{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T14:40:10Z","timestamp":1786718410271,"version":"build-2736575974"},"reference-count":59,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neural Regen Res"],"published-print":{"date-parts":[[2018]]},"DOI":"10.4103\/1673-5374.235017","type":"journal-article","created":{"date-parts":[[2018,7,13]],"date-time":"2018-07-13T04:16:41Z","timestamp":1531455401000},"page":"1145","source":"Crossref","is-referenced-by-count":54,"title":["Glaucomatous optic neuropathy treatment options: the promise of novel therapeutics, techniques and tools to help preserve vision"],"prefix":"10.4103","volume":"13","author":[{"given":"NajamA","family":"Sharif","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"key-10.4103\/1673-5374.235017-1","doi-asserted-by":"crossref","unstructured":"Aung T, Khor CC (2016) Glaucoma genetics: recent advances and future directions. Asia Pac J Ophthalmol (Phila) 5:256-259.","DOI":"10.1097\/APO.0000000000000229"},{"key":"key-10.4103\/1673-5374.235017-2","doi-asserted-by":"crossref","unstructured":"Auricchio F, Scavone C, Cimmaruta D, Di Mauro G, Capuano A, Sportiello L, Rafaniello C (2017) Drugs approved for the treatment of multiple sclerosis: review of their safety profile. Expert Opin. Drug Saf 16:1359-1371.","DOI":"10.1080\/14740338.2017.1388371"},{"key":"key-10.4103\/1673-5374.235017-3","doi-asserted-by":"crossref","unstructured":"Barar J, Aghanejad A, Fathi M, Omidi Y (2016) Advanced drug delivery and targeting technologies for the ocular diseases. BioImpacts 6:49-67.","DOI":"10.15171\/bi.2016.07"},{"key":"key-10.4103\/1673-5374.235017-4","doi-asserted-by":"crossref","unstructured":"Batlle JF, Fantes F, Riss I, Pinchuk L, Alburquerque R, Kato YP, Arrieta E, Peralta AC, Palmberg P, Parrish RK 2nd, Weber BA, Parel JM (2016) Three-year follow-up of a novel aqueous humor microshunt. J Glaucoma 25:e58-e65.","DOI":"10.1097\/IJG.0000000000000368"},{"key":"key-10.4103\/1673-5374.235017-5","doi-asserted-by":"crossref","unstructured":"Bertram J, Saluja SS, McKain JA, Lavik EB (2009) Sustained delivery of timolol maleate from poly (lactic-co-glycolic Novel drug delivery systems acid)\/poly (lactic acid) microspheres for over 3 months. J Microencapsul 26:18-26.","DOI":"10.1080\/02652040802095250"},{"key":"key-10.4103\/1673-5374.235017-6","doi-asserted-by":"crossref","unstructured":"Brandt JD, DuBiner HB, Benza R, Sall KN, Walker GA, Semba CP; Collaborators (2017) Long-term safety and efficacy of a sustained-release bimatoprost ocular ring. Ophthalmol 124:1565-1566.","DOI":"10.1016\/j.ophtha.2017.04.022"},{"key":"key-10.4103\/1673-5374.235017-7","doi-asserted-by":"crossref","unstructured":"Cheung LTY, Manthey AL, Lai JSM, Chiu K (2017) Targeted delivery of mitochondrial calcium channel regulators: the future of glaucoma treatment? Front Neurosci 11:648.","DOI":"10.3389\/fnins.2017.00648"},{"key":"key-10.4103\/1673-5374.235017-8","doi-asserted-by":"crossref","unstructured":"Chi W, Li F, Chen H, Wang Y, Zhu Y, Yang X, Zhu J, Wu F, Ouyang H, Ge J, Weinreb RN, Zhang K, Zhuo Y (2014) Caspase-8 promotes NLRP1\/NLRP3 inflammasome activation and IL-1\u03b2 production in acute glaucoma. Proc Natl Acad Sci U S A 111:1118-1116.","DOI":"10.1073\/pnas.1402819111"},{"key":"key-10.4103\/1673-5374.235017-9","doi-asserted-by":"crossref","unstructured":"Cordeiro MF, Normando EM, Cardoso MJ, Miodragovic S, Jeylani S, Davis