{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T13:46:08Z","timestamp":1786715168492,"version":"build-2736575974"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neural Regen Res"],"published-print":{"date-parts":[[2016]]},"DOI":"10.4103\/1673-5374.179073","type":"journal-article","created":{"date-parts":[[2016,3,21]],"date-time":"2016-03-21T02:57:34Z","timestamp":1458529054000},"page":"493","source":"Crossref","is-referenced-by-count":17,"title":["Substance P combined with epidermal stem cells promotes wound healing and nerve regeneration in diabetes mellitus"],"prefix":"10.4103","volume":"11","author":[{"given":"De-ming","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei-bin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang-jing","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De-wu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-ling","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-tie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"key-10.4103\/1673-5374.179073-1","doi-asserted-by":"crossref","unstructured":"Behjati M, Hashemi M (2009) Application of fibrocytes in the treatment of diabetic foot: as a potential new therapeutic approach. Diabetes Res Clin Pract 86:152-153.","DOI":"10.1016\/j.diabres.2009.04.027"},{"key":"key-10.4103\/1673-5374.179073-2","doi-asserted-by":"crossref","unstructured":"Biedermann T, B\u00f6ttcher-Haberzeth S, Klar A, Pontiggia L, Schiestl C, Meuli-Simmen C, Reichmann E, Meuli M (2013) Rebuild, restore, reinnervate: do human tissue engineered dermo-epidermal skin analogs attract host nerve fibers for innervation? Pediatr Surg Int 29:71-78.","DOI":"10.1007\/s00383-012-3208-1"},{"key":"key-10.4103\/1673-5374.179073-3","doi-asserted-by":"crossref","unstructured":"Blais M, Parenteau-Bareil R, Cadau S, Berthod F (2013) Concise review: tissue-engineered skin and nerve regeneration in burn treatment. Stem Cells Transl Med 2:545-551.","DOI":"10.5966\/sctm.2012-0181"},{"key":"key-10.4103\/1673-5374.179073-4","doi-asserted-by":"crossref","unstructured":"Du J, Gao XQ, Deng L, Chang NB, Xiong HL, Zheng Y (2014) Transfection of the glial cell line-derived neurotrophic factor gene promotes neuronal differentiation. Neural Regen Res 9:33-40.","DOI":"10.4103\/1673-5374.125327"},{"key":"key-10.4103\/1673-5374.179073-5","doi-asserted-by":"crossref","unstructured":"Dunnick CA, Gibran NS, Heimbach DM (1996) Substance P has a role in neurogenic mediation of human burn wound healing. J Burn Care Rehabil 17:390-396.","DOI":"10.1097\/00004630-199609000-00004"},{"key":"key-10.4103\/1673-5374.179073-6","doi-asserted-by":"crossref","unstructured":"Edmonds ME, Foster AV (2006) Diabetic foot ulcers. BMJ 332:407-410.","DOI":"10.1136\/bmj.332.7538.407"},{"key":"key-10.4103\/1673-5374.179073-7","doi-asserted-by":"crossref","unstructured":"Fiorina P, Pietramaggiori G, Scherer SS, Jurewicz M, Mathews JC, Vergani A, Thomas G, Orsenigo E, Staudacher C, La Rosa S, Capella C, Carothers A, Zerwes HG, Luzi L, Abdi R, Orgill DP (2010) The mobilization and effect of endogenous bone marrow progenitor cells in diabetic wound healing. Cell Transplant 19:1369-1381.","DOI":"10.3727\/096368910X514288"},{"key":"key-10.4103\/1673-5374.179073-8","doi-asserted-by":"crossref","unstructured":"Gardien KL, Middelkoop E, Ulrich MM (2014) Progress towards cell-based burn wound treatments. Regen Med 9:201-218.","DOI":"10.2217\/rme.13.97"},{"key":"key-10.4103\/1673-5374.179073-9","doi-asserted-by":"crossref","unstructured":"Guo WY, Wang GJ, Wang P, Chen Q, Tan Y, Cai L (2010) Acceleration of diabetic wound healing by low-dose radiation is associated with peripheral mobilization of bone marrow stem cells. Radiat Res 174:467-479.","DOI":"10.1667\/RR1980.1"},{"key":"key-10.4103\/1673-5374.179073-10","unstructured":"Guo WZ, Lai XN, Wang ZG, Liu YJ, Wang LL (2008) Application of exogenous substance P in wound healing of skin injury in diabetic rat. Chuangshang Waike Zazhi 10:251-253."