{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T13:41:56Z","timestamp":1786714916082,"version":"build-2736575974"},"reference-count":45,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Saudi J Gastroenterol"],"published-print":{"date-parts":[[2016]]},"DOI":"10.4103\/1319-3767.182461","type":"journal-article","created":{"date-parts":[[2016,5,13]],"date-time":"2016-05-13T09:47:57Z","timestamp":1463132877000},"page":"240","source":"Crossref","is-referenced-by-count":4,"title":["Hepatitis c virus genotype 4 replication in the hepatocellular carcinoma cell line HepG2\/C3A"],"prefix":"10.4103","volume":"22","author":[{"given":"MedhatK","family":"Shier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MohammadS","family":"El-Wetidy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HebatallahH","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MohammadM","family":"Al-Qattan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"key-10.4103\/1319-3767.182461-1","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.3748\/wjg.v13.i17.2436","article-title":"Epidemiology of hepatitis C virus infection","author":"Alter","year":"2007","journal-title":"World J Gastroenterol"},{"key":"key-10.4103\/1319-3767.182461-2","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/S1473-3099(05)70216-4","article-title":"Global epidemiology of hepatitis C virus infection","author":"Shepard","year":"2005","journal-title":"Lancet Infect Dis"},{"key":"key-10.4103\/1319-3767.182461-3","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1126\/science.2523562","article-title":"Isolation of a cDNA clone derived from a blood-born non-A, non-B viral hepatitis genome","author":"Choo","year":"1989","journal-title":"Science"},{"key":"key-10.4103\/1319-3767.182461-4","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/0140-6736(92)91508-6","article-title":"High HCV prevalence in Egyptian blood donors","author":"Kamel","year":"1992","journal-title":"Lancet"},{"key":"key-10.4103\/1319-3767.182461-5","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/0140-6736(91)91094-B","article-title":"Hepatitis C virus infection in Egyptian volunteer blood-donors in Riyadh","author":"Saeed","year":"1991","journal-title":"Lancet"},{"key":"key-10.4103\/1319-3767.182461-6","first-page":"55","article-title":"Overview of hepatitis C virus genome structure, polyprotein processing, and protein properties","author":"Reed","year":"2000","journal-title":"Curr Top Microbiol Immunol"},{"key":"key-10.4103\/1319-3767.182461-7","doi-asserted-by":"crossref","unstructured":"McLauchlan J. Properties of the hepatitis C virus core protein: A structural protein that modulates cellular processes. J Viral Hepatitis 2000;7:2-14.","DOI":"10.1046\/j.1365-2893.2000.00201.x"},{"key":"key-10.4103\/1319-3767.182461-8","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1006\/viro.1995.0018","article-title":"Differential subcellular localization of hepatitis C virus core gene products","author":"Lo","year":"1995","journal-title":"Virology"},{"key":"key-10.4103\/1319-3767.182461-9","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1007\/BF02931636","article-title":"Structure and functions of hepatitis C virus proteins: 15 years after","author":"Krekulov\u00e1","year":"2006","journal-title":"Folia Microbiol (Praha)"},{"key":"key-10.4103\/1319-3767.182461-10","first-page":"413","article-title":"HCV-RNA and HCV genotype in mother-to-infant transmission of HCV","author":"Nagata","year":"1995","journal-title":"Nihon Rinsho"},{"key":"key-10.4103\/1319-3767.182461-11","doi-asserted-by":"crossref","first-page":"4713","DOI":"10.1128\/JVI.73.6.4713-4720.1999","article-title":"Hepatitis C virus core protein inhibits Fas- and tumor necrosis factor alpha-mediated apoptosis via NF-kappa B activation","author":"Marusawa","year":"1999","journal-title":"J Virol"},{"key":"key-10.4103\/1319-3767.182461-12","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1128\/jvi.70.1.127-132.1996","article-title":"Identification of the sequence on NS4A required for enhanced cleavage of the NS5A\/5B site by hepatitis C virus NS3 protease","author":"Shimizu","year":"1996","journal-title":"J Virol"},{"key":"key-10.4103\/1319-3767.182461-13","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1099\/0022-1317-77-5-1043","article-title":"Cultivation of hepatitis C virus in primary hepatocyte culture from patients with chronic hepatitis C results in release of high titer infection virus","author":"Ito","year":"1996","journal-title":"J Gen Virol"},{"key":"key-10.4103\/1319-3767.182461-14","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1002\/jcp.20083","article-title":"Hepatitis C virus replication in stably transfected HepG2 cells promotes hepatocellular growth and tumorigenesis","author":"Sun","year":"2004","journal-title":"J Cell