{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T16:09:47Z","timestamp":1761581387223},"reference-count":15,"publisher":"Georg Thieme Verlag KG","issue":"03","license":[{"start":{"date-parts":[[2022,5,19]],"date-time":"2022-05-19T00:00:00Z","timestamp":1652918400000},"content-version":"vor","delay-in-days":2148,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Nucl Med"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:p>Cancer-associated inflammation has been receiving increased attention due to its role in cancer development. It is known that tumors can cause an inflammatory reaction and inflammatory cells play an important role in neoplastic growth. In this study, we aimed to investigate any relationship between bone metastases and the neutrophil-to-lymphocyte ratio (NLR). Patients who were referred for bone scintigraphy to investigate bone metastasis were enrolled in the study. Patients\u2032 hematological parameters were obtained from the hospital database retrospectively. Patients with a nonmetastatic bone scan were categorized as Group A (N = 171), patients who had metastatic bone disease without any other organ metastases were categorized as group B (N = 25), and patients who had metastatic bone disease with the other organ metastases were categorized as Group C (N = 48). The median NLR of the patients in Group A was 2.55 (range: 0.38-20.7), in Group B was 2.83 (range: 1.56-31.8), and in Group C was 4.12 (range: 1.79-38). NLR was significantly higher in Group C patients compared to Group A and B patients (P &lt; 0.001). In conclusion, the NLR is significantly associated with the other organ metastases but has no significant correlation with bone metastases.<\/jats:p>","DOI":"10.4103\/1450-1147.174711","type":"journal-article","created":{"date-parts":[[2016,1,22]],"date-time":"2016-01-22T06:53:35Z","timestamp":1453445615000},"page":"196-199","source":"Crossref","is-referenced-by-count":9,"title":["Can neutrophil\/lymphocyte ratio be a predictor for bone metastases of solid tumors?"],"prefix":"10.1055","volume":"15","author":[{"given":"Billur","family":"Caliskan","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Abant Izzet Baysal University, Bolu, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ay\u015fe","family":"Korkmaz","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Abant Izzet Baysal University, Bolu, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,5,19]]},"reference":[{"key":"key-10.4103\/1450-1147.174711-1","first-page":"31","volume-title":"A systematic review and meta-analysis on the impact of pre-operative neutrophil lymphocyte ratio on long term outcomes after curative intent resection of solid tumours","author":"Paramanathan","year":"2014","journal-title":"Surg Oncol"},{"key":"key-10.4103\/1450-1147.174711-2","first-page":"860","volume-title":"Inflammation and cancer","author":"Coussens","year":"2002","journal-title":"Nature"},{"key":"key-10.4103\/1450-1147.174711-3","first-page":"2403","volume-title":"Prognostic role of neutrophil-to-lymphocyte ratio in colorectal cancer: A systematic review and meta-analysis","author":"Li","year":"2014","journal-title":"Int J Cancer"},{"key":"key-10.4103\/1450-1147.174711-4","first-page":"5237","volume-title":"Are neutrophil\/lymphocyte and platelet\/lymphocyte rates in patients with non-small cell lung cancer associated with treatment response and prognosis?","author":"Unal","year":"2013","journal-title":"Asian Pac J Cancer Prev"},{"key":"key-10.4103\/1450-1147.174711-5","first-page":"55","volume-title":"Usefulness of pretreatment neutrophil to lymphocyte ratio in predicting disease-specific survival in breast cancer patients","author":"Noh","year":"2013","journal-title":"J Breast Cancer"},{"key":"key-10.4103\/1450-1147.174711-6","first-page":"e78225","volume-title":"External validation of the derived neutrophil to lymphocyte ratio as a prognostic marker on a large cohort of pancreatic cancer patients","author":"Szkandera","year":"2013","journal-title":"PloS One"},{"key":"key-10.4103\/1450-1147.174711-7","first-page":"735","volume-title":"The neutrophil\/lymphocyte ratio is an independent prognostic indicator in patients with bone metastasis","author":"Wang","year":"2011","journal-title":"Oncol Lett"},{"key":"key-10.4103\/1450-1147.174711-8","first-page":"539","volume-title":"Inflammation and cancer: Back to Virchow?","author":"Balkwill","year":"2001","journal-title":"Lancet"},{"key":"key-10.4103\/1450-1147.174711-9","first-page":"436","volume-title":"Cancer-related inflammation","author":"Mantovani","year":"2008","journal-title":"Nature"},{"key":"key-10.4103\/1450-1147.174711-10","first-page":"283","volume-title":"Platelets and granulocytes, in particular the neutrophils, form important compartments for circulating vascular endothelial growth factor","author":"Kusumanto","year":"2003","journal-title":"Angiogenesis"},{"key":"key-10.4103\/1450-1147.174711-11","first-page":"64","volume-title":"Circulating lymphocyte is an important determinant of the effectiveness of preoperative radiotheraphy in advanced rectal cancer","author":"Kitayama","year":"2011","journal-title":"BMC Cancer"},{"key":"key-10.4103\/1450-1147.174711-12","first-page":"6412","volume-title":"Lymphocytic reaction to colorectal cancer is associated with longer survival, independent of lymph node count, microsatellite instability, and CpG island methylator phenotype","author":"Ogino","year":"2009","journal-title":"Clin Cancer Res"},{"key":"key-10.4103\/1450-1147.174711-13","first-page":"1949","volume-title":"Tumor-infiltrating CD8+lymphocytes predict clinical outcome in breast cancer","author":"Mahmoud","year":"2011","journal-title":"J Clin Oncol"},{"key":"key-10.4103\/1450-1147.174711-14","first-page":"1303","volume-title":"Prognostic value of tumor infiltrating lymphocytes in the vertical growth phase of primary cutaneous melanoma","author":"Clemente","year":"1996","journal-title":"Cancer"},{"key":"key-10.4103\/1450-1147.174711-15","first-page":"841","volume-title":"Predicting survival for multipl myeloma patients using baseline neutrophil\/lymphocyte ratio","author":"Kelkitli","year":"2014","journal-title":"Ann Hematol"}],"container-title":["World Journal of Nuclear Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.4103\/1450-1147.174711.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,19]],"date-time":"2022-05-19T22:31:51Z","timestamp":1652999511000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.4103\/1450-1147.174711"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":15,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2022,5,19]]},"published-print":{"date-parts":[[2016,7]]}},"URL":"https:\/\/doi.org\/10.4103\/1450-1147.174711","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["1450-1147","1607-3312"],"issn-type":[{"value":"1450-1147","type":"print"},{"value":"1607-3312","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7]]}}}