{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:33:01Z","timestamp":1787761981795,"version":"build-2784847793"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022]]},"abstract":"\n Anti-M-type phospholipase A\n 2<\/jats:sub>\n receptor (anti-PLA\n 2<\/jats:sub>\n R) antibody is believed to be associated with primary membranous nephropathy (pMN) and absent in secondary MN (sMN). There are few data regarding utility of anti-PLA\n 2<\/jats:sub>\n R antibody as a prognosticator. Our study aimed to compare the incidence of positive serum anti-PLA\n 2<\/jats:sub>\n R antibody titer in pMN versus sMN and correlation with clinical outcome. From August 2015 to July 2019, patients with biopsy-proven MN were evaluated for serum anti-PLA\n 2<\/jats:sub>\n R antibody titers by the enzyme-linked immunosorbent assay. The subset of cases was repeated to monitor the clinical response in terms of 24 h proteinuria. A total of 169 patients, 65 pMN and 104 sMN were studied. Anti-PLA\n 2<\/jats:sub>\n R antibody was found in 41 (63.08%) pMN with mean titer, 232.62 RU\/mL, and 40 (38.46%) sMN with mean titer 253.59 RU\/mL. Out of positive antiPLA\n 2<\/jats:sub>\n R antibody titer in pMN cases, 15 were retested twice to 5 times with mean titers of 78.95, 36.27, 13.9, and 15.45 RU\/mL, respectively. Out of positive anti-PLA\n 2<\/jats:sub>\n R antibody in sMN cases, 11 were retested twice to five times with mean titers of 104.42, 122.49, 12.33, and 17.2 RU\/mL, respectively. All patients with decreasing anti-PLA\n 2<\/jats:sub>\n R antibody titer in both groups had clinical remission, with a decrease in mean 24 h proteinuria from 7.11 g to 3.36 g in pMN and 5.97 g to 3.41 g in sMN. Ten pMN and 11 sMN patients without remission showed persistent positive anti-PLA\n 2<\/jats:sub>\n R antibody titer. Anti-PLA\n 2<\/jats:sub>\n R antibody titer may be elevated in pMN\/sMN. It can also be used as a noninvasive prognostic marker for MN.\n <\/jats:p>","DOI":"10.4103\/1319-2442.379026","type":"journal-article","created":{"date-parts":[[2023,6,17]],"date-time":"2023-06-17T06:38:15Z","timestamp":1686983895000},"page":"280-287","source":"Crossref","is-referenced-by-count":2,"title":["Anti-phospholipase A2 Receptor Antibody in Differentiation and Prognostication of Membranous Nephropathy"],"prefix":"10.4103","volume":"33","author":[{"given":"Kamlesh S.","family":"Suthar","sequence":"first","affiliation":[{"name":"Department of Pathology, Lab Medicine, Transfusion Services and Immunohematology, G. R. Doshi and K. M. Mehta Institute of Kidney Diseases and Research Center and Dr. H. L. Trivedi Institute of Transplantation Sciences, Civil Hospital Campus, Asarwa, Ahmedabad, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aruna V.","family":"Vanikar","sequence":"additional","affiliation":[{"name":"Department of Pathology, Lab Medicine, Transfusion Services and Immunohematology, G. R. Doshi and K. M. Mehta Institute of Kidney Diseases and Research Center and Dr. H. L. Trivedi Institute of Transplantation Sciences, Civil Hospital Campus, Asarwa, Ahmedabad, India"},{"name":"Department of Regenerative Medicine and Cell Therapy, G. R. Doshi and K. M. Mehta Institute of Kidney Diseases and Research Center and Dr. H. L. Trivedi Institute of Transplantation Sciences, Civil Hospital Campus, Asarwa, Ahmedabad, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashmi D.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Pathology, Lab Medicine, Transfusion Services and Immunohematology, G. R. Doshi and K. M. Mehta Institute of Kidney Diseases and Research Center and Dr. H. L. Trivedi Institute of Transplantation Sciences, Civil Hospital Campus, Asarwa, Ahmedabad, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamal V.","family":"Kanodia","sequence":"additional","affiliation":[{"name":"Department of Pathology, Lab Medicine, Transfusion Services and Immunohematology, G. R. Doshi and K. M. Mehta Institute of Kidney Diseases and Research Center and Dr. H. L. Trivedi Institute of Transplantation Sciences, Civil Hospital Campus, Asarwa, Ahmedabad, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lovelesh A.","family":"Nigam","sequence":"additional","affiliation":[{"name":"Department of Pathology, Lab Medicine, Transfusion Services and Immunohematology, G. R. Doshi and K. M. Mehta Institute of Kidney Diseases and Research Center and Dr. H. L. Trivedi Institute of Transplantation Sciences, Civil Hospital Campus, Asarwa, Ahmedabad, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulin A.","family":"Gandhi","sequence":"additional","affiliation":[{"name":"Department of Pathology, Lab Medicine, Transfusion Services and Immunohematology, G. R. Doshi and K. M. Mehta Institute of Kidney Diseases and Research Center and Dr. H. L. Trivedi Institute of Transplantation Sciences, Civil Hospital Campus, Asarwa, Ahmedabad, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aanal H.","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Bio-Statistics, G. R. Doshi and K. M. Mehta Institute of Kidney Diseases and Research Center and Dr. H. L. Trivedi Institute of Transplantation Sciences, Civil Hospital