{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T02:29:30Z","timestamp":1793672970568,"version":"4.5.1"},"reference-count":30,"publisher":"Georg Thieme Verlag KG","issue":"01","license":[{"start":{"date-parts":[[2022,5,21]],"date-time":"2022-05-21T00:00:00Z","timestamp":1653091200000},"content-version":"vor","delay-in-days":2697,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Nucl Med"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:p>Radiosynovectomy is a well-established therapy in arthritis and involves an intra-articular injection of small radioactive particles to treat a synovitis. In Europe, frequent indications are rheumatoid and poly-arthritis. Especially in Germany radiosynovectomy is the second common therapy in Nuclear Medicine with about 40,000-60,000 treated joints per year. In Spain, USA, Turkey, Argentines and Philippines the therapy is more use in hemophilic arthritis with excellent results. Especially in developing countries with low availability of clotting factors, the radiosynovectomy represent a cost effective therapeutic option for repeated bleedings in hemophilic arthropathy. The special focus in these countries is maintaining of mobility and work ability. Often only the knee and medium joints (ankle, elbow and shoulder) are treated using yttrium-90, rhenium-186 or phosphorus-32. However, in rheumatoid arthritis most common affected joints are the fingers. For the treatment in these small joints, erbium-169 is necessary. Unfortunately, erbium-169 is only available in Europe. Further indications for radiosynovectomy are osteoarthritis and the articular effusion after joint replacement. The reported response rates in rheumatoid and poly-arthritis range from 60% to 80% depends from the stage of previous arthrosis. The best effectiveness of therapy was observed in hemophilic arthritis with response rate of 90% and significant reducing of bleeding frequency. The therapy is well-tolerated with low rate of side effects. In respect of the specific uptake of particles in the synovia and short range of beta radiation, the radiation exposure outside the joint is very low. The radiosynovectomy has efforts in comparison to surgical synovectomy: it\u2032s a minor intervention with low costs; and simultaneous treatments of multiple joints or treatment in short intervals are possible. The presented paper summarized the published papers and reports our own experiences in &gt;15,000 treated joints.<\/jats:p>","DOI":"10.4103\/1450-1147.150509","type":"journal-article","created":{"date-parts":[[2015,2,2]],"date-time":"2015-02-02T08:45:28Z","timestamp":1422866728000},"page":"10-15","source":"Crossref","is-referenced-by-count":78,"title":["Radiosynovectomy in the Therapeutic Management of Arthritis"],"prefix":"10.1055","volume":"14","author":[{"given":"Liepe","family":"Knut","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Klinikum Frankfurt (Oder) GmbH, Frankfurt (Oder), Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,5,21]]},"reference":[{"key":"key-10.4103\/1450-1147.150509-1","first-page":"317","volume-title":"Radiosynovectomy using yttrium-90, phosphorus-32 or rhenium-188 radiocolloids versus corticoid instillation for rheumatoid arthritis of the knee","author":"Liepe","year":"2011","journal-title":"Ann Nucl Med"},{"key":"key-10.4103\/1450-1147.150509-2","first-page":"344","volume-title":"Effects of radiosynovectomy with p-32 colloid therapy in hemophilia and rheumatoid arthritis","author":"Soroa","year":"2005","journal-title":"Cancer Biother Radiopharm"},{"key":"key-10.4103\/1450-1147.150509-3","first-page":"1036","volume-title":"Osmic acid revisited: Factors that predict a favourable response","author":"Bessant","year":"2003","journal-title":"Rheumatology (Oxford)"},{"key":"key-10.4103\/1450-1147.150509-4","first-page":"435","volume-title":"Evaluation of intra-articular colloidal gold au 198 in the treatment of presistent knee effusions","author":"Ansell","year":"1963","journal-title":"Ann Rheum Dis"},{"key":"key-10.4103\/1450-1147.150509-5","first-page":"95","volume-title":"Effects and side effects of radiosynovectomy with Yttrium 90 on rheumatic joint cartilage","author":"Kerschbaumer","year":"1979","journal-title":"Arch 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yttrium-90 citrate colloid","author":"Turkmen","year":"2007","journal-title":"Cancer Biother Radiopharm"},{"key":"key-10.4103\/1450-1147.150509-18","first-page":"207","volume-title":"Activity leakage and radiation exposure in radiation synovectomy of the knee: Influence of different therapeutic modalities","author":"Klett","year":"1999","journal-title":"Z Rheumatol"},{"key":"key-10.4103\/1450-1147.150509-19","first-page":"405","volume-title":"Exposure of medical personnel to radiation during radionuclide therapy practices","author":"Lancelot","year":"2008","journal-title":"Nucl Med Commun"},{"key":"key-10.4103\/1450-1147.150509-20","first-page":"104","volume-title":"Beta-radiation exposure at the finger tips during the radionuclide synovectomy","author":"Liepe","year":"2003","journal-title":"Nuklearmedizin"},{"key":"key-10.4103\/1450-1147.150509-21","first-page":"151","volume-title":"Radiation protection in radiosynovectomy of the knee","author":"Liepe","year":"2005","journal-title":"Health Phys"},{"key":"key-10.4103\/1450-1147.150509-22","first-page":"683","volume-title":"Clinical outcome of radiosynoviorthesis: A meta-analysis including 2190 treated joints","author":"Kresnik","year":"2002","journal-title":"Nucl Med Commun"},{"key":"key-10.4103\/1450-1147.150509-23","first-page":"409","volume-title":"Phosphate-32 colloid radiosynovectomy in hemophilia: Outcome of 125 procedures","author":"Siegel","year":"2001","journal-title":"Clin Orthop Relat Res"},{"key":"key-10.4103\/1450-1147.150509-24","first-page":"547","volume-title":"Isotopic synovectomy with P-32 in paediatric patients with haemophilia","author":"Mathew","year":"2000","journal-title":"Haemophilia"},{"key":"key-10.4103\/1450-1147.150509-25","first-page":"1113","volume-title":"Radiation synovectomy revisited","author":"Deutsch","year":"1993","journal-title":"Eur J Nucl Med"},{"key":"key-10.4103\/1450-1147.150509-26","unstructured":"Liepe K, Zagnun J, Soroa VE, Barrenechea E, Shrikant S, Jeong JM. Radiosynovectomy using yttrium-90, phosphorus-32 and rhenium-188 colloids in rheumatoid arthritis. Eur J Nucl Med 2007;34:476.(Suppl.)."},{"key":"key-10.4103\/1450-1147.150509-27","unstructured":"Zagnun J, Liepe K, Soroa VE, Barrenechea E, Gaudiano J, Solav SV, et al. Managment of haemarthrosis applying radiosynovectomy in haemophilia patients with emphasis on developing countries. 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