{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:36:20Z","timestamp":1786653380421,"version":"build-2736575974"},"reference-count":48,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neural Regen Res"],"published-print":{"date-parts":[[2015]]},"DOI":"10.4103\/1673-5374.152378","type":"journal-article","created":{"date-parts":[[2015,3,2]],"date-time":"2015-03-02T01:14:01Z","timestamp":1425258841000},"page":"244","source":"Crossref","is-referenced-by-count":1,"title":["Prevention against diffuse spinal cord astrocytoma: can the Notch pathway be a novel treatment target?"],"prefix":"10.4103","volume":"10","author":[{"given":"Jian-jun","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-hui","family":"Lou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling-song","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-yan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-sheng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-bo","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-long","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"key-10.4103\/1673-5374.152378-1","doi-asserted-by":"crossref","unstructured":"Alqudah MA, Agarwal S, Al-Keilani MS, Sibenaller ZA, Ryken TC, Assem M (2013) NOTCH3 is a prognostic factor that promotes glioma cell proliferation, migration and invasion via activation of CCND1 and EGFR. PLoS One 8:e77299.","DOI":"10.1371\/journal.pone.0077299"},{"key":"key-10.4103\/1673-5374.152378-2","doi-asserted-by":"crossref","unstructured":"Azizidoost S, Shanaki Bavarsad M, Shanaki Bavarsad M, Shahrabi S, Jaseb K, Rahim F, Shahjahani M, Saba F, Ghorbani M, Saki N (2014) The role of notch signaling in bone marrow niche. Hematology doi: http:\/\/dx.doi.org\/10.1179\/1607845414Y.0000000167.","DOI":"10.1179\/1607845414Y.0000000167"},{"key":"key-10.4103\/1673-5374.152378-3","doi-asserted-by":"crossref","unstructured":"Bao SD, Wu QL, Sathornsumetee S, Hao YL, Li ZZ, Hjielmeland AB, Shi Q, Mclendon RE, Bigner DD, Rich JN (2006a). Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor. Cancer Res 66:7843-7848.","DOI":"10.1158\/0008-5472.CAN-06-1010"},{"key":"key-10.4103\/1673-5374.152378-4","doi-asserted-by":"crossref","unstructured":"Bao SD, Wu QL, Mclendon RE, Hao YL, Shi Q, Hjielmeland AB, Dewhirst MW, Bigner DD, Rich JN (2006b). Glioma stem cells promote radio resistance by preferential activation of the DNA damage response. Nature 444:756-760.","DOI":"10.1038\/nature05236"},{"key":"key-10.4103\/1673-5374.152378-5","doi-asserted-by":"crossref","unstructured":"Beier D, Hau P, Proescholdt M, Lohmeier A, Wischhusen J, Oefner PJ, Aigner L, Brawanski A, Bogdahn U, Beier CP (2007) CD133(+) and CD133(-) glioblastoma-derived cancer stem cells show differential growth characteristics and molecular profiles. Cancer Res 67:4010-4015.","DOI":"10.1158\/0008-5472.CAN-06-4180"},{"key":"key-10.4103\/1673-5374.152378-6","doi-asserted-by":"crossref","unstructured":"Chen G, Kong J, Tucker-Burden C, Anand M, Rong Y, Rahman F,Moreno CS, Van Meir EG, Hadjipanayis CG, Brat DJ (2014) Human brat Ortholog TRIM3 Is a tumor suppressor that regulates asymmetric cell division in glioblastoma. Cancer Res 74:4536-4548.","DOI":"10.1158\/0008-5472.CAN-13-3703"},{"key":"key-10.4103\/1673-5374.152378-7","doi-asserted-by":"crossref","unstructured":"Chen J, Yakisich JS (2014) Editorial: emerging concepts and therapeutics strategies for the treatment of brain tumors. Anticancer Agents Med Chem 