{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T02:45:30Z","timestamp":1788576330694,"version":"build-2803163510"},"reference-count":41,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:p>\n                    Spinal cord injury (SCI) causes disturbances of motor skills. Free radicals have been shown to be essential for the development of spinal cord trauma. Despite some progress, until now no effective pharmacological therapies against SCI have been verified. The purpose of our experiment was to investigate the neuroprotective effects of ebselen on experimental SCI. Twenty-two rats subjected to SCI were randomly subjected to SCI with no further treatment (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    = 10) or intragastric administration of ebselen (10 mg\/kg) immediately and 24 hours after SCI. Behavioral changes were assessed using the Basso, Beattie, and Bresnahan locomotor scale and footprint test during 12 weeks after SCI. Histopathological and immunohistochemical analyses of spinal cords and brains were performed at 12 weeks after SCI. Magnetic resonance imaging analysis of spinal cords was also performed at 12 weeks after SCI. Rats treated with ebselen presented only limited neurobehavioral progress as well as reduced spinal cord injuries compared with the control group, namely length of lesions (cysts\/scars) visualized histopathologically in the spinal cord sections was less but cavity area was very similar. The same pattern was found in T2-weighted magnetic resonance images (cavities) and diffusion-weighted images (scars). The number of FluoroGold retrogradely labeled neurons in brain stem and motor cortex was several-fold higher in ebselen-treated rats than in the control group. The findings suggest that ebselen has only limited neuroprotective effects on injured spinal cord. All exprimental procedures were approved by the Local Animal Ethics Committee for Experiments on Animals in Katowice (Katowice, Poland) (approval No. 19\/2009).\n                  <\/jats:p>","DOI":"10.4103\/1673-5374.251334","type":"journal-article","created":{"date-parts":[[2019,2,26]],"date-time":"2019-02-26T02:41:03Z","timestamp":1551148863000},"page":"1255-1261","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":11,"title":["Use of ebselen as a neuroprotective agent in rat spinal cord subjected to traumatic injury"],"prefix":"10.4103","volume":"14","author":[{"given":"Wojciech","family":"\u015alusarczyk","sequence":"first","affiliation":[{"name":"Department of Physiology, Medical University of Silesia, Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edyta","family":"Olakowska","sequence":"additional","affiliation":[{"name":"Department of Physiology, Medical University of Silesia, Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Larysz-Brysz","sequence":"additional","affiliation":[{"name":"Department of Physiology, Medical University of Silesia, Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izabella","family":"Woszczycka-Korczy\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Physiology, Medical University of Silesia, Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daria Gendosz","family":"de Carrillo","sequence":"additional","affiliation":[{"name":"Department of Physiology, Medical University of Silesia, Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W\u0142adys\u0142aw P.","family":"W\u0119glarz","sequence":"additional","affiliation":[{"name":"Institute of Nuclear Physics, Polish Academy of Sciences, Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Lewin-Kowalik","sequence":"additional","affiliation":[{"name":"Department of Physiology, Medical University of Silesia, Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8914-7273","authenticated-orcid":false,"given":"Wies\u0142aw","family":"Marcol","sequence":"additional","affiliation":[{"name":"Department of Physiology, Medical University of Silesia, Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20260525","doi-asserted-by":"crossref","first-page":"771","DOI":"10.3109\/00207454.2013.879581","article-title":"Effects of ebselen on ischemia\/reperfusion injury in rat brains","volume":"124","author":"Aras","year":"2014","journal-title":"Int J 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effects of ebselen in traumatic brain injury model: involvement of nitric oxide and p38 mitogen-activated protein kinase signalling pathway","volume":"41","author":"Wei","year":"2014","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"R39-20260525","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1111\/j.1471-4159.2006.04312.x","article-title":"Role of peroxynitrite in secondary oxidative damage after spinal cord injury","volume":"100","author":"Xiong","year":"2007","journal-title":"J Neurochem"},{"key":"R40-20260525","doi-asserted-by":"crossref","first-page":"412","DOI":"10.4103\/1673-5374.153689","article-title":"Feasibility of 3.0 T diffusion-weighted nuclear magnetic resonance imaging in the evaluation of functional recovery of rats with complete spinal cord injury","volume":"10","author":"Zhang","year":"2015","journal-title":"Neural Regen 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Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01300535-201914070-00026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T19:28:43Z","timestamp":1786735723000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/1673-5374.251334"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":41,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019]]}},"URL":"https:\/\/doi.org\/10.4103\/1673-5374.251334","relation":{},"ISSN":["1673-5374","1876-7958"],"issn-type":[{"value":"1673-5374","type":"print"},{"value":"1876-7958","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"2018-07-03","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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