BM, Guo L, Ourselin S, A\u2019Hern R, Bloom PA (2017) Real-time imaging of single neuronal cell apoptosis in patients with glaucoma. Brain 140:1757-1767.","DOI":"10.1093\/brain\/awx088"},{"key":"key-10.4103\/1673-5374.235017-10","doi-asserted-by":"crossref","unstructured":"Crabb DP (2016) A view on glaucoma--are we seeing it clearly? Eye (Lond) 30:304-313.","DOI":"10.1038\/eye.2015.244"},{"key":"key-10.4103\/1673-5374.235017-11","doi-asserted-by":"crossref","unstructured":"Danford ID, Verkuil LD, Choi DJ, Collins DW, Gudiseva HV, Uyhazi KE, Lau MK, Kanu LN, Grant GR, Chavali VRM, O\u2019Brien JM (2017) Characterizing the \u201cPOAGome\u201d: A bioinformatics-driven approach to primary open-angle glaucoma. Progress Ret Eye Res 58:89-114.","DOI":"10.1016\/j.preteyeres.2017.02.001"},{"key":"key-10.4103\/1673-5374.235017-12","doi-asserted-by":"crossref","unstructured":"Dalari K, Ljubimov AV, Hekmatimoghaddan S (2017) Glaucoma, stem cells, and gene therapy: where are we now? Int J Stem Cells 10:119-128.","DOI":"10.15283\/ijsc17029"},{"key":"key-10.4103\/1673-5374.235017-13","doi-asserted-by":"crossref","unstructured":"Dismuke WM, Sharif NA, Ellis DZ (2009) Human trabecular meshwork cell volume decrease by NO-independent soluble guanylate cyclase activators YC-1 and BAY-58-2667 involves the BKCa ion channel. Invest Ophthalmol Vis Sci 50:3353-3359.","DOI":"10.1167\/iovs.08-3127"},{"key":"key-10.4103\/1673-5374.235017-14","doi-asserted-by":"crossref","unstructured":"Dismuke WM, Sharif NA, Ellis DZ (2010) Endogenous regulation of human Schlemm\u2019s canal cell volume by nitric oxide signaling. Invest Ophthalmol Vis Sci 51:5817-5824.","DOI":"10.1167\/iovs.09-5072"},{"key":"key-10.4103\/1673-5374.235017-15","doi-asserted-by":"crossref","unstructured":"Fujikado T, Morimoto T, Matsushita K, Shimojo H, Okawa Y, Tano Y (2006). Effect of transcorneal electrical stimulation in patients with non-arteritic ischemic optic neuropathy or traumatic optic neuropathy. Jpn J Ophthalmol 50:266-273.","DOI":"10.1007\/s10384-005-0304-y"},{"key":"key-10.4103\/1673-5374.235017-16","doi-asserted-by":"crossref","unstructured":"Guo L, Davis B, Nizari S, Normando EM, Shi H, Galvao J, Turner L, Shi J, Clements M, Parrinello S, Cordeiro MF (2014) Direct optic nerve sheath (DONS) application of Schwann cells prolongs retinal ganglion cell survival in vivo. Cell Death Dis 5:e1460.","DOI":"10.1038\/cddis.2014.399"},{"key":"key-10.4103\/1673-5374.235017-17","doi-asserted-by":"crossref","unstructured":"Hartman RR, Kompella UB (2018) Intravitreal, subretinal, and suprachoroidal injections: evolution of microneedles for drug delivery. J Ocular Pharmacol Ther 34:141-153.","DOI":"10.1089\/jop.2017.0121"},{"key":"key-10.4103\/1673-5374.235017-18","doi-asserted-by":"crossref","unstructured":"He S, Stankowska DL, Ellis DZ, Krishnamoorthy RR, Yorio T (2018) Targets of neuroprotection in glaucoma. J Ocular Pharmacol Ther 34:85-106.","DOI":"10.1089\/jop.2017.0041"},{"key":"key-10.4103\/1673-5374.235017-19","doi-asserted-by":"crossref","unstructured":"Hines-Beard J, Bond WS, Backstrom JR, Rex TS (2016) Virus-mediated EpoR76E gene therapy preserves vision in a glaucoma model by modulating neuroinflammation and decreasing oxidative stress. J Neuroinflam 13:39.","DOI":"10.1186\/s12974-016-0499-5"},{"key":"key-10.4103\/1673-5374.235017-20","doi-asserted-by":"crossref","unstructured":"Hollander H, Makarov F, Stefani FH, Stone