{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:43:28Z","timestamp":1787071408799,"version":"build-2736575974"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>One of the major complications of cardiac surgery is the presence of post-operative bleeding. The aim of the present study was to investigate the topical application of tranexamic acid in the pericardial cavity on post-operative bleeding in off-pump coronary artery bypass graft (CABG) surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>This study was on 71 patients who underwent off-pump CABG. The anesthesia and surgery methods were the same for all patients. Patients were assigned to two equal groups. In the first group, 1 g of tranexamic acid in 100 mL of normal saline solution (NSS) was applied to pericardium and mediastinal cavity at the end of surgery. In the second group, only 100 mL of NSS was applied. Chest drainage of the patients after 24 h and the amounts of blood and blood products transfusion were also recorded during this time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Patients were the same regarding demographic information and surgery. The average volume of blood loss after 24 h was 366 mL for the first group and 788 mL for the control group. There was a statistically significant difference between the two groups (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). The amount of packed red blood cells transfusion in the first group was less than that of the control group, which was not statistically significant. There was no statistically significant difference between the amount of hemoglobin, hematocrit, platelets, prothrombin time and partial thromboplastin time in the post-operative stage in the two groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The topical application of tranexamic acid in off-pump CABG patients leads to a decreased post-operative blood loss.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/1658-354x.130724","type":"journal-article","created":{"date-parts":[[2014,4,15]],"date-time":"2014-04-15T06:27:05Z","timestamp":1397543225000},"page":"224-228","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":14,"title":["Evaluations of topical application of tranexamic acid on post-operative blood loss in off-pump coronary artery bypass surgery"],"prefix":"10.4103","volume":"8","author":[{"given":"Habibollah","family":"Hosseini","sequence":"first","affiliation":[{"name":"Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali Akbar","family":"Rahimianfar","sequence":"additional","affiliation":[{"name":"Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Hassan","family":"Abdollahi","sequence":"additional","affiliation":[{"name":"Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Hossein","family":"Moshtaghiyoon","sequence":"additional","affiliation":[{"name":"Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahdi","family":"Haddadzadeh","sequence":"additional","affiliation":[{"name":"Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asefeh","family":"Fekri","sequence":"additional","affiliation":[{"name":"Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazem","family":"Barzegar","sequence":"additional","affiliation":[{"name":"Faculty member at the English Language Department, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Rahimianfar","sequence":"additional","affiliation":[{"name":"Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20250926","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1067\/mtc.2002.117281","article-title":"Does tranexamic acid reduce desmopressin-induced hyperfibrinolysis?","volume":"123","author":"Ozal","year":"2002","journal-title":"J Thorac Cardiovasc Surg"},{"key":"R2-20250926","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1749-8090-4-25","article-title":"Can local application of Tranexamic acid reduce post-coronary bypass surgery blood loss. A randomized controlled trial?","volume":"4","author":"Fawzy","year":"2009","journal-title":"J Cardiothorac Surg"},{"key":"R3-20250926","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1053\/j.jvca.2010.08.012","article-title":"Tranexamic acid is associated with less blood transfusion in off-pump coronary artery bypass graft surgery: A systematic review and meta-analysis","volume":"25","author":"Adler Ma","year":"2011","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"R4-20250926","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1213\/ANE.0b013e3182264a11","article-title":"Tranexamic acid reduces blood loss after off-pump coronary surgery: A prospective, randomized, double-blind, placebo-controlled study","volume":"115","author":"Wang","year":"2012","journal-title":"Anesth Analg"},{"key":"R5-20250926","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.ejcts.2006.12.003","article-title":"Topical use of antifibrinolytic agents reduces postoperative bleeding: A double-blind, prospective, randomized study","volume":"31","author":"Baric","year":"2007","journal-title":"Eur J Cardiothorac Surg"},{"key":"R6-20250926","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/j.1365-2516.2006.01386.x","article-title":"Topical use of tranexamic acid to control perioperative local bleeding in gynaecology patients with clotting disorders: Two cases","volume":"13","author":"Sarris","year":"2007","journal-title":"Haemophilia"},{"key":"R7-20250926","first-page":"504","article-title":"Tranexamic acid mouthwash -A prospective randomized study of a 2-day regimen vs 5-day regimen to prevent postoperative bleeding in anticoagulated patients requiring dental extractions","volume":"32","author":"Carter","year":"2003","journal-title":"Int J Oral Maxillofac Surg"},{"key":"R8-20250926","doi-asserted-by":"crossref","first-page":"737","DOI":"10.2500\/ajr.2007.21.3097","article-title":"Effects of topical antifibrinolytics in endoscopic sinus surgery: A pilot randomized controlled trial","volume":"21","author":"Athanasiadis","year":"2007","journal-title":"Am J Rhinol"},{"key":"R9-20250926","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1017\/S0265021505001894","article-title":"Effect of topical tranexamic acid in open heart surgery","volume":"23","author":"Abul-Azm","year":"2006","journal-title":"Eur J Anaesthesiol"},{"key":"R10-20250926","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.2106\/JBJS.I.01518","article-title":"Topical application of tranexamic acid reduces postoperative blood loss in total knee arthroplasty: A randomized, controlled trial","volume":"92","author":"Wong","year":"2010","journal-title":"J Bone Joint Surg Am"},{"key":"R11-20250926","first-page":"116","article-title":"Evaluation of the effects of systematic or topical use of tranexamic acid and aprotinin on the blood loss and the used amount of blood products following cardiopulmonary bypass surgery","volume":"5","author":"Kurt","year":"2011","journal-title":"AJCI"}],"container-title":["Saudi Journal of Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01437113-201408020-00015","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:45:43Z","timestamp":1787067943000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01437113-201408020-00015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4]]},"references-count":11,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.4103\/1658-354x.130724","relation":{},"ISSN":["1658-354X","0975-3125"],"issn-type":[{"value":"1658-354X","type":"print"},{"value":"0975-3125","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4]]}}}