{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T14:09:18Z","timestamp":1793196558630,"version":"4.5.0"},"reference-count":80,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neural Regen Res"],"published-print":{"date-parts":[[2017]]},"DOI":"10.4103\/1673-5374.200812","type":"journal-article","created":{"date-parts":[[2017,2,22]],"date-time":"2017-02-22T04:16:25Z","timestamp":1487736985000},"page":"290","source":"Crossref","is-referenced-by-count":56,"title":["Adenyl cyclase activator forskolin protects against Huntington's disease-like neurodegenerative disorders"],"prefix":"10.4103","volume":"12","author":[{"given":"Sidharth","family":"Mehan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaba","family":"Parveen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjeev","family":"Kalra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"key-10.4103\/1673-5374.200812-1","doi-asserted-by":"crossref","unstructured":"Aebi H, Wyss, Scherz B, Skvaril F (1974) Heterogeneity of erythrocyte catalase II. Isolation and characterization of normal and variant erythrocyte catalase and their subunits. Eur J Biochem 48:137-45.","DOI":"10.1111\/j.1432-1033.1974.tb03751.x"},{"key":"key-10.4103\/1673-5374.200812-2","doi-asserted-by":"crossref","unstructured":"Basso M (2012) Targeting Transcriptional Dysregulation in Huntington's Disease: Description of Therapeutic Approaches. INTECH Open Access Publisher.","DOI":"10.5772\/31579"},{"key":"key-10.4103\/1673-5374.200812-3","doi-asserted-by":"crossref","unstructured":"Benito E, Barco A (2010) CREB's control of intrinsic and synaptic plasticity: implications for CREB-dependent memory models. Trends Neurosci 33:230-240.","DOI":"10.1016\/j.tins.2010.02.001"},{"key":"key-10.4103\/1673-5374.200812-4","doi-asserted-by":"crossref","unstructured":"Binawade Y, Jagtap A (2013) Neuroprotective effect of lutein against 3-nitropropionic acid-induced Huntington's disease-like symptoms: possible behavioral, biochemical, and cellular alterations. J Med Food 16:934-943.","DOI":"10.1089\/jmf.2012.2698"},{"key":"key-10.4103\/1673-5374.200812-5","doi-asserted-by":"crossref","unstructured":"Bitner RS (2012) Cyclic AMP response element-binding protein (CREB) phosphorylation: A mechanistic marker in the development of memory enhancing Alzheimer's disease therapeutics. Biochem Pharmacol 83:705\u2013714.","DOI":"10.1016\/j.bcp.2011.11.009"},{"key":"key-10.4103\/1673-5374.200812-6","doi-asserted-by":"crossref","unstructured":"Boulanger L, Poo MM (1999) Gating of BDNF-Induced Synaptic Potentiation by cAMP. Science 284:1982-1984.","DOI":"10.1126\/science.284.5422.1982"},{"key":"key-10.4103\/1673-5374.200812-7","unstructured":"Breton RR, Rodr\u00edguez JC (2012) Excitotoxicity and oxidative stress in acute ischemic stroke. Stroke 8."