{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:15:25Z","timestamp":1791994525519,"version":"4.4.0"},"reference-count":67,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neural Regen Res"],"published-print":{"date-parts":[[2022]]},"DOI":"10.4103\/1673-5374.313016","type":"journal-article","created":{"date-parts":[[2021,6,11]],"date-time":"2021-06-11T05:13:01Z","timestamp":1623388381000},"page":"31","source":"Crossref","is-referenced-by-count":39,"title":["Presenilin mutations and their impact on neuronal differentiation in Alzheimer\u2019s disease"],"prefix":"10.4103","volume":"17","author":[{"given":"AlejandroA","family":"Canales-Aguirre","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MercedesA","family":"Hernandez-Sapiens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"EdwinE","family":"Reza-Zald\u00edvar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AnaL","family":"M\u00e1rquez-Aguirre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulises","family":"G\u00f3mez-Pinedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Matias-Guiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RicardoR","family":"Cevallos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JuanC","family":"Mateos-D\u00edaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00edctorJ","family":"S\u00e1nchez-Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"key-10.4103\/1673-5374.313016-1","doi-asserted-by":"crossref","unstructured":"Baki L, Marambaud P, Efthimiopoulos S, Georgakopoulos A, Wen P, Cui W, Shioi J, Koo E, Ozawa M, Friedrich VL, Robakis NK (2001) Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits cadherin\/p120 association, and regulates stability and function of the cadherin\/catenin adhesion complex. Proc Natl Acad Sci U S A 98:2381-2386.","DOI":"10.1073\/pnas.041603398"},{"key":"key-10.4103\/1673-5374.313016-2","doi-asserted-by":"crossref","unstructured":"Barber M, Pierani A (2016) Tangential migration of glutamatergic neurons and cortical patterning during development: lessons from Cajal-Retzius cells. Dev Neurobiol 76:847-881.","DOI":"10.1002\/dneu.22363"},{"key":"key-10.4103\/1673-5374.313016-3","doi-asserted-by":"crossref","unstructured":"Bonds JA, Kuttner-Hirshler Y, Bartolotti N, Tobin MK, Pizzi M, Marr R, Lazarov O (2015) Presenilin-1 dependent neurogenesis regulates hippocampal learning and memory. PLoS One 10:e0131266.","DOI":"10.1371\/journal.pone.0131266"},{"key":"key-10.4103\/1673-5374.313016-4","doi-asserted-by":"crossref","unstructured":"Borghese L, Dolezalova D, Opitz T, Haupt S, Leinhaas A, Steinfarz B, Koch P, Edenhofer F, Hampl A, Br\u00fcstle O (2010) Inhibition of notch signaling in human embryonic stem cell-derived neural stem cells delays G1\/S phase transition and accelerates neuronal differentiation in vitro and in vivo. Stem Cells 28:955-964.","DOI":"10.1002\/stem.408"},{"key":"key-10.4103\/1673-5374.313016-5","doi-asserted-by":"crossref","unstructured":"Buchsbaum IY, Cappello S (2019) Neuronal migration in the CNS during development and disease: insights from in vivo and in vitro models. Development 146:dev163766.","DOI":"10.1242\/dev.163766"},{"key":"key-10.4103\/1673-5374.313016-6","doi-asserted-by":"crossref","unstructured":"Bustos FJ, Jury N, Martinez P, Ampuero E, Campos M, Abarz\u00faa S, Jaramillo K, Ibing S, Mardones MD, Haensgen H, Kzhyshkowska J, Tevy MF, Neve R, Sanhueza M, Varela-Nallar L, Montecino M, van Zundert B (2017) NMDA receptor subunit composition controls dendritogenesis of hippocampal neurons