{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T12:07:31Z","timestamp":1793189251118,"version":"4.5.0"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neural Regen Res"],"published-print":{"date-parts":[[2016]]},"DOI":"10.4103\/1673-5374.193225","type":"journal-article","created":{"date-parts":[[2016,10,28]],"date-time":"2016-10-28T08:05:17Z","timestamp":1477641917000},"page":"1557","source":"Crossref","is-referenced-by-count":33,"title":["Axon injury induced endoplasmic reticulum stress and neurodegeneration"],"prefix":"10.4103","volume":"11","author":[{"given":"Yang","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"key-10.4103\/1673-5374.193225-1","doi-asserted-by":"crossref","unstructured":"Baleriola J, Walker CA, Jean YY, Crary JF, Troy CM, Nagy PL, Hengst U (2014) Axonally synthesized ATF4 transmits a neurodegenerative signal across brain regions. Cell 158:1159-1172.","DOI":"10.1016\/j.cell.2014.07.001"},{"key":"key-10.4103\/1673-5374.193225-2","doi-asserted-by":"crossref","unstructured":"Conforti L, Gilley J, Coleman MP (2014) Wallerian degeneration: an emerging axon death pathway linking injury and disease. Nat Rev Neurosci 15:394-409.","DOI":"10.1038\/nrn3680"},{"key":"key-10.4103\/1673-5374.193225-3","doi-asserted-by":"crossref","unstructured":"Gerdts J, Summers DW, Milbrandt J, DiAntonio A (2016) Axon self-destruction: new links among SARM1, MAPKs, and NAD+ metabolism. Neuron 89:449-460.","DOI":"10.1016\/j.neuron.2015.12.023"},{"key":"key-10.4103\/1673-5374.193225-4","doi-asserted-by":"crossref","unstructured":"Halliday M, Radford H, Sekine Y, Moreno J, Verity N, le Quesne J, Ortori CA, Barrett DA, Fromont C, Fischer PM, Harding HP, Ron D, Mallucci GR (2015) Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity. Cell Death Dis 6:e1672.","DOI":"10.1038\/cddis.2015.49"},{"key":"key-10.4103\/1673-5374.193225-5","doi-asserted-by":"crossref","unstructured":"Hayashi A, Kasahara T, Iwamoto K, Ishiwata M, Kametani M, Kakiuchi C, Furuichi T, Kato T (2007) The role of brain-derived neurotrophic factor (BDNF)-induced XBP1 splicing during brain development. J Biol Chem 282:34525-34534.","DOI":"10.1074\/jbc.M704300200"},{"key":"key-10.4103\/1673-5374.193225-6","doi-asserted-by":"crossref","unstructured":"Hetz C, Mollereau B (2014) Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases. Nat Rev Neurosci 15:233-249.","DOI":"10.1038\/nrn3689"},{"key":"key-10.4103\/1673-5374.193225-7","doi-asserted-by":"crossref","unstructured":"Hiramatsu N, Messah C, Han J, LaVail MM, Kaufman RJ, Lin JH (2014) Translational and posttranslational regulation of XIAP by eIF2alpha and ATF4 promotes ER stress-induced cell death during the unfolded protein response. Mol Biol Cell 25:1411-1420.","DOI":"10.1091\/mbc.E13-11-0664"},{"key":"key-10.4103\/1673-5374.193225-8","doi-asserted-by":"crossref","unstructured":"Hu Y, Park KK, Yang L, Wei X, Yang Q, Cho KS, Thielen P, Lee AH, Cartoni R, Glimcher LH, Chen DF, He Z (2012) Differential effects of unfolded protein response pathways on axon injury-induced death of retinal ganglion cells. Neuron 73:445-452.","DOI":"10.1016\/j.neuron.2011.11.026"},{"key":"key-10.4103\/1673-5374.193225-9","doi-asserted-by":"crossref","unstructured":"Kohl S, Zobor D, Chiang WC, Weisschuh N, Staller J, Gonzalez Menendez I, Chang S, Beck SC, Garcia Garrido M, Sothilingam V, Seeliger MW, Stanzial F, Benedicenti F, Inzana F, H\u00e9on E, Vincent A, Beis J, Strom TM, Rudolph G, Roosing S, et al. (2015) Mutations in the unfolded protein response regulator ATF6 cause the cone dysfunction disorder achromatopsia. Nat Genet 