14:1063-1064.","DOI":"10.2174\/187152061408140908113346"},{"key":"key-10.4103\/1673-5374.152378-8","doi-asserted-by":"crossref","unstructured":"Claes A, Idema AJ, Wesseling P (2007) Diffuse glioma growth: a guerilla war. Acta Neuropathol 114:443-458.","DOI":"10.1007\/s00401-007-0293-7"},{"key":"key-10.4103\/1673-5374.152378-9","doi-asserted-by":"crossref","unstructured":"Dasari VR, Kaur K, Velpula KK, Guirati M, Fassett D, Klopfenstein JD, Dinh DH, Rao JS (2010) Upregulation of PTEN in glioma cells by cord blood mesenchymal stem cells inhibits migration via downregulation of the PI3K\/Akt pathway. PLoS One 5:e10350.","DOI":"10.1371\/journal.pone.0010350"},{"key":"key-10.4103\/1673-5374.152378-10","doi-asserted-by":"crossref","unstructured":"Eyler CE, Foo WC, LaFiura KM, Mclendon RE, Hielmeland AB, Rich JN (2008) Brain cancer stem cells display preferential sensitivity to Akt inhibition. Stem Cells 26:3027-3036.","DOI":"10.1634\/stemcells.2007-1073"},{"key":"key-10.4103\/1673-5374.152378-11","doi-asserted-by":"crossref","unstructured":"Fan X, Khaki L, Zhu TS, Soules ME, Talsma CE, Gul N, Koh C, Zhang J, Li YM, Maciaczyk J, Nikkhah G, Dimeco F, Piccirillo S, Vescovi AL, Eberhart CG (2010) Notch pathway blockade depletes CD133-positive glioblastoma cells and inhibits growth of tumor neurospheres and xenografts. Stem Cells 28:5-16.","DOI":"10.1002\/stem.254"},{"key":"key-10.4103\/1673-5374.152378-12","doi-asserted-by":"crossref","unstructured":"Fang KM, Lin TC, Chan TC, Ma SZ, Tzou BC, Chang WR, Liu JJ, Chiou SH, Yang CS, Tzeng SF (2013) Enhanced cell growth and tumorigenicity of rat glioma cells by stable expression of human CD133 through multiple molecular actions. Glia 61:1402-1417.","DOI":"10.1002\/glia.22521"},{"key":"key-10.4103\/1673-5374.152378-13","doi-asserted-by":"crossref","unstructured":"Furnari FB, Fenton T, Bachoo RM, Mukasa A, Stommel JM, Stegh A, Hahn WC, Ligon KL, Louis DN, Brennan C, Chin L, DePinho RA, Cavenee WK (2007) Malignant astrocyticglioma: genetics, biology, and paths to treatment. Genes Dev 21:2683-2710.","DOI":"10.1101\/gad.1596707"},{"key":"key-10.4103\/1673-5374.152378-14","doi-asserted-by":"crossref","unstructured":"Garner JM, Fan M, Yang CH, Du Z, Sims M, Davidoff AM, Pfeffer LM (2013). Constitutive activation of signal transducer and activator of transcription 3(STAT3) and nuclear factor \u00eaB signaling in glioblastoma cancer stem cellsregulates the Notch pathway. J Biol Chem 288:26167-26176.","DOI":"10.1074\/jbc.M113.477950"},{"key":"key-10.4103\/1673-5374.152378-15","doi-asserted-by":"crossref","unstructured":"Goodenberger ML, Jenkins RB (2012) Genetics of adult glioma. Cancer Genet 205:613-621.","DOI":"10.1016\/j.cancergen.2012.10.009"},{"key":"key-10.4103\/1673-5374.152378-16","doi-asserted-by":"crossref","unstructured":"Guichet PO, Guelfi S, Teigell M, Hoppe L, Bakalara N, Bauchet L, Duffau H, Lamszus K, Rothhut B, Hugnot JP (2014) Notch1 stimulation induces a vascularization switch with pericyte-like celldifferentiation of glioblastoma stem cells. Stem Cells doi: 10.1002\/stem.1767.","DOI":"10.1002\/stem.1767"},{"key":"key-10.4103\/1673-5374.152378-17","doi-asserted-by":"crossref","unstructured":"Holmberg J, He X, Peredo I, Orrego A, Hesselager G, Xie K, Huang S (2011) Activation of neural and pluripotent stem cell signatures correlates with increased malignancy in human glioma. PLoS One 6:e18454.","DOI":"10.1371\/journal.pone.0018454"},{"key":"key-10.4103\/1673-5374.152378-18","doi-asserted-by":"crossref","unstructured":"Hu