{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:34:23Z","timestamp":1790768063678,"version":"4.1.0"},"reference-count":50,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","license":[{"start":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T00:00:00Z","timestamp":1589155200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:p>\n                    Trans-(-)-\u03b5-viniferin (\u03b5-viniferin) has antioxidative and anti-inflammatory effects. It also has neuroprotective effects in Huntington\u2019s disease by activating the SIRT3\/LKB1\/AMPK signaling pathway; however, it remains unknown whether \u03b5-viniferin also has a neuroprotective role in Parkinson\u2019s disease. A Parkinson\u2019s disease cell model was induced by exposing SH-SY5Y cells to 3.0 \u03bcM rotenone for 24 hours, and cells were then treated with 1.0 \u03bcM \u03b5-viniferin for 24 hours. Treatment with \u03b5-viniferin upregulated SIRT3 expression, which promoted FOXO3 deacetylation and nuclear localization. \u03b5-Viniferin also increased ATP production and decreased reactive oxygen species production. Furthermore, \u03b5-viniferin treatment alleviated rotenone-induced mitochondrial depolarization and reduced cell apoptosis, and restored the expression of mitochondrial homeostasis-related proteins. However, when cells were transfected with\n                    <jats:italic toggle=\"yes\">SIRT3<\/jats:italic>\n                    or\n                    <jats:italic toggle=\"yes\">FOXO3<\/jats:italic>\n                    shRNA prior to rotenone and \u03b5-viniferin treatment, these changes were reversed. The results from the present study indicate that \u03b5-viniferin enhances SIRT3-mediated FOXO3 deacetylation, reduces oxidative stress, and maintains mitochondrial homeostasis, thus inhibiting rotenone-induced cell apoptosis. \u03b5-Viniferin may therefore be a promising treatment strategy for Parkinson\u2019s disease.\n                  <\/jats:p>","DOI":"10.4103\/1673-5374.282264","type":"journal-article","created":{"date-parts":[[2020,5,10]],"date-time":"2020-05-10T15:18:06Z","timestamp":1589123886000},"page":"2143-2153","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":61,"title":["Neuroprotective mechanisms of \u03b5-viniferin in a rotenone-induced cell model of Parkinson's disease: significance of SIRT3-mediated FOXO3 deacetylation"],"prefix":"10.4103","volume":"15","author":[{"given":"Shuo","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Neurology, Shengjing Hospital of China Medical 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