{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:22:39Z","timestamp":1791202959281,"version":"4.2.0"},"reference-count":150,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neural Regen Res"],"published-print":{"date-parts":[[2018]]},"DOI":"10.4103\/1673-5374.238604","type":"journal-article","created":{"date-parts":[[2018,8,23]],"date-time":"2018-08-23T03:15:23Z","timestamp":1534994123000},"page":"1693","source":"Crossref","is-referenced-by-count":74,"title":["Depression following a traumatic brain injury: uncovering cytokine dysregulation as a pathogenic mechanism"],"prefix":"10.4103","volume":"13","author":[{"given":"AdamD","family":"Bachstetter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ColleenN","family":"Bodnar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JoshM","family":"Morganti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"key-10.4103\/1673-5374.238604-1","doi-asserted-by":"crossref","unstructured":"Aisiku IP, Yamal JM, Doshi P, Benoit JS, Gopinath S, Goodman JC, Robertson CS (2016) Plasma cytokines IL-6, IL-8, and IL-10 are associated with the development of acute respiratory distress syndrome in patients with severe traumatic brain injury. Crit Care 20:288.","DOI":"10.1186\/s13054-016-1470-7"},{"key":"key-10.4103\/1673-5374.238604-2","doi-asserted-by":"crossref","unstructured":"Albrecht JS, Kiptanui Z, Tsang Y, Khokhar B, Liu X, Simoni-Wastila L, Zuckerman IH (2015) Depression among older adults after traumatic brain injury: a national analysis. Am J Geriatr Psychiatry 23:607-614.","DOI":"10.1016\/j.jagp.2014.07.006"},{"key":"key-10.4103\/1673-5374.238604-3","doi-asserted-by":"crossref","unstructured":"Bachstetter AD, Rowe RK, Kaneko M, Goulding D, Lifshitz J, Van Eldik LJ (2013) The p38alpha MAPK regulates microglial responsiveness to diffuse traumatic brain injury. J Neurosci 33:6143-6153.","DOI":"10.1523\/JNEUROSCI.5399-12.2013"},{"key":"key-10.4103\/1673-5374.238604-4","doi-asserted-by":"crossref","unstructured":"Bachstetter AD, Webster SJ, Goulding DS, Morton JE, Watterson DM, Van Eldik LJ (2015) Attenuation of traumatic brain injury-induced cognitive impairment in mice by targeting increased cytokine levels with a small molecule experimental therapeutic. J Neuroinflammation 12:69.","DOI":"10.1186\/s12974-015-0289-5"},{"key":"key-10.4103\/1673-5374.238604-5","doi-asserted-by":"crossref","unstructured":"Bachstetter AD, Norris CM, Sompol P, Wilcock DM, Goulding D, Neltner JH, St Clair D, Watterson DM, Van Eldik LJ (2012) Early stage drug treatment that normalizes proinflammatory cytokine production attenuates synaptic dysfunction in a mouse model that exhibits age-dependent progression of Alzheimer's disease-related pathology. J Neurosci 32:10201-10210.","DOI":"10.1523\/JNEUROSCI.1496-12.2012"},{"key":"key-10.4103\/1673-5374.238604-6","doi-asserted-by":"crossref","unstructured":"Beattie EC, Stellwagen D, Morishita W, Bresnahan JC, Ha BK, Von Zastrow M, Beattie MS, Malenka RC (2002) Control of synaptic strength by glial TNFalpha. Science 295:2282-2285.","DOI":"10.1126\/science.1067859"},{"key":"key-10.4103\/1673-5374.238604-7","doi-asserted-by":"crossref","unstructured":"Bell MJ, Kochanek PM, Doughty LA, Carcillo JA, Adelson PD, Clark RS, Whalen MJ, DeKosky ST (1997a) Comparison of the interleukin-6 and interleukin-10 response in children after severe traumatic brain injury or septic shock. Acta Neurochir Suppl 70:96-97.","DOI":"10.1007\/978-3-7091-6837-0_30"},{"key":"key-10.4103\/1673-5374.238604-8","doi-asserted-by":"crossref","unstructured":"Bell MJ, Kochanek PM, Doughty LA, Carcillo JA, Adelson PD, Clark RS, Wisniewski SR, Whalen MJ, DeKosky ST (1997b) Interleukin-6 and interleukin-10 in cerebrospinal fluid after severe traumatic brain injury in children. J Neurotrauma 14:451-457.","DOI":"10.1089\/neu.1997.14.451"},{"key":"key-10.4103\/1673-5374.238604-9","doi-asserted-by":"crossref","unstructured":"Belmaker RH, Agam G (2008) Major depressive disorder. N Engl J Med 358:55-68.","DOI":"10.1056\/NEJMra073096"},{"key":"key-10.4103\/1673-5374.238604-10","doi-asserted-by":"crossref","unstructured":"Bernardino L, Xapelli S, Silva AP, Jakobsen B, Poulsen FR, Oliveira CR, Vezzani A, Malva JO, Zimmer J (2005) Modulator effects of interleukin-1beta and tumor necrosis factor-alpha on AMPA-induced excitotoxicity in mouse organotypic hippocampal slice cultures. J Neurosci 25:6734-6744.","DOI":"10.1523\/JNEUROSCI.1510-05.2005"},{"key":"key-10.4103\/1673-5374.238604-11","doi-asserted-by":"crossref","unstructured":"Bertani I, Iori V, Trusel M, Maroso M, Foray C, Mantovani S, Tonini R, Vezzani A, Chiesa R (2017) Inhibition of IL-1\u03b2 signaling normalizes NMDA-dependent neurotransmission and reduces seizure susceptibility in a mouse model of Creutzfeldt-Jakob disease. J Neurosci 37:10278-10289.","DOI":"10.1523\/JNEUROSCI.1301-17.2017"},{"key":"key-10.4103\/1673-5374.238604-12","doi-asserted-by":"crossref","unstructured":"Blennow K, Brody DL, Kochanek PM, Levin H, McKee A, Ribbers GM, Yaffe K, Zetterberg H (2016) Traumatic brain injuries. Nat Rev Dis Primers 2:16084.","DOI":"10.1038\/nrdp.2016.84"},{"key":"key-10.4103\/1673-5374.238604-13","doi-asserted-by":"crossref","unstructured":"Bombardier CH, Fann JR, Temkin NR, Esselman PC, Barber J, Dikmen SS (2010) Rates of major depressive disorder and clinical outcomes following traumatic brain injury. JAMA 303:1938-1945.","DOI":"10.1001\/jama.2010.599"},{"key":"key-10.4103\/1673-5374.238604-14","doi-asserted-by":"crossref","unstructured":"Bowen A, Neumann V, Conner M, Tennant A, Chamberlain MA (1998) Mood disorders following traumatic brain injury: identifying the extent of the problem and the people at risk. Brain Inj 12:177-190.","DOI":"10.1080\/026990598122656"},{"key":"key-10.4103\/1673-5374.238604-15","doi-asserted-by":"crossref","unstructured":"Burda JE, Bernstein AM, Sofroniew MV (2016) Astrocyte roles in traumatic brain injury. Exp Neurol 275:305-315.","DOI":"10.1016\/j.expneurol.2015.03.020"},{"key":"key-10.4103\/1673-5374.238604-16","doi-asserted-by":"crossref","unstructured":"Buttram SD, Wisniewski SR, Jackson EK, Adelson PD, Feldman K, Bayir H, Berger RP, Clark RS, Kochanek PM (2007) Multiplex assessment of cytokine and chemokine levels in cerebrospinal fluid following severe pediatric traumatic brain injury: effects of moderate hypothermia. J Neurotrauma 24:1707-1717.","DOI":"10.1089\/neu.2007.0349"},{"key":"key-10.4103\/1673-5374.238604-17","doi-asserted-by":"crossref","unstructured":"Casamenti