{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T12:21:44Z","timestamp":1790511704806,"version":"4.1.0"},"reference-count":52,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neural Regen Res"],"published-print":{"date-parts":[[2017]]},"DOI":"10.4103\/1673-5374.206650","type":"journal-article","created":{"date-parts":[[2017,5,22]],"date-time":"2017-05-22T01:01:58Z","timestamp":1495414918000},"page":"787","source":"Crossref","is-referenced-by-count":25,"title":["Correlation between white matter damage and gray matter lesions in multiple sclerosis patients"],"prefix":"10.4103","volume":"12","author":[{"given":"Xia","family":"Cao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-mei","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-ji","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ce","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie-bing","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohit","family":"Bakshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"key-10.4103\/1673-5374.206650-1","doi-asserted-by":"crossref","unstructured":"Asaf A, Evan S, Anat A (2015) Injury to white matter tracts in relapsing-remitting multiple sclerosis: A possible therapeutic window within thefirst 5 years from onset using diffusion-tensor imaging tract-based spatial statistics. Neuroimage Clin 8:261-266.","DOI":"10.1016\/j.nicl.2015.04.020"},{"key":"key-10.4103\/1673-5374.206650-2","doi-asserted-by":"crossref","unstructured":"Audoin B, Zaaraoui W, Reuter F, Rico A, Malikova I, Confort-Gouny S, Cozzone PJ, Pelletier J, Ranjeva JP (2010) Atrophy mainly affects the limbic system and the deep grey matter at thefirst stage of multiple sclerosis. J Neurol Neurosurg Psychiatry 81:690-695.","DOI":"10.1136\/jnnp.2009.188748"},{"key":"key-10.4103\/1673-5374.206650-3","doi-asserted-by":"crossref","unstructured":"B\u00f8 L, Vedeler CA, Nyland HI, Trapp BD, M\u00f8rk SJ (2003) Subpial demyelination in the cerebral cortex of multiple sclerosis patients. J Neuropathol Exp Neurol 62:723-732.","DOI":"10.1093\/jnen\/62.7.723"},{"key":"key-10.4103\/1673-5374.206650-4","doi-asserted-by":"crossref","unstructured":"B\u00f6 L, Geurts JJ, van der Valk P, Polman C, Barkhof F (2007) Lack of correlation between cortical demyelination and white matter pathologic changes in multiple sclerosis. Arch Neurol 64:76-80.","DOI":"10.1001\/archneur.64.1.76"},{"key":"key-10.4103\/1673-5374.206650-5","doi-asserted-by":"crossref","unstructured":"Banaszek A, Bladowska J, Pokryszko-Dragan A, Podemski R, Sasiadek MJ (2015) Evaluation of the degradation of the selected projectile, commissural and association white matter tracts within normal appearing white matter in patients with multiple sclerosis using diffusion tensor mr imaging - a preliminary study. Pol J Radiol 80:457-463.","DOI":"10.12659\/PJR.894661"},{"key":"key-10.4103\/1673-5374.206650-6","doi-asserted-by":"crossref","unstructured":"Battaglini M, Giorgio A, Stromillo ML, Bartolozzi ML, Guidi L, Federico A, De Stefano N (2009) Voxel-wise assessment of progression of regional brain atrophy in relapsing-remitting multiple sclerosis. J Neurol Sci 282:55-60.","DOI":"10.1016\/j.jns.2009.02.322"},{"key":"key-10.4103\/1673-5374.206650-7","doi-asserted-by":"crossref","unstructured":"Bergsland N, Tavazzi E, Lagana MM, Baglio F, Cecconi P, Viotti S, Zivadinov R, Baselli G, Rovaris M (2017) White matter tract injury is associated with deep gray matter iron deposition in multiple sclerosis. J Neuroimaging 27:107-113.","DOI":"10.1111\/jon.12364"},{"key":"key-10.4103\/1673-5374.206650-8","doi-asserted-by":"crossref","unstructured":"Bermel