47:757-765.","DOI":"10.1038\/ng.3319"},{"key":"key-10.4103\/1673-5374.193225-10","doi-asserted-by":"crossref","unstructured":"Li S, Yang L, Selzer ME, Hu Y (2013) Neuronal endoplasmic reticulum stress in axon injury and neurodegeneration. Ann Neurol 74:768-777.","DOI":"10.1002\/ana.24005"},{"key":"key-10.4103\/1673-5374.193225-11","doi-asserted-by":"crossref","unstructured":"Lin JH, Li H, Yasumura D, Cohen HR, Zhang C, Panning B, Shokat KM, Lavail MM, Walter P (2007) IRE1 signaling affects cell fate during the unfolded protein response. Science 318:944-949.","DOI":"10.1126\/science.1146361"},{"key":"key-10.4103\/1673-5374.193225-12","doi-asserted-by":"crossref","unstructured":"Mattson MP, LaFerla FM, Chan SL, Leissring MA, Shepel PN, Geiger JD (2000) Calcium signaling in the ER: its role in neuronal plasticity and neurodegenerative disorders. Trends Neurosci 23:222-229.","DOI":"10.1016\/S0166-2236(00)01548-4"},{"key":"key-10.4103\/1673-5374.193225-13","doi-asserted-by":"crossref","unstructured":"Prilloff S, Noblejas MI, Chedhomme V, Sabel BA (2007) Two faces of calcium activation after optic nerve trauma: life or death of retinal ganglion cells in vivo depends on calcium dynamics. Eur J Neurosci 25:3339-3346.","DOI":"10.1111\/j.1460-9568.2007.05550.x"},{"key":"key-10.4103\/1673-5374.193225-14","doi-asserted-by":"crossref","unstructured":"Stirling DP, Stys PK (2010) Mechanisms of axonal injury: internodal nanocomplexes and calcium deregulation. Trends Mol Med 16:160-170.","DOI":"10.1016\/j.molmed.2010.02.002"},{"key":"key-10.4103\/1673-5374.193225-15","doi-asserted-by":"crossref","unstructured":"Wang M, Kaufman RJ (2016) Protein misfolding in the endoplasmic reticulum as a conduit to human disease. Nature 529:326-335.","DOI":"10.1038\/nature17041"},{"key":"key-10.4103\/1673-5374.193225-16","doi-asserted-by":"crossref","unstructured":"Wang R, McGrath BC, Kopp RF, Roe MW, Tang X, Chen G, Cavener DR (2013) Insulin secretion and Ca2+ dynamics in beta-cells are regulated by PERK (EIF2AK3) in concert with calcineurin. J Biol Chem 288:33824-33836.","DOI":"10.1074\/jbc.M113.503664"},{"key":"key-10.4103\/1673-5374.193225-17","doi-asserted-by":"crossref","unstructured":"Yang J, Wu Z, Renier N, Simon DJ, Uryu K, Park DS, Greer PA, Tournier C, Davis RJ, Tessier-Lavigne M (2015) Pathological axonal death through a MAPK cascade that triggers a local energy deficit. Cell 160:161-176.","DOI":"10.1016\/j.cell.2014.11.053"},{"key":"key-10.4103\/1673-5374.193225-18","doi-asserted-by":"crossref","unstructured":"Yang L, Li S, Miao L, Huang H, Liang F, Teng X, Xu L, Wang Q, Xiao W, Ridder WH, 3rd, Ferguson TA, Chen DF, Kaufman RJ, Hu Y (2016) Rescue of glaucomatous neurodegeneration by differentially modulating neuronal endoplasmic reticulum stress molecules. J Neurosci 36:5891-5903.","DOI":"10.1523\/JNEUROSCI.3709-15.2016"},{"key":"key-10.4103\/1673-5374.193225-19","doi-asserted-by":"crossref","unstructured":"Zhou Y, Lee J, Reno CM, Sun C, Park SW, Chung J, Fisher SJ, White MF, Biddinger SB, Ozcan U (2011) Regulation of glucose homeostasis through a XBP-1-FoxO1 interaction. Nat Med 17:356-365.","DOI":"10.1038\/nm.2293"}],"container-title":["Neural Regeneration Research"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T13:28:45Z","timestamp":1786714125000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/1673-5374.193225"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":19,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016]]}},"alternative-id":["193225"],"URL":"https:\/\/doi.org\/10.4103\/1673-5374.193225","relation":{},"ISSN":["1673-5374"],"issn-type":[{"value":"1673-5374","type":"print"}],"subject":[],"published":{"date-parts":[[2016]]}}}