YY, Fu LA, Li SZ, Chen Y, Li JC, Han J, Liang L, Li L, Ji CC, Zheng MH, Han H (2014) Hif-1\u03b1 and Hif-2\u03b1 differentially regulate Notch signaling through competitive interaction with the intracellular domain of Notch receptors in glioma stem cells. Cancer Lett 349:67-76.","DOI":"10.1016\/j.canlet.2014.03.035"},{"key":"key-10.4103\/1673-5374.152378-19","doi-asserted-by":"crossref","unstructured":"Huse JT, Holland EC (2009) Genetically engineered mouse models of brain cancer and the promise of preclinical testing. Brain Pathol 19:132-143.","DOI":"10.1111\/j.1750-3639.2008.00234.x"},{"key":"key-10.4103\/1673-5374.152378-20","doi-asserted-by":"crossref","unstructured":"Ivkovic S, Beadle C, Noticewala S, Massey SC, Swanson KR, Toro LN, Bresnick AR, Canoll P, Rosenfeld SS (2012) Direct inhibition of myosin II effectively blocks glioma invasion in the presence of multiple motogens. Mol Biol Cell 23:533-542.","DOI":"10.1091\/mbc.E11-01-0039"},{"key":"key-10.4103\/1673-5374.152378-21","doi-asserted-by":"crossref","unstructured":"Jiang X, Xing H, Kim TM, Jung Y, Huang W, Yang HW, Song S, Park PJ, CarrollRS, Johnson MD (2012) Numb regulates glioma stem cell fate and growth by altering epidermal growth factor receptor and Skp1-Cullin-F-box ubiquitin ligase activity. Stem Cells 30:1313-1326.","DOI":"10.1002\/stem.1120"},{"key":"key-10.4103\/1673-5374.152378-22","doi-asserted-by":"crossref","unstructured":"Jiang Y, Uhrbom L (2012) On the origin of glioma. Ups J Med Sci 117:113-121.","DOI":"10.3109\/03009734.2012.658976"},{"key":"key-10.4103\/1673-5374.152378-23","doi-asserted-by":"crossref","unstructured":"Jin X, Kim SH, Jeon HM, Beck S, Sohn YW, Yin J, Kim JK, Lim YC, Lee JH, Kim SH, Kang SH, Pian X, Song MS, Park JB, Chae YS, Chung YG, Lee SH, Choi YJ, Nam DH, Choi YK, et al. (2012) Interferon regulatory factor 7 regulates glioma stem cells via interleukin-6 and Notch signalling. Brain 135:1055-1069.","DOI":"10.1093\/brain\/aws028"},{"key":"key-10.4103\/1673-5374.152378-24","doi-asserted-by":"crossref","unstructured":"Kristoffersen K, Villingsh\u00f8j M, Poulsen HS, Stockhausen MT (2013) Level of Notch activation determines the effect on growth and stem cell-likefeatures in glioblastoma multiforme neurosphere cultures. Cancer Biol Ther 14:625-637.","DOI":"10.4161\/cbt.24595"},{"key":"key-10.4103\/1673-5374.152378-25","doi-asserted-by":"crossref","unstructured":"Lagadec C, Vlashi E, Frohnen P, Alhiyari Y, Chan M, Pajonk F (2014) The RNA-binding protein Musashi-1 regulates proteasome subunit expression inbreast cancer- and glioma-initiating cells. Stem Cells 32:135-144.","DOI":"10.1002\/stem.1537"},{"key":"key-10.4103\/1673-5374.152378-26","doi-asserted-by":"crossref","unstructured":"Liu M, Inoue K, Leng T, Guo S, Xiong ZG (2014) TRPM7 channels regulate glioma stem cell through STAT3 and Notch signaling pathways. Cell Signal 26:2773-2781.","DOI":"10.1016\/j.cellsig.2014.08.020"},{"key":"key-10.4103\/1673-5374.152378-27","doi-asserted-by":"crossref","unstructured":"Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A, Scheithauer BW, Kleihues P (2007) The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol 114:97-109.","DOI":"10.1007\/s00401-007-0243-4"},{"key":"key-10.4103\/1673-5374.152378-28","doi-asserted-by":"crossref","unstructured":"Muto J, Imai T, Ogawa D, Nishimoto Y, Okada Y, Mabuchi Y, Kawase T, Iwanami A, Mischel PS, Saya H, Yoshida K, Matsuzaki Y, Okano H (2012) RNA-binding protein musashi1 