{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T19:52:59Z","timestamp":1786737179689,"version":"build-2736575974"},"reference-count":59,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neural Regen Res"],"published-print":{"date-parts":[[2021]]},"DOI":"10.4103\/1673-5374.293132","type":"journal-article","created":{"date-parts":[[2020,10,9]],"date-time":"2020-10-09T15:15:01Z","timestamp":1602256501000},"page":"694","source":"Crossref","is-referenced-by-count":6,"title":["Nerve growth factor in muscle afferent neurons of peripheral artery disease and autonomic function"],"prefix":"10.4103","volume":"16","author":[{"given":"Lu","family":"Qin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"key-10.4103\/1673-5374.293132-1","doi-asserted-by":"crossref","unstructured":"Baccelli G, Reggiani P, Mattioli A, Corbellini E, Garducci S, Catalano M (1999) The exercise pressor reflex and changes in radial arterial pressure and heart rate during walking in patients with arteriosclerosis obliterans. Angiology 50:361-374.","DOI":"10.1177\/000331979905000502"},{"key":"key-10.4103\/1673-5374.293132-2","doi-asserted-by":"crossref","unstructured":"Bakke EF, Hisdal J, Jorgensen JJ, Kroese A, Stranden E (2007) Blood pressure in patients with intermittent claudication increases continuously during walking. Eur J Vasc Endovasc Surg 33:20-25.","DOI":"10.1016\/j.ejvs.2006.06.023"},{"key":"key-10.4103\/1673-5374.293132-3","doi-asserted-by":"crossref","unstructured":"Balamurugan K (2016) HIF-1 at the crossroads of hypoxia, inflammation, and cancer. Int J Cancer 138:1058-1066.","DOI":"10.1002\/ijc.29519"},{"key":"key-10.4103\/1673-5374.293132-4","doi-asserted-by":"crossref","unstructured":"Birdsong WT, Fierro L, Williams FG, Spelta V, Naves LA, Knowles M, Marsh-Haffner J, Adelman JP, Almers W, Elde RP, McCleskey EW (2010) Sensing muscle ischemia: coincident detection of acid and ATP via interplay of two ion channels. Neuron 68: 739-749.","DOI":"10.1016\/j.neuron.2010.09.029"},{"key":"key-10.4103\/1673-5374.293132-5","doi-asserted-by":"crossref","unstructured":"Burnstock G (2016) Purinergic mechanisms and pain. Adv Pharmacol 75:91-137.","DOI":"10.1016\/bs.apha.2015.09.001"},{"key":"key-10.4103\/1673-5374.293132-6","doi-asserted-by":"crossref","unstructured":"Burnstock G (2017) Purinergic signalling: therapeutic developments. Front Pharmacol 8:661.","DOI":"10.3389\/fphar.2017.00661"},{"key":"key-10.4103\/1673-5374.293132-7","doi-asserted-by":"crossref","unstructured":"Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D (1997) The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 389:816-824.","DOI":"10.1038\/39807"},{"key":"key-10.4103\/1673-5374.293132-8","doi-asserted-by":"crossref","unstructured":"Coelho A, Oliveira R, Antunes-Lopes T, Cruz CD (2019) Partners in crime: NGF and BDNF in visceral dysfunction. Curr Neuropharmacol 17:1021-1038.","DOI":"10.2174\/1570159X17666190617095844"},{"key":"key-10.4103\/1673-5374.293132-9","doi-asserted-by":"crossref","unstructured":"De Logu F, Geppetti P (2019) Ion channel pharmacology for pain modulation. Handb Exp Pharmacol 260:161-186.","DOI":"10.1007\/164_2019_336"},{"key":"key-10.4103\/1673-5374.293132-10","doi-asserted-by":"crossref","unstructured":"Denk F, Bennett DL, McMahon SB (2017) Nerve growth factor and pain mechanisms. Annu Rev Neurosci 40:307-325.","DOI":"10.1146\/annurev-neuro-072116-031121"},{"key":"key-10.4103\/1673-5374.293132-11","doi-asserted-by":"crossref","unstructured":"Deval E, Gasull X, Noel J, Salinas M, Baron A, Diochot S, Lingueglia E (2010) Acid-sensing ion channels (ASICs): pharmacology and implication in pain. Pharmacol Ther 