{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T07:03:37Z","timestamp":1760425417945},"reference-count":10,"publisher":"Georg Thieme Verlag KG","issue":"01","license":[{"start":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T00:00:00Z","timestamp":1652832000000},"content-version":"vor","delay-in-days":1963,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Nucl Med"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p>Case report describing the finding of central pontine myelinolysis (CPM) using combined fluorine-18 ( 18 F)-fluorodeoxyglucose (FDG) positron emission tomography\/computed tomography (PET\/CT). The patient was a known alcoholic who, during admission was under treatment for hyponatremia, showed a significant decline in both motor and cognitive function. Combined 18 F-FDG PET\/CT showed localized FDG uptake in the pons, consistent with the finding of CPM observed on magnetic resonance imaging (MRI). CPM is a demyelinating lesion of the pons, resulting in several neurological symptoms. The exact cause of CPM is not clear, but a strong relations between loss of myelin and osmotic stress exists, especially during rapid correction of hyponatremia. The osmotic stress is thought to induce disruption of the blood-brain barrier, allowing access for inflammatory mediators in extravascular brain tissue, which most likely attracts glial cells of the brain, attracts macrophages and activates astocytes. We suggest that metabolism in these activated cells could be responsible for the localized FDG uptake during active CPM.<\/jats:p>","DOI":"10.4103\/1450-1147.174707","type":"journal-article","created":{"date-parts":[[2016,1,22]],"date-time":"2016-01-22T06:53:35Z","timestamp":1453445615000},"page":"56-58","source":"Crossref","is-referenced-by-count":10,"title":["Central pontine myelinolysis and localized fluorodeoxyglucose uptake seen on 18 f-FDG PET\/CT"],"prefix":"10.1055","volume":"16","author":[{"given":"Frederik","family":"R\u00f8nne","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine, Bispebjerg University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peer","family":"Tfelt-Hansen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Glostrup University Hospital, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lene","family":"R\u00f8rdam","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine, Bispebjerg University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,5,18]]},"reference":[{"key":"key-10.4103\/1450-1147.174707-1","first-page":"154","volume-title":"Central pontine myelinolysis: A hitherto undescribed disease occurring in alcoholic and malnourished patients","author":"Adams","year":"1959","journal-title":"AMA Arch Neurol Psychiatry"},{"key":"key-10.4103\/1450-1147.174707-2","first-page":"561","volume-title":"Osmotic demyelination syndrome","author":"King","year":"2010","journal-title":"Am J Med Sci"},{"key":"key-10.4103\/1450-1147.174707-3","first-page":"221","volume-title":"Blood-brain barrier disruption and complement activation in the brain following rapid correction of chronic hyponatremia","author":"Baker","year":"2000","journal-title":"Exp Neurol"},{"key":"key-10.4103\/1450-1147.174707-4","first-page":"647","volume-title":"Central pontine and extrapontine myelinolysis after alcohol withdrawal","author":"Yoon","year":"2008","journal-title":"Alcohol Alcohol"},{"key":"key-10.4103\/1450-1147.174707-5","first-page":"167","volume-title":"Asymptomatic central pontine myelinolysis: A case report","author":"Shah","year":"2012","journal-title":"Case Rep Neurol"},{"key":"key-10.4103\/1450-1147.174707-6","first-page":"99","volume-title":"A case of central pontine and extrapontine myelinolysis with early hypermetabolism on 18FDG-PET scan","author":"Roh","year":"1998","journal-title":"J Korean Med Sci"},{"key":"key-10.4103\/1450-1147.174707-7","first-page":"369","volume-title":"Central pontine myelinolysis: A metabolic disorder of myelin","author":"Hurley","year":"2011","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"key-10.4103\/1450-1147.174707-8","first-page":"1151","volume-title":"Demyelinating diseases","author":"Love","year":"2006","journal-title":"J Clin Pathol"},{"key":"key-10.4103\/1450-1147.174707-9","first-page":"361","volume-title":"A case of asymptomatic pontine myelinolysis","author":"Lupato","year":"2010","journal-title":"Neurol Sci"},{"key":"key-10.4103\/1450-1147.174707-10","first-page":"157","volume-title":"Cerebellar ataxia with complete clinical recovery and resolution of MRI lesions related to central pontine myelinolysis: Case report and literature review","author":"Dolciotti","year":"2010","journal-title":"Case Rep Neurol"}],"container-title":["World Journal of Nuclear Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.4103\/1450-1147.174707.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T22:58:36Z","timestamp":1652914716000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.4103\/1450-1147.174707"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":10,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2022,5,18]]},"published-print":{"date-parts":[[2017,1]]}},"URL":"https:\/\/doi.org\/10.4103\/1450-1147.174707","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["1450-1147","1607-3312"],"issn-type":[{"value":"1450-1147","type":"print"},{"value":"1607-3312","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1]]}}}