},{"key":"key-10.4103\/1673-5374.200812-8","doi-asserted-by":"crossref","unstructured":"Burke WJ, Kumar VB, Panday N, Pannteon WM, Gan Q, Franko MW, O'Dell M, Li SW, Pan Y, Chung HD, Galvin JE (2008) Aggregation of synuclein by DOPAL, the monoamine oxidase metabolite of dopamine. Acta Neuropathol 115:193-203.","DOI":"10.1007\/s00401-007-0303-9"},{"key":"key-10.4103\/1673-5374.200812-9","doi-asserted-by":"crossref","unstructured":"Chaturvedi RK, Beal MF (2013) Mitochondrial diseases of the brain. Free Radical Biol Med 63:1-92.","DOI":"10.1016\/j.freeradbiomed.2013.03.018"},{"key":"key-10.4103\/1673-5374.200812-10","doi-asserted-by":"crossref","unstructured":"Chen JY, Wang EA, Cepeda C, Levine MS (2013) Dopamine imbalance in Huntington's disease: a mechanism for the lack of behavioral flexibility. Front Neurosci 7:1-14.","DOI":"10.3389\/fnins.2013.00114"},{"key":"key-10.4103\/1673-5374.200812-11","doi-asserted-by":"crossref","unstructured":"Choi EJ, Lee BH (2004) Evidence for genistein mediated cytotoxicity and apoptosis in rat brain. Life Sci 75:499-502.","DOI":"10.1016\/j.lfs.2004.01.010"},{"key":"key-10.4103\/1673-5374.200812-12","doi-asserted-by":"crossref","unstructured":"Choi YS, Lee B, Cho HY (2009) CREB is a key regulator of striatal vulnerability in chemical and genetic models of Huntington's Disease. Neurobiol Dis 36:259-268.","DOI":"10.1016\/j.nbd.2009.07.014"},{"key":"key-10.4103\/1673-5374.200812-13","doi-asserted-by":"crossref","unstructured":"Chong YH, Shin YJ, Suh YH (2003) Cyclic AMP inhibition of Tumor necrosis factor \u03b1 production induced by Amyloidogenic C \u2013terminal peptide of Alzheimer's Amyloidprecursor protein in macrophages: involvement of multiple intracellular pathways and cyclic AMP response element binding protein. Mol Pharmacol 63:690-698.","DOI":"10.1124\/mol.63.3.690"},{"key":"key-10.4103\/1673-5374.200812-14","doi-asserted-by":"crossref","unstructured":"Cohen S, Greenberg ME (2008) Communication between the synapse and the nucleus in neuronal development, plasticity, and disease. Annu Rev Cell Dev Biol 24:183-209.","DOI":"10.1146\/annurev.cellbio.24.110707.175235"},{"key":"key-10.4103\/1673-5374.200812-15","doi-asserted-by":"crossref","unstructured":"Colle D, Santos DB, Moreira EL, Hartwig JM, dos Santos AA, Zimmermann LT, Hort MA, Farina M (2013) Probucol increases striatal glutathione peroxidase activity and protects against 3-nitropropionic acid-induced pro-oxidative damage in rats. PLoS One 8:e67658.","DOI":"10.1371\/journal.pone.0067658"},{"key":"key-10.4103\/1673-5374.200812-16","doi-asserted-by":"crossref","unstructured":"Costa V, Scorrano Z (2012) Shaping the role of mitochondria in the pathogenesis Huntington's disease. EMBO J 31:1853-1864.","DOI":"10.1038\/emboj.2012.65"},{"key":"key-10.4103\/1673-5374.200812-17","doi-asserted-by":"crossref","unstructured":"Dalle-Donnea I, Rossib R, Giustarinib D, Milzania A, Colomboa R (2003) Protein carbonyl groups as biomarkers of oxidative stress. Clinica Chimica Acta 329:23-38.","DOI":"10.1016\/S0009-8981(03)00003-2"},{"key":"key-10.4103\/1673-5374.200812-18","doi-asserted-by":"crossref","unstructured":"Damiano M, Galvan L, D\u00e9glon N, Brouillet E (2010) Mitochondria in Huntington's disease. Biochim Biophys Acta 1802:52-61.","DOI":"10.1016\/j.bbadis.2009.07.012"},{"key":"key-10.4103\/1673-5374.200812-19","doi-asserted-by":"crossref","unstructured":"Delorme T, Najafi M, Nasr P (2012) The spatial and temporal relationship between oxidative stress and neuronal degeneration in 3-nitropropionic acid model. World J Neurosci 2:234-247.","DOI":"10.4236\/wjns.2012.24036"},{"key":"key-10.4103\/1673-5374.200812-20","doi-asserted-by":"crossref","unstructured":"Deshmukh