RA, Bakshi R (2006) The measurement and clinical relevance of brain atrophy in multiple sclerosis. Lancet Neurol 5:158-170.","DOI":"10.1016\/S1474-4422(06)70349-0"},{"key":"key-10.4103\/1673-5374.206650-9","doi-asserted-by":"crossref","unstructured":"Calabrese M, Rinaldi F, Mattisi I, Grossi P, Favaretto A, Atzori M, Bernardi V, Barachino L, Romualdi C, Rinaldi L, Perini P, Gallo P (2010) Widespread cortical thinning characterizes patients with MS with mild cognitive impairment. Neurology 74:321-328.","DOI":"10.1212\/WNL.0b013e3181cbcd03"},{"key":"key-10.4103\/1673-5374.206650-10","doi-asserted-by":"crossref","unstructured":"Ceccarelli A, Rocca MA, Pagani E, Colombo B, Martinelli V, Comi G, Filippi M (2008) A voxel-based morphometry study of grey matter loss in MS patients with different clinical phenotypes. Neuroimage 42:315-322.","DOI":"10.1016\/j.neuroimage.2008.04.173"},{"key":"key-10.4103\/1673-5374.206650-11","doi-asserted-by":"crossref","unstructured":"Ceccarelli A, Filippi M, Neema M, Arora A, Valsasina P, Rocca MA, Healy BC, Bakshi R (2009) T2 hypointensity in the deep gray matter of patients with benign multiple sclerosis. Mult Scler 15:678-686.","DOI":"10.1177\/1352458509103611"},{"key":"key-10.4103\/1673-5374.206650-12","doi-asserted-by":"crossref","unstructured":"Charil A, Dagher A, Lerch JP, Zijdenbos AP, Worsley KJ, Evans AC (2007) Focal cortical atrophy in multiple sclerosis: relation to lesion load and disability. Neuroimage 34:509-517.","DOI":"10.1016\/j.neuroimage.2006.10.006"},{"key":"key-10.4103\/1673-5374.206650-13","doi-asserted-by":"crossref","unstructured":"Chen J, Zhou C, Zhu L, Yan X, Wang Y, Chen X, Fang S (2017) Magnetic resonance diffusion tensor imaging for occult lesion detection in multiple sclerosis. Exp Ther Med 13:91-96.","DOI":"10.3892\/etm.2016.3950"},{"key":"key-10.4103\/1673-5374.206650-14","doi-asserted-by":"crossref","unstructured":"Chu Z, Wilde EA, Hunter JV, McCauley SR, Bigler ED, Troyanskaya M, Yallampalli R, Chia JM, Levin HS (2010) Voxel-based analysis of diffusion tensor imaging in mild traumatic brain injury in adolescents. AJNR Am J Neuroradiol 31:340-346.","DOI":"10.3174\/ajnr.A1806"},{"key":"key-10.4103\/1673-5374.206650-15","doi-asserted-by":"crossref","unstructured":"Cui Z, Zhong S, Xu P, He Y, Gong G (2013) PANDA: a pipeline toolbox for analyzing brain diffusion images. Front Hum Neurosci 7:42.","DOI":"10.3389\/fnhum.2013.00042"},{"key":"key-10.4103\/1673-5374.206650-16","doi-asserted-by":"crossref","unstructured":"De Stefano N, Guidi L, Stromillo ML, Bartolozzi ML, Federico A (2003a) Imaging neuronal and axonal degeneration in multiple sclerosis. Neurol Sci 24 Suppl 5:S283-286.","DOI":"10.1007\/s10072-003-0175-2"},{"key":"key-10.4103\/1673-5374.206650-17","doi-asserted-by":"crossref","unstructured":"De Stefano N, Matthews PM, Filippi M, Agosta F, De Luca M, Bartolozzi ML, Guidi L, Ghezzi A, Montanari E, Cifelli A, Federico A, Smith SM (2003b) Evidence of early cortical atrophy in MS: relevance to white matter changes and disability. Neurology 60:1157-1162.","DOI":"10.1212\/01.WNL.0000055926.69643.03"},{"key":"key-10.4103\/1673-5374.206650-18","doi-asserted-by":"crossref","unstructured":"Dineen RA, Vilisaar J, Hlinka J, Bradshaw CM, Morgan PS, Constantinescu CS, Auer DP (2009) Disconnection as a mechanism for cognitive dysfunction in multiple sclerosis. Brain 132:239-249.","DOI":"10.1093\/brain\/awn275"},{"key":"key-10.4103\/1673-5374.206650-19","doi-asserted-by":"crossref","unstructured":"Duan Y, Liu Y, Liang P, Jia X, Yu C, Qin W, Sun H, Liao Z, Ye J, Li K (2012) Comparison of