F, Prosperi C, Scali C, Giovannelli L, Colivicchi MA, Faussone-Pellegrini MS, Pepeu G (1999) Interleukin-1beta activates forebrain glial cells and increases nitric oxide production and cortical glutamate and GABA release in vivo: implications for Alzheimer's disease. Neuroscience 91:831-842.","DOI":"10.1016\/S0306-4522(98)00680-0"},{"key":"key-10.4103\/1673-5374.238604-18","doi-asserted-by":"crossref","unstructured":"Chekroud AM, Zotti RJ, Shehzad Z, Gueorguieva R, Johnson MK, Trivedi MH, Cannon TD, Krystal JH, Corlett PR (2016) Cross-trial prediction of treatment outcome in depression: a machine learning approach. Lancet Psychiatry 3:243-250.","DOI":"10.1016\/S2215-0366(15)00471-X"},{"key":"key-10.4103\/1673-5374.238604-19","doi-asserted-by":"crossref","unstructured":"Chiaretti A, Genovese O, Aloe L, Antonelli A, Piastra M, Polidori G, Di Rocco C (2005) Interleukin 1beta and interleukin 6 relationship with paediatric head trauma severity and outcome. Childs Nerv Syst 21:185-194.","DOI":"10.1007\/s00381-004-1032-1"},{"key":"key-10.4103\/1673-5374.238604-20","doi-asserted-by":"crossref","unstructured":"Chiaretti A, Antonelli A, Riccardi R, Genovese O, Pezzotti P, Di Rocco C, Tortorolo L, Piedimonte G (2008) Nerve growth factor expression correlates with severity and outcome of traumatic brain injury in children. Eur J Paediatr Neurol 12:195-204.","DOI":"10.1016\/j.ejpn.2007.07.016"},{"key":"key-10.4103\/1673-5374.238604-21","doi-asserted-by":"crossref","unstructured":"Chrisman SP, Richardson LP (2014) Prevalence of diagnosed depression in adolescents with history of concussion. J Adolesc Health 54:582-586.","DOI":"10.1016\/j.jadohealth.2013.10.006"},{"key":"key-10.4103\/1673-5374.238604-22","doi-asserted-by":"crossref","unstructured":"Coughlin JM et al. (2017) Imaging of glial cell activation and white matter integrity in brains of active and recently retired National Football League players. JAMA Neurol 74:67-74.","DOI":"10.1001\/jamaneurol.2016.3764"},{"key":"key-10.4103\/1673-5374.238604-23","doi-asserted-by":"crossref","unstructured":"Dantzer R, O\u2019Connor JC, Freund GG, Johnson RW, Kelley KW (2008) From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci 9:46-56.","DOI":"10.1038\/nrn2297"},{"key":"key-10.4103\/1673-5374.238604-24","doi-asserted-by":"crossref","unstructured":"Davis CN, Tabarean I, Gaidarova S, Behrens MM, Bartfai T (2006a) IL-1beta induces a MyD88-dependent and ceramide-mediated activation of Src in anterior hypothalamic neurons. J Neurochem 98:1379-1389.","DOI":"10.1111\/j.1471-4159.2006.03951.x"},{"key":"key-10.4103\/1673-5374.238604-25","doi-asserted-by":"crossref","unstructured":"Davis CN, Mann E, Behrens MM, Gaidarova S, Rebek M, Rebek J Jr, Bartfai T (2006b) MyD88-dependent and -independent signaling by IL-1 in neurons probed by bifunctional Toll\/IL-1 receptor domain\/BB-loop mimetics. Proc Natl Acad Sci U S A 103:2953-2958.","DOI":"10.1073\/pnas.0510802103"},{"key":"key-10.4103\/1673-5374.238604-26","doi-asserted-by":"crossref","unstructured":"Devoto C, Arcurio L, Fetta J, Ley M, Rodney T, Kanefsky R, Gill J (2017) Inflammation relates to chronic behavioral and neurological symptoms in military personnel with traumatic brain injuries. Cell Transplant 26:1169-1177.","DOI":"10.1177\/0963689717714098"},{"key":"key-10.4103\/1673-5374.238604-27","doi-asserted-by":"crossref","unstructured":"Diaz-Gonzalez F, Sanchez-Madrid F (2015) NSAIDs: learning new tricks from old drugs. Eur J Immunol 45:679-686.","DOI":"10.1002\/eji.201445222"},{"key":"key-10.4103\/1673-5374.238604-28","doi-asserted-by":"crossref","unstructured":"Faden AI, Wu JF, Stoica BA, Loane DJ (2016) Progressive inflammation-mediated neurodegeneration after traumatic brain or spinal cord injury. Br J Pharmacol 173:681-691.","DOI":"10.1111\/bph.13179"},{"key":"key-10.4103\/1673-5374.238604-29","doi-asserted-by":"crossref","unstructured":"Fann JR, Bombardier CH, Temkin N, Esselman P, Warms C, Barber J, Dikmen S (2017) Sertraline for major depression during the year following traumatic brain injury: a randomized controlled trial. J Head Trauma Rehabil 32:332-342.","DOI":"10.1097\/HTR.0000000000000322"},{"key":"key-10.4103\/1673-5374.238604-30","doi-asserted-by":"crossref","unstructured":"Faul M, Xu L, Wald MM, Coronado VG (2010) Traumatic Brain Injury in the United States: Emergency Department Visits, Hospitalizations and Deaths 2002\u20132006. Atlanta, GA, USA: Centers for Disease Control and Prevention, National Center for Injury Prevention and Control.","DOI":"10.15620\/cdc.5571"},{"key":"key-10.4103\/1673-5374.238604-31","doi-asserted-by":"crossref","unstructured":"Fenn AM, Gensel JC, Huang Y, Popovich PG, Lifshitz J, Godbout JP (2014) Immune activation promotes depression 1 month after diffuse brain injury: a role for primed microglia. Biol Psychiatry 76:575-584.","DOI":"10.1016\/j.biopsych.2013.10.014"},{"key":"key-10.4103\/1673-5374.238604-32","doi-asserted-by":"crossref","unstructured":"Fenn AM, Skendelas JP, Moussa DN, Muccigrosso MM, Popovich PG, Lifshitz J, Eiferman DS, Godbout JP (2015) Methylene blue attenuates traumatic brain injury-associated neuroinflammation and acute depressive-like behavior in mice. J Neurotrauma 32:127-138.","DOI":"10.1089\/neu.2014.3514"},{"key":"key-10.4103\/1673-5374.238604-33","doi-asserted-by":"crossref","unstructured":"Fogal B, Li J, Lobner D, McCullough LD, Hewett SJ (2007) System x(c)- activity and astrocytes are necessary for interleukin-1 beta-mediated hypoxic neuronal injury. J Neurosci 27:10094-10105.","DOI":"10.1523\/JNEUROSCI.2459-07.2007"},{"key":"key-10.4103\/1673-5374.238604-34","doi-asserted-by":"crossref","unstructured":"Frugier T, Morganti-Kossmann MC, O\u2019Reilly D, McLean CA (2010) In situ detection of inflammatory mediators in post mortem human brain tissue after traumatic injury. J Neurotrauma 27:497-507.","DOI":"10.1089\/neu.2009.1120"},{"key":"key-10.4103\/1673-5374.238604-35","doi-asserted-by":"crossref","unstructured":"Furman JL, Sama DM, Gant JC, Beckett TL, Murphy MP, Bachstetter AD, Van Eldik LJ, Norris CM (2012) Targeting astrocytes ameliorates neurologic changes in a mouse model of Alzheimer's disease. J Neurosci 32:16129-16140.","DOI":"10.1523\/JNEUROSCI.2323-12.2012"},{"key":"key-10.4103\/1673-5374.238604-36","doi-asserted-by":"crossref","unstructured":"Gardner RC, Yaffe K (2015) Epidemiology of mild traumatic brain injury and neurodegenerative disease. Mol Cell Neurosci 