{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T20:31:44Z","timestamp":1786739504813,"version":"build-2736575974"},"reference-count":80,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","license":[{"start":{"date-parts":[[2020,4,3]],"date-time":"2020-04-03T00:00:00Z","timestamp":1585872000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:p>\n                    Hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S) is considered as a protective factor against cardiovascular disorders. However, there are few reports on the effects of H\n                    <jats:sub>2<\/jats:sub>\n                    S in the central nervous system during stress or injury. Previous studies on goldfish have shown that astrocytic response occurs in the damaged and contralateral optic nerves. Glial fibrillary acidic protein (GFAP) concentration in the optic nerves of rainbow trout has not been measured previously. This study further characterized the astrocytic response in the optic nerve and the brain of a rainbow trout (\n                    <jats:italic toggle=\"yes\">Oncorhynchus mykiss<\/jats:italic>\n                    ) after unilateral eye injury and estimated the amount of H\n                    <jats:sub>2<\/jats:sub>\n                    S-producing enzyme cystathionine \u03b2-synthase (CBS) in the brain of the rainbow trout. Within 1 week after unilateral eye injury, a protein band corresponding to a molecular weight of 50 kDa was identified in the ipsi- and contralateral optic nerves of the rainbow trout. The concentration of GFAP in the injured optic nerve increased compared to the protein concentration on the contralateral side. The results of a quantitative analysis of GFAP\n                    <jats:sup>+<\/jats:sup>\n                    cell distribution in the contralateral optic nerve showed the largest number of GFAP\n                    <jats:sup>+<\/jats:sup>\n                    cells and fibers in the optic nerve head. In the damaged optic nerve, patterns of GFAP\n                    <jats:sup>+<\/jats:sup>\n                    cell migration and large GFAP\n                    <jats:sup>+<\/jats:sup>\n                    bipolar activated astrocytes were detected at 1 week after unilateral eye injury. The study of H\n                    <jats:sub>2<\/jats:sub>\n                    S-producing system after unilateral eye injury in the rainbow trout was conducted using enzyme-linked immunosorbent assay, western blot analysis, and immunohistochemistry of polyclonal antibodies against CBS in the integrative centers of the brain: telencephalon, optic tectum, and cerebellum. Enzyme-linked immunosorbent assay results showed a 1.7-fold increase in CBS expression in the rainbow trout brain at 1 week after unilateral eye injury compared with that in intact animals. In the ventricular and subventricular regions of the rainbow trout telencephalon, CBS\n                    <jats:sup>+<\/jats:sup>\n                    radial glia and neuroepithelial cells were identified. After unilateral eye injury, the number of CBS\n                    <jats:sup>+<\/jats:sup>\n                    neuroepithelial cells in the pallial and subpallial periventricular regions of the telencephalon increased. In the optic tectum, unilateral eye injury led to an increase in CBS expression in radial glial cells; simultaneously, the number of CBS\n                    <jats:sup>+<\/jats:sup>\n                    neuroepithelial cells decreased in intact animals. In the cerebellum of the rainbow trout, neuroglial interrelationships were revealed, where H\n                    <jats:sub>2<\/jats:sub>\n                    S was released, apparently, from astrocyte-like cells. The organization of H\n                    <jats:sub>2<\/jats:sub>\n                    S-producing cell complexes suggests that, the amount of glutamate produced in the rainbow trout cerebellum and its reuptake was controlled by astrocyte-like cells, reducing its excitotoxicity. In the dorsal matrix zone and granular eminences of the rainbow trout cerebellum, CBS was expressed in neuroepithelial cells. After unilateral eye injury, the level of CBS activity increased in all parts of the cerebellum. An increase in the number of H\n                    <jats:sub>2<\/jats:sub>\n                    S-producing cells was a response to oxidative stress after unilateral eye injury, and the overproduction of H\n                    <jats:sub>2<\/jats:sub>\n                    S in the cerebellum occurred to neutralize reactive oxygen species, providing the cells of the rainbow trout cerebellum with a protective effect. A structural reorganization in the dorsal matrix zone, associated with the appearance of an additional CBS\n                    <jats:sup>+<\/jats:sup>\n                    apical zone, and a decrease in the enzyme activity in the dorsal matrix zone, was revealed in the zones of constitutive neurogenesis. All experiments were approved by the Commission on Biomedical Ethics, A.V. Zhirmunsky National Scientific Center of Marine Biology (NSCMB), Far Eastern Branch, Russian Academy of Science (FEB RAS) (approval No. 1) on July 31, 2019.