{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T12:41:40Z","timestamp":1794573700935,"version":"4.9.1"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:p>\n                    Malignant hyperthermia (MH) is a rare hypermetabolic disorder of skeletal muscles that manifests as a life-threatening crisis in susceptible individuals, after exposure to triggering agents, most commonly halothane and succinylcholine. MH presents with multiple nonspecific signs and laboratory findings such as tachycardia, hyperthermia, hypercarbia, acidosis, and muscle rigidity. Caffeine halothane contracture test is not available at most centers in India. Larach\n                    <jats:italic toggle=\"yes\">et al<\/jats:italic>\n                    . have described a clinical grading scale for determining the MH raw score based on clinical findings and biochemical tests. The high degree of suspicion, early recognition and aggressive treatment should commence immediately. It is imperative to avoid triggering agents, such as volatile anesthetics and succinylcholine, and promote the use of total intravenous anesthesia in MH susceptible patients. We report a case of 6-month-old child undergoing laparotomy under general anesthesia, who presented with signs and symptoms of MH, had MH rank 5 and raw score 36.\n                  <\/jats:p>","DOI":"10.4103\/1658-354x.174915","type":"journal-article","created":{"date-parts":[[2016,1,27]],"date-time":"2016-01-27T00:27:33Z","timestamp":1453854453000},"page":"353-355","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["Malignant hyperthermia in a 6-month-old infant"],"prefix":"10.4103","volume":"10","author":[{"given":"PR","family":"Mathur","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Jawaharlal Nehru Medical College, Ajmer, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Rundla","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Fortis Escorts Hospital, Jaipur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Jawaharlal Nehru Medical College, Ajmer, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Mathur","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Jawaharlal Nehru Medical College, Ajmer, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20250926","first-page":"1039","article-title":"Creatine kinase alterations after acute malignant hyperthermia episodes and common surgical procedures","volume":"81","author":"Antognini","year":"1995","journal-title":"Anesth Analg"},{"key":"R2-20250926","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1093\/bja\/aer132","article-title":"Malignant hyperthermia: Pharmacology of triggering","volume":"107","author":"Hopkins","year":"2011","journal-title":"Br J Anesth"},{"key":"R3-20250926","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0031-3955(16)38700-4","article-title":"Malignant hyperthermia","volume":"41","author":"Kaus","year":"1994","journal-title":"Pediatr Clin North Am"},{"key":"R4-20250926","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1097\/00000542-199404000-00008","article-title":"A clinical grading scale to predict malignant hyperthermia susceptibility","volume":"80","author":"Larach","year":"1994","journal-title":"Anesthesiology"},{"key":"R5-20250926","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1213\/00000539-198910000-00003","article-title":"Malignant hyperthermia in humans \u2013 standardization of contracture testing protocol","volume":"69","author":"Melton","year":"1989","journal-title":"Anesth Analg"},{"key":"R6-20250926","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1093\/bja\/aeq243","article-title":"Recognizing and managing a malignant hyperthermia crisis: Guidelines from the European Malignant Hyperthermia Group","volume":"105","author":"Glahn","year":"2010","journal-title":"Br J Anesth"},{"key":"R7-20250926","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1213\/ANE.0b013e3181c6b9b2","article-title":"Clinical presentation, treatment, and complications of malignant hyperthermia in North America from 1987 to 2006","volume":"110","author":"Larach","year":"2010","journal-title":"Anesth Analg"},{"key":"R8-20250926","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1056\/NEJMsa1204720","article-title":"Simulation-based trial of surgical-crisis checklists","volume":"368","author":"Arriaga","year":"2013","journal-title":"N Engl J Med"}],"container-title":["Saudi Journal of Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01437113-201610030-00024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:45:32Z","timestamp":1787067932000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01437113-201610030-00024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":8,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.4103\/1658-354x.174915","relation":{},"ISSN":["1658-354X","0975-3125"],"issn-type":[{"value":"1658-354X","type":"print"},{"value":"0975-3125","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7]]}}}