66:75-80.","DOI":"10.1016\/j.mcn.2015.03.001"},{"key":"key-10.4103\/1673-5374.238604-37","doi-asserted-by":"crossref","unstructured":"Gardoni F, Boraso M, Zianni E, Corsini E, Galli CL, Cattabeni F, Marinovich M, Di Luca M, Viviani B (2011) Distribution of interleukin-1 receptor complex at the synaptic membrane driven by interleukin-1beta and NMDA stimulation. J Neuroinflammation 8:14.","DOI":"10.1186\/1742-2094-8-14"},{"key":"key-10.4103\/1673-5374.238604-38","doi-asserted-by":"crossref","unstructured":"Garlanda C, Dinarello CA, Mantovani A (2013) The interleukin-1 family: back to the future. Immunity 39:1003-1018.","DOI":"10.1016\/j.immuni.2013.11.010"},{"key":"key-10.4103\/1673-5374.238604-39","doi-asserted-by":"crossref","unstructured":"Ghezzi A, Torri V, Zaffaroni M (1996) Isolated optic neuritis and its prognosis for multiple sclerosis: a clinical and paraclinical study with evoked potentials. CSF examination and brain MRI. Ital J Neurol Sci 17:325-332.","DOI":"10.1007\/BF01999894"},{"key":"key-10.4103\/1673-5374.238604-40","doi-asserted-by":"crossref","unstructured":"Ghosh B, Green MV, Krogh KA, Thayer SA (2016) Interleukin-1beta activates an Src family kinase to stimulate the plasma membrane Ca2+ pump in hippocampal neurons. J Neurophysiol 115:1875-1885.","DOI":"10.1152\/jn.00541.2015"},{"key":"key-10.4103\/1673-5374.238604-41","doi-asserted-by":"crossref","unstructured":"Grell M, Douni E, Wajant H, Lohden M, Clauss M, Maxeiner B, Georgopoulos S, Lesslauer W, Kollias G, Pfizenmaier K, Scheurich P (1995) The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor. Cell 83:793-802.","DOI":"10.1016\/0092-8674(95)90192-2"},{"key":"key-10.4103\/1673-5374.238604-42","doi-asserted-by":"crossref","unstructured":"Gulati P (2009) Janeway's Immunobiology, 7th Edition. In: Biochemistry and Molecular Biology Education (Murphy K, Travers P, Walport M, eds), p 134: Wiley-Blackwell.","DOI":"10.1002\/bmb.20272"},{"key":"key-10.4103\/1673-5374.238604-43","doi-asserted-by":"crossref","unstructured":"Guskiewicz KM, Marshall SW, Bailes J, McCrea M, Harding HP Jr, Matthews A, Mihalik JR, Cantu RC (2007) Recurrent concussion and risk of depression in retired professional football players. Med Sci Sports Exerc 39:903-909.","DOI":"10.1249\/mss.0b013e3180383da5"},{"key":"key-10.4103\/1673-5374.238604-44","doi-asserted-by":"crossref","unstructured":"Hayakata T, Shiozaki T, Tasaki O, Ikegawa H, Inoue Y, Toshiyuki F, Hosotubo H, Kieko F, Yamashita T, Tanaka H, Shimazu T, Sugimoto H (2004) Changes in CSF S100B and cytokine concentrations in early-phase severe traumatic brain injury. Shock 22:102-107.","DOI":"10.1097\/01.shk.0000131193.80038.f1"},{"key":"key-10.4103\/1673-5374.238604-45","doi-asserted-by":"crossref","unstructured":"He P, Liu Q, Wu J, Shen Y (2012) Genetic deletion of TNF receptor suppresses excitatory synaptic transmission via reducing AMPA receptor synaptic localization in cortical neurons. FASEB J 26:334-345.","DOI":"10.1096\/fj.11-192716"},{"key":"key-10.4103\/1673-5374.238604-46","doi-asserted-by":"crossref","unstructured":"Hellewell S, Semple BD, Morganti-Kossmann MC (2016) Therapies negating neuroinflammation after brain trauma. Brain Res 1640:36-56.","DOI":"10.1016\/j.brainres.2015.12.024"},{"key":"key-10.4103\/1673-5374.238604-47","doi-asserted-by":"crossref","unstructured":"Helmy A, Carpenter KL, Menon DK, Pickard JD, Hutchinson PJ (2011) The cytokine response to human traumatic brain injury: temporal profiles and evidence for cerebral parenchymal production. J Cereb Blood Flow Metab 31:658-670.","DOI":"10.1038\/jcbfm.2010.142"},{"key":"key-10.4103\/1673-5374.238604-48","doi-asserted-by":"crossref","unstructured":"Helmy A, Carpenter KL, Skepper JN, Kirkpatrick PJ, Pickard JD, Hutchinson PJ (2009) Microdialysis of cytokines: methodological considerations, scanning electron microscopy, and determination of relative recovery. J Neurotrauma 26:549-561.","DOI":"10.1089\/neu.2008.0719"},{"key":"key-10.4103\/1673-5374.238604-49","doi-asserted-by":"crossref","unstructured":"Huang Y, Smith DE, Ibanez-Sandoval O, Sims JE, Friedman WJ (2011) Neuron-specific effects of interleukin-1beta are mediated by a novel isoform of the IL-1 receptor accessory protein. J Neurosci 31:18048-18059.","DOI":"10.1523\/JNEUROSCI.4067-11.2011"},{"key":"key-10.4103\/1673-5374.238604-50","doi-asserted-by":"crossref","unstructured":"Jassam YN, Izzy S, Whalen M, McGavern DB, El Khoury J (2017) Neuroimmunology of traumatic brain injury: time for a paradigm shift. Neuron 95:1246-1265.","DOI":"10.1016\/j.neuron.2017.07.010"},{"key":"key-10.4103\/1673-5374.238604-51","doi-asserted-by":"crossref","unstructured":"Jones NC, Cardamone L, Williams JP, Salzberg MR, Myers D, O\u2019Brien TJ (2008) Experimental traumatic brain injury induces a pervasive hyperanxious phenotype in rats. J Neurotrauma 25:1367-1374.","DOI":"10.1089\/neu.2008.0641"},{"key":"key-10.4103\/1673-5374.238604-52","doi-asserted-by":"crossref","unstructured":"Jorge RE, Acion L, Burin DI, Robinson RG (2016) Sertraline for preventing mood disorders following traumatic brain injury: a randomized clinical trial. JAMA Psychiatry 73:1041-1047.","DOI":"10.1001\/jamapsychiatry.2016.2189"},{"key":"key-10.4103\/1673-5374.238604-53","doi-asserted-by":"crossref","unstructured":"Juengst SB, Kumar RG, Arenth PM, Wagner AK (2014) Exploratory associations with tumor necrosis factor-alpha, disinhibition and suicidal endorsement after traumatic brain injury. Brain Behav Immun 41:134-143.","DOI":"10.1016\/j.bbi.2014.05.020"},{"key":"key-10.4103\/1673-5374.238604-54","doi-asserted-by":"crossref","unstructured":"Juengst SB, Kumar RG, Failla MD, Goyal A, Wagner AK (2015) Acute inflammatory biomarker profiles predict depression risk following moderate to severe traumatic brain injury. J Head Trauma Rehabil 30:207-218.","DOI":"10.1097\/HTR.0000000000000031"},{"key":"key-10.4103\/1673-5374.238604-55","doi-asserted-by":"crossref","unstructured":"Kappelmann N, Lewis G, Dantzer R, Jones PB, Khandaker GM (2018) Antidepressant activity of anti-cytokine treatment: a systematic review and meta-analysis of clinical trials of chronic inflammatory conditions. Mol Psychiatry 23:335-343.","DOI":"10.1038\/mp.2016.167"},{"key":"key-10.4103\/1673-5374.238604-56","doi-asserted-by":"crossref","unstructured":"Kawasaki Y, Zhang L, Cheng JK, Ji RR (2008) Cytokine mechanisms of central sensitization: distinct and overlapping role of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in regulating synaptic and neuronal activity in the superficial spinal cord. J Neurosci 28:5189-5194.","DOI":"10.1523\/JNEUROSCI.3338-07.2008"},{"key":"key-10.4103\/1673-5374.238604-57","doi-asserted-by":"crossref","unstructured":"Kohler CA, Freitas TH, Maes M, de Andrade NQ, Liu CS, Fernandes BS, Stubbs B, Solmi M, Veronese N, Herrmann N, Raison CL, Miller BJ, Lanctot KL, Carvalho AF (2017) Peripheral cytokine and chemokine alterations in depression: a meta-analysis of 82 studies. Acta Psychiatr Scand 135:373-387.","DOI":"10.1111\/acps.12698"},{"key":"key-10.4103\/1673-5374.238604-58","unstructured":"Kohler CA, Freitas TH, Stubbs B, Maes M, Solmi M, Veronese N, de Andrade NQ, Morris G, Fernandes BS, Brunoni AR, Herrmann N, Raison CL, Miller BJ, Lanctot KL, Carvalho AF (2018) Peripheral alterations in cytokine and chemokine levels after antidepressant drug treatment for major depressive disorder: systematic review and meta-analysis. Mol Neurobiol 55:4195-4206."