{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T15:57:44Z","timestamp":1786636664628,"version":"build-2736575974"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neural Regen Res"],"published-print":{"date-parts":[[2017]]},"DOI":"10.4103\/1673-5374.202945","type":"journal-article","created":{"date-parts":[[2017,3,24]],"date-time":"2017-03-24T08:47:17Z","timestamp":1490345237000},"page":"417","source":"Crossref","is-referenced-by-count":22,"title":["Neuroprotective effects of autophagy inhibition on hippocampal glutamate receptor subunits after hypoxia-ischemia-induced brain damage in newborn rats"],"prefix":"10.4103","volume":"12","author":[{"given":"Bin","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Feng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-xiao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-juan","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-yuan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-fang","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-hong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"key-10.4103\/1673-5374.202945-1","doi-asserted-by":"crossref","unstructured":"Blommaart EF, Krause U, Schellens JP, Vreeling-Sindel\u00e1rov\u00e1 H, Meijer AJ (1997) The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes. Eur J Biochem 243:240-246.","DOI":"10.1111\/j.1432-1033.1997.0240a.x"},{"key":"key-10.4103\/1673-5374.202945-2","doi-asserted-by":"crossref","unstructured":"Chen H, Qu Y, Tang B, Xiong T, Mu D (2012) Role of mammalian target of rapamycin in hypoxic or ischemic brain injury: potential neuroprotection and limitations. Rev Neurosci 23:279-287.","DOI":"10.1515\/revneuro-2012-0001"},{"key":"key-10.4103\/1673-5374.202945-3","doi-asserted-by":"crossref","unstructured":"Dixon BJ, Reis C, Ho WM, Tang J, Zhang JH (2015) Neuroprotective strategies after neonatal hypoxic ischemic encephalopathy. Int J Mol Sci 16:22368-22401.","DOI":"10.3390\/ijms160922368"},{"key":"key-10.4103\/1673-5374.202945-4","doi-asserted-by":"crossref","unstructured":"Gainey MA, Hurvitz-Wolff JR, Lambo ME, Turrigiano GG (2009) Synaptic scaling requires the GluR2 subunit of the AMPA receptor. J Neurosci 29:6479-6489.","DOI":"10.1523\/JNEUROSCI.3753-08.2009"},{"key":"key-10.4103\/1673-5374.202945-5","doi-asserted-by":"crossref","unstructured":"Guo H, Zhou H, Lu J, Qu Y, Yu D, Tong Y (2016) Vascular endothelial growth factor: an attractive target in the treatment of hypoxic\/ischemic brain injury. Neural Regen Res 11:174-179.","DOI":"10.4103\/1673-5374.175067"},{"key":"key-10.4103\/1673-5374.202945-6","doi-asserted-by":"crossref","unstructured":"Hollmann M, Hartley M, Heinemann S (1991) Ca2+ permeability of KA-AMPA-gated glutamate receptor channels depends on subunit composition. Science 252:851-853.","DOI":"10.1126\/science.1709304"},{"key":"key-10.4103\/1673-5374.202945-7","doi-asserted-by":"crossref","unstructured":"Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, et al. (2016) Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 12:1-222.","DOI":"10.1080\/15548627.2015.1100356"},{"key":"key-10.4103\/1673-5374.202945-8","doi-asserted-by":"crossref","unstructured":"Li Q, Li H, Roughton K, Wang X, Kroemer G, Blomgren K, Zhu C (2010) Lithium reduces apoptosis and autophagy after neonatal hypoxia\u2013ischemia. Cell Death Dis 1:e56.","DOI":"10.1038\/cddis.2010.33"},{"key":"key-10.4103\/1673-5374.202945-9","doi-asserted-by":"crossref","unstructured":"Liu SJ, Savtchouk I (2012) Ca(2+) permeable AMPA receptors switch allegiances: mechanisms and consequences. J Physiol 590:13-20.","DOI":"10.1113\/jphysiol.2011.213926"},{"key":"key-10.4103\/1673-5374.202945-10","doi-asserted-by":"crossref","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25:402-408.","DOI":"10.1006\/meth.2001.1262"},{"key":"key-10.4103\/1673-5374.202945-11","doi-asserted-by":"crossref","unstructured":"Matsuda S, Miura E, Matsuda K, Kakegawa W, Kohda K, Watanabe M, Yuzaki M (2008) Accumulation of AMPA receptors in autophagosomes in neuronal axons lacking adaptor protein AP-4. Neuron 57:730-745.","DOI":"10.1016\/j.neuron.2008.02.012"},{"key":"key-10.4103\/1673-5374.202945-12","doi-asserted-by":"crossref","unstructured":"Patel Shyama D, Pierce L, Ciardiello Amber J, Vannucci Susan J (2014) Neonatal encephalopathy: pre-clinical studies in neuroprotection. Biochem Soc Trans 42:564-568.","DOI":"10.1042\/BST20130247"},{"key":"key-10.4103\/1673-5374.202945-13","doi-asserted-by":"crossref","unstructured":"Perlman M, Shah PS (2011) Hypoxic-ischemic encephalopathy: challenges in outcome and prediction. J Pediatr 158:e51-e54.","DOI":"10.1016\/j.jpeds.2010.11.014"},{"key":"key-10.4103\/1673-5374.202945-14","doi-asserted-by":"crossref","unstructured":"Puyal J, Ginet V, Grishchuk Y, Truttmann