J (1995) Evidence of constriction of optic axons at the lamina cribrosa in the normotensive eye in humans and other mammals. Ophthalmic Res 27:296-309.","DOI":"10.1159\/000267739"},{"key":"key-10.4103\/1673-5374.235017-21","doi-asserted-by":"crossref","unstructured":"Hollo G, Topouzis F, Fetchner RD (2014) Fixed-combination intraocular pressure-lowering therapy for glaucoma and ocular hypertension: advantages in clinical practice. Expert Opin Pharmacother 15:1737-1747.","DOI":"10.1517\/14656566.2014.936850"},{"key":"key-10.4103\/1673-5374.235017-22","doi-asserted-by":"crossref","unstructured":"Irnaten M, Zhdanov A, Brennan D, Crotty T, Clark A, Papkovsky D, O\u2019Brien C (2018) Activation of the NFAT-calcium signaling pathway in human lamina cribosa cells in glaucoma. Invest Ophthalmol Vis Sci 59:831-842.","DOI":"10.1167\/iovs.17-22531"},{"key":"key-10.4103\/1673-5374.235017-23","doi-asserted-by":"crossref","unstructured":"Ito YA, Di Polo A (2017) Mitochondrial dynamics, transport, and quality control: a bottleneck for retinal ganglion cell viability in optic neuropathies. Mitochond 36:186-192.","DOI":"10.1016\/j.mito.2017.08.014"},{"key":"key-10.4103\/1673-5374.235017-24","doi-asserted-by":"crossref","unstructured":"Jonas JB, Aung T, Bourne RR, Bron AM, Ritch R, Panda-Jonas S (2017) Glaucoma. Lancet 390:2183-2193.","DOI":"10.1016\/S0140-6736(17)31469-1"},{"key":"key-10.4103\/1673-5374.235017-25","doi-asserted-by":"crossref","unstructured":"Jonas JB, Ritch R, Panda-Jonas S (2015) Cerebrospinal fluid pressure in the pathogenesis of glaucoma. Prog Brain Res 221:33-47.","DOI":"10.1016\/bs.pbr.2015.06.002"},{"key":"key-10.4103\/1673-5374.235017-26","doi-asserted-by":"crossref","unstructured":"Kador KE, Montero RB, Venugopalan P, Hertz J, Zindell AN, Valenzuela DA, Uddin MS, Lavik EB, Muller KJ, Andreopoulos FM, Goldberg JL (2013) Tissue engineering the retinal ganglion cell nerve fiber layer. Biomaterials 34:4242-4250.","DOI":"10.1016\/j.biomaterials.2013.02.027"},{"key":"key-10.4103\/1673-5374.235017-27","doi-asserted-by":"crossref","unstructured":"Kashani AH, Lebkowski JS, Rahhal FM, Avery RL, Salehi-Had H, Dang W, Lin CM, Mitra D, Zhu D, Thomas BB, Hikita ST, Pennington BO, Johnson LV, Clegg DO, Hinton DR, Humayun MS (2018) A bioengineered retinal pigment epithelial monolayer for advanced, dry age-related macular degeneration. Sci Transl Med 10:eaao4097.","DOI":"10.1126\/scitranslmed.aao4097"},{"key":"key-10.4103\/1673-5374.235017-28","doi-asserted-by":"crossref","unstructured":"Kim J, Kudisch M, Mudumba S, Asada H, Aya-Shibuya E, Bhisitkul RB, Desai TA (2016) Biocompatibility and pharmacokinetic analysis of an intracameral polycaprolactone drug delivery implant for glaucoma. Invest Ophthalmol Vis Sci 57:4341-4346.","DOI":"10.1167\/iovs.16-19585"},{"key":"key-10.4103\/1673-5374.235017-29","doi-asserted-by":"crossref","unstructured":"Kurimoto T, Oono S, Oku H, Tagami Y, Kashimoto R, Takata M, Okamoto N, Ikeda T, Mimura O (2010) Transcorneal electrical stimulation increases chorioretinal blood flow in normal human subjects. Clin Ophthalmol 4:1441-1446.","DOI":"10.2147\/OPTH.S14573"},{"key":"key-10.4103\/1673-5374.235017-30","doi-asserted-by":"crossref","unstructured":"Lewis RA, Levy B, Ramirez N, Kopczynski CC, Usner DW, Novack GD; PG324-CS201 Study Group (2016) Fixed-dose combination of AR-13324 and latanoprost: a double-masked, 28-day, randomised, controlled study in