modulates glioma cell growth through the post-transcriptional regulation of Notch and PI3 Kinase\/Akt signaling pathways. PLoS One 7:e33431.","DOI":"10.1371\/journal.pone.0033431"},{"key":"key-10.4103\/1673-5374.152378-29","doi-asserted-by":"crossref","unstructured":"Najbauer J, Huszthy PC, Barish ME, Garcia E, Metz MZ, Myers SM, Gutova M, Frank RT, Miletic H, Kendall SE, Glackin CA, Bjerkvig R, Aboody KS (2012) Cellular host responses to gliomas. PLoS One 7:e35150.","DOI":"10.1371\/journal.pone.0035150"},{"key":"key-10.4103\/1673-5374.152378-30","doi-asserted-by":"crossref","unstructured":"Noell S, Ritz R, Wolburg-Buchholz K, Wolburg H, Fallier-Becker P (2012) An allograft glioma model reveals the dependence of aquaporin-4 expression on the brain microenvironment. PLoS One 7:e36555.","DOI":"10.1371\/journal.pone.0036555"},{"key":"key-10.4103\/1673-5374.152378-31","unstructured":"Qiu S, Tan XH, Huang H (2012) Progress in the source and surface markers of brain tumor stem cells. Zhongguo Zuzhi Gongcheng Yanjiu 16:1095-1098."},{"key":"key-10.4103\/1673-5374.152378-32","doi-asserted-by":"crossref","unstructured":"Ranjan M, Santosh V, Tandon A, Anandh B, Sampath S, Devi BI, Chandramouli BA (2011) Factors predicting progression of low-grade diffusely infiltrating astrocytoma. Neurol India 59:248-253.","DOI":"10.4103\/0028-3886.79137"},{"key":"key-10.4103\/1673-5374.152378-33","doi-asserted-by":"crossref","unstructured":"Saito N, Fu J, Zheng S, Yao J, Wang S, Liu DD, Yuan Y, Sulman EP, Lang FF, Colman H, Verhaak RG, Yung WK, Koul D (2014) A high Notch pathway activation predicts response to \u00e3 secretase inhibitors inproneural subtype of glioma tumor-initiating cells. Stem Cells 32:301-312.","DOI":"10.1002\/stem.1528"},{"key":"key-10.4103\/1673-5374.152378-34","doi-asserted-by":"crossref","unstructured":"Shackleton M, Quintana E, Fearon ER, Morrison SJ (2009) Heterogeneity in cancer: cancer stem cells versus clonal evolution. Cell 138:822-829.","DOI":"10.1016\/j.cell.2009.08.017"},{"key":"key-10.4103\/1673-5374.152378-35","doi-asserted-by":"crossref","unstructured":"Son MI, Woolard K, Nam DH, Lee J, Fine HA (2009) SSEA-a is an enrichment marker for tumor-initiating cells in human glioblastoma. Cell Stem Cell 4:440-452.","DOI":"10.1016\/j.stem.2009.03.003"},{"key":"key-10.4103\/1673-5374.152378-36","unstructured":"Song XB, Yang ZY, Deng XL, Wang XP, Zhang SP, Huang J, Zhang XK (2013) In vitro isolation, culture and identification of brain tumor stem cells from human astrogliomas. Zhongguo Zuzhi Gongcheng Yanjiu 17:56-61."},{"key":"key-10.4103\/1673-5374.152378-37","doi-asserted-by":"crossref","unstructured":"Turchi L, Debruyne DN, Almairac F, Virolle V, Fareh M, Neirijnck Y,Burel-Vandenbos F, Paquis P, Junier MP, Van Obberghen-Schilling E, Chneiweiss H, Virolle T (2013) Tumorigenic potential of miR-18A in glioma initiating cells requires NOTCH-1signaling. Stem Cells 31:1252-1265.","DOI":"10.1002\/stem.1373"},{"key":"key-10.4103\/1673-5374.152378-38","doi-asserted-by":"crossref","unstructured":"Wang H, Sun T, Hu J, Zhang R, Rao Y, Wang S, Chen R, McLendon RE, Friedman AH, Keir ST, Bigner DD, Li QJ, Wang H, Wang XF (2014) miR-33a promotes glioma-initiating cell self-renewal via PKA and NOTCH pathways. J Clin Invest doi: 10.1172\/JCI75284.","DOI":"10.1172\/JCI75284"},{"key":"key-10.4103\/1673-5374.152378-39","doi-asserted-by":"crossref","unstructured":"Wang JL, Wakeman TP, Lathia JD, Hielmeland AB, Wang XE, White RR, Rich JN, Sullenger BA (2010) Notch promotes radio resistance of glioma stem cells. Stem Cells 28:17-28.","DOI":"10.1002\/stem.261"},{"key":"key-10.4103\/1673-5374.152378-40","unstructured":"Wang XX, Liu JP (2012) Research progress in brain tumor stem cells. Zhongguo Zuzhi Gongcheng Yanjiu 16:2637-2640."