{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:28:08Z","timestamp":1787776088920,"version":"build-2784847793"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:p>Evans syndrome (ES) is a rare autoimmune disorder characterized by autoimmune hemolytic anemia (AIHA) and immune thrombocytopenic purpura (ITP). We report a case of a 4-month old infant who presented with a history of acute pallor and jaundice. She had no family history of any hematological or autoimmune disorders. Her laboratory investigations revealed a positive direct Coombs test with immunoglobulin G autoantibodies, anemia and thrombocytopenia. She was managed initially by blood transfusion and started on high-dose steroid therapy with marked improvement. Very few cases of ES in infants have been reported in the literature. We concluded that this case report may support the possibility of an early-onset ES among infants &lt;6 months of age.<\/jats:p>","DOI":"10.4103\/1658-631x.204852","type":"journal-article","created":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T06:24:13Z","timestamp":1682490253000},"page":"177-180","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Early-onset Evans Syndrome in a 4-Month-Old Infant: A Case Report and Review of Literature"],"prefix":"10.4103","volume":"5","author":[{"given":"Khaled Kamaleddin","family":"Mohamed","sequence":"first","affiliation":[{"name":"Department of Pediatrics, King Fahd Hospital of the University, University of Dammam, Dammam, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faisal Othman","family":"Al-Qurashi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, King Fahd Hospital of the University, University of Dammam, Dammam, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Hussain","family":"Al-Qahtani","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, King Fahd Hospital of the University, University of Dammam, Dammam, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasser Shawki","family":"Osman","sequence":"additional","affiliation":[{"name":"Department of Pathology, King Fahd Hospital of the University, University of Dammam, Dammam, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2017,4,20]]},"reference":[{"key":"R1-20250519","doi-asserted-by":"crossref","first-page":"3167","DOI":"10.1182\/blood-2009-04-215368","article-title":"The spectrum of Evans syndrome in adults: New insight into the disease based on the analysis of 68 cases","volume":"114","author":"Michel","year":"2009","journal-title":"Blood"},{"key":"R2-20250519","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1001\/archinte.1951.03810010058005","article-title":"Primary thrombocytopenic purpura and acquired hemolytic anemia; evidence for a common etiology","volume":"87","author":"Evans","year":"1951","journal-title":"AMA Arch Intern Med"},{"key":"R3-20250519","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1097\/00043426-199709000-00005","article-title":"Evans syndrome: Results of a national survey","volume":"19","author":"Mathew","year":"1997","journal-title":"J Pediatr Hematol Oncol"},{"key":"R4-20250519","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/S0022-3476(80)80258-7","article-title":"Evans syndrome in childhood","volume":"97","author":"Pui","year":"1980","journal-title":"J Pediatr"},{"key":"R5-20250519","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1136\/adc.77.3.245","article-title":"The spectrum of Evans' syndrome","volume":"77","author":"Savasan","year":"1997","journal-title":"Arch Dis Child"},{"key":"R6-20250519","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1097\/00043426-198824000-00013","article-title":"Evans syndrome in childhood: Pathophysiology, clinical course, and treatment","volume":"10","author":"Wang","year":"1988","journal-title":"Am J Pediatr Hematol Oncol"},{"key":"R7-20250519","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.bjhh.2015.03.002","article-title":"Experience with Evans syndrome in an academic referral center","volume":"37","author":"Jaime-P\u00e9rez","year":"2015","journal-title":"Rev Bras Hematol Hemoter"},{"key":"R8-20250519","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3389\/fped.2015.00079","article-title":"Evans syndrome in children: Long-term outcome in a prospective french national observational cohort","volume":"3","author":"Aladjidi","year":"2015","journal-title":"Front Pediatr"},{"key":"R10-20250519","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/j.1365-2141.2005.05809.x","article-title":"Management of Evans syndrome","volume":"132","author":"Norton","year":"2006","journal-title":"Br J Haematol"}],"container-title":["Saudi Journal of Medicine &amp; Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01797456-201705020-00018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:51:00Z","timestamp":1787773860000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01797456-201705020-00018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,20]]},"references-count":9,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017]]}},"URL":"https:\/\/doi.org\/10.4103\/1658-631x.204852","relation":{},"ISSN":["1658-631X","2321-4856"],"issn-type":[{"value":"1658-631X","type":"print"},{"value":"2321-4856","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,20]]}}}