Physiol"},{"key":"key-10.4103\/1319-3767.182461-15","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1126\/science.1113329","article-title":"Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA","author":"Jopling","year":"2005","journal-title":"Science"},{"key":"key-10.4103\/1319-3767.182461-16","doi-asserted-by":"crossref","first-page":"12087","DOI":"10.1128\/JVI.05843-11","article-title":"HepG2 cells expressing microRNA miR-122 support the entire hepatitis C virus life cycle","author":"Narbus","year":"2011","journal-title":"J Virol"},{"key":"key-10.4103\/1319-3767.182461-17","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1006\/viro.1993.1069","article-title":"Reproducible high level infection of cultured adult human hepatocytes by hepatitis B virus: Effect of polyethylene glycol on adsorption and penetration","author":"Gripon","year":"1993","journal-title":"Virology"},{"key":"key-10.4103\/1319-3767.182461-18","doi-asserted-by":"crossref","first-page":"6786","DOI":"10.1016\/S0021-9258(18)83498-6","article-title":"Mechanism of fusion of Sendai virus: Role of hydrophobic interactions and mobility constraints of viral membrane proteins.Effects of polyethylene glycol","author":"Hoekstra","year":"1989","journal-title":"J Biol Chem"},{"key":"key-10.4103\/1319-3767.182461-19","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1099\/0022-1317-76-9-2375","article-title":"Defective entry of herpes simplex virus types 1 and 2 into porcine cells and lack of infection in infant pigs indicate species tropism","author":"Subramanian","year":"1995","journal-title":"J Gen Virol"},{"key":"key-10.4103\/1319-3767.182461-20","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/0042-6822(91)90014-3","article-title":"Differentiation of acid-pH dependent and -nondependent entry pathways for mouse hepatitis virus","author":"Kooi","year":"1991","journal-title":"Virology"},{"key":"key-10.4103\/1319-3767.182461-21","doi-asserted-by":"crossref","first-page":"5158","DOI":"10.1128\/JCM.43.10.5158-5163.2005","article-title":"Rapid genotyping of hepatitis C virus by primer-specific extension analysis","author":"Antonishyn","year":"2005","journal-title":"J Clin Microbiol"},{"key":"key-10.4103\/1319-3767.182461-22","first-page":"4836","article-title":"HepG2 cells support viral replication and gene expression of hepatitis C virus genotype 4 in vitro","author":"el-Awady","year":"2006","journal-title":"World J Gastroenterol"},{"key":"key-10.4103\/1319-3767.182461-23","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1099\/0022-1317-74-11-2391","article-title":"Classification of hepatitis C virus into six major genotypes and a series of subtypes by phylogenetic analysis of the NS-5 region","author":"Simmonds","year":"1993","journal-title":"J Gen Virol"},{"key":"key-10.4103\/1319-3767.182461-24","doi-asserted-by":"crossref","first-page":"41","DOI":"10.7150\/ijms.3.41","article-title":"Epidemiology of hepatitis C virus (HCV) infection","author":"Sy","year":"2006","journal-title":"Int J Med Sci"},{"key":"key-10.4103\/1319-3767.182461-25","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/j.1348-0421.2007.tb03883.x","article-title":"In vitro infection of immortalized primary hepatocytes by HCV genotype 4a and inhibition of virus replication by cyclosporine","author":"El-Farrash","year":"2007","journal-title":"Microbiol Immunol"},{"key":"key-10.4103\/1319-3767.182461-26","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1128\/CMR.13.2.223","article-title":"Clinical significance of hepatitis C virus genotypes","author":"Zein","year":"2000","journal-title":"Clin Microbiol Rev"},{"key":"key-10.4103\/1319-3767.182461-27","first-page":"439","article-title":"A meta-analysis of genotyping methods and nucleotide variation in Hepatitis C Virus","author":"Nagarapu","year":"2013","journal-title":"Int J Adv Res"},{"key":"key-10.4103\/1319-3767.182461-28","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1042\/BC20070127","article-title":"Whichin vitro models could be best used to study hepatocyte polarity?","author":"Decaens","year":"2008","journal-title":"Biol Cell"},{"key":"key-10.4103\/1319-3767.182461-29","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.antiviral.2005.02.002","article-title":"Investigation into the ability of GB virus B to replicate in various immortalized cell lines","author":"Buckwold","year":"2005","journal-title":"Antiviral Res"},{"key":"key-10.4103\/1319-3767.182461-30","first-page":"292591","article-title":"In vitro systems for the study of hepatitis C virus infection","author":"Wilson","year":"2012","journal-title":"Int J Hepatol"},{"key":"key-10.4103\/1319-3767.182461-31","doi-asserted-by":"crossref","first-page":"16990","DOI":"10.1073\/pnas.0407402101","article-title":"Coordinated assembly of human translation initiation complexes by the hepatitis C virus internal ribosome entry site RNA","author":"Ji","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key-10.4103\/1319-3767.182461-32","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.crvi.2005.02.004","article-title":"Translation