{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:44:05Z","timestamp":1787071445045,"version":"build-2736575974"},"reference-count":7,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:p>An otherwise healthy 13 year old developed hypercarbia and increased temperature during anesthesia with sevoflurane. Discontinuation of sevoflurane, surface cooling, and hyperventilation resulted in prompt resolution. However, hyperkalemia continued to raise the suspicion for malignant hyperthermia, which was ultimately confirmed by ryanodine receptor gene sequencing. The case underlines the importance of intraoperative monitoring of end-tidal CO2 and temperature and the potential benefits of early discontinuation of inhalational anesthetics in the presence of signs and symptoms suspicious for malignant hyperthermia. The severe hyperkalemia suggests that standard guidelines for diagnosis and treatment of malignant hyperthermia, including dantrolene treatment, should be followed whenever malignant hyperthermia is suspected.<\/jats:p>","DOI":"10.4103\/1658-354x.82816","type":"journal-article","created":{"date-parts":[[2011,7,7]],"date-time":"2011-07-07T04:52:58Z","timestamp":1310014378000},"page":"229-232","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Malignant hyperthermia resolving with discontinuation of sevoflurane alone"],"prefix":"10.4103","volume":"5","author":[{"given":"Abdullah","family":"Abolkhair","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, St. Elizabeth's Medical Center, Boston, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Seefelder","sequence":"additional","affiliation":[{"name":"Perioperative and Pain Medicine, Children's Hospital Boston, 300 Longwood Avenue, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R2-20250926","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1093\/bja\/86.2.283","article-title":"European malignant hyperthermia group. Guidelines for molecular genetic detection of susceptibility to malignant hyperthermia","volume":"86","author":"Urwyler","year":"2001","journal-title":"Br J Anaesth"},{"key":"R3-20250926","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1097\/ALN.0b013e318200197d","article-title":"Prevalence of malignant hyperthermia and relationship with anesthetics in Japan","volume":"114","author":"Sumitani","year":"2011","journal-title":"Anesthesiology"},{"key":"R4-20250926","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1213\/ANE.0b013e3181c6b9b2","article-title":"Clinical presentation, treatment, and complications of malignant hyperthermia in North America from 1987 to 2006","volume":"110","author":"Larach","year":"2010","journal-title":"Anesth Analg"},{"key":"R5-20250926","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1097\/00000542-199404000-00008","article-title":"A clinical grading scale to predict malignant hyperthermia susceptibility","volume":"80","author":"Larach","year":"1994","journal-title":"Anesthesiology"},{"key":"R6-20250926","doi-asserted-by":"crossref","first-page":"2918","DOI":"10.1001\/jama.293.23.2918","article-title":"Malignant hyperthermia. Update on susceptibility testing","volume":"293","author":"Litman","year":"2005","journal-title":"JAMA"},{"key":"R7-20250926","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/j.1460-9592.2006.02051.x","article-title":"Minor increase of end-tidal CO2 during sevoflurane-induced malignant hyperthermia","volume":"17","author":"Bonciu","year":"2007","journal-title":"Pediatr Anesth"},{"key":"R9-20250926","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1093\/bja\/aeq243","article-title":"Recognizing and managing a malignant hyperthermia crisis: Guidelines from the European Malignant Hyperthermia Group","volume":"105","author":"Glahn","year":"2010","journal-title":"Br J Anaesth"}],"container-title":["Saudi Journal of Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01437113-201105020-00024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:46:15Z","timestamp":1787067975000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01437113-201105020-00024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4]]},"references-count":7,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.4103\/1658-354x.82816","relation":{},"ISSN":["1658-354X","0975-3125"],"issn-type":[{"value":"1658-354X","type":"print"},{"value":"0975-3125","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,4]]}}}