\n                  <\/jats:p>","DOI":"10.4103\/1673-5374.280320","type":"journal-article","created":{"date-parts":[[2020,4,3]],"date-time":"2020-04-03T15:00:30Z","timestamp":1585926030000},"page":"1867-1886","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":9,"title":["GFAP expression in the optic nerve and increased H2S generation in the integration centers of the rainbow trout (Oncorhynchus mykiss) brain after unilateral eye injury"],"prefix":"10.4103","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0388-3147","authenticated-orcid":false,"given":"Evgeniya V.","family":"Pushchina","sequence":"first","affiliation":[{"name":"A.V. Zhirmunsky National Scientific Center of Marine Biology, Far Eastern Branch, Russian Academy of Sciences, Vladivostok, Russia"},{"name":"A.A. Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kiev, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anatoly A.","family":"Varaksin","sequence":"additional","affiliation":[{"name":"A.V. Zhirmunsky National Scientific Center of Marine Biology, Far Eastern Branch, Russian Academy of Sciences, Vladivostok, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitry K.","family":"Obukhov","sequence":"additional","affiliation":[{"name":"St. Petersburg State University, St. Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor M.","family":"Prudnikov","sequence":"additional","affiliation":[{"name":"A.A. Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kiev, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2020,10]]},"reference":[{"key":"R1-20260525","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.ydbio.2006.03.023","article-title":"Conserved and acquired features of adult neurogenesis in the zebrafish telencephalon","volume":"29","author":"Adolf","year":"2006","journal-title":"Dev Biol"},{"key":"R2-20260525","first-page":"51","article-title":"Characterization of glial fibrillary acidic protein and astroglial architecture in the brain of a continuously growing fish, the rainbow trout","volume":"49","author":"Alunni","year":"2005","journal-title":"Eur J Histochem"},{"key":"R3-20260525","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1002\/cne.11021","article-title":"Development of vimentin and glial fibrillary acidic protein immunoreactivities in the brain of gray mullet (Chelon labrosus), an advanced teleost","volume":"46","author":"Arochena","year":"2004","journal-title":"J Comp Neurol"},{"key":"R4-20260525","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/BF00185897","article-title":"Astroglial pattern in the spinal cord of the adult barbel (Barbus comiza)","volume":"187","author":"Bodega","year":"1993","journal-title":"Anat Embryol (Berl)"},{"key":"R5-20260525","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal Biochem"},{"key":"R6-20260525","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/j.1476-5381.2011.01480.x","article-title":"System Xc\u2013 cystine\/glutamate antiporter: an update on molecular pharmacology and roles within the CNS","volume":"165","author":"Bridges","year":"2012","journal-title":"Br J Pharmacol"},{"key":"R7-20260525","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1002\/glia.440030305","article-title":"Comparative immunohistochemical study of glial filament proteins (glial fibrillary acidic protein and vimentin) in goldfish, octopus and snail","volume":"3","author":"Cardone","year":"1990","journal-title":"Glia"},{"key":"R8-20260525","doi-asserted-by":"crossref","first-page":"392","DOI":"10.3389\/fnins.2018.00392","article-title":"The role of gaseous molecules in traumatic brain injury: an updated review","volume":"12","author":"Che","year":"2018","journal-title":"Front Neurosci"},{"key":"R9-20260525","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0165-3806(01)00193-6","article-title":"Neuronal regeneration in the cerebellum of adult teleost fish. 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