R, Sharma V, Mehan S, Sharma N, Bedi KL (2009) Amelioration of intracerebroventricular streptozotocin induced cognitive dysfunction and oxidative stress by vinpocetine - a PDE1 inhibitor. Eur J Pharmacol 620:49-56.","DOI":"10.1016\/j.ejphar.2009.08.027"},{"key":"key-10.4103\/1673-5374.200812-21","doi-asserted-by":"crossref","unstructured":"Dhingra D, Kumar V (2012) Memory-Enhancing Activity of Palmatine inMice Using Elevated Plus Maze andMorris Water Maze. Adv Pharmacol Sci 1-7.","DOI":"10.1155\/2012\/357368"},{"key":"key-10.4103\/1673-5374.200812-22","doi-asserted-by":"crossref","unstructured":"Dhir A, Akula KK, Kulkarni SK (2008) Tiagabine, a GABA uptake inhibitor, attenuates 3-nitropropionic acid-induced alterations in various behavioral and biochemical parameters in rats. Prog Neuro-Psychopharmacol Biol Psych 32:835\u2013843.","DOI":"10.1016\/j.pnpbp.2007.12.017"},{"key":"key-10.4103\/1673-5374.200812-23","doi-asserted-by":"crossref","unstructured":"Dillingham MA, Kim JK, Horster MF, Anderson RJ (1984) Forskolin increases osmotic water permeability of rabbit cortical collecting tubule. J Memb Biol 80:243-248.","DOI":"10.1007\/BF01868442"},{"key":"key-10.4103\/1673-5374.200812-24","doi-asserted-by":"crossref","unstructured":"Ellman G (1959) Tissue sulfhydryl groups. Arch Biochem Biophys 82:70-77.","DOI":"10.1016\/0003-9861(59)90090-6"},{"key":"key-10.4103\/1673-5374.200812-25","doi-asserted-by":"crossref","unstructured":"Ellman GL, Courtney KD, Anders V, Featherstone RM (1961) A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 7:88-94.","DOI":"10.1016\/0006-2952(61)90145-9"},{"key":"key-10.4103\/1673-5374.200812-26","doi-asserted-by":"crossref","unstructured":"Fontan-Lozano A, Romero-Granados R, Perez-Villegas EM, Carri\u00f3n AM (2012) The role of CREB in neuronal plasticity, learning and memory, and in neuropsychiatric disorders. In: Transcription Factors CREB and NF-\u03baB: Involvement in Synaptic Plasticity and Memory Formation (Grilli M, Meneghini V). DOI: 10.2174\/97816080525781120101.","DOI":"10.2174\/97816080525781120101"},{"key":"key-10.4103\/1673-5374.200812-27","doi-asserted-by":"crossref","unstructured":"Gao Y, Chu SF, Li JP, Zhang Z, Yan JQ, Wen ZL, Xia CY, Mou Z, Wang ZZ, He WB, Guo XF, Wei GN, Chen NH (2015) Protopanaxtriol protects against 3-nitropropionic acid-induced oxidative stress in a rat model of Huntington's disease. Acta Pharmacol Sin 36:311-322.","DOI":"10.1038\/aps.2014.107"},{"key":"key-10.4103\/1673-5374.200812-28","doi-asserted-by":"crossref","unstructured":"Gloerich M, Bos JL (2010) Epac: defining a new mechanism for cAMP action. Annu Rev Pharmacol Toxicol 50:355-375.","DOI":"10.1146\/annurev.pharmtox.010909.105714"},{"key":"key-10.4103\/1673-5374.200812-29","doi-asserted-by":"crossref","unstructured":"Gong B, Vitolo OV, Trinchese F, Liu S, Shelanski M, Arancio1 O (2004) Persistent improvement in synaptic and cognitive functions in an Alzheimer mouse model after rolipram treatment. J Clin Invest 114:1624-1634.","DOI":"10.1172\/JCI22831"},{"key":"key-10.4103\/1673-5374.200812-30","doi-asserted-by":"crossref","unstructured":"Gornall AG, Bardawill CJ, David MM (1949) Determination of serum proteins by means of the biuret reaction. J Biol Chem 177:751\u201366.","DOI":"10.1016\/S0021-9258(18)57021-6"},{"key":"key-10.4103\/1673-5374.200812-31","doi-asserted-by":"crossref","unstructured":"Green LC, Wagner DA, Glogowski J, Skipper PL, Wishnok JS, Tannenbaum SR (1982) Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. Anal Biochem 126:131-138.","DOI":"10.1016\/0003-2697(82)90118-X"},{"key":"key-10.4103\/1673-5374.200812-32","doi-asserted-by":"crossref","unstructured":"Harper SQ, Staber PD, He X, Eliason SL, Martins IH, Mao Q, Yang L, Kotin RM, Paulson HL, Davidson BL (2005) RNA interference improves motor and neuropathological abnormalities in a Huntington's disease mouse model. Proc Natl Acad Sci U S A 102:5820-5825.","DOI":"10.1073\/pnas.0501507102"},{"key":"key-10.4103\/1673-5374.200812-33","doi-asserted-by":"crossref","unstructured":"Heo H, Yoo M, Han D, Cho Y, Joung I, Kwon YK (2013) Upregulation of TrkB by forskolin facilitated survival of MSC and functional recovery of memory deficient model rats. Biochem Biophys Res Comm 431:796-801.","DOI":"10.1016\/j.bbrc.2012.12.122"},{"key":"key-10.4103\/1673-5374.200812-34","doi-asserted-by":"crossref","unstructured":"Ishrat T, Khan MB, Hoda MN, Yousuf S, Ahmad M, Ansari MA, Ahmad AS, Islam F (2006) Coenzyme Q10 modulates cognitive impairment against intracerebroventricular injection of streptozotocin in rats. Behav Brain Res 171:9-16.","DOI":"10.1016\/j.bbr.2006.03.009"},{"key":"key-10.4103\/1673-5374.200812-35","unstructured":"Jadiswami C, Megha HM, Shivsharan BD, Sharanbasappa D, Pandharinath PP, Thippeswamy BS, Veerapur VP (2014) Piroxicam attenuates 3-nitropropionic acid-induced brain oxidative stress and behavioral alteration in mice. Toxicol Mech Methods 24:1-7."},{"key":"key-10.4103\/1673-5374.200812-36","doi-asserted-by":"crossref","unstructured":"Ji Y, Pang PT, Feng L, Lu B (2005) Cyclic AMP controls BDNF- induced TrkB phosphorylation and dentritic spine formation in mature hippocampal neurons. Nat Neurosci 8:165-172.","DOI":"10.1038\/nn1381"},{"key":"key-10.4103\/1673-5374.200812-37","doi-asserted-by":"crossref","unstructured":"Kim GW, Copin JC, Kawase M, Chen SF, Sato S, Gobbel GT, Chan PH (2000) Excitotoxicity is required for induction of oxidative stress and apoptosis in mouse striatum by the mitochondrial toxin, 3-nitropropionic acid. J Cereb Blood Flow Metab 20:119-129.","DOI":"10.1097\/00004647-200001000-00016"},{"key":"key-10.4103\/1673-5374.200812-38","doi-asserted-by":"crossref","unstructured":"Kim SH, Thomas CA, Andr\u00e9 VM, Cummings DM, Cepeda C, Levine MS, Ehrlich ME (2011) Forebrain striatal-specific expression of mutant huntingtin protein in vivo induces cell-autonomous age-dependent alterations in sensitivity to excitotoxicity and mitochondrial function. ASN Neuro 3:e00060.","DOI":"10.1042\/AN20110009"},{"key":"key-10.4103\/1673-5374.200812-39","doi-asserted-by":"crossref","unstructured":"Kumar P, Kumar A (2009) Protective effect of rivastigmine against 3-nitropropionic acid-induced Huntington's disease like symptoms: Possible behavioural, biochemical and cellular alterations. Eur J Pharmacol 