{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:44:08Z","timestamp":1787071448212,"version":"build-2736575974"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:p>Multiple endocrine neoplasia 2A (MEN 2A), or Sipple's syndrome is a rare inherited dominant syndrome, characterised by medullary thyroid carcinoma, adrenal pheochromocytoma and hyperparathyroidism, due to specific RET proto-oncogene mutations. The women with MEN 2A syndrome are at risk of complicated pregnancy because of unrecognised pheochromocytoma and transmission of RET mutation to the progeny. We report a case of a woman with MEN 2A diagnosed in early pregnancy. Alpha-blockade medical therapy was used effectively and time was given for fetal maturation. Uncomplicated vaginal delivery performed under epidural analgesia. Six weeks postpartum adrenalectomy, thyroidectomy and parathyroidectomy were performed uneventfully.<\/jats:p>","DOI":"10.4103\/1658-354x.136652","type":"journal-article","created":{"date-parts":[[2014,7,10]],"date-time":"2014-07-10T08:33:25Z","timestamp":1404981205000},"page":"437-439","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Vaginal delivery in a patient with pheochromocytoma, medullary thyroid cancer, and primary hyperparathyroidism (multiple endocrine neoplasia type 2A, Sipple's syndrome)"],"prefix":"10.4103","volume":"8","author":[{"given":"Muhammad Anas","family":"Muzannara","sequence":"first","affiliation":[{"name":"Department of Anesthesia, King Abdulaziz Medical City, Riyadh, KSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasser","family":"Tawfeeq","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, King Abdulaziz Medical City, Riyadh, KSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmood","family":"Nasir","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, King Abdulaziz Medical City, Riyadh, KSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Khulaif","family":"Al Harbi","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, King Abdulaziz Medical City, Riyadh, KSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georges","family":"Geldhof","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, King Abdulaziz Medical City, Riyadh, KSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vassilios","family":"Dimitriou","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, King Abdulaziz Medical City, Riyadh, KSA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20250926","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1097\/GIM.0b013e318216cc6d","article-title":"Multiple endocrine neoplasia type 2: An overview","volume":"13","author":"Moline","year":"2011","journal-title":"Genet Med"},{"key":"R2-20250926","first-page":"226","article-title":"Pheochromocytoma storm presenting as cardiovascular collapse at term pregnancy","volume":"5","author":"Langerman","year":"2004","journal-title":"Rev Cardiovasc Med"},{"key":"R3-20250926","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1530\/eje.0.1510771","article-title":"Multiple endocrine neoplasia 2A syndrome presenting as peripartum cardiomyopathy due to catecholamine excess","volume":"151","author":"Kim","year":"2004","journal-title":"Eur J Endocrinol"},{"key":"R4-20250926","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0028-2243(85)90074-7","article-title":"Cerebral haemorrhage in a pregnant woman with a multiple endocrine neoplasia syndrome (type 2A or Sipple's syndrome)","volume":"20","author":"Moraca-Kvapilov\u00e1","year":"1985","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"R5-20250926","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1007\/s00404-009-1057-5","article-title":"Bilateral pheochromocytoma during the postpartum period","volume":"280","author":"Wattanachanya","year":"2009","journal-title":"Arch Gynecol Obstet"},{"key":"R6-20250926","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1001\/jama.1996.03540190047028","article-title":"The relationship between specific RET proto-oncogene mutations and disease phenotype in multiple endocrine neoplasia type 2.International RET mutation consortium analysis","volume":"276","author":"Eng","year":"1996","journal-title":"JAMA"},{"key":"R7-20250926","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1089\/thy.2008.0403","article-title":"Medullary thyroid cancer: Management guidelines of the American Thyroid Association","volume":"19","author":"Kloos","year":"2009","journal-title":"Thyroid"},{"key":"R8-20250926","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1002\/bjs.8976","article-title":"Systematic review of phaeochromocytoma in pregnancy","volume":"100","author":"Biggar","year":"2013","journal-title":"Br J Surg"},{"key":"R9-20250926","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1111\/j.1471-0528.1989.tb03262.x","article-title":"Phaeochromocytoma in pregnancy. Five cases and a review of the literature","volume":"96","author":"Harper","year":"1989","journal-title":"Br J Obstet Gynaecol"},{"key":"R10-20250926","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1089\/jwh.2007.0382","article-title":"Pheochromocytoma in pregnancy: When is operative intervention indicated?","volume":"16","author":"Junglee","year":"2007","journal-title":"J Womens Health (Larchmt)"}],"container-title":["Saudi Journal of Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01437113-201408030-00033","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:46:18Z","timestamp":1787067978000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01437113-201408030-00033"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.4103\/1658-354x.136652","relation":{},"ISSN":["1658-354X","0975-3125"],"issn-type":[{"value":"1658-354X","type":"print"},{"value":"0975-3125","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7]]}}}