},{"key":"key-10.4103\/1673-5374.152378-41","doi-asserted-by":"crossref","unstructured":"Wieland A, Trageser D, Gogolok S, Reinartz R, H\u00f6fer H, Keller M, Leinhaas A,Schelle R, Normann S, Klaas L, Waha A, Koch P, Fimmers R, Pietsch T, Yachnis AT, Pincus DW, Steindler DA, Br\u00fcstle O, Simon M, Glas M, et al. (2013) Anticancer effects of niclosamide in human glioblastoma. Clin Cancer Res 19:4124-4136.","DOI":"10.1158\/1078-0432.CCR-12-2895"},{"key":"key-10.4103\/1673-5374.152378-42","doi-asserted-by":"crossref","unstructured":"Wu J, Ji Z, Liu H, Liu Y, Han D, Shi C, Wang C, Yang G, Chen X, Shen C,Li H, Bi Y, Zhang D, Zhao S (2013a) Arsenic trioxide depletes cancer stem-like cells and inhibits repopulation ofneurosphere derived from glioblastoma by downregulation of Notch pathway. Toxicol Lett 220:61-69.","DOI":"10.1016\/j.toxlet.2013.03.019"},{"key":"key-10.4103\/1673-5374.152378-43","doi-asserted-by":"crossref","unstructured":"Wu N, Lin X, Zhao X, Zheng L, Xiao L, Liu J, Ge L, Cao S (2013b) MiR-125b acts as an oncogene in glioblastoma cells and inhibits cell apoptosis through p53 and p38MAPK-independent pathways. Br J Cancer 109:2853-2863.","DOI":"10.1038\/bjc.2013.672"},{"key":"key-10.4103\/1673-5374.152378-44","unstructured":"Wu W (2012) Effect of Wnt\/\u03b2-Catenin signal pathway adjusted by suppressor of cytokine signaling 3 on tumor stem cells and its application in treatment of glioblastoma multiforme. Zhongguo Zuzhi Gongcheng Yanjiu 16:5988-5992."},{"key":"key-10.4103\/1673-5374.152378-45","unstructured":"Yi F, Ma J, Ni W, Chang R, Liu W, Han X, Pan D, Liu X, Qiu J (2013) The top cited articles on glioma stem cells in Web of Science. Neural Regen Res 8:1431-1438."},{"key":"key-10.4103\/1673-5374.152378-46","doi-asserted-by":"crossref","unstructured":"Yin J, Park G, Lee JE, Park JY, Kim TH, Kim YJ, Lee SH, Yoo H, Kim JH, Park JB (2014) CPEB1 modulates differentiation of glioma stem cells via downregulation of HES1 and SIRT1 expression. Oncotarget 5:6756-6769.","DOI":"10.18632\/oncotarget.2250"},{"key":"key-10.4103\/1673-5374.152378-47","doi-asserted-by":"crossref","unstructured":"Zhang Y, Zhang N, Dai B, Liu M, Sawaya R, Xie K, Huang S (2008) FoxM1B transcriptionally regulates vascular endothelial growth factor expression and promotes the angiogenesis and growth of glioma cells. Cancer Res 68:8733-8742.","DOI":"10.1158\/0008-5472.CAN-08-1968"},{"key":"key-10.4103\/1673-5374.152378-48","unstructured":"Zhao ZF, Fan RT, Yang Y, Sun JR, Hu X, Eileen S, Yang B (2013) In vitro radiosensitivity of brain cancer stem cells in brain glioma. Zhongguo Zuzhi Gongcheng Yanjiu 17:3455-3460."}],"container-title":["Neural Regeneration Research"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:36:17Z","timestamp":1786649777000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/1673-5374.152378"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":48,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015]]}},"alternative-id":["152378"],"URL":"https:\/\/doi.org\/10.4103\/1673-5374.152378","relation":{},"ISSN":["1673-5374"],"issn-type":[{"value":"1673-5374","type":"print"}],"subject":[],"published":{"date-parts":[[2015]]}}}