initiation by factor-independent binding of eukaryotic ribosomes to internal ribosomal entry sites","author":"Pisarev","year":"2005","journal-title":"C R Biol"},{"key":"key-10.4103\/1319-3767.182461-33","doi-asserted-by":"crossref","unstructured":"Rosenfeld AB, Racaniello VR. Hepatitis C virus internal ribosome entry site-dependent translation in Saccharomyces cerevisiae is independent of polypyrimidine tract-binding protein, poly(rC)-binding protein 2, and La protein, J Virol 2005;79:10126-37.","DOI":"10.1128\/JVI.79.16.10126-10137.2005"},{"key":"key-10.4103\/1319-3767.182461-34","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0168-8278(05)80481-7","article-title":"Optimization for the detection of hepatitis C virus antigens in the liver","author":"Gonz\u00e1lez-Peralta","year":"1994","journal-title":"J Hepatol"},{"key":"key-10.4103\/1319-3767.182461-35","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1046\/j.1365-2893.2003.00474.x","article-title":"Detection and quantitation of HCV core protein in single hepatocytes by means of laser capture microdissection and enzyme-linked immunosorbent assay","author":"Sansonno","year":"2004","journal-title":"J Viral Hepat"},{"key":"key-10.4103\/1319-3767.182461-36","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1128\/JVI.79.2.1271-1281.2005","article-title":"Molecular determinants for subcellular localization of hepatitis C virus core protein","author":"Suzuki","year":"2005","journal-title":"J Virol"},{"key":"key-10.4103\/1319-3767.182461-37","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1099\/0022-1317-78-10-2467","article-title":"Establishment of persistent hepatitis C virus infection and replication in vitro","author":"Seipp","year":"1997","journal-title":"J Gen Virol"},{"key":"key-10.4103\/1319-3767.182461-38","doi-asserted-by":"crossref","first-page":"4356","DOI":"10.1093\/nar\/24.21.4356","article-title":"Electroporation efficiency in mammalian cells is increased by dimethyl sulfoxide (DMSO)","author":"Melkonyan","year":"1996","journal-title":"Nucleic Acids Res"},{"key":"key-10.4103\/1319-3767.182461-39","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1006\/excr.1999.4542","article-title":"Dimethyl sulfoxide restores contact inhibition-induced growth arrest and inhibits cell density-dependent apoptosis in hamster cells","author":"Fiore","year":"1999","journal-title":"Exp Cell Res"},{"key":"key-10.4103\/1319-3767.182461-40","doi-asserted-by":"crossref","first-page":"3402","DOI":"10.1016\/S0021-9258(18)69085-4","article-title":"Immunochemical evidence that three protein A tale of two strands: Reverse-transcriptase polymerase chain reaction detection of hepatitis C virus replication abundance during HL-60 differentiation induced by dimethyl sulfoxide and retinoic acid","author":"Makowske","year":"1988","journal-title":"J Biol Chem"},{"key":"key-10.4103\/1319-3767.182461-41","doi-asserted-by":"crossref","first-page":"17597","DOI":"10.1074\/jbc.M011769200","article-title":"Dimethyl sulfoxide affects the selection of splice sites","author":"Bolduc","year":"2001","journal-title":"J Biol Chem"},{"key":"key-10.4103\/1319-3767.182461-42","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1242\/jcs.88.3.389","article-title":"Movements of fluorescent probes in the mechanism of cell fusion induced by poly (ethylene glycol)","author":"Ahkong","year":"1987","journal-title":"J Cell Sci"},{"key":"key-10.4103\/1319-3767.182461-43","doi-asserted-by":"crossref","first-page":"10253","DOI":"10.1128\/JVI.01059-06","article-title":"Production of infectious hepatitis C virus by well-differentiated, growth-arrested human hepatoma-derived cells","author":"Sainz","year":"2006","journal-title":"J Virol"},{"key":"key-10.4103\/1319-3767.182461-44","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/0005-2736(82)90313-3","article-title":"Effects of poly(ethylene glycol) on liposomes and erythrocytes.Permeability changes and membrane fusion","author":"Aldwinckle","year":"1982","journal-title":"Biochim Biophys Acta"},{"key":"key-10.4103\/1319-3767.182461-45","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1002\/hep.510280501","article-title":"A tale of two strands: Reverse-transcriptase polymerase chain reaction detection of hepatitis C virus replication","author":"Sangar","year":"1998","journal-title":"Hepatology"}],"container-title":["Saudi Journal of Gastroenterology"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T13:23:00Z","timestamp":1786713780000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/1319-3767.182461"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":45,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016]]}},"alternative-id":["182461"],"URL":"https:\/\/doi.org\/10.4103\/1319-3767.182461","relation":{},"ISSN":["1319-3767"],"issn-type":[{"value":"1319-3767","type":"print"}],"subject":[],"published":{"date-parts":[[2016]]}}}