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Other variants of the disease involve autoimmune attack of non-receptor scaffolding proteins or enzymes essential for building or maintaining the integrity of this peripheral synapse. This review summarizes the participation of the above proteins in building the neuromuscular junction and the destruction of this cholinergic synapse by autoimmune aggression in myasthenia gravis. The review also covers the application of a powerful biophysical technique, superresolution optical microscopy, to image the nicotinic receptor in live cells and follow its motional dynamics. The hypothesis is entertained that anomalous nanocluster formation by antibody crosslinking may lead to accelerated endocytic internalization and elevated turnover of the receptor, as observed in myasthenia gravis.<\/jats:p>","DOI":"10.4103\/1673-5374.290880","type":"journal-article","created":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T16:15:06Z","timestamp":1598285706000},"page":"242-246","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Possible implications of dysregulated nicotinic acetylcholine receptor diffusion and nanocluster formation in myasthenia gravis"],"prefix":"10.4103","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4745-681X","authenticated-orcid":false,"given":"Francisco J.","family":"Barrantes","sequence":"first","affiliation":[{"name":"Biomedical Research Institute (BIOMED) UCA-CONICET, Buenos Aires, 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