grey matter atrophy between patients with neuromyelitis optica and multiple sclerosis: a voxel-based morphometry study. Eur J Radiol 81:e110-114.","DOI":"10.1016\/j.ejrad.2011.01.065"},{"key":"key-10.4103\/1673-5374.206650-20","doi-asserted-by":"crossref","unstructured":"Duong TQ, Watts LT (2016) A brief report on MRI investigation of experimental traumatic brain injury. Neural Regen Res 11:15-17.","DOI":"10.4103\/1673-5374.169604"},{"key":"key-10.4103\/1673-5374.206650-21","doi-asserted-by":"crossref","unstructured":"Filippi M, Rocca MA (2008) Multiple sclerosis and allied white matter diseases. Neurol Sci 29 Suppl 3:319-322.","DOI":"10.1007\/s10072-008-1007-1"},{"key":"key-10.4103\/1673-5374.206650-22","doi-asserted-by":"crossref","unstructured":"Frisoni GB, Galluzzi S, Pantoni L, Filippi M (2007) The effect of white matter lesions on cognition in the elderly--small but detectable. Nat Clin Pract Neurol 3:620-627.","DOI":"10.1038\/ncpneuro0638"},{"key":"key-10.4103\/1673-5374.206650-23","doi-asserted-by":"crossref","unstructured":"Ge Y, Law M, Grossman RI (2005) Applications of diffusion tensor MR imaging in multiple sclerosis. Ann N Y Acad Sci 1064:202-219.","DOI":"10.1196\/annals.1340.039"},{"key":"key-10.4103\/1673-5374.206650-24","doi-asserted-by":"crossref","unstructured":"Giorgio A, De Stefano N (2016) Advanced Structural and Functional Brain MRI in Multiple Sclerosis. Semin Neurol 36:163-176.","DOI":"10.1055\/s-0036-1579737"},{"key":"key-10.4103\/1673-5374.206650-25","doi-asserted-by":"crossref","unstructured":"Giorgio A, Battaglini M, Smith SM, De Stefano N (2008) Brain atrophy assessment in multiple sclerosis: importance and limitations. Neuroimaging Clin N Am 18:675-686, xi.","DOI":"10.1016\/j.nic.2008.06.007"},{"key":"key-10.4103\/1673-5374.206650-26","doi-asserted-by":"crossref","unstructured":"Giorgio A, Palace J, Johansen-Berg H, Smith SM, Ropele S, Fuchs S, Wallner-Blazek M, Enzinger C, Fazekas F (2010) Relationships of brain white matter microstructure with clinical and MR measures in relapsing-remitting multiple sclerosis. J Magn Reson Imaging 31:309-316.","DOI":"10.1002\/jmri.22062"},{"key":"key-10.4103\/1673-5374.206650-27","doi-asserted-by":"crossref","unstructured":"Henry RG, Shieh M, Amirbekian B, Chung S, Okuda DT, Pelletier D (2009) Connecting white matter injury and thalamic atrophy in clinically isolated syndromes. J Neurol Sci 282:61-66.","DOI":"10.1016\/j.jns.2009.02.379"},{"key":"key-10.4103\/1673-5374.206650-28","doi-asserted-by":"crossref","unstructured":"Kennedy KM, Raz N (2009) Aging white matter and cognition: differential effects of regional variations in diffusion properties on memory, executive functions, and speed. Neuropsychologia 47:916-927.","DOI":"10.1016\/j.neuropsychologia.2009.01.001"},{"key":"key-10.4103\/1673-5374.206650-29","doi-asserted-by":"crossref","unstructured":"Keser Z, Hasan KM, Mwangi B, Gabr RE, Steinberg JL, Wilken J, Wolinsky JS, Nelson FM (2017) Limbic pathway correlates of cognitive impairment in multiple sclerosis. J Neuroimaging 27:37-42.","DOI":"10.1111\/jon.12381"},{"key":"key-10.4103\/1673-5374.206650-30","doi-asserted-by":"crossref","unstructured":"Kurtzke JF (1983) Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 33:1444-1452.","DOI":"10.1212\/WNL.33.11.1444"},{"key":"key-10.4103\/1673-5374.206650-31","doi-asserted-by":"crossref","unstructured":"Kutzelnigg A, Lucchinetti CF, Stadelmann C, Bruck W, Rauschka H, Bergmann M, Schmidbauer M, Parisi JE, Lassmann H (2005) Cortical demyelination and diffuse white matter injury in multiple sclerosis. Brain 