{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T01:39:29Z","timestamp":1792978769704,"version":"4.5.0"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neural Regen Res"],"published-print":{"date-parts":[[2018]]},"DOI":"10.4103\/1673-5374.239434","type":"journal-article","created":{"date-parts":[[2018,9,12]],"date-time":"2018-09-12T07:29:37Z","timestamp":1536737377000},"page":"1879","source":"Crossref","is-referenced-by-count":236,"title":["Cadmium-induced neurotoxicity: still much ado"],"prefix":"10.4103","volume":"13","author":[{"given":"Alessandra","family":"Pacini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JacopoJunio Valerio","family":"Branca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Morucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"key-10.4103\/1673-5374.239434-1","unstructured":"Agency for Toxic Substance and Disease Registry USA (2017) Toxicological Profile for Cadmium. Department of Health and Humans Services, Public Health Service, Centers for Disease Control, Atlanta, GA, USA."},{"key":"key-10.4103\/1673-5374.239434-2","doi-asserted-by":"crossref","unstructured":"Antonio MT, L\u00f3pez N, Leret ML (2002) Pb and Cd poisoning during development alters cerebellar and striatal function in rats. Toxicology 176:59-66.","DOI":"10.1016\/S0300-483X(02)00137-3"},{"key":"key-10.4103\/1673-5374.239434-3","doi-asserted-by":"crossref","unstructured":"Barton M, Filardo EJ, Lolait SJ, Thomas P, Maggiolini M, Prossnitz ER (2018) Twenty years of the G protein-coupled estrogen receptor GPER: Historical and personal perspectives. J Steroid Biochem Mol Biol 176:4-15.","DOI":"10.1016\/j.jsbmb.2017.03.021"},{"key":"key-10.4103\/1673-5374.239434-4","doi-asserted-by":"crossref","unstructured":"Berridge MJ, Lipp P, Bootman MD (2000) The versatility and universality of calcium signalling. Nat Rev Mol Cell Biol 1:11-21.","DOI":"10.1038\/35036035"},{"key":"key-10.4103\/1673-5374.239434-5","doi-asserted-by":"crossref","unstructured":"Branca JJV, Morucci G, Maresca M, Tenci B, Cascella R, Paternostro F, Ghelardini C, Gulisano M, Di Cesare Mannelli L, Pacini A (2018) Selenium and zinc: Two key players against cadmium-induced neuronal toxicity. Toxicol In Vitro 48:159-169.","DOI":"10.1016\/j.tiv.2018.01.007"},{"key":"key-10.4103\/1673-5374.239434-6","doi-asserted-by":"crossref","unstructured":"Bridges CC, Zalups RK (2005) Molecular and ionic mimicry and the transport of toxic metals. Toxicol Appl Pharmacol 204:274-308.","DOI":"10.1016\/j.taap.2004.09.007"},{"key":"key-10.4103\/1673-5374.239434-7","doi-asserted-by":"crossref","unstructured":"Chin-Chan M, Navarro-Yepes J, Quintanilla-Vega B (2015) Environmental pollutants as risk factors for neurodegenerative disorders: Alzheimer and Parkinson diseases. Front Cell Neurosci 9:124.","DOI":"10.3389\/fncel.2015.00124"},{"key":"key-10.4103\/1673-5374.239434-8","doi-asserted-by":"crossref","unstructured":"Choong G, Liu Y, Templeton DM (2014) Interplay of calcium and cadmium in mediating cadmium toxicity. Chem Biol Interact 211:54-65.","DOI":"10.1016\/j.cbi.2014.01.007"},{"key":"key-10.4103\/1673-5374.239434-9","doi-asserted-by":"crossref","unstructured":"Giaginis C, Gatzidou E, Theocharis S (2006) DNA repair systems as targets of cadmium toxicity. Toxicol Appl Pharmacol 213:282-290.","DOI":"10.1016\/j.taap.2006.03.008"},{"key":"key-10.4103\/1673-5374.239434-10","doi-asserted-by":"crossref","unstructured":"Hartwig A, Asmuss M, Blessing H, Hoffmann S, Jahnke G, Khandelwal S, Pelzer A, Burkle A (2002) Interference by toxic metal ions with zinc-dependent proteins involved in maintaining genomic stability. Food Chem Toxicol 40:1179-1184.","DOI":"10.1016\/S0278-6915(02)00043-1"},{"key":"key-10.4103\/1673-5374.239434-11","doi-asserted-by":"crossref","unstructured":"Jomova