615:91-101.","DOI":"10.1016\/j.ejphar.2009.04.058"},{"key":"key-10.4103\/1673-5374.200812-40","doi-asserted-by":"crossref","unstructured":"Kumar P, Padi SS, Naidu PS, Kumar A (2007) Cyclooxygenase inhibition attenuates 3-nitropropionic acid-induced neurotoxicity in rats: possible antioxidant mechanisms. Fund Clin Pharmacol 21:297-306.","DOI":"10.1111\/j.1472-8206.2007.00485.x"},{"key":"key-10.4103\/1673-5374.200812-41","doi-asserted-by":"crossref","unstructured":"Kumar P, Padi SSV, Naidu, PS and Kumar A (2006) Effect of resveratrol on 3-nitropropionic acid- induced biochemical and behavioural changes: possible neuroprotective mechanisms. Behav Pharmacol 17:485-492.","DOI":"10.1097\/00008877-200609000-00014"},{"key":"key-10.4103\/1673-5374.200812-42","doi-asserted-by":"crossref","unstructured":"Leenders AG, Sheng ZH (2005) Modulation of neurotransmitter release by the second messenger-activated protein kinases: implications for presynaptic plasticity. Pharmacol Ther 105:69-84.","DOI":"10.1016\/j.pharmthera.2004.10.012"},{"key":"key-10.4103\/1673-5374.200812-43","doi-asserted-by":"crossref","unstructured":"Lin B, Levy S, Raval AP, Perez-Pinzon MA, DeFazio RA (2010) Forebrain ischemia triggers GABAergic system degeneration in substantial nigra at chronic stages in rats. Cardiovas Psych Neurol 2010:1-16.","DOI":"10.1155\/2010\/506952"},{"key":"key-10.4103\/1673-5374.200812-44","doi-asserted-by":"crossref","unstructured":"Liot G, Bossy B, Lubitz S, Kushnareva Y, Sejbuk N, Bossy-Wetzel E (2009) Complex II inhibition by 3-NP causes mitochondrial fragmentation and neuronal cell death via an NMDA- and ROS-dependent pathway. Cell Death Differ 16:899-909.","DOI":"10.1038\/cdd.2009.22"},{"key":"key-10.4103\/1673-5374.200812-45","doi-asserted-by":"crossref","unstructured":"Liu M, Gua L, Sulkin MS (2013) Mitochondrial dysfunction causing cardiac sodium channel downregulation in cardiomyopathy. J Mol Cell Cardiol 54:25-34.","DOI":"10.1016\/j.yjmcc.2012.10.011"},{"key":"key-10.4103\/1673-5374.200812-46","doi-asserted-by":"crossref","unstructured":"Maharaj DS, Walker RB, Glass BD, Daya S (2003) 6-Hydroxymelatonin protects against cyanide induced oxidative stress in rat brain homogenates. J Chem Neuroanat 26:103-107.","DOI":"10.1016\/S0891-0618(03)00034-6"},{"key":"key-10.4103\/1673-5374.200812-47","doi-asserted-by":"crossref","unstructured":"Massaad CA, Klann E (2011) Reactive oxygen species in the regulation of synaptic plasticity and memory. Antioxid Redox Signal 14:2013-2054.","DOI":"10.1089\/ars.2010.3208"},{"key":"key-10.4103\/1673-5374.200812-48","doi-asserted-by":"crossref","unstructured":"McGaugh JL (2002) Memory consolidation and the amygdala: a systems perspective. Trends Neurosci 25:456.","DOI":"10.1016\/S0166-2236(02)02211-7"},{"key":"key-10.4103\/1673-5374.200812-49","unstructured":"Mehan S, Nain VS, Meena H, Sharma D, Sankhla R, Singh M (2010) Comparative effect of phosphodiesterase inhibitors on intracerebroventricular cochicine model of memory impairement in rats. Int J Pharma Prof Res 1:122-136."