{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T18:16:06Z","timestamp":1788545766426,"version":"build-2803163510"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022]]},"abstract":"<jats:p>\n                    Henoch\u2013Sch\u00f6nlein purpura (HSP) is a small vessel vasculitis with multiorgan involvement. Renal involvement is the key factor predicting morbidity. We have aimed to analyze the clinicopathological spectrum of HSP vasculitis and HSP nephritis to assess the risk factors associated with kidney involvement. This retrospective study was performed in the department of pathology with collaboration of department of dermatology and department of nephrology of a tertiary care center. All clinical details along with biopsy findings were retrieved. Starting materials of the study were cases of leukocytoclastic vasculitis with only perivascular IgA deposit of more than ++ in the absence of other immunoglobulin and trace complements. To investigate the possible factors that are influential on the development of biopsy-proven HSP nephritis, we divided the whole study population in two groups -group 1: with and group 2: without biopsy-proven nephritis. One-way analysis of variance was carried out during comparative analysis between two groups using IBM SPSS statistics software, version 19 and MedCalc software, version 12.3.0.0. HSP vasculitis comprised 11.6% (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    = 19) of total cutaneous vasculitis in 2 years (164 cases) with a mean age of 13.52 \u00b1 8.10 (range: 4\u201333 years). Three cases developed\n                    <jats:italic toggle=\"yes\">de novo<\/jats:italic>\n                    kidney disease (15.79%). A correlation analysis revealed that predictors were seasonal variation (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.018), severe gastrointestinal involvement (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.03), and subcutaneous edema (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.005). Various clinical and laboratory parameters were associated with renal consequences. Occult nephritis was the most common presentation with crescent as a constant histopathological feature.\n                  <\/jats:p>","DOI":"10.4103\/1319-2442.389429","type":"journal-article","created":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T09:04:09Z","timestamp":1699347849000},"page":"693-701","source":"Crossref","is-referenced-by-count":2,"title":["Clinicopathological Spectrum of Henoch\u2013Sch\u00f6nlein Purpura Vasculitis: An Experience from a Tertiary Care Center"],"prefix":"10.4103","volume":"33","author":[{"given":"Keya","family":"Basu","sequence":"first","affiliation":[{"name":"Department of Pathology, Institute of Post-Graduate Medical Education and Research and Seth Sukhlal Karnani Memorial Hospital, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soma","family":"Addya","sequence":"additional","affiliation":[{"name":"Department of Pathology, Institute of Post-Graduate Medical Education and Research and Seth Sukhlal Karnani Memorial Hospital, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sriranjan","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"Department of Pathology, Institute of Post-Graduate Medical Education and Research and Seth Sukhlal Karnani Memorial Hospital, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moumita","family":"Sengupta","sequence":"additional","affiliation":[{"name":"Department of Pathology, Institute of Post-Graduate Medical Education and Research and Seth Sukhlal Karnani Memorial Hospital, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajendra","family":"Pandey","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Institute of Post-Graduate Medical Education and Research and Seth Sukhlal Karnani Memorial Hospital, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gobinda","family":"Chatterjee","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Institute of Post-Graduate Medical Education and Research and Seth Sukhlal Karnani Memorial Hospital, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manimoy","family":"Bandopadhyay","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Institute of Post-Graduate Medical Education and Research and Seth Sukhlal Karnani Memorial Hospital, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,11,7]]},"reference":[{"key":"R1-20231113","doi-asserted-by":"crossref","first-page":"257","DOI":"10.3389\/fped.2019.00257","article-title":"Childhood IgA vasculitis (Henoch Schonlein purpura)-advances and knowledge gaps","volume":"7","author":"Oni","year":"2019","journal-title":"Front Pediatr"},{"key":"R2-20231113","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/S0140-6736(02)11279-7","article-title":"Incidence of Henoch\u2013Sch\u00f6nlein purpura, Kawasaki disease, and rare vasculitides in children of different ethnic origins","volume":"360","author":"Gardner-Medwin","year":"2002","journal-title":"Lancet"},{"key":"R3-20231113","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/art.37715","article-title":"2012 