{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T18:30:15Z","timestamp":1790274615882,"version":"4.1.0"},"reference-count":50,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neural Regen Res"],"published-print":{"date-parts":[[2014]]},"DOI":"10.4103\/1673-5374.125351","type":"journal-article","created":{"date-parts":[[2014,4,4]],"date-time":"2014-04-04T03:29:29Z","timestamp":1396582169000},"page":"205","source":"Crossref","is-referenced-by-count":34,"title":["Effects of Wen Dan Tang on insomnia-related anxiety and levels of the brain-gut peptide Ghrelin"],"prefix":"10.4103","volume":"9","author":[{"given":"Yuehan","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liye","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengzhi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinai","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binghe","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"key-10.4103\/1673-5374.125351-1","first-page":"213","volume-title":"Comorbidity of chronic insomnia with medical problems.Sleep","author":"Taylor","year":"2007","journal-title":""},{"key":"key-10.4103\/1673-5374.125351-2","first-page":"6","volume-title":"Middle-aged sleep disorders survey: sleep disorders seriously endanger the quality of life and safety of the middle-aged population.Shoudu Yiyao","author":"Li","year":"2005","journal-title":""},{"key":"key-10.4103\/1673-5374.125351-3","first-page":"27","volume-title":"Association between sleep disorders, obesity, and exercise: a review.Nat Sci Sleep","author":"Hargens","year":"2013","journal-title":""},{"key":"key-10.4103\/1673-5374.125351-4","first-page":"2409","volume-title":"Sleep loss and hypertension: a systematic review.Curr Pharm Des","author":"Palagini","year":"2013","journal-title":""},{"key":"key-10.4103\/1673-5374.125351-5","unstructured":"R\u00f6\u00f6st M, Nilsson P. Sleep disorders--a public health problem. Potential risk factor in the development of type 2 diabetes, hypertension, dyslipidemia and premature aging. Lakartidningen. 2002;99(3):154-157."},{"key":"key-10.4103\/1673-5374.125351-6","first-page":"287","volume-title":"Clinical implications of the causal relationship between insomnia and depression: how individually tailored treatment of sleeping difficulties could prevent the onset of depression.EPMA J","author":"Baglioni","year":"2011","journal-title":""},{"key":"key-10.4103\/1673-5374.125351-7","first-page":"559","volume-title":"Greater risk of Alzheimer\u2032s disease in older adults with insomnia.J Am Geriatr Soc","author":"Osorio","year":"2011","journal-title":""},{"key":"key-10.4103\/1673-5374.125351-8","first-page":"e62","volume-title":"Short sleep duration is associated with reduced leptin, elevated ghrelin, and increased body mass index.PLoS Med","author":"Taheri","year":"2004","journal-title":""},{"key":"key-10.4103\/1673-5374.125351-9","first-page":"553","volume-title":"Sleep deprivation: Impact on cognitive performance.Neuropsychiatr Dis Treat","author":"Alhola","year":"2007","journal-title":""},{"key":"key-10.4103\/1673-5374.125351-10","first-page":"873","volume-title":"Chronic insomnia as a risk factor for developing anxiety and depression.Sleep","author":"Neckelmann","year":"2007","journal-title":""},{"key":"key-10.4103\/1673-5374.125351-11","first-page":"45","volume-title":"The long-term effect of statins on the risk of new-onset diabetes mellitus in elderly Taiwanese patients with hypertension and dyslipidaemia: a retrospective longitudinal cohort study.Drugs Aging","author":"Ma","year":"2012","journal-title":""},{"key":"key-10.4103\/1673-5374.125351-12","first-page":"1289","volume-title":"Inadequate sleep as a risk factor for obesity: analyses of the NHANES I.Sleep","author":"Gangwisch","year":"2005","journal-title":""},{"key":"key-10.4103\/1673-5374.125351-13","first-page":"16","volume-title":"White blood cells and cortisol after sleep deprivation and recovery sleep in humans.Eur Arch Psychiatry Clin Neurosci","author":"Heiser","year":"2000","journal-title":""},{"key":"key-10.4103\/1673-5374.125351-14","first-page":"325","volume-title":"Modified Wendan Decoction can Attenuate Neurotoxic Action Associated with Alzheimer\u2032s Disease.Evid Based Complement Alternat Med","author":"Liu","year":"2009","journal-title":""},{"key":"key-10.4103\/1673-5374.125351-15","first-page":"1005","volume-title":"Amyloid-beta