},{"key":"key-10.4103\/1673-5374.238604-59","doi-asserted-by":"crossref","unstructured":"Kokiko-Cochran ON, Godbout JP (2018) The inflammatory continuum of traumatic brain injury and Alzheimer's disease. Front Immunol 9:672.","DOI":"10.3389\/fimmu.2018.00672"},{"key":"key-10.4103\/1673-5374.238604-60","doi-asserted-by":"crossref","unstructured":"Konefal SC, Stellwagen D (2017) Tumour necrosis factor-mediated homeostatic synaptic plasticity in behavioural models: testing a role in maternal immune activation. Philos Trans R Soc Lond B Biol Sci 372:20160160.","DOI":"10.1098\/rstb.2016.0160"},{"key":"key-10.4103\/1673-5374.238604-61","doi-asserted-by":"crossref","unstructured":"Kossmann T, Hans VH, Imhof HG, Stocker R, Grob P, Trentz O, Morganti-Kossmann C (1995) Intrathecal and serum interleukin-6 and the acute-phase response in patients with severe traumatic brain injuries. Shock 4:311-317.","DOI":"10.1097\/00024382-199511000-00001"},{"key":"key-10.4103\/1673-5374.238604-62","doi-asserted-by":"crossref","unstructured":"Kumar RG, Rubin JE, Berger RP, Kochanek PM, Wagner AK (2016) Principal components derived from CSF inflammatory profiles predict outcome in survivors after severe traumatic brain injury. Brain Behav Immun 53:183-193.","DOI":"10.1016\/j.bbi.2015.12.008"},{"key":"key-10.4103\/1673-5374.238604-63","doi-asserted-by":"crossref","unstructured":"Kumar RG, Gao S, Juengst SB, Wagner AK, Fabio A (2018) The effects of post-traumatic depression on cognition, pain, fatigue, and headache after moderate-to-severe traumatic brain injury: a thematic review. Brain Inj 32:383-394.","DOI":"10.1080\/02699052.2018.1427888"},{"key":"key-10.4103\/1673-5374.238604-64","doi-asserted-by":"crossref","unstructured":"Lai AY, Swayze RD, El-Husseini A, Song C (2006) Interleukin-1 beta modulates AMPA receptor expression and phosphorylation in hippocampal neurons. J Neuroimmunol 175:97-106.","DOI":"10.1016\/j.jneuroim.2006.03.001"},{"key":"key-10.4103\/1673-5374.238604-65","doi-asserted-by":"crossref","unstructured":"Lang UE, Borgwardt S (2013) Molecular mechanisms of depression: perspectives on new treatment strategies. Cell Physiol Biochem 31:761-777.","DOI":"10.1159\/000350094"},{"key":"key-10.4103\/1673-5374.238604-66","doi-asserted-by":"crossref","unstructured":"Leighton SP, Nerurkar L, Krishnadas R, Johnman C, Graham GJ, Cavanagh J (2018) Chemokines in depression in health and in inflammatory illness: a systematic review and meta-analysis. Mol Psychiatry 23:48-58.","DOI":"10.1038\/mp.2017.205"},{"key":"key-10.4103\/1673-5374.238604-67","doi-asserted-by":"crossref","unstructured":"Leonoudakis D, Zhao P, Beattie EC (2008) Rapid tumor necrosis factor alpha-induced exocytosis of glutamate receptor 2-lacking AMPA receptors to extrasynaptic plasma membrane potentiates excitotoxicity. J Neurosci 28:2119-2130.","DOI":"10.1523\/JNEUROSCI.5159-07.2008"},{"key":"key-10.4103\/1673-5374.238604-68","doi-asserted-by":"crossref","unstructured":"Lim SW, Sung KC, Shiue YL, Wang CC, Chio CC, Kuo JR (2017a) Hyperbaric oxygen effects on depression-like behavior and neuroinflammation in traumatic brain injury rats. World Neurosurg 100:128-137.","DOI":"10.1016\/j.wneu.2016.12.118"},{"key":"key-10.4103\/1673-5374.238604-69","doi-asserted-by":"crossref","unstructured":"Lim SW, Shiue YL, Liao JC, Wee HY, Wang CC, Chio CC, Chang CH, Hu CY, Kuo JR (2017b) Simvastatin therapy in the acute stage of traumatic brain injury attenuates brain trauma-induced depression-like behavior in rats by reducing neuroinflammation in the hippocampus. Neurocrit Care 26:122-132.","DOI":"10.1007\/s12028-016-0290-6"},{"key":"key-10.4103\/1673-5374.238604-70","doi-asserted-by":"crossref","unstructured":"Liu X, Quan N (2018) Microglia and CNS interleukin-1: beyond immunological concepts. Front Neurol 9:8.","DOI":"10.3389\/fneur.2018.00008"},{"key":"key-10.4103\/1673-5374.238604-71","doi-asserted-by":"crossref","unstructured":"Liu X, Yamashita T, Chen Q, Belevych N, McKim DB, Tarr AJ, Coppola V, Nath N, Nemeth DP, Syed ZW, Sheridan JF, Godbout JP, Zuo J, Quan N (2015) Interleukin 1 type 1 receptor restore: a genetic mouse model for studying interleukin 1 receptor-mediated effects in specific cell types. J Neurosci 35:2860-2870.","DOI":"10.1523\/JNEUROSCI.3199-14.2015"},{"key":"key-10.4103\/1673-5374.238604-72","doi-asserted-by":"crossref","unstructured":"Loane DJ, Kumar A (2016) Microglia in the TBI brain: The good, the bad, and the dysregulated. Exp Neurol 275:316-327.","DOI":"10.1016\/j.expneurol.2015.08.018"},{"key":"key-10.4103\/1673-5374.238604-73","doi-asserted-by":"crossref","unstructured":"Mac Donald CL, Johnson AM, Wierzechowski L, Kassner E, Stewart T, Nelson EC, Werner NJ, Adam OR, Rivet DJ, Flaherty SF, Oh JS, Zonies D, Fang R, Brody DL (2017) Outcome trends after US military concussive traumatic brain injury. J Neurotrauma 34:2206-2219.","DOI":"10.1089\/neu.2016.4434"},{"key":"key-10.4103\/1673-5374.238604-74","doi-asserted-by":"crossref","unstructured":"Machado I, Schi\u00f6th HB, Lasaga M, Scimonelli T (2018) IL-1\u03b2 reduces GluA1 phosphorylation and its surface expression during memory reconsolidation and \u03b1-melanocyte-stimulating hormone can modulate these effects. Neuropharmacology 128:314-323.","DOI":"10.1016\/j.neuropharm.2017.09.041"},{"key":"key-10.4103\/1673-5374.238604-75","doi-asserted-by":"crossref","unstructured":"Malkesman O, Tucker LB, Ozl J, McCabe JT (2013) Traumatic brain injury - modeling neuropsychiatric symptoms in rodents. Front Neurol 