revised international Chapel Hill consensus conference nomenclature of vasculitides","volume":"65","author":"Jennette","year":"2013","journal-title":"Arthritis Rheum"},{"key":"R4-20231113","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1136\/ard.2009.116624","article-title":"EULAR\/PRINTO\/PRES criteria for Henoch\u2013Sch\u00f6nlein purpura, childhood polyarteritis nodosa, childhood Wegener granulomatosis and childhood Takayasu arteritis: Ankara 2008. Part I: Overall methodology and clinical characte-nation","volume":"69","author":"Ruperto","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"R5-20231113","doi-asserted-by":"crossref","first-page":"e0223218","DOI":"10.1371\/journal.pone.0223218","article-title":"Risk factors associated with IgA vasculitis with nephritis (Henoch\u2013Sch\u00f6nlein purpura nephritis) progressing to unfavorable outcomes: A meta-analysis","volume":"14","author":"Shi","year":"2019","journal-title":"PLoS One"},{"key":"R6-20231113","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1007\/s00467-017-3608-5","article-title":"The ISKDC classification and a new semiquantitative classification for predicting outcomes of Henoch\u2013Sch\u00f6nlein purpura nephritis","volume":"32","author":"Koskela","year":"2017","journal-title":"Pediatr Nephrol"},{"key":"R7-20231113","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3109\/01913123.2012.670035","article-title":"Electron-microscopic and immunohistochemical study in Henoch-Schoenlein nephritis","volume":"37","author":"Wozniak","year":"2013","journal-title":"Ultrastruct Pathol"},{"key":"R8-20231113","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1080\/14397595.2019.1687074","article-title":"Clinical manifestations and outcomes of 420 children with Henoch Sch\u00f6nlein purpura from a single referral center from Turkey: A three-year experience","volume":"30","author":"Ekinci","year":"2020","journal-title":"Mod Rheumatol"},{"key":"R9-20231113","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s42358-019-0064-x","article-title":"The profile and clinical outcomes of patients with renal involvement due to IgA vasculitis: Is azathioprine a good option for treatment?","volume":"59","author":"Schinzel","year":"2019","journal-title":"Adv Rheumatol"},{"key":"R10-20231113","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1111\/1756-185X.13221","article-title":"Differences between adult and pediatric onset Henoch\u2013Sch\u00f6nlein purpura from North India","volume":"21","author":"Gupta","year":"2018","journal-title":"Int J Rheum Dis"},{"key":"R11-20231113","doi-asserted-by":"crossref","first-page":"679","DOI":"10.2215\/CJN.06710810","article-title":"Henoch\u2013Sch\u00f6nlein purpura nephritis: Pathophysiology, treatment, and future strategy","volume":"6","author":"Davin","year":"2011","journal-title":"Clin J Am Soc Nephrol"},{"key":"R12-20231113","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1080\/03009742.2018.1448111","article-title":"Comparing immunoglobulin A vasculitis (Henoch\u2013Sch\u00f6nlein purpura) in children and adults: A single-centre study from Turkey","volume":"47","author":"Batu","year":"2018","journal-title":"Scand J Rheumatol"},{"key":"R13-20231113","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1007\/s00467-014-3016-z","article-title":"Comparison between adults and children with Henoch\u2013Sch\u00f6nlein purpura nephritis","volume":"30","author":"Lu","year":"2015","journal-title":"Pediatr Nephrol"},{"key":"R14-20231113","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1046\/j.1523-1755.2001.059003823.x","article-title":"What is the difference between IgA nephropathy and Henoch\u2013Sch\u00f6nlein purpura nephritis?","volume":"59","author":"Davin","year":"2001","journal-title":"Kidney Int"},{"key":"R15-20231113","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1111\/j.1365-4632.2009.04162.x","article-title":"Pediatric Henoch\u2013Sch\u00f6nlein purpura","volume":"48","author":"Gonz\u00e1lez","year":"2009","journal-title":"Int J Dermatol"},{"key":"R16-20231113","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s12969-019-0311-z","article-title":"Different histological classifications for Henoch\u2013Sch\u00f6nlein purpura nephritis: Which one should be used?","volume":"17","author":"Jelusic","year":"2019","journal-title":"Pediatr Rheumatol Online J"}],"container-title":["Saudi Journal of Kidney Diseases and Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/1319-2442.389429","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:50:32Z","timestamp":1787763032000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/1319-2442.389429"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":16,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/1319-2442.389429","relation":{},"ISSN":["1319-2442","2320-3838"],"issn-type":[{"value":"1319-2442","type":"print"},{"value":"2320-3838","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]}}}