{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T17:27:10Z","timestamp":1786728430385,"version":"build-2736575974"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:p>Sjogren's syndrome is a prevalent and underdiagnosed systemic disease that primarily affects epithelial tissue. It may affect renal function, either as an epithelial disease causing tubulointerstitial nephritis (TIN) or as an immune complex-mediated glomerulopathy. These lesions may cause a variety of clinical features, both overt and occult. The epithelial disease is mediated by B and T cells. The prevalence of renal involvement in primary Sjogren's syndrome has been reported to range approximately from 10% to 30%. Patients with renal involvement in primary Sjogren's syndrome may have renal manifestations, such as renal tubular acidosis (RTA) Type I, TIN, diabetes insipidus, nephrolithiasis, and Fanconi syndrome. Distal RTA was reported more commonly than proximal RTA, which can present as acute hypokalemic paralysis. We present three cases of primary Sjogren's syndrome with significant renal involvement and various clinicopathological presentations.<\/jats:p>","DOI":"10.4103\/1319-2442.384195","type":"journal-article","created":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T04:44:50Z","timestamp":1692679490000},"page":"S255-S259","source":"Crossref","is-referenced-by-count":1,"title":["Renal Involvement in Primary Sjogren's Syndrome: A Case Series of Three Cases with Various Clinicopathological Presentations"],"prefix":"10.4103","volume":"33","author":[{"given":"Bhawna","family":"Agnani","sequence":"first","affiliation":[{"name":"Department of Pathology, Sawai Man Singh Medical College, Jaipur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranjana","family":"Solanki","sequence":"additional","affiliation":[{"name":"Department of Pathology, Sawai Man Singh Medical College, Jaipur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepika","family":"Hemrajani","sequence":"additional","affiliation":[{"name":"Department of Pathology, Sawai Man Singh Medical College, Jaipur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,8,22]]},"reference":[{"key":"R1-20230915","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1755-3768.1935.tb04186.x","article-title":"ZurKenntnis der keratoconjunctivitis sicca II","volume":"13","year":"1935","journal-title":"Acta Ophthalmol"},{"key":"R2-20230915","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1111\/j.1601-0825.2006.01292.x","article-title":"Sj\u00f6gren's syndrome: Why autoimmune epithelitis?","volume":"12","author":"Mitsias","year":"2006","journal-title":"Oral Dis"},{"key":"R3-20230915","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/nrneph.2015.174","article-title":"Renal involvement in primary Sj\u00f6gren syndrome","volume":"12","author":"Fran\u00e7ois","year":"2016","journal-title":"Nat Rev Nephrol"},{"key":"R4-20230915","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s12891-015-0858-x","article-title":"Tubulointerstitial nephritis in primary Sj\u00f6gren syndrome: Clinical manifestations and response to treatment","volume":"17","author":"Evans","year":"2016","journal-title":"BMC Musculoskelet Disord"},{"key":"R5-20230915","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1097\/MD.0b013e318181e6af","article-title":"Primary Sj\u00f6gren syndrome in spain: Clinical and immunologic expression in 1010 patients","volume":"87","author":"Ramos-Casals","year":"2008","journal-title":"Medicine (Baltimore)"},{"key":"R6-20230915","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1128\/cdli.3.4.483-484.1996","article-title":"An unusual presen-tation of Sj\u00f6gren's syndrome","volume":"3","author":"Crooks","year":"1996","journal-title":"Clin Diagn Lab Immunol"},{"key":"R7-20230915","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1002\/art.1780110607","article-title":"Renal tubular acidosis, glomerulonephritis and immunologic factors in Sj\u00f6gren's syndrome","volume":"11","author":"Talal","year":"1968","journal-title":"Arthritis Rheum"},{"key":"R8-20230915","first-page":"278","article-title":"Renal involvement and followup of 130 patients with primary Sj\u00f6gren's syndrome","volume":"35","author":"Ren","year":"2008","journal-title":"J Rheumatol"}],"container-title":["Saudi Journal of Kidney Diseases and Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/1319-2442.384195","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T16:26:55Z","timestamp":1786724815000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/1319-2442.384195"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":8,"journal-issue":{"issue":"Suppl 2","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/1319-2442.384195","relation":{},"ISSN":["1319-2442","2320-3838"],"issn-type":[{"value":"1319-2442","type":"print"},{"value":"2320-3838","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4]]}}}