},{"key":"key-10.4103\/1673-5374.200812-50","doi-asserted-by":"crossref","unstructured":"Mehrotra A, Kanwal A, Banerjee SK, Sandhir R (2015) Mitochondrial modulators in experimental Huntington's disease: reversal of mitochondrial dysfunctions and cognitive deficits. Neurobiol Aging 36:2186-2200.","DOI":"10.1016\/j.neurobiolaging.2015.02.004"},{"key":"key-10.4103\/1673-5374.200812-51","doi-asserted-by":"crossref","unstructured":"Misra HP, Fridovich I (1972) The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. J Biol Chem 247:3170-3175.","DOI":"10.1016\/S0021-9258(19)45228-9"},{"key":"key-10.4103\/1673-5374.200812-52","doi-asserted-by":"crossref","unstructured":"Monsalve M, Borniquel S, Valle I, Lamas S (2012) Mitochondrial dysfunction in human pathologies. Front Biosci 12:1131-1153.","DOI":"10.2741\/2132"},{"key":"key-10.4103\/1673-5374.200812-53","doi-asserted-by":"crossref","unstructured":"Nagakura A, Niimura M, Takeo S (2002) Effects of a phosphodiesterase IV inhibitor rolipram on microsphere embolism-induced defects in memory function and cerebral cyclic AMP signal transduction system in rats. Brit J Pharmacol 135:1783-1793.","DOI":"10.1038\/sj.bjp.0704629"},{"key":"key-10.4103\/1673-5374.200812-54","doi-asserted-by":"crossref","unstructured":"Nishihara H, Kizaka-Kondoh S, Insel PA, Eckmann L (2003) Inhibition of apoptosis in normal and transformed intestinal epithelial cells by cAMP through induction of inhibitor of apoptosis protein (IAP)-2. Proc Natl Acad Sci U S A 100:8921-8926.","DOI":"10.1073\/pnas.1533221100"},{"key":"key-10.4103\/1673-5374.200812-55","doi-asserted-by":"crossref","unstructured":"Oda Y (1999) Choline acetyltransferase: the structure, distribution and pathologic changes in the central nervous system. Pathol Int 49:921-937.","DOI":"10.1046\/j.1440-1827.1999.00977.x"},{"key":"key-10.4103\/1673-5374.200812-56","doi-asserted-by":"crossref","unstructured":"Oliveira JM, Jekabsons MB, Chen S, Lin A, Rego AC, Gon\u00e7alves J, Ellerby LM, Nicholls DG (2007) Mitochondrial dysfunction in Huntington's disease: the bioenergetics of isolated and in situ mitochondria from transgenic mice. J Neurochem 101:241-249.","DOI":"10.1111\/j.1471-4159.2006.04361.x"},{"key":"key-10.4103\/1673-5374.200812-57","unstructured":"Origlia N, Kuczewski N, Pesavento E, Aztiria E, Domenici L (2008) The role of cholinergic system in neuronal plasticity: focus on visual cortex and muscarinic receptors. Arch Ital Biol 146:165-188."},{"key":"key-10.4103\/1673-5374.200812-58","doi-asserted-by":"crossref","unstructured":"Pahan K, Namboodiri AM, Sheikh FG, Smith BT, Singh I (1997) Increasing cAMP attenuates induction of inducible nitric-oxide synthase in rat primary astrocytes. J Biol Chem 272:7786-7791.","DOI":"10.1074\/jbc.272.12.7786"},{"key":"key-10.4103\/1673-5374.200812-59","doi-asserted-by":"crossref","unstructured":"Pizzorusso T, Ratto GM, Putignano E, Maffei L (2000) Brain-derived neurotrophic factor causes cAMP response element-binding protein phosphorylation in absence of calcium increases in slices and cultured neurons from rat visual cortex. J Neurosci 20:2809-2816.","DOI":"10.1523\/JNEUROSCI.20-08-02809.2000"},{"key":"key-10.4103\/1673-5374.200812-60","doi-asserted-by":"crossref","unstructured":"Puzzo D, Vitolo O, Trinchese F, Jacob JP, Palmeri A, Arancio O (2005) Amyloid-beta peptide inhibits activation of the nitric oxide\/cGMP\/cAMP-responsive element-binding protein pathway during hippocampal synaptic plasticity. J Neurosci 25:6887-6897.","DOI":"10.1523\/JNEUROSCI.5291-04.2005"},{"key":"key-10.4103\/1673-5374.200812-61","unstructured":"Ramanathan M, Babu CS, Justin A, Shanthakumari S (2012) Elucidation of neuroprotective role of endogenous GABAand energy metabolites in middle cerebral artery occluted model in rats. Ind J Exp Biol 50:391-397."