patients with open-angle glaucoma or ocular hypertension. Br J Ophthalmol 100:339-344.","DOI":"10.1136\/bjophthalmol-2015-306778"},{"key":"key-10.4103\/1673-5374.235017-31","doi-asserted-by":"crossref","unstructured":"Li Y, Li D, Ying X, Khaw PT, Raisman G (2015) An energy theory of glaucoma. Glia 63:1537-1552.","DOI":"10.1002\/glia.22825"},{"key":"key-10.4103\/1673-5374.235017-32","unstructured":"McElnea EM, Quill B, Docherty NG, Irnaten M, Siah WF, Clark AF, O\u2019Brien CJ, Wallace DM (2011) Oxidative stress, mitochondrial dysfunction and calcium overload in human lamina cribrosa cells from glaucoma donors. Mol Vis 17:1182-1189."},{"key":"key-10.4103\/1673-5374.235017-33","doi-asserted-by":"crossref","unstructured":"Morgan-Warren PJ, O\u2019Neill J, de Cogan F, Spivak I, Ashush H, Kalinski H, Ahmed Z, Berry M, Feinstein E, Scott RA, Logan A (2016) siRNA-mediated knockdown of the mtor inhibitor rtp801 promotes retinal ganglion cell survival and axon elongation by direct and indirect mechanisms. Invest Ophthalmol Vis Sci 57:429-443.","DOI":"10.1167\/iovs.15-17511"},{"key":"key-10.4103\/1673-5374.235017-34","doi-asserted-by":"crossref","unstructured":"Morimoto T, Kamei M, Nishida K, Sakaguchi H, Kanda H, Ikuno Y, Kishima H, Maruo T, Konoma K, Ozawa M, Nishida K, Fujikado T (2011) Chronic implantation of newly developed suprachoroidal-transretinal stimulation prosthesis in dogs. Invest Ophthalmol Vis Sci 52:6785-6792.","DOI":"10.1167\/iovs.10-6971"},{"key":"key-10.4103\/1673-5374.235017-35","doi-asserted-by":"crossref","unstructured":"Nagai N, Yamada S, Kawasaki J, Koyanagi E, Saijo S, Kaji H, Nishizawa M, Nakazawa T, Abe T (2018). Pharmacokinetic and safety evaluation of a transscleral sustained unoprostone release device in monkey eyes. Invest Ophthalmol Vis Sci 59:644-652.","DOI":"10.1167\/iovs.17-22429"},{"key":"key-10.4103\/1673-5374.235017-36","doi-asserted-by":"crossref","unstructured":"Nickells RW, Howell GR, Soto I, John SW (2012) Under pressure: cellular and molecular responses during glaucoma, a common neurodegeneration with axonopathy. Annu Rev Neurosci 35:153-179.","DOI":"10.1146\/annurev.neuro.051508.135728"},{"key":"key-10.4103\/1673-5374.235017-37","doi-asserted-by":"crossref","unstructured":"O\u2019Callaghan J, Crosbie DE, Cassidy PS, Sherwood JM, Fl\u00fcgel-Koch C, L\u00fctjen-Drecoll E, Humphries MM, Reina-Torres E, Wallace D, Kiang AS, Campbell M, Stamer WD, Overby DR, O\u2019Brien C, Tam LCS, Humphries P (2017) Therapeutic potential of AAV-mediated MMP-3 secretion from corneal endothelium in treating glaucoma. Hum Mol Genet 26:1230-1246.","DOI":"10.1093\/hmg\/ddx028"},{"key":"key-10.4103\/1673-5374.235017-38","doi-asserted-by":"crossref","unstructured":"O\u2019Rourke C, Day AGE, Murray-Dunning C, Thanabalasundaram L, Cowan J, Stevanato L, Grace N, Cameron G, Drake RAL, Sinden J, Phillips JB (2018) An allogeneic \u201cOff the shelf\u201d therapeutic strategy for peripheral nerve tissue engineering using clinical grade human neural stem cells. Sci Rep 8:2951.","DOI":"10.1038\/s41598-018-20927-8"},{"key":"key-10.4103\/1673-5374.235017-39","doi-asserted-by":"crossref","unstructured":"Osborne NN, \u00c1lvarez CN, del Olmo Aguado S (2014) Targeting mitochondrial dysfunction as in aging and glaucoma. Drug Discov Today 19:1613-1622.","DOI":"10.1016\/j.drudis.2014.05.010"},{"key":"key-10.4103\/1673-5374.235017-40","doi-asserted-by":"crossref","unstructured":"Ota