4:157.","DOI":"10.3389\/fneur.2013.00157"},{"key":"key-10.4103\/1673-5374.238604-76","doi-asserted-by":"crossref","unstructured":"Mandolesi G, Musella A, Gentile A, Grasselli G, Haji N, Sepman H, Fresegna D, Bullitta S, De Vito F, Musumeci G, Di Sanza C, Strata P, Centonze D (2013) Interleukin-1\u03b2 alters glutamate transmission at purkinje cell synapses in a mouse model of multiple sclerosis. J Neurosci 33:12105-12121.","DOI":"10.1523\/JNEUROSCI.5369-12.2013"},{"key":"key-10.4103\/1673-5374.238604-77","doi-asserted-by":"crossref","unstructured":"Max JE, Keatley E, Wilde EA, Bigler ED, Schachar RJ, Saunders AE, Ewing-Cobbs L, Chapman SB, Dennis M, Yang TT, Levin HS (2012) Depression in children and adolescents in the first 6 months after traumatic brain injury. Int J Dev Neurosci 30:239-245.","DOI":"10.1016\/j.ijdevneu.2011.12.005"},{"key":"key-10.4103\/1673-5374.238604-78","doi-asserted-by":"crossref","unstructured":"McCoy MK, Tansey MG (2008) TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease. J Neuroinflammation 5:45.","DOI":"10.1186\/1742-2094-5-45"},{"key":"key-10.4103\/1673-5374.238604-79","doi-asserted-by":"crossref","unstructured":"Mellergard P, Aneman O, Sjogren F, Saberg C, Hillman J (2011) Differences in cerebral extracellular response of interleukin-1\u03b2, interleukin-6, and interleukin-10 after subarachnoid hemorrhage or severe head trauma in humans. Neurosurgery 68:12-19.","DOI":"10.1227\/NEU.0b013e3181ef2a40"},{"key":"key-10.4103\/1673-5374.238604-80","doi-asserted-by":"crossref","unstructured":"Miller AH, Raison CL (2016) The role of inflammation in depression: from evolutionary imperative to modern treatment target. Nat Rev Immunol 16:22-34.","DOI":"10.1038\/nri.2015.5"},{"key":"key-10.4103\/1673-5374.238604-81","doi-asserted-by":"crossref","unstructured":"Milman A, Rosenberg A, Weizman R, Pick CG (2005) Mild traumatic brain injury induces persistent cognitive deficits and behavioral disturbances in mice. J Neurotrauma 22:1003-1010.","DOI":"10.1089\/neu.2005.22.1003"},{"key":"key-10.4103\/1673-5374.238604-82","doi-asserted-by":"crossref","unstructured":"Mironets E, Osei-Owusu P, Bracchi-Ricard V, Fischer R, Owens EA, Ricard J, Wu D, Saltos T, Collyer E, Hou S, Bethea JR, Tom VJ (2018) Soluble TNF\u03b1 signaling within the spinal cord contributes to the development of autonomic dysreflexia and ensuing vascular and immune dysfunction after spinal cord injury. J Neurosci 38:4146-4162.","DOI":"10.1523\/JNEUROSCI.2376-17.2018"},{"key":"key-10.4103\/1673-5374.238604-83","doi-asserted-by":"crossref","unstructured":"Montani C, Ramos-Brossier M, Ponzoni L, Gritti L, Cwetsch AW, Braida D, Saillour Y, Terragni B, Mantegazza M, Sala M, Verpelli C, Billuart P, Sala C (2017) The X-linked intellectual disability protein IL1RAPL1 regulates dendrite complexity. J Neurosci 37:6606-6627.","DOI":"10.1523\/JNEUROSCI.3775-16.2017"},{"key":"key-10.4103\/1673-5374.238604-84","doi-asserted-by":"crossref","unstructured":"Mori F, Nistic\u00f2 R, Mandolesi G, Piccinin S, Mango D, Kusayanagi H, Berretta N, Bergami A, Gentile A, Musella A, Nicoletti CG, Nicoletti F, Buttari F, Mercuri NB, Martino G, Furlan R, Centonze D (2014) Interleukin-1\u03b2 promotes long-term potentiation in patients with multiple sclerosis. Neuromolecular Med 16:38-51.","DOI":"10.1007\/s12017-013-8249-7"},{"key":"key-10.4103\/1673-5374.238604-85","doi-asserted-by":"crossref","unstructured":"Mossner R, Heils A, Stober G, Okladnova O, Daniel S, Lesch KP (1998) Enhancement of serotonin transporter function by tumor necrosis factor alpha but not by interleukin-6. Neurochem Int 33:251-254.","DOI":"10.1016\/S0197-0186(98)00026-6"},{"key":"key-10.4103\/1673-5374.238604-86","doi-asserted-by":"crossref","unstructured":"Mukherjee BB, Mobry PM (1979) Selective transcription of genomic sequences common to both N- and X-tropic endogenous retroviruses in BALB\/c mouse tissues. J Gen Virol 43:723-728.","DOI":"10.1099\/0022-1317-43-3-723"},{"key":"key-10.4103\/1673-5374.238604-87","doi-asserted-by":"crossref","unstructured":"Murray CA, Lynch MA (1998) Evidence that increased hippocampal expression of the cytokine interleukin-1 beta is a common trigger for age- and stress-induced impairments in long-term potentiation. J Neurosci 18:2974-2981.","DOI":"10.1523\/JNEUROSCI.18-08-02974.1998"},{"key":"key-10.4103\/1673-5374.238604-88","unstructured":"National Center for Injury Prevention and Control (2003) Report to Congress on Mild Traumatic Brain Injury in the United States: Steps to Prevent a Serious Public Health Problem. Atlanta, GA, USA: Centers for Disease Control and Prevention."},{"key":"key-10.4103\/1673-5374.238604-89","doi-asserted-by":"crossref","unstructured":"Nwachuku EL, Puccio AM, Adeboye A, Chang YF, Kim J, Okonkwo DO (2016) Time course of cerebrospinal fluid inflammatory biomarkers and relationship to 6-month neurologic outcome in adult severe traumatic brain injury. Clin Neurol Neurosurg 149:1-5.","DOI":"10.1016\/j.clineuro.2016.06.009"},{"key":"key-10.4103\/1673-5374.238604-90","doi-asserted-by":"crossref","unstructured":"O\u2019Brien SM, Scully P, Fitzgerald P, Scott LV, Dinan TG (2007) Plasma cytokine profiles in depressed patients who fail to respond to selective serotonin reuptake inhibitor therapy. J Psychiatr Res 41:326-331.","DOI":"10.1016\/j.jpsychires.2006.05.013"},{"key":"key-10.4103\/1673-5374.238604-91","doi-asserted-by":"crossref","unstructured":"Otto VI, Heinzel-Pleines UE, Gloor SM, Trentz O, Kossmann T, Morganti-Kossmann MC (2000) sICAM-1 and TNF-alpha induce MIP-2 with distinct kinetics in astrocytes and brain microvascular endothelial cells. J Neurosci Res 60:733-742.","DOI":"10.1002\/1097-4547(20000615)60:6<733::AID-JNR5>3.0.CO;2-X"},{"key":"key-10.4103\/1673-5374.238604-92","doi-asserted-by":"crossref","unstructured":"Park W, Li J, Song R, Messing J, Chen X (2002) CARPEL FACTORY, a Dicer homolog, and HEN1, a novel protein, act in microRNA metabolism in Arabidopsis thaliana. Curr Biol 12:1484-1495.","DOI":"10.1016\/S0960-9822(02)01017-5"},{"key":"key-10.4103\/1673-5374.238604-93","doi-asserted-by":"crossref","unstructured":"Pavlowsky A, Zanchi A, Pallotto M, Giustetto M, Chelly J, Sala C, Billuart P (2010) Neuronal JNK pathway activation by IL-1 is mediated through IL1RAPL1, a protein required for development of cognitive functions. Commun Integr Biol 3:245-247.","DOI":"10.4161\/cib.3.3.11414"},{"key":"key-10.4103\/1673-5374.238604-94","doi-asserted-by":"crossref","unstructured":"Petraglia