128:549-558.","DOI":"10.1016\/j.pharmthera.2010.08.006"},{"key":"key-10.4103\/1673-5374.293132-12","doi-asserted-by":"crossref","unstructured":"Diaz-Franulic I, Caceres-Molina J, Sepulveda RV, Gonzalez-Nilo F, Latorre R (2016) Structure-driven pharmacology of transient receptor potential channel vanilloid 1. Mol Pharmacol 90:300-308.","DOI":"10.1124\/mol.116.104430"},{"key":"key-10.4103\/1673-5374.293132-13","doi-asserted-by":"crossref","unstructured":"Ducrocq GP, Estrada JA, Kim JS, Kaufman MP (2019) Blocking the transient receptor potential vanilloid-1 does not reduce the exercise pressor reflex in healthy rats. Am J Physiol Regul Integr Comp Physiol 317:R576-R587.","DOI":"10.1152\/ajpregu.00174.2019"},{"key":"key-10.4103\/1673-5374.293132-14","doi-asserted-by":"crossref","unstructured":"Ducrocq GP, Kaufman MP (2020) Inorganic phosphate and lactate potentiate the pressor response to acidic stimuli in rats. Exp Physiol 105:613-621.","DOI":"10.1113\/EP088349"},{"key":"key-10.4103\/1673-5374.293132-15","doi-asserted-by":"crossref","unstructured":"Ducrocq GP, Kim JS, Estrada JA, Kaufman MP (2020) ASIC1a plays a key role in evoking the metabolic component of the exercise pressor reflex in rats. Am J Physiol Heart Circ Physiol 2020;318:H78-89.","DOI":"10.1152\/ajpheart.00565.2019"},{"key":"key-10.4103\/1673-5374.293132-16","doi-asserted-by":"crossref","unstructured":"Encinas JFA, Foncesca CH, Perez MM, Sim\u00f5es DP, da Costa Aguiar Alves B, Bacci MR, Maifrino LBM, Fonseca FLA, da Veiga GL (2019) Role of hypoxia-inducible factor 1\u03b1 as a potential biomarker for renal diseases-A systematic review. Cell Biochem Funct 37:443-451.","DOI":"10.1002\/cbf.3425"},{"key":"key-10.4103\/1673-5374.293132-17","doi-asserted-by":"crossref","unstructured":"Frias B, Merighi A (2016) Capsaicin, nociception and pain. Molecules 21:797.","DOI":"10.3390\/molecules21060797"},{"key":"key-10.4103\/1673-5374.293132-18","unstructured":"Gao W, Li J (2013) Femoral artery occlusion increases muscle pressor reflex and expression of hypoxia-inducible factor-1\u03b1 in sensory neurons. J Cardiovas Disease 1:34-40."},{"key":"key-10.4103\/1673-5374.293132-19","doi-asserted-by":"crossref","unstructured":"Gao Z, Henig O, Kehoe V, Sinoway LI, Li J (2006) Vanilloid type 1 receptor and the acid-sensing ion channel mediate acid phosphate activation of muscle afferent nerves in rats. J Appl Physiol 100:421-426.","DOI":"10.1152\/japplphysiol.00659.2005"},{"key":"key-10.4103\/1673-5374.293132-20","doi-asserted-by":"crossref","unstructured":"Gao Z, Li JD, Sinoway LI, Li J (2007) Effect of muscle interstitial pH on P2X and TRPV1 receptor-mediated pressor response. J Appl Physiol 102:2288-2293.","DOI":"10.1152\/japplphysiol.00161.2007"},{"key":"key-10.4103\/1673-5374.293132-21","doi-asserted-by":"crossref","unstructured":"Hanna RL, Hayes SG, Kaufman M (2002) Alpha,beta-methylene ATP elicits a reflex pressor response arising from muscle in decerebrate cats. J Appl Physiol 93:834-841.","DOI":"10.1152\/japplphysiol.00237.2002"},{"key":"key-10.4103\/1673-5374.293132-22","doi-asserted-by":"crossref","unstructured":"Hanna RL, Kaufman MP (2004) Activation of thin-fiber muscle afferents by a P2X agonist in cats. J Appl Physiol 96:1166-1169.","DOI":"10.1152\/japplphysiol.01020.2003"},{"key":"key-10.4103\/1673-5374.293132-23","doi-asserted-by":"crossref","unstructured":"Hayes SG McCord JL, Kaufman MP (2008) Role played by P2X and P2Y receptors in evoking the muscle chemoreflex. J Appl Physiol 104:538-541.","DOI":"10.1152\/japplphysiol.00929.2007"},{"key":"key-10.4103\/1673-5374.293132-24","doi-asserted-by":"crossref","unstructured":"Hefti F (2020) Pharmacology of nerve growth factor and discovery of tanezumab, an anti-nerve growth factor antibody and pain therapeutic. Pharmacol