dynamics are regulated by orexin and the sleep-wake cycle.Science","author":"Kang","year":"2009","journal-title":""},{"key":"key-10.4103\/1673-5374.125351-16","first-page":"1","volume-title":"Rhythmic, reciprocal ghrelin and leptin signaling: new insight in the development of obesity.Regul Pept","author":"Kalra","year":"2003","journal-title":""},{"key":"key-10.4103\/1673-5374.125351-17","first-page":"846","volume-title":"Brief communication: Sleep curtailment in healthy young men is associated with decreased leptin levels, elevated ghrelin levels, and increased hunger and appetite.Ann Intern Med","author":"Spiegel","year":"2004","journal-title":""},{"key":"key-10.4103\/1673-5374.125351-18","first-page":"17","volume-title":"Treatment of insomnia by Tanreneizu.Jiangxi Zhongyiyao","author":"Liu","year":"2006","journal-title":""},{"key":"key-10.4103\/1673-5374.125351-19","first-page":"63","volume-title":"Antidepressant function of modified wendan decoction.Zhongguo Linchuang Kangfu","author":"Wu","year":"2006","journal-title":""},{"key":"key-10.4103\/1673-5374.125351-20","first-page":"964","volume-title":"Application of Wendan Tang in treating neurological disease.Zhongyi Xuebao","author":"Wang","year":"2012","journal-title":""},{"key":"key-10.4103\/1673-5374.125351-21","first-page":"932","volume-title":"Screening of antidepressant fractions of banxia houpu decoction.Zhongguo Zhong Yao Za Zhi","author":"Wang","year":"2002","journal-title":""},{"key":"key-10.4103\/1673-5374.125351-22","first-page":"1114","volume-title":"Clinical observation on treatment of somatic disorder with combination of Xiaoyao Powder and Wendan Decoction.Zhongguo Zhong Xi Yi Jie He Za Zhi","author":"Yu","year":"2006","journal-title":""},{"key":"key-10.4103\/1673-5374.125351-23","first-page":"55","volume-title":"Behavioral and biochemical studies on chronic mild stress models in rats treated with a Chinese traditional prescription Banxia-houpu decoction.Life Sci","author":"Li","year":"2003","journal-title":""},{"key":"key-10.4103\/1673-5374.125351-24","first-page":"325","volume-title":"Sedative, hypnotic and anticonvulsant activities of the ethanol fraction from Rhizoma Pinelliae Praeparatum.J Ethnopharmacol","author":"Wu","year":"2011","journal-title":""},{"key":"key-10.4103\/1673-5374.125351-25","first-page":"45","volume-title":"Relationship between the amelioration effect of Wendan Tang on sleep and the expression of cholecystokinin 8 in brains of insomnia rats.Zhongguo Linchuang Kangfu","author":"Ma","year":"2006","journal-title":""},{"key":"key-10.4103\/1673-5374.125351-26","first-page":"1738","volume-title":"Identification, characterization, and biological activity of specific receptors for natural (ghrelin) and synthetic growth hormone secretagogues and analogs in human breast carcinomas and cell lines.J Clin Endocrinol Metab","author":"Cassoni","year":"2001","journal-title":""},{"key":"key-10.4103\/1673-5374.125351-27","first-page":"421","volume-title":"Effects of ghrelin on psychopathology, sleep and secretion of cortisol and growth hormone in patients with major depression.J Psychiatr Res","author":"Kluge","year":"2011","journal-title":""},{"key":"key-10.4103\/1673-5374.125351-28","first-page":"550","volume-title":"Filling the interstices: ghrelin neurons plug several holes in regulation of energy balance.Neuron","author":"Dallman","year":"2003","journal-title":""},{"key":"key-10.4103\/1673-5374.125351-29","first-page":"739","volume-title":"Ghrelin increases anxiety-like behavior and memory retention in rats.Biochem Biophys Res Commun","author":"Carlini","year":"2002","journal-title":""},{"key":"key-10.4103\/1673-5374.125351-30","first-page":"E407","volume-title":"Ghrelin promotes slow-wave sleep in humans.Am J Physiol Endocrinol Metab","author":"Weikel","year":"2003","journal-title":""},{"key":"key-10.4103\/1673-5374.125351-31","first-page":"795","volume-title":"Ghrelin protects cortical neuron against focal ischemia\/reperfusion in rats.Biochem Biophys Res Commun","author":"Miao","year":"2007","journal-title":""},{"key":"key-10.4103\/1673-5374.125351-32","first-page":"107","volume-title":"Ghrelin and synthetic growth hormone secretagogues are cardioactive molecules with identities and differences.Semin Vasc