{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T12:01:36Z","timestamp":1704196896550},"reference-count":19,"publisher":"Georg Thieme Verlag KG","issue":"04","license":[{"start":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T00:00:00Z","timestamp":1652832000000},"content-version":"vor","delay-in-days":1690,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Nucl Med"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:p>The aim of the study was to evaluate the diagnostic accuracy of positron emission tomography\/computed tomography (PET\/CT) in staging patients with primary cutaneous malignant melanoma (CMM). We further compared the performance of PET\/CT with conventional imaging (CI) (CT and ultrasonography [USG]) and assessed the impact of PET\/CT on disease management. This was a single institution, prospective, double-blinded study, recruiting a total of 70 treatment na\u00efve patients. The sensitivity, specificity, negative predictive value (NPV), and positive predictive value (PPV) of PET\/CT for N staging were 86%, 96%, 80%, and 97%, respectively. The sensitivity, specificity, NPV, and PPV of PET\/CT for M staging were 87%, 100%, 93%, and 100%, respectively. The diagnostic accuracy of the PET\/CT was superior to CI for N staging (90% vs. 84% for CT and 80% for USG) and M staging (95% vs. 90% for CT). No statistically significant difference was noted between PET\/CT and CI for N staging (PET\/CT vs. CT, P = 0.125; PET\/CT vs. USG, P- 0.063) or M staging (PET\/CT vs. CT, P = 0.125). PET\/CT upstaged 23% of patients with clinically localized disease and 58% of patients with clinically palpable regional nodes. To conclude, fluorodeoxyglucose PET\/CT is a highly sensitive and specific imaging modality for preoperative staging of primary CMMs. PET\/CT impacts disease management in significant number of patients and should be especially recommended in all patients with clinically palpable regional nodes.<\/jats:p>","DOI":"10.4103\/1450-1147.215491","type":"journal-article","created":{"date-parts":[[2017,9,22]],"date-time":"2017-09-22T09:00:58Z","timestamp":1506070858000},"page":"286-292","source":"Crossref","is-referenced-by-count":5,"title":["Diagnostic accuracy and impact of fluorodeoxyglucose positron emission tomography\/computed tomography in preoperative staging of cutaneous malignant melanoma: Results of a prospective study in Indian population"],"prefix":"10.1055","volume":"16","author":[{"given":"Piyush","family":"Chandra","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Molecular Imaging, Tata Memorial Hospital, Mumbai, Maharashtra"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nilendu","family":"Purandare","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Molecular Imaging, Tata Memorial Hospital, Mumbai, Maharashtra"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sneha","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Molecular Imaging, Tata Memorial Hospital, Mumbai, Maharashtra"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Archi","family":"Agrawal","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Molecular Imaging, Tata Memorial Hospital, Mumbai, Maharashtra"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajay","family":"Puri","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Bone and Soft Tissue Disease Management Group, Tata Memorial Hospital, Mumbai, Maharashtra"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashish","family":"Gulia","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Bone and Soft Tissue Disease Management Group, Tata Memorial Hospital, Mumbai, Maharashtra"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Venkatesh","family":"Rangarajan","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Molecular Imaging, Tata Memorial Hospital, Mumbai, Maharashtra"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,5,18]]},"reference":[{"key":"key-10.4103\/1450-1147.215491-1","first-page":"3","volume-title":"Melanoma epidemiology and trends","author":"Garbe","year":"2009","journal-title":"Clin Dermatol"},{"key":"key-10.4103\/1450-1147.215491-2","first-page":"114","volume-title":"A brief history of melanoma: From mummies to mutations","author":"Rebecca","year":"2012","journal-title":"Melanoma Res"},{"key":"key-10.4103\/1450-1147.215491-3","first-page":"185","volume-title":"Racial differences in melanoma incidence","author":"Crombie","year":"1979","journal-title":"Br J Cancer"},{"key":"key-10.4103\/1450-1147.215491-4","first-page":"17","volume-title":"Melanoma: Differences between Asian and Caucasian patients","author":"Lee","year":"2012","journal-title":"Ann Acad Med Singapore"},{"key":"key-10.4103\/1450-1147.215491-5","unstructured":"Globocan 2012 \u2013 Population Factsheets \u2013 India. Available from: http: \/\/www.globocan.iarc.fr\/Pages\/fact_sheets_population.aspx. [Last accessed on 2016 Oct 03]."