Campus, Asarwa, Ahmedabad, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,6,20]]},"reference":[{"key":"R1-20230720","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1056\/NEJMoa0810457","article-title":"M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy","volume":"361","author":"Beck","year":"2009","journal-title":"N Engl J Med"},{"key":"R2-20230720","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1056\/NEJMc1011678","article-title":"PLA2R autoantibodies and PLA2R glomerular deposits in membranous nephropathy","volume":"364","author":"Debiec","year":"2011","journal-title":"N Engl J Med"},{"key":"R3-20230720","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1681\/ASN.2013040430","article-title":"Phospholipase A2 receptor autoantibodies and clinical outcome in patients with primary membranous nephropathy","volume":"25","author":"Hoxha","year":"2014","journal-title":"J Am Soc Nephrol"},{"key":"R4-20230720","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.1053\/j.ajkd.2015.07.006","article-title":"AJKD Atlas of Renal Pathology: Membranous nephropathy","volume":"66","author":"Fogo","year":"2015","journal-title":"Am J Kidney Dis"},{"key":"R5-20230720","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1159\/000445361","article-title":"Serum AntiPLA2R Antibody predicts treatment outcome in idiopathic membranous nephropathy","volume":"43","author":"Wei","year":"2016","journal-title":"Am J Nephrol"},{"key":"R6-20230720","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1681\/ASN.2012030242","article-title":"Antiphospholipase A2 receptor antibody titer and subclass in idiopathic membranous nephropathy","volume":"23","author":"Hofstra","year":"2012","journal-title":"J Am Soc Nephrol"},{"key":"R7-20230720","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1038\/ki.2012.486","article-title":"Anti-PLA2R antibodies measured by ELISA predict long-term outcome in a prevalent population of patients with idiopathic membranous nephropathy","volume":"83","author":"Kanigicherla","year":"2013","journal-title":"Kidney Int"},{"key":"R8-20230720","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1111\/nep.12624","article-title":"PLA2R and membranous nephropathy: A 3 year prospective Australian study","volume":"21","author":"Hill","year":"2016","journal-title":"Nephrology (Carlton)"},{"key":"R9-20230720","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1053\/j.ajkd.2013.06.002","article-title":"KDOQI US commentary on the 2012 KDIGO clinical practice guideline for glomerulonephritis","volume":"62","author":"Beck","year":"2013","journal-title":"Am J Kidney Dis"},{"key":"R10-20230720","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1111\/nep.12478","article-title":"Antibodies to m-type phospholipase A2 receptor in children with idiopathic membranous nephropathy","volume":"20","author":"Kumar","year":"2015","journal-title":"Nephrology (Carlton)"},{"key":"R11-20230720","doi-asserted-by":"crossref","first-page":"257","DOI":"10.4103\/0971-4065.160334","article-title":"Prevalence of serum anti M-type phospholipase A2 receptor antibody in primary membranous nephropathy: A single center experience","volume":"26","author":"Gopalakrishnan","year":"2016","journal-title":"Indian J Nephrol"},{"key":"R12-20230720","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.kint.2018.10.021","article-title":"Noninvasive diagnosis of primary membranous nephropathy using phospholipase A2 receptor antibodies","volume":"95","author":"Bobart","year":"2019","journal-title":"Kidney Int"},{"key":"R13-20230720","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1038\/ki.2015.310","article-title":"Serial monitoring of anti-PLA2R in initial PLA2R-negative patients with primary membranous nephropathy","volume":"88","author":"Ramachandran","year":"2015","journal-title":"Kidney Int"},{"key":"R14-20230720","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1097\/TP.0b013e31828a947b","article-title":"Phospholipase A2 receptor (PLA2R) staining is useful in the determination of de novo versus recurrent membranous glomerulopathy","volume":"95","author":"Larsen","year":"2013","journal-title":"Transplantation"},{"key":"R15-20230720","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.1093\/ndt\/gfu252","article-title":"Prediction of membranous nephropathy recurrence after transplantation by monitoring of anti-PLA2R1 (M-type phospholipase A2 receptor) autoantibodies: A case series of 15 patients","volume":"29","author":"Seitz-Polski","year":"2014","journal-title":"Nephrol Dial Transplant"},{"key":"R16-20230720","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1093\/ndt\/gfx366","article-title":"Anti-phospholipase A2 receptor antibodies in primary membranous nephropathy-10 key points","volume":"33","author":"McQuarrie","year":"2018","journal-title":"Nephrol Dial Transplant"}],"container-title":["Saudi Journal of Kidney Diseases and Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/1319-2442.379026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:13:03Z","timestamp":1787760783000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/1319-2442.379026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/1319-2442.379026","relation":{},"ISSN":["1319-2442","2320-3838"],"issn-type":[{"value":"1319-2442","type":"print"},{"value":"2320-3838","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]}}}