{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T17:27:05Z","timestamp":1786728425812,"version":"build-2736575974"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,4]]},"abstract":"\n Urinary tract infection (UTI) is common in children. It is caused by bacteria and can lead to complications such as renal scarring in cases of late diagnosis and a lack of early treatment. Vesicoureteral reflux (VUR) occurs when urine flows from the bladder to the ureter and kidney, and is more common in children with UTI. VUR predisposes patients to pyelonephritis and can cause renal scarring. This retrospective study aimed to determine whether VUR was associated with the evolution to renal scarring in 132 infants aged 9 days to 24 months admitted to a tertiary care hospital in Jeddah, Saudi Arabia, with the first episode of febrile UTI (mean age = 4.48 months [standard deviation = 5.48]; 82 [62.1%] males; 50 [37.9%] females). Data from their medical records were investigated\n \n \n \n JOURNAL\/sjkdt\/04.03\/00936703-202233002-00009\/inline-graphic1\/v\/2023-09-15T111903Z\/r\/image-tiff\n \n \n \n for VUR and renal scarring. The VUR was related to renal scarring (\n P<\/jats:italic>\n = 0.001). C-reactive protein (CRP) levels were significantly higher in patients with VUR (\n P<\/jats:italic>\n = 0.027) and renal scars (\n P<\/jats:italic>\n = 0.05). There was a statistically significant difference between VUR and renal scarring with the first UTI (\n P<\/jats:italic>\n = 0.001). In conclusion, our study revealed a significant association of CRP with renal scarring (\n P<\/jats:italic>\n = 0.05) and VUR and (\n P<\/jats:italic>\n = 0.027).\n <\/jats:p>","DOI":"10.4103\/1319-2442.384190","type":"journal-article","created":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T04:44:50Z","timestamp":1692679490000},"page":"S179-S183","source":"Crossref","is-referenced-by-count":1,"title":["Vesicoureteral Reflux and Renal Scarring in Infants after the First Febrile Urinary Tract Infection"],"prefix":"10.4103","volume":"33","author":[{"given":"Yaser Saleh","family":"Bamshmous","sequence":"first","affiliation":[{"name":"Department of Pediatrics, King Abdulaziz University Hospital, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rawabi Mohammad","family":"Alamri","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Taif University, Taif, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shomookh Mohannad","family":"Alsalm","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Taif University, Taif, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shatha Ali","family":"Alharbi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Taibah University, Madinah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahaoth Manal","family":"Shareef","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Taif University, Taif, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maha Hameed","family":"Alsyed","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Ibn Sina University, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,8,22]]},"reference":[{"key":"R1-20230915","doi-asserted-by":"crossref","first-page":"367","DOI":"10.3345\/kjp.2012.55.10.367","article-title":"Renal scar formation after urinary tract infection in children","volume":"55","year":"2012","journal-title":"Korean J Pediatr"},{"key":"R2-20230915","doi-asserted-by":"crossref","first-page":"272","DOI":"10.5455\/medarh.2018.72.272-275","article-title":"Vesicoureteral reflux and renal scarring in infants after the first febrile urinary tract infection","volume":"72","author":"Pokrajac","year":"2018","journal-title":"Med Arch"},{"key":"R3-20230915","doi-asserted-by":"crossref","first-page":"v1000","DOI":"10.12688\/f1000research.8390.1","article-title":"Urinary tract infection in the setting of vesicoureteral reflux","volume":"5","author":"Garcia-Roig","year":"2016","journal-title":"F1000Res"},{"key":"R4-20230915","first-page":"1","article-title":"Clinical course of 250 pediatric cases of vesicoureteral reflux in Zahedan, Southeast of Iran","volume":"2","author":"Sadeghi-Bojd","year":"2017","journal-title":"J Ped Nephrol"},{"key":"R5-20230915","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1159\/000443536","article-title":"Vesicoureteral reflux and renal scarring risk in children after the first febrile urinary tract infection","volume":"132","author":"Y\u0131lmaz","year":"2016","journal-title":"Nephron"},{"key":"R6-20230915","doi-asserted-by":"crossref","first-page":"e13","DOI":"10.1542\/peds.2015-0409","article-title":"Risk factors for recurrent urinary tract infection and renal scarring","volume":"136","author":"Keren","year":"2015","journal-title":"Pediatrics"},{"key":"R7-20230915","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/j.juro.2011.10.164","article-title":"Risk factors for renal scar formation in infants with first episode of acute pyelonephritis: A prospective clinical study","volume":"187","author":"Lee","year":"2012","journal-title":"J Urol"},{"key":"R8-20230915","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1007\/s00467-017-3705-5","article-title":"Urinary tract infection in small children: The evolution of renal damage over time","volume":"32","author":"Swerkersson","year":"2017","journal-title":"Pediatr Nephrol"}],"container-title":["Saudi Journal of Kidney Diseases and Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/1319-2442.384190","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T16:26:55Z","timestamp":1786724815000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/1319-2442.384190"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":8,"journal-issue":{"issue":"Suppl 2","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/1319-2442.384190","relation":{},"ISSN":["1319-2442","2320-3838"],"issn-type":[{"value":"1319-2442","type":"print"},{"value":"2320-3838","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4]]}}}