K, Valko M (2011) Advances in metal-induced oxidative stress and human disease. Toxicology 283:65-87.","DOI":"10.1016\/j.tox.2011.03.001"},{"key":"key-10.4103\/1673-5374.239434-12","doi-asserted-by":"crossref","unstructured":"Joseph P (2009) Mechanisms of cadmium carcinogenesis. Toxicol Appl Pharmacol 238:272-279.","DOI":"10.1016\/j.taap.2009.01.011"},{"key":"key-10.4103\/1673-5374.239434-13","doi-asserted-by":"crossref","unstructured":"Kumar R, Agarwal AK, Seth PK (1996) Oxidative stress-mediated neurotoxicity of cadmium. Toxicol Lett 89:65-69.","DOI":"10.1016\/S0378-4274(96)03780-0"},{"key":"key-10.4103\/1673-5374.239434-14","doi-asserted-by":"crossref","unstructured":"L\u00f3pez E, Figueroa S, Oset-Gasque MJ, Gonz\u00e1lez MP (2003) Apoptosis and necrosis: two distinct events induced by cadmium in cortical neurons in culture. Br J Pharmacol 138:901-911.","DOI":"10.1038\/sj.bjp.0705111"},{"key":"key-10.4103\/1673-5374.239434-15","doi-asserted-by":"crossref","unstructured":"Marchetti C (2014) Interaction of metal ions with neurotransmitter receptors and potential role in neurodiseases. Biometals 27:1097-1113.","DOI":"10.1007\/s10534-014-9791-y"},{"key":"key-10.4103\/1673-5374.239434-16","doi-asserted-by":"crossref","unstructured":"Matovi\u0107 V, Buha A, Bulat Z, Duki\u0107-\u0106osi\u0107 D (2011) Cadmium toxicity revisited: focus on oxidative stress induction and interactions with zinc and magnesium. Arh Hig Rada Toksikol 62:65-76.","DOI":"10.2478\/10004-1254-62-2011-2075"},{"key":"key-10.4103\/1673-5374.239434-17","doi-asserted-by":"crossref","unstructured":"Mead MN (2010) Cadmium confusion: do consumers need protection? Environ Health Perspect 118:a528-534.","DOI":"10.1289\/ehp.118-a528"},{"key":"key-10.4103\/1673-5374.239434-18","doi-asserted-by":"crossref","unstructured":"Miura S, Takahashi K, Imagawa T, Uchida K, Saito S, Tominaga M, Ohta T (2013) Involvement of TRPA1 activation in acute pain induced by cadmium in mice. Mol Pain 9:7.","DOI":"10.1186\/1744-8069-9-7"},{"key":"key-10.4103\/1673-5374.239434-19","unstructured":"Nemmiche S (2017) Oxidative signaling response to cadmium exposure. Toxicol Sci 156:4-10."},{"key":"key-10.4103\/1673-5374.239434-20","unstructured":"Oberd\u00f6rster G (1992) Pulmonary deposition, clearance and effects of inhaled soluble and insoluble cadmium compounds. IARC Sci Publ:189-204."},{"key":"key-10.4103\/1673-5374.239434-21","doi-asserted-by":"crossref","unstructured":"Pacini S, Punzi T, Morucci G, Gulisano M, Ruggiero M (2009) A paradox of cadmium: a carcinogen that impairs the capability of human breast cancer cells to induce angiogenesis. J Environ Pathol Toxicol Oncol 28:85-88.","DOI":"10.1615\/JEnvironPatholToxicolOncol.v28.i1.90"},{"key":"key-10.4103\/1673-5374.239434-22","doi-asserted-by":"crossref","unstructured":"Rani A, Kumar A, Lal A, Pant M (2014) Cellular mechanisms of cadmium-induced toxicity: a review. Int J Environ Health Res 24:378-399.","DOI":"10.1080\/09603123.2013.835032"},{"key":"key-10.4103\/1673-5374.239434-23","doi-asserted-by":"crossref","unstructured":"Rowlands DJ, Chapple S, Siow RC, Mann GE (2011) Equol-stimulated mitochondrial reactive oxygen species activate endothelial nitric oxide synthase and redox signaling in endothelial cells: roles for F-actin and GPR30. Hypertension 57:833-840.","DOI":"10.1161\/HYPERTENSIONAHA.110.162198"},{"key":"key-10.4103\/1673-5374.239434-24","doi-asserted-by":"crossref","unstructured":"Sandbichler AM, H\u00f6ckner M (2016) Cadmium protection strategies--a hidden trade-off? Int J Mol Sci 17:E139.","DOI":"10.3390\/ijms17010139"},{"key":"key-10.4103\/1673-5374.239434-25","doi-asserted-by":"crossref","unstructured":"Sheykhansari S, Kozielski K, Bill J, Sitti