":"De Castro","year":"2015","journal-title":"Genet Med"},{"key":"R23-12-20230924","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1111\/ene.12685","article-title":"Diagnostic power of the non-ischaemic forearm exercise test in detecting glycogenosis type V","volume":"22","author":"Hogrel","year":"2015","journal-title":"Eur J Neurol"},{"key":"R24-12-20230924","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s13760-018-1038-1","article-title":"Single-centre experience on genotypic and phenotypic features of southern Brazilian patients with McArdle disease","volume":"120","author":"Lorenzoni","year":"2020","journal-title":"Acta Neurol Belg"},{"key":"R25-12-20230924","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1097\/01.TA.0000130761.78627.10","article-title":"Preventing renal failure in patients with rhabdomyolysis: Do bicarbonate and mannitol make a difference?","volume":"56","author":"Brown","year":"2004","journal-title":"J Trauma"},{"key":"R26-12-20230924","first-page":"80","article-title":"Rhabdomyolisis \u2013 A clinical case study and brief theoretical revision","volume":"9","author":"Raposo","year":"2002","journal-title":"Med Int"},{"key":"R27-12-20230924","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1111\/pan.12164","article-title":"McArdle\u2019s disease (glycogen storage disease type V) and anesthesia a case report and review of the literature","volume":"23","author":"Bollig","year":"2013","journal-title":"Paediatr Anaesth"},{"key":"R28-12-20230924","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1136\/bjsports-2012-091130","article-title":"The \u2018McArdle paradox\u2019: Exercise is a good advice for the exercise intolerant","volume":"47","author":"Lucia","year":"2013","journal-title":"Br J Sports Med"},{"key":"R29-12-20230924","first-page":"9658251","article-title":"Resistance exercise training in McArdle disease: Myth or reality?","volume":"2018","author":"Pietrusz","year":"2018","journal-title":"Case Rep Neurol Med"},{"key":"R30-12-20230924","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1080\/02640414.2014.906045","article-title":"Heart rate and perceived muscle pain responses to a functional walking test in McArdle disease","volume":"32","author":"Buckley","year":"2014","journal-title":"J Sports Sci"},{"key":"R31-12-20230924","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1152\/physiolgenomics.00076.2015","article-title":"Genes and exercise intolerance: Insights from McArdle disease","volume":"48","author":"Nogales-Gadea","year":"2016","journal-title":"Physiol Genomics"}],"container-title":["Saudi Journal of Kidney Diseases and Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/1319-2442.374387","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:02:15Z","timestamp":1787760135000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/1319-2442.374387"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":28,"journal-issue":{"issue":"Suppl 1","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/1319-2442.374387","relation":{},"ISSN":["1319-2442"],"issn-type":[{"value":"1319-2442","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]}}}