},{"key":"key-10.4103\/1673-5374.179073-11","doi-asserted-by":"crossref","unstructured":"Ikeda Y, Takei H, Matsumoto C, Mase A, Yamamoto M, Takeda S, Ishige A, Watanabe K (2007) Administration of substance P during a primary immune response amplifies the secondary immune response via a long-lasting effect on CD8+ T lymphocytes. Arch Dermatol Res 299:345-351.","DOI":"10.1007\/s00403-007-0767-4"},{"key":"key-10.4103\/1673-5374.179073-12","doi-asserted-by":"crossref","unstructured":"Kaur P, Li A (2000) Adhesive properties of human basal epidermal cells: an analysis of keratinocyte stem cells, transit amplifying cells, and postmitotic differentiating cells. J Investig Dermatol 114:413-420.","DOI":"10.1046\/j.1523-1747.2000.00884.x"},{"key":"key-10.4103\/1673-5374.179073-13","doi-asserted-by":"crossref","unstructured":"Kawana S, Liang Z, Nagano M, Suzuki H (2006) Role of substance P in stress-derived degranulation of dermal mast cells in mice. J Dermatol Sci 42:47-54.","DOI":"10.1016\/j.jdermsci.2005.12.004"},{"key":"key-10.4103\/1673-5374.179073-14","doi-asserted-by":"crossref","unstructured":"Kishi K, Ohyama K, Satoh H, Kubota Y, Tanaka T, Imanishi N, Nakajima H, Kawamura K, Nakajima T (2006) Mutual dependence of murine fetal cutaneous regeneration and peripheral nerve regeneration. Wound Repair Regen 14:91-99.","DOI":"10.1111\/j.1524-475X.2005.00093.x"},{"key":"key-10.4103\/1673-5374.179073-15","doi-asserted-by":"crossref","unstructured":"Li B, Wang JH (2011) Fibroblasts and myofibroblasts in wound healing: force generation and measurement. Journal of tissue viability 20:108-120.","DOI":"10.1016\/j.jtv.2009.11.004"},{"key":"key-10.4103\/1673-5374.179073-16","unstructured":"Li JF, Fu XB, Sheng ZY, Sun TZ (2003) Redistribution of epidermal stem cells in wound edge in the process of re-epithelialization. Zhonghua Yixue Zazhi 83:228-231."},{"key":"key-10.4103\/1673-5374.179073-17","unstructured":"Liu S, Chen L, Cai HW, Chen B (2006) Detection and significance of substance P in plasma and skin tissue of diabetic rats. Disan Junyi Daxue Xuebao 28:1038-1039."},{"key":"key-10.4103\/1673-5374.179073-18","doi-asserted-by":"crossref","unstructured":"Mahjour SB, Ghaffarpasand F, Wang H (2012) Hair follicle regeneration in skin grafts: current concepts and future perspectives. Tissue Eng Part B Rev 18:15-23.","DOI":"10.1089\/ten.teb.2011.0064"},{"key":"key-10.4103\/1673-5374.179073-19","doi-asserted-by":"crossref","unstructured":"Matsuda H, Koyama H, Sato H, Sawada J, Itakura A, Tanaka A, Matsumoto M, Konno K, Ushio H, Matsuda K (1998) Role of nerve growth factor in cutaneous wound healing: accelerating effects in normal and healing-impaired diabetic mice. J Exp Med 187:297-306.","DOI":"10.1084\/jem.187.3.297"},{"key":"key-10.4103\/1673-5374.179073-20","doi-asserted-by":"crossref","unstructured":"O\u2032Connor TM, O\u2032Connell J, O\u2032Brien DI, Goode T, Bredin CP, Shanahan F (2004) The role of substance P in inflammatory disease. J Cell Physiol 201:167-180.","DOI":"10.1002\/jcp.20061"},{"key":"key-10.4103\/1673-5374.179073-21","doi-asserted-by":"crossref","unstructured":"Rathur HM, Boulton AJ (2007) The diabetic foot. Clin Dermatol 25:109-120.","DOI":"10.1016\/j.clindermatol.2006.09.015"},{"key":"key-10.4103\/1673-5374.179073-22","doi-asserted-by":"crossref","unstructured":"Rees DA, Alcolado JC (2005) Animal models of diabetes mellitus. Diabetic Med 22:359-370.","DOI":"10.1111\/j.1464-5491.2005.01499.x"},{"key":"key-10.4103\/1673-5374.179073-23","doi-asserted-by":"crossref","unstructured":"Reiisi S, Esmaeili F, Shirazi A (2010) Isolation, culture and identification of epidermal stem cells from newborn mouse skin. In Vitro Cell Dev Biol Anim 46:54-59.","DOI":"10.1007\/s11626-009-9245-y"},{"key":"key-10.4103\/1673-5374.179073-24","doi-asserted-by":"crossref","unstructured":"Sahbaie P, Shi X, Guo TZ, Qiao Y, Yeomans DC, Kingery WS, Clark JD (2009) Role of substance P signaling in enhanced nociceptive sensitization and local cytokine production after incision. Pain 