{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T08:09:35Z","timestamp":1787731775137,"version":"build-2784847793"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Dry eye disease has been recognized to be a global public health problem, as it has many consequences starting from daily life activities restrictions to economical costs of management. At present, there is a lack of knowledge regarding the most important risk factors for eye dryness. This problem is becoming important worldwide especially with the increase use of technology, smartphones, computers, and contact lenses. The aim of this systematic review is to determine the most relevant factors associated with dry eye symptoms to help in its early recognition, prevention and reduce its subsequent implications. PRIMSA 2009 checklist was used to conduct this systematic review. The inclusion and exclusion criteria were implemented first. Then, PubMed Database was explored for articles. The data extraction was based on three categories: Sociodemographic, diseases, and medications in the form of odds ratios. Predictive values, confidence intervals, and prevalence were recorded when the data were sufficient. This systematic review included 6 Articles and 48 evaluated variables. Female gender, contact lenses, use of computers, thyroid abnormalities, hypertension, antidepressant, and antihistamine were identified to be the strongest and the most common risk factors for dry eye syndrome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/1319-4534.337849","type":"journal-article","created":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T05:45:37Z","timestamp":1645076737000},"page":"131-139","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":50,"title":["Dry eye syndrome risk factors"],"prefix":"10.4103","volume":"35","author":[{"given":"Zahra A.","family":"I.Y. 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