Res 154:104240.","DOI":"10.1016\/j.phrs.2019.04.024"},{"key":"key-10.4103\/1673-5374.293132-25","doi-asserted-by":"crossref","unstructured":"Ivanova IG, Park CV, Kenneth NS (2019) Translating the hypoxic response-the role of HIF protein translation in the cellular response to low oxygen. Cells 8:114.","DOI":"10.3390\/cells8020114"},{"key":"key-10.4103\/1673-5374.293132-26","doi-asserted-by":"crossref","unstructured":"Jardin I, Lopez JJ, Diez R, Sanchez-Collado J, Cantonero C, Albarran L, Woodard GE, Redondo PC, Salido GM, Smani T, Rosado JA (2017) TRPs in pain sensation. Front Physiol 8:392.","DOI":"10.3389\/fphys.2017.00392"},{"key":"key-10.4103\/1673-5374.293132-27","doi-asserted-by":"crossref","unstructured":"Kashyap MP, Roberts C, Waseem M, Tyagi P (2018) Drug targets in neurotrophin signaling in the central and peripheral nervous system. Mol Neurobiol 55:6939-6955.","DOI":"10.1007\/s12035-018-0885-3"},{"key":"key-10.4103\/1673-5374.293132-28","doi-asserted-by":"crossref","unstructured":"Kaufman MP, Forster HV (1996) Reflexes controlling circulatory, ventilatory and airway responses to exercise. In: Handbook of Physiology, Exercise: Regulation and Integration of Multiple Systems (Rowell LB, and Shepherd JT, eds), pp381-447. New York: Oxford UP.","DOI":"10.1002\/cphy.cp120110"},{"key":"key-10.4103\/1673-5374.293132-29","doi-asserted-by":"crossref","unstructured":"Kaufman MP, Iwamoto GA, Longhurst JC, Mitchell JH (1982) Effects of capsaicin and bradykinin on afferent fibers with endings in skeletal muscle. Circ Res 50:133-139.","DOI":"10.1161\/01.RES.50.1.133"},{"key":"key-10.4103\/1673-5374.293132-30","doi-asserted-by":"crossref","unstructured":"Kim JS, Harms JE, Ruiz-Velasco V, Kaufman MP (2019) Effect of knockout of the ASIC3 on cardiovascular reflexes arising from hindlimb muscle in decerebrated rats. Am J Physiol Regul Integr Comp Physiol 317:R641-648.","DOI":"10.1152\/ajpregu.00148.2019"},{"key":"key-10.4103\/1673-5374.293132-31","doi-asserted-by":"crossref","unstructured":"Li J, Maile MD, Sinoway AN, Sinoway LI (2004) Muscle pressor reflex: potential role of vanilloid type 1 receptor and acid-sensing ion channel. J Appl Physiol 97:1709-1714.","DOI":"10.1152\/japplphysiol.00389.2004"},{"key":"key-10.4103\/1673-5374.293132-32","doi-asserted-by":"crossref","unstructured":"Li J, Sinoway LI (2002) ATP stimulates chemically sensitive and sensitizes mechanically sensitive afferents. Am J Physiol Heart Circ Physiol 283:H2636-2643.","DOI":"10.1152\/ajpheart.00395.2002"},{"key":"key-10.4103\/1673-5374.293132-33","doi-asserted-by":"crossref","unstructured":"Light AR, Hughen RW, Zhang J, Rainier J, Liu Z, Lee J (2008) Dorsal root ganglion neurons innervating skeletal muscle respond to physiological combinations of protons, ATP, and lactate mediated by ASIC, P2X, and TRPV1. J Neurophysiol 100:1184-1201.","DOI":"10.1152\/jn.01344.2007"},{"key":"key-10.4103\/1673-5374.293132-34","doi-asserted-by":"crossref","unstructured":"Liu J, Gao Z, Li J (2010) Femoral artery occlusion increases expression of ASIC3 in dorsal root ganglion neurons. Am J Physiol Heart Circ Physiol 299:H1357-1364.","DOI":"10.1152\/ajpheart.00612.2010"},{"key":"key-10.4103\/1673-5374.293132-35","doi-asserted-by":"crossref","unstructured":"Liu J, Li J, Lu J, Xing J, Li J (2011) Contribution of nerve growth factor to upregulation of P2X3 expression in DRG neurons of rats with femoral artery occlusion. Am J Physiol Heart Circ Physiol 301:H1070-H1079.","DOI":"10.1152\/ajpheart.00188.2011"},{"key":"key-10.4103\/1673-5374.293132-36","doi-asserted-by":"crossref","unstructured":"Lomb DJ, Straub JA, Freeman RS (2007) Prolyl hydroxylase inhibitors delay neuronal cell death caused by trophic factor