128:2705-2712.","DOI":"10.1093\/brain\/awh641"},{"key":"key-10.4103\/1673-5374.206650-32","doi-asserted-by":"crossref","unstructured":"Lanz M, Hahn HK, Hildebrandt H (2007) Brain atrophy and cognitive impairment in multiple sclerosis: a review. J Neurol 254 Suppl 2:II43-48.","DOI":"10.1007\/s00415-007-2011-8"},{"key":"key-10.4103\/1673-5374.206650-33","doi-asserted-by":"crossref","unstructured":"Liang Y, Sun X, Xu S, Liu Y, Huang R, Jia J, Zhang Z (2016) Preclinical cerebral network connectivity evidence of deficits in mild white matter lesions. Front Aging Neurosci 8:27.","DOI":"10.3389\/fnagi.2016.00027"},{"key":"key-10.4103\/1673-5374.206650-34","doi-asserted-by":"crossref","unstructured":"Liu Y, Duan Y, He Y, Yu C, Wang J, Huang J, Ye J, Parizel PM, Li K, Shu N (2012) Whole brain white matter changes revealed by multiple diffusion metrics in multiple sclerosis: a TBSS study. Eur J Radiol 81:2826-2832.","DOI":"10.1016\/j.ejrad.2011.11.022"},{"key":"key-10.4103\/1673-5374.206650-35","doi-asserted-by":"crossref","unstructured":"Mehta S, Grabowski TJ, Trivedi Y, Damasio H (2003) Evaluation of voxel-based morphometry for focal lesion detection in individuals. Neuroimage 20:1438-1454.","DOI":"10.1016\/S1053-8119(03)00377-X"},{"key":"key-10.4103\/1673-5374.206650-36","doi-asserted-by":"crossref","unstructured":"Miyata J, Hirao K, Namiki C, Fujiwara H, Shimizu M, Fukuyama H, Sawamoto N, Hayashi T, Murai T (2009) Reduced white matter integrity correlated with cortico-subcortical gray matter deficits in schizophrenia. Schizophr Res 111:78-85.","DOI":"10.1016\/j.schres.2009.03.010"},{"key":"key-10.4103\/1673-5374.206650-37","doi-asserted-by":"crossref","unstructured":"Polman CH, Reingold SC, Banwell B, Clanet M, Cohen JA, Filippi M, Fujihara K, Havrdova E, Hutchinson M, Kappos L, Lublin FD, Montalban X, O'Connor P, Sandberg-Wollheim M, Thompson AJ, Waubant E, Weinshenker B, Wolinsky JS (2011) Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann Neurol 69:292-302.","DOI":"10.1002\/ana.22366"},{"key":"key-10.4103\/1673-5374.206650-38","doi-asserted-by":"crossref","unstructured":"Prinster A, Quarantelli M, Lanzillo R, Orefice G, Vacca G, Carotenuto B, Alfano B, Brunetti A, Morra VB, Salvatore M (2010) A voxel-based morphometry study of disease severity correlates in relapsing--remitting multiple sclerosis. Mult Scler 16:45-54.","DOI":"10.1177\/1352458509351896"},{"key":"key-10.4103\/1673-5374.206650-39","doi-asserted-by":"crossref","unstructured":"Qiu D, Tan LH, Zhou K, Khong PL (2008) Diffusion tensor imaging of normal white matter maturation from late childhood to young adulthood: voxel-wise evaluation of mean diffusivity, fractional anisotropy, radial and axial diffusivities, and correlation with reading development. Neuroimage 41:223-232.","DOI":"10.1016\/j.neuroimage.2008.02.023"},{"key":"key-10.4103\/1673-5374.206650-40","unstructured":"Qiu MG, Wang J, Xie B, Wu BH, Zhang SX (2006) Primary study of the white matter fibers in human brain by using diffusion tensor imaging. Yiyong Shengwu Lixue 21:192-197."},{"key":"key-10.4103\/1673-5374.206650-41","doi-asserted-by":"crossref","unstructured":"Raz E, Cercignani M, Sbardella E, Totaro P, Pozzilli C, Bozzali M, Pantano P (2010) Clinically isolated syndrome suggestive of multiple sclerosis: voxelwise regional investigation of white and gray matter. Radiology 254:227-234.","DOI":"10.1148\/radiol.2541090817"},{"key":"key-10.4103\/1673-5374.206650-42","doi-asserted-by":"crossref","unstructured":"Ridgway GR, Henley SM, Rohrer JD, Scahill RI, Warren JD, Fox NC (2008) Ten simple rules for reporting voxel-based morphometry studies. Neuroimage 