AL, Plog BA, Dayawansa S, Chen M, Dashnaw ML, Czerniecka K, Walker CT, Viterise T, Hyrien O, Iliff JJ, Deane R, Nedergaard M, Huang JH (2014) The spectrum of neurobehavioral sequelae after repetitive mild traumatic brain injury: a novel mouse model of chronic traumatic encephalopathy. J Neurotrauma 31:1211-1224.","DOI":"10.1089\/neu.2013.3255"},{"key":"key-10.4103\/1673-5374.238604-95","doi-asserted-by":"crossref","unstructured":"Pleines UE, Morganti-Kossmann MC, Rancan M, Joller H, Trentz O, Kossmann T (2001) S-100 beta reflects the extent of injury and outcome, whereas neuronal specific enolase is a better indicator of neuroinflammation in patients with severe traumatic brain injury. J Neurotrauma 18:491-498.","DOI":"10.1089\/089771501300227297"},{"key":"key-10.4103\/1673-5374.238604-96","doi-asserted-by":"crossref","unstructured":"Pozzi D, Menna E, Canzi A, Desiato G, Mantovani C, Matteoli M (2018) The Communication Between the Immune and Nervous Systems: The Role of IL-1beta in Synaptopathies. Front Mol Neurosci 11:111.","DOI":"10.3389\/fnmol.2018.00111"},{"key":"key-10.4103\/1673-5374.238604-97","doi-asserted-by":"crossref","unstructured":"Pribiag H, Stellwagen D (2013) TNF-alpha downregulates inhibitory neurotransmission through protein phosphatase 1-dependent trafficking of GABA(A) receptors. J Neurosci 33:15879-15893.","DOI":"10.1523\/JNEUROSCI.0530-13.2013"},{"key":"key-10.4103\/1673-5374.238604-98","doi-asserted-by":"crossref","unstructured":"Pribiag H, Stellwagen D (2014) Neuroimmune regulation of homeostatic synaptic plasticity. Neuropharmacology 78:13-22.","DOI":"10.1016\/j.neuropharm.2013.06.008"},{"key":"key-10.4103\/1673-5374.238604-99","doi-asserted-by":"crossref","unstructured":"Prieto GA, Snigdha S, Baglietto-Vargas D, Smith ED, Berchtold NC, Tong L, Ajami D, LaFerla FM, Rebek J Jr, Cotman CW (2015) Synapse-specific IL-1 receptor subunit reconfiguration augments vulnerability to IL-1\u03b2 in the aged hippocampus. Proc Natl Acad Sci U S A 112:E5078-E5087.","DOI":"10.1073\/pnas.1514486112"},{"key":"key-10.4103\/1673-5374.238604-100","doi-asserted-by":"crossref","unstructured":"Qian J, Zhu L, Li Q, Belevych N, Chen Q, Zhao F, Herness S, Quan N (2012) Interleukin-1R3 mediates interleukin-1-induced potassium current increase through fast activation of Akt kinase. Proc Natl Acad Sci U S A 109:12189-12194.","DOI":"10.1073\/pnas.1205207109"},{"key":"key-10.4103\/1673-5374.238604-101","doi-asserted-by":"crossref","unstructured":"Rabinowitz AR, Li X, McCauley SR, Wilde EA, Barnes A, Hanten G, Mendez D, McCarthy JJ, Levin HS (2015) Prevalence and predictors of poor recovery from mild traumatic brain injury. J Neurotrauma 32:1488-1496.","DOI":"10.1089\/neu.2014.3555"},{"key":"key-10.4103\/1673-5374.238604-102","doi-asserted-by":"crossref","unstructured":"Raison CL, Demetrashvili M, Capuron L, Miller AH (2005) Neuropsychiatric adverse effects of interferon-alpha: recognition and management. CNS Drugs 19:105-123.","DOI":"10.2165\/00023210-200519020-00002"},{"key":"key-10.4103\/1673-5374.238604-103","doi-asserted-by":"crossref","unstructured":"Raison CL, Rutherford RE, Woolwine BJ, Shuo C, Schettler P, Drake DF, Haroon E, Miller AH (2013) A randomized controlled trial of the tumor necrosis factor antagonist infliximab for treatment-resistant depression: the role of baseline inflammatory biomarkers. JAMA Psychiatry 70:31-41.","DOI":"10.1001\/2013.jamapsychiatry.4"},{"key":"key-10.4103\/1673-5374.238604-104","doi-asserted-by":"crossref","unstructured":"Ramamoorthy S, Ramamoorthy JD, Prasad PD, Bhat GK, Mahesh VB, Leibach FH, Ganapathy V (1995) Regulation of the human serotonin transporter by interleukin-1 beta. Biochem Biophys Res Commun 216:560-567.","DOI":"10.1006\/bbrc.1995.2659"},{"key":"key-10.4103\/1673-5374.238604-105","doi-asserted-by":"crossref","unstructured":"Ramlackhansingh AF, Brooks DJ, Greenwood RJ, Bose SK, Turkheimer FE, Kinnunen KM, Gentleman S, Heckemann RA, Gunanayagam K, Gelosa G, Sharp DJ (2011) Inflammation after trauma: microglial activation and traumatic brain injury. Ann Neurol 70:374-383.","DOI":"10.1002\/ana.22455"},{"key":"key-10.4103\/1673-5374.238604-106","doi-asserted-by":"crossref","unstructured":"Rao V, Bertrand M, Rosenberg P, Makley M, Schretlen DJ, Brandt J, Mielke MM (2010) Predictors of new-onset depression after mild traumatic brain injury. J Neuropsychiatry Clin Neurosci 22:100-104.","DOI":"10.1176\/jnp.2010.22.1.100"},{"key":"key-10.4103\/1673-5374.238604-107","doi-asserted-by":"crossref","unstructured":"Rapoport MJ (2012) Depression following traumatic brain injury: epidemiology, risk factors and management. CNS Drugs 26:111-121.","DOI":"10.2165\/11599560-000000000-00000"},{"key":"key-10.4103\/1673-5374.238604-108","doi-asserted-by":"crossref","unstructured":"Roberts DJ, Jenne CN, Leger C, Kramer AH, Gallagher CN, Todd S, Parney IF, Doig CJ, Yong VW, Kubes P, Zygun DA (2013) Association between the cerebral inflammatory and matrix metalloproteinase responses after severe traumatic brain injury in humans. J Neurotrauma 30:1727-1736.","DOI":"10.1089\/neu.2012.2842"},{"key":"key-10.4103\/1673-5374.238604-109","doi-asserted-by":"crossref","unstructured":"Rogers JT, Morganti JM, Bachstetter AD, Hudson CE, Peters MM, Grimmig BA, Weeber EJ, Bickford PC, Gemma C (2011) CX3CR1 deficiency leads to impairment of hippocampal cognitive function and synaptic plasticity. J Neurosci 31:16241-16250.","DOI":"10.1523\/JNEUROSCI.3667-11.2011"},{"key":"key-10.4103\/1673-5374.238604-110","doi-asserted-by":"crossref","unstructured":"Rosenblat JD, McIntyre RS (2018) Efficacy and tolerability of minocycline for depression: A systematic review and meta-analysis of clinical trials. J Affect Disord 227:219-225.","DOI":"10.1016\/j.jad.2017.10.042"},{"key":"key-10.4103\/1673-5374.238604-111","doi-asserted-by":"crossref","unstructured":"Roseti C, van Vliet EA, Cifelli P, Ruffolo G, Baayen JC, Di Castro MA, Bertollini C, Limatola C, Aronica E, Vezzani A, Palma E (2015) GABAA currents are decreased by IL-1beta in epileptogenic tissue of patients with temporal lobe epilepsy: implications for ictogenesis. Neurobiol Dis 82:311-320.","DOI":"10.1016\/j.nbd.2015.07.003"},{"key":"key-10.4103\/1673-5374.238604-112","doi-asserted-by":"crossref","unstructured":"Ross FM, Allan SM, Rothwell NJ, Verkhratsky A (2003) A dual role for interleukin-1 in LTP in mouse hippocampal slices. J Neuroimmunol 