AC, Clarke PG (2012) Neuronal autophagy as a mediator of life and death: contrasting roles in chronic neurodegenerative and acute neural disorders. Neuroscientist 18:224-236.","DOI":"10.1177\/1073858411404948"},{"key":"key-10.4103\/1673-5374.202945-15","doi-asserted-by":"crossref","unstructured":"Quintana P, Alberi S, Hakkoum D, Muller D (2006) Glutamate receptor changes associated with transient anoxia\/hypoglycaemia in hippocampal slice cultures. Eur J Neurosci 23:975-983.","DOI":"10.1111\/j.1460-9568.2006.04617.x"},{"key":"key-10.4103\/1673-5374.202945-16","doi-asserted-by":"crossref","unstructured":"Rocha-Ferreira and Hristova (2016) Plasticity in the neonatal brain following hypoxic-ischaemic injury. Neural Plast 2016:4901014.","DOI":"10.1155\/2016\/4901014"},{"key":"key-10.4103\/1673-5374.202945-17","doi-asserted-by":"crossref","unstructured":"Samokhvalov V, Scott BA, Crowder CM (2008) Autophagy protects from hypoxic injury in C. elegans. Autophagy 4:1034-1041.","DOI":"10.4161\/auto.6994"},{"key":"key-10.4103\/1673-5374.202945-18","doi-asserted-by":"crossref","unstructured":"Shankaran S (2012) Hypoxic-ischemic encephalopathy and novel strategies for neuroprotection. Clin Perinatol 39:919-929.","DOI":"10.1016\/j.clp.2012.09.008"},{"key":"key-10.4103\/1673-5374.202945-19","doi-asserted-by":"crossref","unstructured":"Shehata M, Matsumura H, Okubo-Suzuki R, Ohkawa N, Inokuchi K (2012) Neuronal stimulation induces autophagy in hippocampal neurons that is involved in AMPA receptor degradation after chemical long-term depression. J Neurosci 32:10413-10422.","DOI":"10.1523\/JNEUROSCI.4533-11.2012"},{"key":"key-10.4103\/1673-5374.202945-20","doi-asserted-by":"crossref","unstructured":"Shi SH, Hayashi Y, Esteban JA, Malinow R (2001) Subunit-specific rules governing AMPA receptor trafficking to synapses in hippocampal pyramidal neurons. Cell 105:331-343.","DOI":"10.1016\/S0092-8674(01)00321-X"},{"key":"key-10.4103\/1673-5374.202945-21","doi-asserted-by":"crossref","unstructured":"Tang XJ, Xing F (2013) Calcium-permeable AMPA receptors in neonatal hypoxic-ischemic encephalopathy (Review). Biomed Rep 1:828-832.","DOI":"10.3892\/br.2013.154"},{"key":"key-10.4103\/1673-5374.202945-22","doi-asserted-by":"crossref","unstructured":"Umeda K, Kotake Y, Miyara M, Ishida K, Sanoh S, Ohta S (2016) Methoxychlor and fenvalerate induce neuronal death by reducing GluR2 expression. J Toxicol Sci 41:255-264.","DOI":"10.2131\/jts.41.255"},{"key":"key-10.4103\/1673-5374.202945-23","doi-asserted-by":"crossref","unstructured":"Vannucci RC, Vannucci SJ (1997) A model of perinatal hypoxic-ischemic brain damage. Ann N Y Acad Sci 835:234-249.","DOI":"10.1111\/j.1749-6632.1997.tb48634.x"},{"key":"key-10.4103\/1673-5374.202945-24","doi-asserted-by":"crossref","unstructured":"Wang Y, Barbaro MF, Baraban SC (2006) A role for the mTOR pathway in surface expression of AMPA receptors. Neurosci Lett 401:35-39.","DOI":"10.1016\/j.neulet.2006.03.011"},{"key":"key-10.4103\/1673-5374.202945-25","doi-asserted-by":"crossref","unstructured":"Xie C, Ginet V, Sun Y, Koike M, Zhou K, Li T, Li H, Li Q, Wang X, Uchiyama Y, Truttmann AC, Kroemer G, Puyal J, Blomgren K, Zhu C (2016) Neuroprotection by selective neuronal deletion of Atg7 in neonatal brain injury. Autophagy 12:410-423.","DOI":"10.1080\/15548627.2015.1132134"},{"key":"key-10.4103\/1673-5374.202945-26","doi-asserted-by":"crossref","unstructured":"Yang Y, Coleman M, Zhang L, Zheng X, Yue Z (2013) Autophagy in axonal and dendritic degeneration. Trends Neurosci 36:418-428.","DOI":"10.1016\/j.tins.2013.04.001"},{"key":"key-10.4103\/1673-5374.202945-27","doi-asserted-by":"crossref","unstructured":"Yao Y, Zheng XR, Zhang SS, Wang X, Yu XH, Tan JL, Yang YJ (2016) Transplantation of vascular endothelial growth factor-modified neural stem\/progenitor cells promotes the recovery of neurological function following hypoxic-ischemic brain damage. Neural Regen Res 11:1456-1463.","DOI":"10.4103\/1673-5374.191220"},{"key":"key-10.4103\/1673-5374.202945-28","doi-asserted-by":"crossref","unstructured":"Zalewska T, Jaworska J, Ziemka-Nalecz M (2015) Current and experimental pharmacological approaches in neonatal hypoxic-ischemic encephalopathy. Curr Pharm Des 21:1433-1439.","DOI":"10.2174\/1381612820999141029162457"}],"container-title":["Neural Regeneration Research"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T14:59:42Z","timestamp":1786633182000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/1673-5374.202945"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017]]}},"alternative-id":["202945"],"URL":"https:\/\/doi.org\/10.4103\/1673-5374.202945","relation":{},"ISSN":["1673-5374"],"issn-type":[{"value":"1673-5374","type":"print"}],"subject":[],"published":{"date-parts":[[2017]]}}}