{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:33:01Z","timestamp":1787761981840,"version":"build-2784847793"},"reference-count":3,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022]]},"abstract":"<jats:p>Lecithin-cholesterol acyltransferase (LCAT) is a liver enzyme necessary for the formation of cholesteryl esters in plasma from free cholesterol. The rare autosomal recessive disease resulting from familial deficiency of this enzyme can lead to nephropathy with kidney involvement generally being the most common cause of death. In addition, the disease process can engender corneal opacity, very low high-density lipoprotein, normochromic anemia, and nephropathy. We present this case of a 35-year-old male who initially visited for a second opinion for renal failure and nephrotic range proteinuria. He underwent renal biopsy which displayed focal segmental glomerulosclerosis-type injury pattern and was started on futile high-dose steroid therapy. A second renal biopsy coincided with the development of corneal opacity leading to a confirmatory testing of LCAT deficiency through biochemistry panel.<\/jats:p>","DOI":"10.4103\/1319-2442.379033","type":"journal-article","created":{"date-parts":[[2023,6,17]],"date-time":"2023-06-17T06:38:15Z","timestamp":1686983895000},"page":"334-336","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Dilemma of Corneal Opacity, Very Low High-density Lipoprotein, and Nephrotic Syndrome: Mystery Revealed"],"prefix":"10.4103","volume":"33","author":[{"given":"Rupesh","family":"Raina","sequence":"first","affiliation":[{"name":"Department of Nephrology, Akron General Medical Center, Akron, OH, USA"},{"name":"Department of Nephrology, Akron Children\u2019s Hospital, Akron, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siddhartha","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Akron General Medical Center, Akron, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritika","family":"Chakraborty","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Akron General Medical Center, Akron, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sidharth K.","family":"Sethi","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Kidney and Urology Institute, Medanta, The Medicity Hospital, Gurgaon, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronith","family":"Chakraborty","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Akron General Medical Center, Akron, OH, USA"},{"name":"Department of Nephrology, Akron Children\u2019s Hospital, Akron, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,6,20]]},"reference":[{"key":"R1-20230720","first-page":"309","article-title":"A case of familial lecithin: Cholesterol acyltransferase deficiency","volume":"34","author":"Baba","year":"1992","journal-title":"Nihon Jinzo Gakkai Shi"},{"key":"R3-20230720","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0272-6386(86)80055-5","article-title":"Nephropathy of familial lecithin-cholesterol acyltransferase deficiency: Report of a case","volume":"7","author":"Ohta","year":"1986","journal-title":"Am J Kidney Dis"},{"key":"R4-20230720","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/j.0954-6820.1983.tb08591.x","article-title":"A new case of familial LCAT deficiency","volume":"214","author":"Vergani","year":"1983","journal-title":"Acta Med Scand"}],"container-title":["Saudi Journal of Kidney Diseases and Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/1319-2442.379033","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:13:03Z","timestamp":1787760783000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/1319-2442.379033"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":3,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/1319-2442.379033","relation":{},"ISSN":["1319-2442","2320-3838"],"issn-type":[{"value":"1319-2442","type":"print"},{"value":"2320-3838","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]}}}