M, Gemmati D, Zamboni P, Singh AV (2018) Redox metals homeostasis in multiple sclerosis and amyotrophic lateral sclerosis: a review. Cell Death Dis 9:348.","DOI":"10.1038\/s41419-018-0379-2"},{"key":"key-10.4103\/1673-5374.239434-26","doi-asserted-by":"crossref","unstructured":"Shukla A, Shukla GS, Srimal RC (1996) Cadmium-induced alterations in blood-brain barrier permeability and its possible correlation with decreased microvessel antioxidant potential in rat. Hum Exp Toxicol 15:400-405.","DOI":"10.1177\/096032719601500507"},{"key":"key-10.4103\/1673-5374.239434-27","doi-asserted-by":"crossref","unstructured":"Shukla GS, Chandra SV (1987) Concurrent exposure to lead, manganese, and cadmium and their distribution to various brain regions, liver, kidney, and testis of growing rats. Arch Environ Contam Toxicol 16:303-310.","DOI":"10.1007\/BF01054947"},{"key":"key-10.4103\/1673-5374.239434-28","doi-asserted-by":"crossref","unstructured":"Shukla GS, Hussain T, Chandra SV (1987) Possible role of regional superoxide dismutase activity and lipid peroxide levels in cadmium neurotoxicity: in vivo and in vitro studies in growing rats. Life Sci 41:2215-2221.","DOI":"10.1016\/0024-3205(87)90518-2"},{"key":"key-10.4103\/1673-5374.239434-29","unstructured":"Sunderman FW Jr (2001) Nasal toxicity, carcinogenicity, and olfactory uptake of metals. Ann Clin Lab Sci 31:3-24."},{"key":"key-10.4103\/1673-5374.239434-30","doi-asserted-by":"crossref","unstructured":"Th\u00e9venod F (2010) Catch me if you can! Novel aspects of cadmium transport in mammalian cells. Biometals 23:857-875.","DOI":"10.1007\/s10534-010-9309-1"},{"key":"key-10.4103\/1673-5374.239434-31","doi-asserted-by":"crossref","unstructured":"Tr\u00e9panier G, Furling D, Puymirat J, Mirault ME (1996) Immunocytochemical localization of seleno-glutathione peroxidase in the adult mouse brain. Neuroscience 75:231-243.","DOI":"10.1016\/0306-4522(96)00222-9"},{"key":"key-10.4103\/1673-5374.239434-32","doi-asserted-by":"crossref","unstructured":"Usai C, Barberis A, Moccagatta L, Marchetti C (1999) Pathways of cadmium influx in mammalian neurons. J Neurochem 72:2154-2161.","DOI":"10.1046\/j.1471-4159.1999.0722154.x"},{"key":"key-10.4103\/1673-5374.239434-33","doi-asserted-by":"crossref","unstructured":"Wang B, Du Y (2013) Cadmium and its neurotoxic effects. Oxid Med Cell Longev 2013:898034.","DOI":"10.1155\/2013\/898034"},{"key":"key-10.4103\/1673-5374.239434-34","doi-asserted-by":"crossref","unstructured":"Yang HY, Lee TH (2015) Antioxidant enzymes as redox-based biomarkers: a brief review. BMB Reports 48:200-208.","DOI":"10.5483\/BMBRep.2015.48.4.274"},{"key":"key-10.4103\/1673-5374.239434-35","doi-asserted-by":"crossref","unstructured":"Yu X, Filardo EJ, Shaikh ZA (2010) The membrane estrogen receptor GPR30 mediates cadmium-induced proliferation of breast cancer cells. Toxicol Appl Pharmacol 245:83-90.","DOI":"10.1016\/j.taap.2010.02.005"},{"key":"key-10.4103\/1673-5374.239434-36","doi-asserted-by":"crossref","unstructured":"Zheng W (2001) Toxicology of choroid plexus: special reference to metal-induced neurotoxicities. Microsc Res Tech 52:89-103.","DOI":"10.1002\/1097-0029(20010101)52:1<89::AID-JEMT11>3.0.CO;2-2"}],"container-title":["Neural Regeneration Research"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T18:37:51Z","timestamp":1786732671000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/1673-5374.239434"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":36,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2018]]}},"alternative-id":["239434"],"URL":"https:\/\/doi.org\/10.4103\/1673-5374.239434","relation":{},"ISSN":["1673-5374"],"issn-type":[{"value":"1673-5374","type":"print"}],"subject":[],"published":{"date-parts":[[2018]]}}}