},{"key":"key-10.4103\/1450-1147.215491-6","first-page":"3622","volume-title":"Prognostic factors analysis of 17,600 melanoma patients: Validation of the American Joint Committee on Cancer melanoma staging system","author":"Balch","year":"2001","journal-title":"J Clin Oncol"},{"key":"key-10.4103\/1450-1147.215491-7","first-page":"1178","volume-title":"Diagnostic performance of whole body dual modality 18F-FDG PET\/CT imaging for N-and M-staging of malignant melanoma: Experience with 250 consecutive patients","author":"Reinhardt","year":"2006","journal-title":"J Clin Oncol"},{"key":"key-10.4103\/1450-1147.215491-8","first-page":"4774","volume-title":"Prospective comparison of [18F]fluorodeoxyglucose positron emission tomography and computed tomography in patients with melanoma with palpable lymph node metastases: Diagnostic accuracy and impact on treatment","author":"Bastiaannet","year":"2009","journal-title":"J Clin Oncol"},{"key":"key-10.4103\/1450-1147.215491-9","first-page":"902","volume-title":"PET\/CT in the management of patients with stage IIIC and IV metastatic melanoma considered candidates for surgery: Evaluation of the additive value after conventional imaging","author":"Bronstein","year":"2012","journal-title":"AJR Am J Roentgenol"},{"key":"key-10.4103\/1450-1147.215491-10","first-page":"557","volume-title":"Prospective comparison of 18F-fluorodeoxyglucose positron emission tomography\/computed tomography and whole-body magnetic resonance imaging in staging of advanced malignant melanoma","author":"Pfannenberg","year":"2007","journal-title":"Eur J Cancer"},{"key":"key-10.4103\/1450-1147.215491-11","first-page":"395","volume-title":"Melanoma, version 2.2013: Featured updates to the NCCN guidelines","author":"Coit","year":"2013","journal-title":"J Natl Compr Canc Netw"},{"key":"key-10.4103\/1450-1147.215491-12","first-page":"1508","volume-title":"Prospective study of fluorodeoxyglucose-positron emission tomography imaging of lymph node basins in melanoma patients undergoing sentinel node biopsy","author":"Wagner","year":"1999","journal-title":"J Clin Oncol"},{"key":"key-10.4103\/1450-1147.215491-13","first-page":"2674","volume-title":"Comparison of positron emission tomography scanning and sentinel node biopsy in the detection of micrometastases of primary cutaneous malignant melanoma","author":"Acland","year":"2001","journal-title":"J Clin Oncol"},{"key":"key-10.4103\/1450-1147.215491-14","first-page":"1491","volume-title":"Which kinds of lymph node metastases can FDG PET detect.A clinical study in melanoma?","author":"Crippa","year":"2000","journal-title":"J Nucl Med"},{"key":"key-10.4103\/1450-1147.215491-15","first-page":"910","volume-title":"Diagnostic accuracy of contrast-enhanced FDG-PET\/CT in primary staging of cutaneous malignant melanoma","author":"Veit-Haibach","year":"2009","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"key-10.4103\/1450-1147.215491-16","first-page":"2773","volume-title":"Utility of preoperative 18F-FDG PET\/CT and brain MRI in melanoma patients with palpable lymph node metastases","author":"Aukema","year":"2010","journal-title":"Ann Surg Oncol"},{"key":"key-10.4103\/1450-1147.215491-17","first-page":"172","volume-title":"Popliteal lymph node metastasis from primary cutaneous melanoma","author":"Thompson","year":"2000","journal-title":"Eur J Surg Oncol"},{"key":"key-10.4103\/1450-1147.215491-18","first-page":"1002","volume-title":"Lymphatic drainage to the popliteal basin in distal lower extremity malignant melanoma","author":"Menes","year":"2004","journal-title":"Arch Surg"},{"key":"key-10.4103\/1450-1147.215491-19","first-page":"443","volume-title":"Malignant melanoma metastasis to the sentinel node in the popliteal fossa","author":"Georgeu","year":"2002","journal-title":"Br J Plast Surg"}],"container-title":["World Journal of Nuclear Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.4103\/1450-1147.215491.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T22:49:10Z","timestamp":1652914150000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.4103\/1450-1147.215491"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":19,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2022,5,18]]},"published-print":{"date-parts":[[2017,10]]}},"URL":"https:\/\/doi.org\/10.4103\/1450-1147.215491","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["1450-1147","1607-3312"],"issn-type":[{"value":"1450-1147","type":"print"},{"value":"1607-3312","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10]]}}}