},{"key":"key-10.4103\/1673-5374.200812-62","doi-asserted-by":"crossref","unstructured":"Reynolds DS, Carter RJ, and A. Morton AJ (1998) Dopamine modulates the susceptibility of striatal neurons to 3-nitropropionic acid in the rat model of Huntington's disease. J Neurosci 18:10116-10127.","DOI":"10.1523\/JNEUROSCI.18-23-10116.1998"},{"key":"key-10.4103\/1673-5374.200812-63","unstructured":"Ribeiro FM, Dobransky T, Carvalho EA, Cruz JS, Oliveira FA (2012) Energy Metabolism in Huntington's Disease. INTECH Open Access Publisher"},{"key":"key-10.4103\/1673-5374.200812-64","doi-asserted-by":"crossref","unstructured":"Rosales-Corral S, Tan DX, Manchester L, Reiter RJ (2015) Diabetes and Alzheimer disease, two overlapping pathologies with the same background: oxidative stress. Oxid Med Cell Longev 2015:985845.","DOI":"10.1155\/2015\/985845"},{"key":"key-10.4103\/1673-5374.200812-65","doi-asserted-by":"crossref","unstructured":"Sassone J, Colciago C, Cislaghi G, Silani V, Ciammola A (2009) Huntington's disease: The current state of research with peripheral tissues. Exp Neurol 219:385\u2013397.","DOI":"10.1016\/j.expneurol.2009.05.012"},{"key":"key-10.4103\/1673-5374.200812-66","doi-asserted-by":"crossref","unstructured":"Sato S, Gobbel GT, Honkaniemi J, Li Y, Kondo T, Murakami K, Sato M, Copin JC, Chan PH (1997) Apoptosis in the striatum of rats following intraperitoneal injection of 3-nitropropionicacid. Brain Res 745: 343-347.","DOI":"10.1016\/S0006-8993(96)01231-0"},{"key":"key-10.4103\/1673-5374.200812-67","doi-asserted-by":"crossref","unstructured":"Sharma M, Gupta YK (2003) Effect of alpha lipoic acid on intracerebroventricular streptozotocin model of cognitive impairment in rats. Eur Neuropsychopharmacol 13:241-247.","DOI":"10.1016\/S0924-977X(03)00008-7"},{"key":"key-10.4103\/1673-5374.200812-68","doi-asserted-by":"crossref","unstructured":"Shear DA, Dong J, Gundy CD, Haik-Creguer KL, Dunbar GL (1998) Comparison of intrastriatal injections of quinolinic acid and 3-nitropropionic acid for use in animal models of Huntington's disease. Prog Neuropsychopharmacol Biol Psychiatry 22:1217-1240.","DOI":"10.1016\/S0278-5846(98)00070-0"},{"key":"key-10.4103\/1673-5374.200812-69","doi-asserted-by":"crossref","unstructured":"Shetty S, Hariharan A, Shirole T, Jagtap AG (2015) Neuroprotective potential of escitalopram against behavioral, mitochondrial and oxidative dysfunction induced by 3-nitropropionic acid. Ann Neurosci 22:11-18.","DOI":"10.5214\/ans.0972.7531.220104"},{"key":"key-10.4103\/1673-5374.200812-70","doi-asserted-by":"crossref","unstructured":"Singh S, Jamwal S, Kumar P (2015) Piperine enhances the protective effect of curcumin against 3-NP induced neurotoxicity: possible neurotransmitters modulation mechanism. Neurochem Res 40:1758-1766.","DOI":"10.1007\/s11064-015-1658-2"},{"key":"key-10.4103\/1673-5374.200812-71","unstructured":"Sundaram RS, Gowtham L, Nayak BS (2012) The role of excitatory neurotransmitter glutamate in brain physiology and pathology. Asian J Pharmaceut Clin Res 5:P1-7."