40:1429-1435.","DOI":"10.1016\/j.neuroimage.2008.01.003"},{"key":"key-10.4103\/1673-5374.206650-43","doi-asserted-by":"crossref","unstructured":"Sailer M, Fischl B, Salat D, Tempelmann C, Schonfeld MA, Busa E, Bodammer N, Heinze HJ, Dale A (2003) Focal thinning of the cerebral cortex in multiple sclerosis. Brain 126:1734-1744.","DOI":"10.1093\/brain\/awg175"},{"key":"key-10.4103\/1673-5374.206650-44","doi-asserted-by":"crossref","unstructured":"Seok JH, Park HJ, Chun JW, Lee SK, Cho HS, Kwon JS, Kim JJ (2007) White matter abnormalities associated with auditory hallucinations in schizophrenia: a combined study of voxel-based analyses of diffusion tensor imaging and structural magnetic resonance imaging. Psychiatry Res 156:93-104.","DOI":"10.1016\/j.pscychresns.2007.02.002"},{"key":"key-10.4103\/1673-5374.206650-45","doi-asserted-by":"crossref","unstructured":"Shen Y, Bai L, Gao Y, Cui F, Tan Z, Tao Y, Sun C, Zhou L (2014) Depressive symptoms in multiple sclerosis from an in vivo study with TBSS. Biomed Res Int 2014:148465.","DOI":"10.1155\/2014\/148465"},{"key":"key-10.4103\/1673-5374.206650-46","doi-asserted-by":"crossref","unstructured":"Snook L, Plewes C, Beaulieu C (2007) Voxel based versus region of interest analysis in diffusion tensor imaging of neurodevelopment. Neuroimage 34:243-252.","DOI":"10.1016\/j.neuroimage.2006.07.021"},{"key":"key-10.4103\/1673-5374.206650-47","doi-asserted-by":"crossref","unstructured":"Wang B, Liu Z, Liu J, Tang Z, Li H, Tian J (2016) Gray and white matter alterations in early HIV-infected patients: Combined voxel-based morphometry and tract-based spatial statistics. J Magn Reson Imaging 43:1474-1483.","DOI":"10.1002\/jmri.25100"},{"key":"key-10.4103\/1673-5374.206650-48","doi-asserted-by":"crossref","unstructured":"Wu XN, Zhang T, Wang J, Liu XY, Li ZS, Xiang W, Du WQ, Yang HJ, Xiong TG, Deng WT, Peng KR, Pan SY (2016) Magnetic resonance diffusion tensor imaging following major ozonated autohemotherapy for treatment of acute cerebral infarction. Neural Regen Res 11:1115-1121.","DOI":"10.4103\/1673-5374.187046"},{"key":"key-10.4103\/1673-5374.206650-49","unstructured":"Yin HM, Jiang S (2011) Advances and application of tract-based spatial statistics. Guoji Yixue Fangshe Xue Zazhi 34:162-165."},{"key":"key-10.4103\/1673-5374.206650-50","unstructured":"Yu CS, Li KC, Lin FC, Jiang TZ, Sun H, Chen B (2006) Diffusion tensor imaging of the normal-appearing brain tissue in relapsing-remitting multiple sclerosis. Zhonghua Yi Xue Za Zhi 86:1260-1264."},{"key":"key-10.4103\/1673-5374.206650-51","doi-asserted-by":"crossref","unstructured":"Zhang X, Zhang F, Huang D, Wu L, Ma L, Liu H, Zhao Y, Yu S, Shi J (2016) Contribution of gray and white matter abnormalities to cognitive impairment in multiple sclerosis. Int J Mol Sci 18.","DOI":"10.3390\/ijms18010046"},{"key":"key-10.4103\/1673-5374.206650-52","unstructured":"Zhang XD, Chen ZG (2008) Principle of diffusion tensor imaging and diffusion tensor tractography and clinical developing application on brain. Zhongguo CT he MRI Zazhi 6:64-67."}],"container-title":["Neural Regeneration Research"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T13:29:21Z","timestamp":1786714161000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/1673-5374.206650"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":52,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017]]}},"alternative-id":["206650"],"URL":"https:\/\/doi.org\/10.4103\/1673-5374.206650","relation":{},"ISSN":["1673-5374"],"issn-type":[{"value":"1673-5374","type":"print"}],"subject":[],"published":{"date-parts":[[2017]]}}}