144:61-67.","DOI":"10.1016\/j.jneuroim.2003.08.030"},{"key":"key-10.4103\/1673-5374.238604-113","doi-asserted-by":"crossref","unstructured":"Rowe RK, Ziebell JM, Harrison JL, Law LM, Adelson PD, Lifshitz J (2016) Aging with traumatic brain injury: effects of age at injury on behavioral outcome following diffuse brain injury in rats. Dev Neurosci 38:195-205.","DOI":"10.1159\/000446773"},{"key":"key-10.4103\/1673-5374.238604-114","doi-asserted-by":"crossref","unstructured":"Sama DM, Mohmmad Abdul H, Furman JL, Artiushin IA, Szymkowski DE, Scheff SW, Norris CM (2012) Inhibition of soluble tumor necrosis factor ameliorates synaptic alterations and Ca2+ dysregulation in aged rats. PLoS One 7:e38170.","DOI":"10.1371\/journal.pone.0038170"},{"key":"key-10.4103\/1673-5374.238604-115","doi-asserted-by":"crossref","unstructured":"Sanchez-Alavez M, Tabarean IV, Behrens MM, Bartfai T (2006) Ceramide mediates the rapid phase of febrile response to IL-1beta. Proc Natl Acad Sci U S A 103:2904-2908.","DOI":"10.1073\/pnas.0510960103"},{"key":"key-10.4103\/1673-5374.238604-116","doi-asserted-by":"crossref","unstructured":"Serantes R, Arnalich F, Figueroa M, Salinas M, Andres-Mateos E, Codoceo R, Renart J, Matute C, Cavada C, Cuadrado A, Montiel C (2006) Interleukin-1beta enhances GABAA receptor cell-surface expression by a phosphatidylinositol 3-kinase\/Akt pathway: relevance to sepsis-associated encephalopathy. J Biol Chem 281:14632-14643.","DOI":"10.1074\/jbc.M512489200"},{"key":"key-10.4103\/1673-5374.238604-117","doi-asserted-by":"crossref","unstructured":"Sharma R, Rosenberg A, Bennett ER, Laskowitz DT, Acheson SK (2017) A blood-based biomarker panel to risk-stratify mild traumatic brain injury. PLoS One 12:e0173798.","DOI":"10.1371\/journal.pone.0173798"},{"key":"key-10.4103\/1673-5374.238604-118","doi-asserted-by":"crossref","unstructured":"Shiozaki T, Hayakata T, Tasaki O, Hosotubo H, Fuijita K, Mouri T, Tajima G, Kajino K, Nakae H, Tanaka H, Shimazu T, Sugimoto H (2005) Cerebrospinal fluid concentrations of anti-inflammatory mediators in early-phase severe traumatic brain injury. Shock 23:406-410.","DOI":"10.1097\/01.shk.0000161385.62758.24"},{"key":"key-10.4103\/1673-5374.238604-119","doi-asserted-by":"crossref","unstructured":"Shore PM, Thomas NJ, Clark RS, Adelson PD, Wisniewski SR, Janesko KL, Bayir H, Jackson EK, Kochanek PM (2004) Continuous versus intermittent cerebrospinal fluid drainage after severe traumatic brain injury in children: effect on biochemical markers. J Neurotrauma 21:1113-1122.","DOI":"10.1089\/neu.2004.21.1113"},{"key":"key-10.4103\/1673-5374.238604-120","doi-asserted-by":"crossref","unstructured":"Silverberg ND, Panenka WJ, Iverson GL (2018) Work productivity loss after mild traumatic brain injury. Arch Phys Med Rehabil 99:250-256.","DOI":"10.1016\/j.apmr.2017.07.006"},{"key":"key-10.4103\/1673-5374.238604-121","doi-asserted-by":"crossref","unstructured":"Simon DW, McGeachy MJ, Bayir H, Clark RS, Loane DJ, Kochanek PM (2017) The far-reaching scope of neuroinflammation after traumatic brain injury. Nat Rev Neurol 13:171-191.","DOI":"10.1038\/nrneurol.2017.13"},{"key":"key-10.4103\/1673-5374.238604-122","doi-asserted-by":"crossref","unstructured":"Singh R, Mason S, Lecky F, Dawson J (2018) Prevalence of depression after TBI in a prospective cohort: The SHEFBIT study. Brain Inj 32:84-90.","DOI":"10.1080\/02699052.2017.1376756"},{"key":"key-10.4103\/1673-5374.238604-123","doi-asserted-by":"crossref","unstructured":"Smith DE, Lipsky BP, Russell C, Ketchem RR, Kirchner J, Hensley K, Huang Y, Friedman WJ, Boissonneault V, Plante MM, Rivest S, Sims JE (2009) A central nervous system-restricted isoform of the interleukin-1 receptor accessory protein modulates neuronal responses to interleukin-1. Immunity 30:817-831.","DOI":"10.1016\/j.immuni.2009.03.020"},{"key":"key-10.4103\/1673-5374.238604-124","doi-asserted-by":"crossref","unstructured":"Smith RS (1991) The macrophage theory of depression. Med Hypotheses 35:298-306.","DOI":"10.1016\/0306-9877(91)90272-Z"},{"key":"key-10.4103\/1673-5374.238604-125","doi-asserted-by":"crossref","unstructured":"Speer K, Upton D, Semple S, McKune A (2018) Systemic low-grade inflammation in post-traumatic stress disorder: a systematic review. J Inflamm Res 11:111-121.","DOI":"10.2147\/JIR.S155903"},{"key":"key-10.4103\/1673-5374.238604-126","doi-asserted-by":"crossref","unstructured":"Steiner JA, Carneiro AM, Blakely RD (2008) Going with the flow: trafficking-dependent and -independent regulation of serotonin transport. Traffic 9:1393-1402.","DOI":"10.1111\/j.1600-0854.2008.00757.x"},{"key":"key-10.4103\/1673-5374.238604-127","doi-asserted-by":"crossref","unstructured":"Stellwagen D, Malenka RC (2006) Synaptic scaling mediated by glial TNF-alpha. Nature 440:1054-1059.","DOI":"10.1038\/nature04671"},{"key":"key-10.4103\/1673-5374.238604-128","doi-asserted-by":"crossref","unstructured":"Stellwagen D, Beattie EC, Seo JY, Malenka RC (2005) Differential regulation of AMPA receptor and GABA receptor trafficking by tumor necrosis factor-alpha. J Neurosci 25:3219-3228.","DOI":"10.1523\/JNEUROSCI.4486-04.2005"},{"key":"key-10.4103\/1673-5374.238604-129","doi-asserted-by":"crossref","unstructured":"Stumpo DJ, Lai WS, Blackshear PJ (2010) Inflammation: cytokines and RNA-based regulation. Wiley Interdiscip Rev RNA 1:60-80.","DOI":"10.1002\/wrna.1"},{"key":"key-10.4103\/1673-5374.238604-130","doi-asserted-by":"crossref","unstructured":"Sullivan PG, Bruce-Keller AJ, Rabchevsky AG, Christakos S, Clair DK, Mattson MP, Scheff SW (1999) Exacerbation of damage and altered NF-kappaB activation in mice lacking tumor necrosis factor receptors after traumatic brain injury. J Neurosci 19:6248-6256.","DOI":"10.1523\/JNEUROSCI.19-15-06248.1999"},{"key":"key-10.4103\/1673-5374.238604-131","doi-asserted-by":"crossref","unstructured":"Takahashi H, Craig AM (2013) Protein tyrosine phosphatases PTP\u03b4, PTP\u03c3, and LAR: presynaptic hubs for synapse organization. Trends Neurosci 36:522-534.","DOI":"10.1016\/j.tins.2013.06.002"},{"key":"key-10.4103\/1673-5374.238604-132","doi-asserted-by":"crossref","unstructured":"Thalhammer A, Cingolani LA (2014) Cell adhesion and homeostatic synaptic plasticity. Neuropharmacology 78:23-30.","DOI":"10.1016\/j.neuropharm.2013.03.015"},{"key":"key-10.4103\/1673-5374.238604-133","doi-asserted-by":"crossref","unstructured":"Theadom A, Starkey N, Barker-Collo S, Jones K, Ameratunga S, Feigin V, Group BIyR (2018) Population-based cohort study of the impacts of mild traumatic brain injury