deprivation. J Neurochem 103:1897-1906.","DOI":"10.1111\/j.1471-4159.2007.04873.x"},{"key":"key-10.4103\/1673-5374.293132-37","doi-asserted-by":"crossref","unstructured":"Lowin T, Straub RH (2015) Cannabinoid-based drugs targeting CB1 and TRPV1, the sympathetic nervous system, and arthritis. Arthritis Res Ther 17:226.","DOI":"10.1186\/s13075-015-0743-x"},{"key":"key-10.4103\/1673-5374.293132-38","doi-asserted-by":"crossref","unstructured":"Lu J, Xing J, Li J (2012) Role for NGF in augmented sympathetic responses to activation of mechanically and metabolically sensitive muscle afferents in rats with femoral artery occlusion. J Appl Physiol 113:1311-1322.","DOI":"10.1152\/japplphysiol.00617.2012"},{"key":"key-10.4103\/1673-5374.293132-39","doi-asserted-by":"crossref","unstructured":"Milkiewicz M, Pugh CW, Egginton S (2004) Inhibition of endogenous HIF inactivation induces angiogenesis in ischaemic skeletal muscles of mice. J Physiol 560:21-26.","DOI":"10.1113\/jphysiol.2004.069757"},{"key":"key-10.4103\/1673-5374.293132-40","doi-asserted-by":"crossref","unstructured":"Mitchell JH, Kaufman MP, Iwamoto GA (1983) The exercise pressor reflex: Its cardiovascular effects, afferent mechanism, and central pathways. Ann Rev Physiol 45:229-242.","DOI":"10.1146\/annurev.ph.45.030183.001305"},{"key":"key-10.4103\/1673-5374.293132-41","doi-asserted-by":"crossref","unstructured":"Orr JE, Malhotra A, Sands SA (2017) Pathogenesis of central and complex sleep apnoea. Respirology 22:43-52.","DOI":"10.1111\/resp.12927"},{"key":"key-10.4103\/1673-5374.293132-42","doi-asserted-by":"crossref","unstructured":"Pezzuto A, Carico E (2018) Role of HIF-1 in cancer progression: novel insights. A review. Curr Mol Med 18:343-351.","DOI":"10.2174\/1566524018666181109121849"},{"key":"key-10.4103\/1673-5374.293132-43","doi-asserted-by":"crossref","unstructured":"Queme LF, Ross JL, Jankowski MP (2017) Peripheral mechanisms of ischemic myalgia. Front Cell Neurosci 11:419.","DOI":"10.3389\/fncel.2017.00419"},{"key":"key-10.4103\/1673-5374.293132-44","doi-asserted-by":"crossref","unstructured":"Queme LF, Weyler AA, Cohen ER, Hudgins RC, Jankowski MP (2020) A dual role for peripheral GDNF signaling in nociception and cardiovascular reflexes in the mouse. Proc Natl Acad Sci U S A 117: 698-707.","DOI":"10.1073\/pnas.1910905116"},{"key":"key-10.4103\/1673-5374.293132-45","doi-asserted-by":"crossref","unstructured":"Ross JL, Queme LF, Lamb JE, Green KJ, Ford ZK, Jankowski MP (2018a) Interleukin 1beta inhibition contributes to the antinociceptive effects of voluntary exercise on ischemia\/reperfusion-induced hypersensitivity. Pain 159: 380-392.","DOI":"10.1097\/j.pain.0000000000001094"},{"key":"key-10.4103\/1673-5374.293132-46","doi-asserted-by":"crossref","unstructured":"Ross JL, Queme LF, Lamb JE, Green KJ, Jankowski MP (2018b) Sex differences in primary muscle afferent sensitization following ischemia and reperfusion injury. Biol Sex Differ 9:2.","DOI":"10.1186\/s13293-017-0163-5"},{"key":"key-10.4103\/1673-5374.293132-47","doi-asserted-by":"crossref","unstructured":"Sinoway LI, Li J (2005) A perspective on the muscle reflex: implications for congestive heart failure. J Appl Physiol 99:5-22.","DOI":"10.1152\/japplphysiol.01405.2004"},{"key":"key-10.4103\/1673-5374.293132-48","doi-asserted-by":"crossref","unstructured":"Stephan G Huang L, Tang Y, Vilotti S, Fabbretti E, Yu Y, N\u00f6renberg W, Franke H, G\u00f6l\u00f6ncs\u00e9r F, Sperl\u00e1gh B, Dopychai A, Hausmann R, Schmalzing G, Rubini P, Illes P (2018) The ASIC3\/P2X3 cognate receptor is a pain-relevant and ligand-gated cationic channel. Nature Communications 9:1354.","DOI":"10.1038\/s41467-018-03728-5"},{"key":"key-10.4103\/1673-5374.293132-49","doi-asserted-by":"crossref","unstructured":"Stone