Med","author":"Benso","year":"2004","journal-title":""},{"key":"key-10.4103\/1673-5374.125351-33","first-page":"2778","volume-title":"Ghrelin promotes thymopoiesis during aging.J Clin Invest","author":"Dixit","year":"2007","journal-title":""},{"key":"key-10.4103\/1673-5374.125351-34","first-page":"143","volume-title":"A role of ghrelin in neuroendocrine and behavioral responses to stress in mice.Neuroendocrinology","author":"Asakawa","year":"2001","journal-title":""},{"key":"key-10.4103\/1673-5374.125351-35","first-page":"114","volume-title":"Acute psychological stress raises plasma ghrelin in the rat.Regul Pept","author":"Kristenssson","year":"2006","journal-title":""},{"key":"key-10.4103\/1673-5374.125351-36","first-page":"753","volume-title":"Behavioural consequences of repeated social defeat in the mouse: preliminary evaluation of a potential animal model of depression.Behav Pharmacol","author":"Keeney","year":"1999","journal-title":""},{"key":"key-10.4103\/1673-5374.125351-37","first-page":"1","volume-title":"The open field as a test of emotionality.Behav Res Methods Instrum Comput","author":"Hendricks","year":"1973","journal-title":""},{"key":"key-10.4103\/1673-5374.125351-38","first-page":"1152","volume-title":"Environmental enrichment requires adult neurogenesis to facilitate the recovery from psychosocial stress.Mol Psychiatry","author":"Schloesser","year":"2010","journal-title":""},{"key":"key-10.4103\/1673-5374.125351-39","first-page":"279","volume-title":"Factor analysis of rat behavior in an open field test.Neurosci Behav Physiol","author":"Markel","year":"1989","journal-title":""},{"key":"key-10.4103\/1673-5374.125351-40","unstructured":"Belzung C. Encyclopedia of Psychopharmacology. Berlin: Springer. 2010."},{"key":"key-10.4103\/1673-5374.125351-41","first-page":"115","volume-title":"Anxiogenic effect of sleep deprivation in the elevated plus-maze test in mice.Psychopharmacology (Berl)","author":"Silva","year":"2004","journal-title":""},{"key":"key-10.4103\/1673-5374.125351-42","unstructured":"The Ministry of Science and Technology of the People\u2032s Republic of China. Guidance Suggestions for the Care and Use of Laboratory Animals. 2006-09-30."},{"key":"key-10.4103\/1673-5374.125351-43","first-page":"309","volume-title":"Social stability attenuates the stress in the modified multiple platform method for paradoxical sleep deprivation in the rat.Physiol Behav","author":"Suchecki","year":"2000","journal-title":""},{"key":"key-10.4103\/1673-5374.125351-44","unstructured":"U.S. Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research (CDER): Guidance for industry: estimating the maximum safe starting dose in initial clinical trials for therapeutics in adult healthy volunteers. 2005."},{"key":"key-10.4103\/1673-5374.125351-45","unstructured":"U.S. Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research (CDER). Guidance for industry: food-effect bioavailability and fed bioequivalence studies. 2002."},{"key":"key-10.4103\/1673-5374.125351-46","doi-asserted-by":"crossref","unstructured":"Gould TD. Mood and anxiety related phenotypes in mice. Hew Jersey: Humana Press, 2011.","DOI":"10.1007\/978-1-61779-313-4"},{"key":"key-10.4103\/1673-5374.125351-47","unstructured":"Zhuge QC. The Rat Brain in Stereotaxic Coordinates. Beijing: People\u2032s Medical Publishing House. 2005."},{"key":"key-10.4103\/1673-5374.125351-48","first-page":"190","volume-title":"One-step real time RT-PCR for detection of microRNAs.Talanta","author":"Yan","year":"2013","journal-title":""},{"key":"key-10.4103\/1673-5374.125351-49","unstructured":"Ghsr growth hormone secretagogue receptor [Rattus norvegicus (Norway rat)]. 2013-05-26. http:\/\/www.ncbi.nlm.nih.gov\/gene\/84022"},{"key":"key-10.4103\/1673-5374.125351-50","unstructured":"Gapdh glyceraldehyde-3-phosphate dehydrogenase [Rattus norvegicus (Norway rat)]. 2013-04-27. http:\/\/www.ncbi.nlm.nih.gov\/gene\/24383"}],"container-title":["Neural Regeneration Research"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:23:10Z","timestamp":1786648990000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/1673-5374.125351"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014]]}},"alternative-id":["125351"],"URL":"https:\/\/doi.org\/10.4103\/1673-5374.125351","relation":{},"ISSN":["1673-5374"],"issn-type":[{"value":"1673-5374","type":"print"}],"subject":[],"published":{"date-parts":[[2014]]}}}