in adults four years post-injury. PLoS One 13:e0191655.","DOI":"10.1371\/journal.pone.0191655"},{"key":"key-10.4103\/1673-5374.238604-134","doi-asserted-by":"crossref","unstructured":"Tong L, Prieto GA, Cotman CW (2018) IL-1beta suppresses cLTP-induced surface expression of GluA1 and actin polymerization via ceramide-mediated Src activation. J Neuroinflammation 15:127.","DOI":"10.1186\/s12974-018-1158-9"},{"key":"key-10.4103\/1673-5374.238604-135","doi-asserted-by":"crossref","unstructured":"Tucker LB, Burke JF, Fu AH, McCabe JT (2017) Neuropsychiatric symptom modeling in male and female C57BL\/6J mice after experimental traumatic brain injury. J Neurotrauma 34:890-905.","DOI":"10.1089\/neu.2016.4508"},{"key":"key-10.4103\/1673-5374.238604-136","doi-asserted-by":"crossref","unstructured":"Vezzani A, Viviani B (2015) Neuromodulatory properties of inflammatory cytokines and their impact on neuronal excitability. Neuropharmacology 96:70-82.","DOI":"10.1016\/j.neuropharm.2014.10.027"},{"key":"key-10.4103\/1673-5374.238604-137","doi-asserted-by":"crossref","unstructured":"Viviani B, Bartesaghi S, Gardoni F, Vezzani A, Behrens MM, Bartfai T, Binaglia M, Corsini E, Di Luca M, Galli CL, Marinovich M (2003) Interleukin-1beta enhances NMDA receptor-mediated intracellular calcium increase through activation of the Src family of kinases. J Neurosci 23:8692-8700.","DOI":"10.1523\/JNEUROSCI.23-25-08692.2003"},{"key":"key-10.4103\/1673-5374.238604-138","doi-asserted-by":"crossref","unstructured":"Vlasova-St Louis I, Bohjanen PR (2014) Post-transcriptional regulation of cytokine signaling by AU-rich and GU-rich elements. J Interferon Cytokine Res 34:233-241.","DOI":"10.1089\/jir.2013.0108"},{"key":"key-10.4103\/1673-5374.238604-139","doi-asserted-by":"crossref","unstructured":"Wang DS, Zurek AA, Lecker I, Yu J, Abramian AM, Avramescu S, Davies PA, Moss SJ, Lu WY, Orser BA (2012) Memory deficits induced by inflammation are regulated by alpha5-subunit-containing GABAA receptors. Cell Rep 2:488-496.","DOI":"10.1016\/j.celrep.2012.08.022"},{"key":"key-10.4103\/1673-5374.238604-140","doi-asserted-by":"crossref","unstructured":"Webster SJ, Van Eldik LJ, Watterson DM, Bachstetter AD (2015) Closed head injury in an age-related Alzheimer mouse model leads to an altered neuroinflammatory response and persistent cognitive impairment. J Neurosci 35:6554-6569.","DOI":"10.1523\/JNEUROSCI.0291-15.2015"},{"key":"key-10.4103\/1673-5374.238604-141","doi-asserted-by":"crossref","unstructured":"Witcher KG, Eiferman DS, Godbout JP (2015) Priming the inflammatory pump of the CNS after traumatic brain injury. Trends Neurosci 38:609-620.","DOI":"10.1016\/j.tins.2015.08.002"},{"key":"key-10.4103\/1673-5374.238604-142","doi-asserted-by":"crossref","unstructured":"Wu J, Zhao Z, Sabirzhanov B, Stoica BA, Kumar A, Luo T, Skovira J, Faden AI (2014) Spinal cord injury causes brain inflammation associated with cognitive and affective changes: role of cell cycle pathways. J Neurosci 34:10989-11006.","DOI":"10.1523\/JNEUROSCI.5110-13.2014"},{"key":"key-10.4103\/1673-5374.238604-143","doi-asserted-by":"crossref","unstructured":"Yamagata A, Yoshida T, Sato Y, Goto-Ito S, Uemura T, Maeda A, Shiroshima T, Iwasawa-Okamoto S, Mori H, Mishina M, Fukai S (2015) Mechanisms of splicing-dependent trans-synaptic adhesion by PTPdelta-IL1RAPL1\/IL-1RAcP for synaptic differentiation. Nat Commun 6:6926.","DOI":"10.1038\/ncomms7926"},{"key":"key-10.4103\/1673-5374.238604-144","doi-asserted-by":"crossref","unstructured":"Yan EB, Satgunaseelan L, Paul E, Bye N, Nguyen P, Agyapomaa D, Kossmann T, Rosenfeld JV, Morganti-Kossmann MC (2014a) Post-traumatic hypoxia is associated with prolonged cerebral cytokine production, higher serum biomarker levels, and poor outcome in patients with severe traumatic brain injury. J Neurotrauma 31:618-629.","DOI":"10.1089\/neu.2013.3087"},{"key":"key-10.4103\/1673-5374.238604-145","doi-asserted-by":"crossref","unstructured":"Yan X, Yadav R, Gao M, Weng HR (2014b) Interleukin-1 beta enhances endocytosis of glial glutamate transporters in the spinal dorsal horn through activating protein kinase C. Glia 62:1093-1109.","DOI":"10.1002\/glia.22665"},{"key":"key-10.4103\/1673-5374.238604-146","doi-asserted-by":"crossref","unstructured":"Yoshida T, Shiroshima T, Lee SJ, Yasumura M, Uemura T, Chen X, Iwakura Y, Mishina M (2012) Interleukin-1 receptor accessory protein organizes neuronal synaptogenesis as a cell adhesion molecule. J Neurosci 32:2588-2600.","DOI":"10.1523\/JNEUROSCI.4637-11.2012"},{"key":"key-10.4103\/1673-5374.238604-147","doi-asserted-by":"crossref","unstructured":"Zhu CB, Blakely RD, Hewlett WA (2006) The proinflammatory cytokines interleukin-1beta and tumor necrosis factor-alpha activate serotonin transporters. Neuropsychopharmacology 31:2121-2131.","DOI":"10.1038\/sj.npp.1301029"},{"key":"key-10.4103\/1673-5374.238604-148","doi-asserted-by":"crossref","unstructured":"Zhu CB, Carneiro AM, Dostmann WR, Hewlett WA, Blakely RD (2005) p38 MAPK activation elevates serotonin transport activity via a trafficking-independent, protein phosphatase 2A-dependent process. J Biol Chem 280:15649-15658.","DOI":"10.1074\/jbc.M410858200"},{"key":"key-10.4103\/1673-5374.238604-149","doi-asserted-by":"crossref","unstructured":"Zhu CB, Lindler KM, Owens AW, Daws LC, Blakely RD, Hewlett WA (2010) Interleukin-1 receptor activation by systemic lipopolysaccharide induces behavioral despair linked to MAPK regulation of CNS serotonin transporters. Neuropsychopharmacology 35:2510-2520.","DOI":"10.1038\/npp.2010.116"},{"key":"key-10.4103\/1673-5374.238604-150","doi-asserted-by":"crossref","unstructured":"Ziebell JM, Rowe RK, Muccigrosso MM, Reddaway JT, Adelson PD, Godbout JP, Lifshitz J (2017) Aging with a traumatic brain injury: Could behavioral morbidities and endocrine symptoms be influenced by microglial priming? Brain Behav Immun 59:1-7.","DOI":"10.1016\/j.bbi.2016.03.008"}],"container-title":["Neural Regeneration Research"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T18:34:44Z","timestamp":1786732484000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/1673-5374.238604"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":150,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018]]}},"alternative-id":["238604"],"URL":"https:\/\/doi.org\/10.4103\/1673-5374.238604","relation":{},"ISSN":["1673-5374"],"issn-type":[{"value":"1673-5374","type":"print"}],"subject":[],"published":{"date-parts":[[2018]]}}}