AJ, Kaufman MP (2015) The exercise pressor reflex and peripheral artery disease. Auton Neurosci 188:69-73.","DOI":"10.1016\/j.autneu.2014.10.014"},{"key":"key-10.4103\/1673-5374.293132-50","doi-asserted-by":"crossref","unstructured":"Tsuchimochi H, McCord JL, Hayes SG, Koba S, Kaufman MP (2010) Chronic femoral artery occlusion augments exercise pressor reflex in decerebrated rats. Am J Physiol Heart Circ Physiol 299:H106-H113.","DOI":"10.1152\/ajpheart.00141.2010"},{"key":"key-10.4103\/1673-5374.293132-51","doi-asserted-by":"crossref","unstructured":"Uchida K, Dezaki K, Yoneshiro T, Watanabe T, Yamazaki J, Saito M, Yada T, Tominaga M, Iwasaki Y (2017) Involvement of thermosensitive TRP channels in energy metabolism. J Physiol Sci 67:549-560.","DOI":"10.1007\/s12576-017-0552-x"},{"key":"key-10.4103\/1673-5374.293132-52","doi-asserted-by":"crossref","unstructured":"Victor RG, Bertocci L, Pryor S, Nunnally R (1988) Sympathetic nerve discharge is coupled to muscle cell pH during exercise in humans. J Clin Invest 82:1301-1305.","DOI":"10.1172\/JCI113730"},{"key":"key-10.4103\/1673-5374.293132-53","doi-asserted-by":"crossref","unstructured":"Xing J, Gao Z, Lu J, Sinoway LI, Li J (2008) Femoral artery occlusion augments TRPV1-mediated sympathetic responsiveness. Am J Physiol Heart Circ Physiol 295:H1262-H1269.","DOI":"10.1152\/ajpheart.00271.2008"},{"key":"key-10.4103\/1673-5374.293132-54","doi-asserted-by":"crossref","unstructured":"Xing J, Lu J, Li J (2009) Contribution of nerve growth factor to augmented TRPV1 responses of muscle sensory neurons by femoral artery occlusion. Am J Physiol Heart Circ Physiol 296:H1380-H1387.","DOI":"10.1152\/ajpheart.00063.2009"},{"key":"key-10.4103\/1673-5374.293132-55","doi-asserted-by":"crossref","unstructured":"Xing J, Lu J, Li J (2012a) Acid-sensing ion channel subtype 3 function and immunolabelling increases in skeletal muscle sensory neurons following femoral artery occlusion. J Physiol 590:1261-1272.","DOI":"10.1113\/jphysiol.2011.221788"},{"key":"key-10.4103\/1673-5374.293132-56","doi-asserted-by":"crossref","unstructured":"Xing J, Lu J, Li J (2012b) ASIC3 Function and Immunolabeling Increases in Skeletal Muscle Sensory Neurons Following Femoral Artery Occlusion. J Physiol 590:1261-1272.","DOI":"10.1113\/jphysiol.2011.221788"},{"key":"key-10.4103\/1673-5374.293132-57","doi-asserted-by":"crossref","unstructured":"Xing J, Lu J, Li J (2013) Augmented P2X response and immunolabeling in dorsal root ganglion neurons innervating skeletal muscle following femoral artery occlusion. J Neurophysiol 109:2161-2168.","DOI":"10.1152\/jn.01068.2012"},{"key":"key-10.4103\/1673-5374.293132-58","doi-asserted-by":"crossref","unstructured":"Xing J, Sinoway L, Li J (2008) Differential responses of sensory neurones innervating glycolytic and oxidative muscle to protons and capsaicin. J Physiol 586:3245-3252.","DOI":"10.1113\/jphysiol.2008.154450"},{"key":"key-10.4103\/1673-5374.293132-59","unstructured":"Zhang Z, Yao L, Yang J, Wang Z, Du G (2018) PI3K\/Akt and HIF1 signaling pathway in hypoxia-ischemia (Review). Mol Med Rep 18:3547-3554."}],"container-title":["Neural Regeneration Research"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T18:51:12Z","timestamp":1786733472000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/1673-5374.293132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":59,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021]]}},"alternative-id":["293132"],"URL":"https:\/\/doi.org\/10.4103\/1673-5374.293132","relation":{},"ISSN":["1673-5374"],"issn-type":[{"value":"1673-5374","type":"print"}],"subject":[],"published":{"date-parts":[[2021]]}}}