},{"key":"key-10.4103\/1673-5374.200812-72","unstructured":"Thakur T, Mehan S, Kaur R, Kalra S (2014) Huntington's disease: A hard nut to break. Int J Rec Adv Pharmaceut Res 4:38-58."},{"key":"key-10.4103\/1673-5374.200812-73","doi-asserted-by":"crossref","unstructured":"Tunez I, Tasset I, Cruz VP, Santamaria A (2010) 3-Nitropropionic acid as a tool to study the mechanisms involved in Huntington's disease: past, present and future. Molecules 15:878-916.","DOI":"10.3390\/molecules15020878"},{"key":"key-10.4103\/1673-5374.200812-74","doi-asserted-by":"crossref","unstructured":"Venkatesan R, Ji E, Kim SY (2015) Phytochemicals that regulate neurodegenerative disease by targeting neurotrophins: a comprehensive review. Biomed Res Int 2015:814068.","DOI":"10.1155\/2015\/814068"},{"key":"key-10.4103\/1673-5374.200812-75","doi-asserted-by":"crossref","unstructured":"Walker RH (2011) Differential diagnosis of Chorea. Curr Neurol Neurosci Rep 11:385-395.","DOI":"10.1007\/s11910-011-0202-2"},{"key":"key-10.4103\/1673-5374.200812-76","doi-asserted-by":"crossref","unstructured":"Wani TA, Al-Omara MA, Zargarb S (2011) Huntington disease: current advances in pathogenesis and recent therapeutic strategies. Int J Pharm Sci Drug Res 3:69-79.","DOI":"10.25004\/IJPSDR.2011.030201"},{"key":"key-10.4103\/1673-5374.200812-77","doi-asserted-by":"crossref","unstructured":"Wills ED (1966) Mechanism of lipid peroxide formation in animal tissue. Biochem J 99:667-676.","DOI":"10.1042\/bj0990667"},{"key":"key-10.4103\/1673-5374.200812-78","doi-asserted-by":"crossref","unstructured":"Zhang J, Wang Q, Zhu N, Yu M, Shen B, Xiang J, Lin A (2008) Cyclic AMP inhibits JNK activation by CREB-mediated induction of c-FLIPL and MKP-1, thereby antagonizing UV-induced apoptosis. Cell Death Different 15:1654-1662.","DOI":"10.1038\/cdd.2008.87"},{"key":"key-10.4103\/1673-5374.200812-79","doi-asserted-by":"crossref","unstructured":"Zhang L, Fang Y, Lian Y, Chen Y, Wu T, Zheng Y, Zong H, Sun L, Zhang R, Wang Z, Xu Y (2015) Brain-derived neurotrophic factor ameliorates learning deficits in a rat model of Alzheimer's disease induced by A\u03b21-42. PLoS One 10:1-14.","DOI":"10.1371\/journal.pone.0122415"},{"key":"key-10.4103\/1673-5374.200812-80","doi-asserted-by":"crossref","unstructured":"Zou J, Crews F (2006) CREB and NF-\u03baB transcription factors regulate sensitivity to excitotoxic and oxidative stress induced neuronal cell death. Cell Mol Neurobiol 26:4-6.","DOI":"10.1007\/s10571-006-9045-9"}],"container-title":["Neural Regeneration Research"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:09:04Z","timestamp":1787065744000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/1673-5374.200812"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":80,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017]]}},"alternative-id":["200812"],"URL":"https:\/\/doi.org\/10.4103\/1673-5374.200812","relation":{},"ISSN":["1673-5374"],"issn-type":[{"value":"1673-5374","type":"print"}],"subject":[],"published":{"date-parts":[[2017]]}}}