{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:20:51Z","timestamp":1787772051574,"version":"build-2784847793"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:p>\n                    Fabry disease (FD) is associated with inflammation, proteinuria, and chronic kidney disease. Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) plays an important role in inflammation in diabetic nephropathy and lupus nephritis. Since there is a close relationship linking serum TWEAK (sTWEAK), inflammation, and carotid intima-media thickness (CIMT) in various kidney diseases, we aimed to determine the relationship between sTWEAK levels and CIMT in subjects with and without proteinuria in a cross-sectional study involving 15 FD patients (seven females, eight males) and seven healthy controls (four females, three males). There were no differences in age, sex, estimated glomerular filtration rate, and biochemical parameters (serum glucose, albumin, creatinine, uric acid, C-reactive protein (CRP), low-density lipoprotein, and high-density lipoprotein) between FD patients and healthy controls. The spot urine protein-creatinine ratios of healthy controls and FD patients were 90 mg\/g and 185 mg\/g, respectively (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.022). STWEAK levels were higher in FD patients than in healthy controls (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.007). The CIMT of FD patients and healthy controls was 0.55 \u00b1 0.14 mm and 0.42 \u00b1 0.04 mm, respectively (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.007). STWEAK was positively correlated with CRP and CIMT, and negatively with proteinuria (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.005,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.013, and\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.018, respectively). In the multivariate analysis, only sTWEAK was an independent variable of increased CIMT. We demonstrated that sTWEAK and CIMT were increased in FD patients. STWEAK might have a role in the pathogenesis of subclinical atherosclerosis in FD.\n                  <\/jats:p>","DOI":"10.4103\/1319-2442.397202","type":"journal-article","created":{"date-parts":[[2024,3,9]],"date-time":"2024-03-09T00:55:51Z","timestamp":1709945751000},"page":"406-415","source":"Crossref","is-referenced-by-count":1,"title":["The Relationship between Serum TWEAK Levels and Carotid Intima-media Thickness in Patients with Fabry Disease"],"prefix":"10.4103","volume":"34","author":[{"given":"Kultigin","family":"Turkmen","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Nephrology, Meram School of Medicine, Necmettin Erbakan University, Konya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismail","family":"Baloglu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Nephrology, Meram School of Medicine, Necmettin Erbakan University, Konya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talat","family":"Aykut","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Internal Medicine, Meram School of Medicine, Necmettin Erbakan University, Konya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salih","family":"Demir","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Internal Medicine, Meram School of Medicine, Necmettin Erbakan University, Konya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebru","family":"Alt\u0131n","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Internal Medicine, Meram School of Medicine, Necmettin Erbakan University, Konya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeynep Aybike","family":"Akguzel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Internal Medicine, Meram School of Medicine, Necmettin Erbakan University, Konya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammet","family":"Kocabas","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Endocrinology, Meram School of Medicine, Necmettin Erbakan University, Konya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma Humeyra","family":"Yerlikaya","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Necmettin Erbakan University, Meram School of Medicine, Konya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,3,11]]},"reference":[{"key":"R1-20240314","doi-asserted-by":"crossref","first-page":"2812","DOI":"10.1073\/pnas.0712309105","article-title":"Elevated globotriaosylsphingosine is a hallmark of fabry 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