{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T15:14:10Z","timestamp":1792854850733,"version":"4.5.0"},"reference-count":224,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T00:00:00Z","timestamp":1598227200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:p>\n                    Various inflammatory stimuli are able to modify or even \u201cre-program\u201d the mitochondrial metabolism that results in generation of reactive oxygen species. In noncommunicable chronic diseases such as atherosclerosis and other cardiovascular pathologies, type 2 diabetes and metabolic syndrome, these modifications become systemic and are characterized by chronic inflammation and, in particular, \u201cneuroinflammation\u201d in the central nervous system. The processes associated with chronic inflammation are frequently grouped into \u201cvicious circles\u201d which are able to stimulate each other constantly amplifying the pathological events. These circles are evidently observed in Alzheimer\u2019s disease, atherosclerosis, type 2 diabetes, metabolic syndrome and, possibly, other associated pathologies. Furthermore, chronic inflammation in peripheral tissues is frequently concomitant to Alzheimer\u2019s disease. This is supposedly associated with some common genetic polymorphisms, for example,\n                    <jats:italic toggle=\"yes\">Apolipoprotein-E \u03b54<\/jats:italic>\n                    allele carriers with Alzheimer\u2019s disease can also develop atherosclerosis. Notably, in the transgenic mice expressing the recombinant mitochondria targeted catalase, that removes hydrogen peroxide from mitochondria, demonstrates the significant pathology amelioration and health improvements. In addition, the beneficial effects of some natural products from the xanthophyll family, astaxanthin and fucoxanthin, which are able to target the reactive oxygen species at cellular or mitochondrial membranes, have been demonstrated in both animal and human studies. We propose that the normalization of mitochondrial functions could play a key role in the treatment of neurodegenerative disorders and other noncommunicable diseases associated with chronic inflammation in ageing. Furthermore, some prospective drugs based on mitochondria targeted catalase or xanthophylls could be used as an effective treatment of these pathologies, especially at early stages of their development.\n                  <\/jats:p>","DOI":"10.4103\/1673-5374.290878","type":"journal-article","created":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T16:15:06Z","timestamp":1598285706000},"page":"223-233","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":19,"title":["Inflammation\/bioenergetics-associated neurodegenerative pathologies and concomitant diseases: a role of mitochondria targeted catalase and xanthophylls"],"prefix":"10.4103","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4739-7482","authenticated-orcid":false,"given":"Mikhail A.","family":"Filippov","sequence":"first","affiliation":[{"name":"Sistema-BioTech, LLC, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga G.","family":"Tatarnikova","sequence":"additional","affiliation":[{"name":"Sistema-BioTech, LLC, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia V.","family":"Pozdnyakova","sequence":"additional","affiliation":[{"name":"Sistema-BioTech, LLC, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7716-2580","authenticated-orcid":false,"given":"Vasily V.","family":"Vorobyov","sequence":"additional","affiliation":[{"name":"Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2021,2]]},"reference":[{"key":"R1-20260525","doi-asserted-by":"crossref","DOI":"10.3390\/genes10030222","article-title":"The genetic variability of APOE in different human populations and its implications for 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