{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:16:47Z","timestamp":1791908207047,"version":"4.3.4"},"reference-count":45,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022]]},"abstract":"<jats:p>\n                    Protein-energy wasting (PEW) is a major risk for morbidity and mortality in hemodialysis (HD) patients. The change in the concentration of dehydroepiandrosterone sulfate (DHEA-S) may play a role in PEW. The aim of this work was to study the possible relationship between serum DHEA-S levels and various nutritional and inflammatory parameters in a cohort of HD patients. In total, 78 HD patients (47 males and 31 females) were included in this crosssectional observational study. In addition to taking their history, clinical examinations, and routine laboratory investigations, the nutritional status was assessed, and their serum DHEA-S was measured. Nutritional status was assessed by anthropometric measures, bioelectrical impedance analysis, malnutrition inflammation scores, and subjective global assessments. A diagnosis of malnutrition was made based on the recommendations of the International Society of Renal Nutrition and Metabolism. The relationship between DHEA-S and various nutritional parameters was analyzed. Eighteen patients (23.1%) suffered from PEW. Those with PEW had a longer duration of HD (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.04), and lower serum levels of creatinine (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.003), hemoglobin (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.01), albumin (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt;0.0001), cholesterol (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.02), and DHEA-S (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.01). Among the variables, serum DHEA-S levels were significant predictors of PEW in this cohort (odds ratio: 0.976; 95% confidence interval: 0.954\u20131.0;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.04). PEW is frequently encountered in HD patients. Decreased serum DHEA-S levels were associated with PEW in male HD patients. Further studies are needed to assess the effect of hormone supplementation on this serious disorder in HD patients.\n                  <\/jats:p>","DOI":"10.4103\/1319-2442.389424","type":"journal-article","created":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T09:02:04Z","timestamp":1699347724000},"page":"639-649","source":"Crossref","is-referenced-by-count":1,"title":["The Relation of Serum Dehydroepiandrosterone Sulfate Level to Protein Energy Wasting in Hemodialysis Patients"],"prefix":"10.4103","volume":"33","author":[{"given":"Mohammed Kamal","family":"Nassar","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Nephrology and Dialysis Unit, Mansoura University, Mansoura, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghada","family":"El Kannishy","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Nephrology and Dialysis Unit, Mansoura University, Mansoura, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eman","family":"Nagy","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Nephrology and Dialysis Unit, Mansoura University, Mansoura, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasha Samir","family":"Shemies","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Nephrology and Dialysis Unit, Mansoura University, Mansoura, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mostafa","family":"Mansour","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, Rheumatology and Immunology Unit, Mansoura University, Mansoura, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Mofreh","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, Rheumatology and Immunology Unit, Mansoura University, Mansoura, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamer Zaki","family":"Gaber","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Nephrology and Dialysis Unit, Mansoura University, Mansoura, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samar","family":"Tharwat","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Rheumatology and Immunology Unit, Mansoura University, Mansoura, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,11,7]]},"reference":[{"key":"R1-20231113","doi-asserted-by":"crossref","first-page":"10633","DOI":"10.1038\/s41598-019-46919-w","article-title":"Risk factors before dialysis predominate as mortality predictors in diabetic maintenance dialysis patients","volume":"9","author":"Tsur","year":"2019","journal-title":"Sci 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