Y, Ozeki N, Yuki K, Shiba D, Kimura I, Tsunoda K, Shinoda K, Ohde H, Tsubota K (2018) The efficacy of transcorneal electrical stimulation for the treatment of primary open-angle glaucoma: a pilot study. Kei J Med doi: 10.2302\/kjm.2017-0015-OA.","DOI":"10.2302\/kjm.2017-0015-OA"},{"key":"key-10.4103\/1673-5374.235017-41","doi-asserted-by":"crossref","unstructured":"Pasquale LR (2016) Vascular and autonomic dysfunction in primary open-angle glaucoma. Curr Opin Ophthalmol 27:94-101.","DOI":"10.1097\/ICU.0000000000000245"},{"key":"key-10.4103\/1673-5374.235017-42","doi-asserted-by":"crossref","unstructured":"Perera SA, Ting DS, Nongpiur ME, Chew PT, Aquino MC, Sng CC, Ho SW, Aung T (2016). Feasibility study of sustained-release travoprost punctum plug for intraocular pressure reduction in an Asian population. Clin Ophthalmol 10:757-764.","DOI":"10.2147\/OPTH.S102181"},{"key":"key-10.4103\/1673-5374.235017-43","doi-asserted-by":"crossref","unstructured":"Pillunat LE, Erb C, Junemann AGM, Kimmich F (2018) Micro-invasive glaucoma surgery (MIGS): a review of surgical procedures using stents. Clin Ophthalmol 11:1583-1600.","DOI":"10.2147\/OPTH.S135316"},{"key":"key-10.4103\/1673-5374.235017-44","unstructured":"Quigley HA, McKinnon SJ, Zack DJ, Pease ME, Kerrigan-Baumrind LA, Kerrigan DF, Mitchell RS (2000). Retrograde axonal transport of BDNF in retinal ganglion cells is blocked by acute IOP elevation in rats. Invest Ophthalmol Vis Sci 41:3460-3466."},{"key":"key-10.4103\/1673-5374.235017-45","doi-asserted-by":"crossref","unstructured":"Robin AL, Clark AF, Covert DW, Krueger S, Bergamini MV, Landry TA, Dickerson JE Jr, Scheib SA, Realini T, Defaller JM, Cagle GD (2009) Anterior juxtascleral delivery of anecortave acetate in eyes with primary open-angle glaucoma: a pilot investigation. Am J Ophthalmol 147:45-50.e2.","DOI":"10.1016\/j.ajo.2008.07.039"},{"key":"key-10.4103\/1673-5374.235017-46","doi-asserted-by":"crossref","unstructured":"Serle JB, Katz LJ, McLaurin E, Heah T, Ramirez-Davis N, Usner DW, Novack GD, Kopczynski CC; ROCKET-1 and ROCKET-2 Study Groups (2018) Two phase-3 clinical trials comparing the safety and efficacy of netarsudil to timolol in patients with elevated intraocular pressure: rho kinase elevated IOP treatment trial 1 and 2 (ROCKET-1 and ROCKET-2). Am J Ophthalmol 186:116-127.","DOI":"10.1016\/j.ajo.2017.11.019"},{"key":"key-10.4103\/1673-5374.235017-47","unstructured":"Sharif NA (2017) Ocular hypertension and glaucoma: a review and current perspectives. Int J Ophthalmol Vis Sci 2:22-36."},{"key":"key-10.4103\/1673-5374.235017-48","doi-asserted-by":"crossref","unstructured":"Sharif NA (2018) idrugs and idevices discovery and development- preclinical assays, techniques and animal models studies for ocular hypotensives and neuroprotectants. J Ocular Pharmacol Ther 34:7-39.","DOI":"10.1089\/jop.2017.0125"},{"key":"key-10.4103\/1673-5374.235017-49","doi-asserted-by":"crossref","unstructured":"Smedowski A, Liu X, Pietrucha-Dutczak M, Matuszek I, Varjosalo M, Lewin-Kowalik J (2016) Predegenerated Schwann cells--a novel prospect for cell therapy for glaucoma: neuroprotection, neuroregeneration and neuroplasticity. Sci Rep 6:23187.","DOI":"10.1038\/srep23187"},{"key":"key-10.4103\/1673-5374.235017-50","doi-asserted-by":"crossref","unstructured":"Tezel G, Yang X, Luo C, Kain AD, Powell DW, Kuehn MH, Kaplan HJ (2010) Oxidative stress and the regulation