145:341-349.","DOI":"10.1016\/j.pain.2009.06.037"},{"key":"key-10.4103\/1673-5374.179073-25","doi-asserted-by":"crossref","unstructured":"Scholzen T, Armstrong CA, Bunnett NW, Luger TA, Olerud JE, Ansel JC (1998) Neuropeptides in the skin: interactions between the neuroendocrine and the skin immune systems. Exp Dermatol 7:81-96.","DOI":"10.1111\/j.1600-0625.1998.tb00307.x"},{"key":"key-10.4103\/1673-5374.179073-26","doi-asserted-by":"crossref","unstructured":"Scott JR, Tamura RN, Muangman P, Isik FF, Xie C, Gibran NS (2008) Topical substance P increases inflammatory cell density in genetically diabetic murine wounds. Wound Repair Regen 16:529-533.","DOI":"10.1111\/j.1524-475X.2008.00400.x"},{"key":"key-10.4103\/1673-5374.179073-27","doi-asserted-by":"crossref","unstructured":"Soller EC, Tzeranis DS, Miu K, So PT, Yannas IV (2012) Common features of optimal collagen scaffolds that disrupt wound contraction and enhance regeneration both in peripheral nerves and in skin. Biomaterials 33:4783-4791.","DOI":"10.1016\/j.biomaterials.2012.03.068"},{"key":"key-10.4103\/1673-5374.179073-28","unstructured":"Sun XY, Fu XB, Sun TZ (2007) Isolation, culture and identification of human epithelial stem cells. Zhonghua Shiyan Waike Zazhi 24:163-165."},{"key":"key-10.4103\/1673-5374.179073-29","doi-asserted-by":"crossref","unstructured":"Sun Y, Zhu L, Huang X, Zhou C, Zhang X (2014) Immunohistochemical localization of nerve fibers in the pseudocapsule of fibroids. Eur J Histochem 58:2249.","DOI":"10.4081\/ejh.2014.2249"},{"key":"key-10.4103\/1673-5374.179073-30","doi-asserted-by":"crossref","unstructured":"Velander P, Theopold C, Bleiziffer O, Bergmann J, Svensson H, Feng Y, Eriksson E (2009) Cell suspensions of autologous keratinocytes or autologous fibroblasts accelerate the healing of full thickness skin wounds in a diabetic porcine wound healing model. J Surg Res 157:14-20.","DOI":"10.1016\/j.jss.2008.10.001"},{"key":"key-10.4103\/1673-5374.179073-31","doi-asserted-by":"crossref","unstructured":"Wang Q, Muffley LA, Hall K, Chase M, Gibran NS (2009) Elevated glucose and fatty acid levels impair substance P-induced dermal microvascular endothelial cell migration and proliferation in an agarose gel model system. Shock 32:491-497.","DOI":"10.1097\/SHK.0b013e3181a1cb2e"},{"key":"key-10.4103\/1673-5374.179073-32","unstructured":"Wu YX, Zhang JH, Ben XM (2013) Neuronal-like cell differentiation of non-adherent bone marrow cell-derived mesenchymal stem cells. Neural Regen Res 8:2078-2085."},{"key":"key-10.4103\/1673-5374.179073-33","unstructured":"Zhong QL, Liu FR, Liu DW, Peng Y, Zhang XR (2011) Expression of \u03b2-catenin and cyclin D1 in epidermal stem cells of diabetic rats. Mol Med Rep 4:377-381."},{"key":"key-10.4103\/1673-5374.179073-34","unstructured":"Zhong QL, Liu DW, Liu FR, Peng Y, Yu M, Xiao LL (2010) Amniotic membrane loading epidermal stem cells accelerates wound healing in diabetic rats. Zhongguo Zuzhi Gongcheng Yanjiu yu Linchuang Kangfu 14:6010-6014."},{"key":"key-10.4103\/1673-5374.179073-35","unstructured":"Zhu FB, Liu DW, Zhang HY, Peng Y, Zhong QL, Li YT (2011) Separation, culture and characteristics of epidermal stem cells in diabetes mellitus rats. Zhongguo Zuzhi Gongcheng Yanjiu yu Linchuang Kangfu 15:96-99."},{"key":"key-10.4103\/1673-5374.179073-36","doi-asserted-by":"crossref","unstructured":"Zhu L, Huang Q, Huang X, Zhang J, Xu H, Zhang X (2014) Decreased nerve fibers in the oviduct isthmus of women with endometriosis. Acta Histochem 116:871-877.","DOI":"10.1016\/j.acthis.2014.02.005"}],"container-title":["Neural Regeneration Research"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T13:25:53Z","timestamp":1786713953000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/1673-5374.179073"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016]]}},"alternative-id":["179073"],"URL":"https:\/\/doi.org\/10.4103\/1673-5374.179073","relation":{},"ISSN":["1673-5374"],"issn-type":[{"value":"1673-5374","type":"print"}],"subject":[],"published":{"date-parts":[[2016]]}}}