of complement activation in human glaucoma. Invest Ophthalmol Vis Sci 51:5071-5082.","DOI":"10.1167\/iovs.10-5289"},{"key":"key-10.4103\/1673-5374.235017-51","doi-asserted-by":"crossref","unstructured":"Tham YC, Li X, Wong TY, Quigley HA, Aung T, Cheng CY (2014) Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis. Ophthalmol 121:2081-2090.","DOI":"10.1016\/j.ophtha.2014.05.013"},{"key":"key-10.4103\/1673-5374.235017-52","unstructured":"Thomas D, Papadopoulo O, Doshi R, Kapin MA, Sharif NA (2000) Retinal ATP and phosphorus metabolites: reduction by hypoxia and recovery with MK-801 and diltiazem. Med Sci Res 28:87-91."},{"key":"key-10.4103\/1673-5374.235017-53","doi-asserted-by":"crossref","unstructured":"Venugopalan P, Wang Y, Nguyen T, Huang A, Muller KJ, Goldberg JL (2016) Transplanted neurons integrate into adult retinas and respond to light. Nat Commun 7:10472.","DOI":"10.1038\/ncomms10472"},{"key":"key-10.4103\/1673-5374.235017-54","doi-asserted-by":"crossref","unstructured":"Weinreb RN, Aung T, Medeiros FA (2014) The pathophysiology and treatment of glaucoma: a review. JAMA 311:1901-1911.","DOI":"10.1001\/jama.2014.3192"},{"key":"key-10.4103\/1673-5374.235017-55","doi-asserted-by":"crossref","unstructured":"Weinreb RN, Liebmann JM, Martin KR, Kaufman PL, Vittitow JL (2018) Latanoprostene bunod 0.024% in subjects with open-angle glaucoma or ocular hypertension: pooled phase 3 study findings. J Glaucoma 27:7-15.","DOI":"10.1097\/IJG.0000000000000831"},{"key":"key-10.4103\/1673-5374.235017-56","doi-asserted-by":"crossref","unstructured":"Williams PA, Harder JM, Foxworth NE, Cochran KE, Philip VM, Porciatti V, Smithies O, John SW (2017) Vitamin B3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice. Science 355:756-760.","DOI":"10.1126\/science.aal0092"},{"key":"key-10.4103\/1673-5374.235017-57","doi-asserted-by":"crossref","unstructured":"Williamson BK, Hawkey NM, Blake DA, Frenkel JW, McDaniel KP, Davis JK, Satija C, Beazer A, Dhungana S, Carlson J, McRitchie S, Ayyala RS (2018) The effects of glaucoma drainage devices on oxygen tension, glycolytic metabolites, and metabolomics profile of aqueous humor in the rabbit. Transl Vis Sci Technol 7:14.","DOI":"10.1167\/tvst.7.1.14"},{"key":"key-10.4103\/1673-5374.235017-58","doi-asserted-by":"crossref","unstructured":"Xu G, Weinreb RN, Leung CK (2014) Optic nerve head deformation in glaucoma: the temporal relationship between optic nerve head surface depression and retinal nerve fiber layer thinning. Ophthalmol 121:2362-2370.","DOI":"10.1016\/j.ophtha.2014.06.035"},{"key":"key-10.4103\/1673-5374.235017-59","doi-asserted-by":"crossref","unstructured":"Yucel YH, Zhang Q, Gupta N, Kaufman PL, Weinreb RN (2000) Loss of neurons in magnocellular and parvocellular layers of the lateral geniculate nucleus in glaucoma. Arch. Ophthalmol 118:378-384.","DOI":"10.1001\/archopht.118.3.378"}],"container-title":["Neural Regeneration Research"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T13:34:51Z","timestamp":1786714491000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/1673-5374.235017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":59,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018]]}},"alternative-id":["235017"],"URL":"https:\/\/doi.org\/10.4103\/1673-5374.235017","relation":{},"ISSN":["1673-5374"],"issn-type":[{"value":"1673-5374","type":"print"}],"subject":[],"published":{"date-parts":[[2018]]}}}