through CAMKII, CREB-P, and H3K27ac. J Cell Physiol 232:3677-3692.","DOI":"10.1002\/jcp.25843"},{"key":"key-10.4103\/1673-5374.313016-7","doi-asserted-by":"crossref","unstructured":"Chevallier NL, Soriano S, Kang DE, Masliah E, Hu G, Koo EH (2005) Perturbed neurogenesis in the adult hippocampus associated with presenilin-1 A246E mutation. Am J Pathol 167:151-159.","DOI":"10.1016\/S0002-9440(10)62962-8"},{"key":"key-10.4103\/1673-5374.313016-8","doi-asserted-by":"crossref","unstructured":"D\u2019Avanzo C, Aronson J, Kim YH, Choi SH, Tanzi RE, Kim DY (2015) Alzheimer\u2019s in 3D culture: challenges and perspectives. Bioessays 37:1139-1148.","DOI":"10.1002\/bies.201500063"},{"key":"key-10.4103\/1673-5374.313016-9","doi-asserted-by":"crossref","unstructured":"De Ferrari GV, Chac\u00f3n MA, Barr\u00eda MI, Garrido JL, Godoy JA, Olivares G, Reyes AE, Alvarez A, Bronfman M, Inestrosa NC (2003) Activation of Wnt signaling rescues neurodegeneration and behavioral impairments induced by beta-amyloid fibrils. Mol Psychiatry 8:195-208.","DOI":"10.1038\/sj.mp.4001208"},{"key":"key-10.4103\/1673-5374.313016-10","doi-asserted-by":"crossref","unstructured":"de Leeuw S, Tackenberg C (2019) Alzheimer\u2019s in a dish \u2013 induced pluripotent stem cell-based disease modeling. Transl Neurodegener 8:21.","DOI":"10.1186\/s40035-019-0161-0"},{"key":"key-10.4103\/1673-5374.313016-11","doi-asserted-by":"crossref","unstructured":"Demars M, Hu Y-S, Gadadhar A, Lazarov O (2010) Impaired neurogenesis is an early event in the etiology of familial Alzheimer\u2019s disease in transgenic mice. J Neurosci Res 88:2103-2117.","DOI":"10.1002\/jnr.22387"},{"key":"key-10.4103\/1673-5374.313016-12","doi-asserted-by":"crossref","unstructured":"DeTure MA, Dickson DW (2019) The neuropathological diagnosis of Alzheimer\u2019s disease. Mol Neurodegener 14:32-32.","DOI":"10.1186\/s13024-019-0333-5"},{"key":"key-10.4103\/1673-5374.313016-13","doi-asserted-by":"crossref","unstructured":"Dhaliwal J, Kannangara TS, Vaculik M, Xue Y, Kumar KL, Maione A, B\u00e9\u00efque J-C, Shen J, Lagace DC (2018) Adult hippocampal neurogenesis occurs in the absence of Presenilin 1 and Presenilin 2. Sci Rep 8:17931.","DOI":"10.1038\/s41598-018-36363-7"},{"key":"key-10.4103\/1673-5374.313016-14","doi-asserted-by":"crossref","unstructured":"Ding XF, Gao X, Ding X-C, Fan M, Chen J (2016) Postnatal dysregulation of Notch signal disrupts dendrite development of adult-born neurons in the hippocampus and contributes to memory impairment. Sci Rep 6:25780.","DOI":"10.1038\/srep25780"},{"key":"key-10.4103\/1673-5374.313016-15","doi-asserted-by":"crossref","unstructured":"Donoviel DB, Hadjantonakis AK, Ikeda M, Zheng H, Hyslop PS, Bernstein A (1999) Mice lacking both presenilin genes exhibit early embryonic patterning defects. Genes Dev 13:2801-2810.","DOI":"10.1101\/gad.13.21.2801"},{"key":"key-10.4103\/1673-5374.313016-16","doi-asserted-by":"crossref","unstructured":"Duggan SP, McCarthy JV (2016) Beyond \u03b3-secretase activity: The multifunctional nature of presenilins in cell signalling pathways. Cell Signal 28:1-11.","DOI":"10.1016\/j.cellsig.2015.10.006"},{"key":"key-10.4103\/1673-5374.313016-17","doi-asserted-by":"crossref","unstructured":"Eder-Colli L, Abad-Estarlich N, Pannetier C, Vallet PG, Walzer C, Elder GA, Robakis NK, Bouras C, Savioz A (2009) The presenilin-1 familial Alzheimer\u2019s disease mutation P117L decreases neuronal differentiation of embryonic murine neural progenitor cells. Brain Res Bull 80:296-301.","DOI":"10.1016\/j.brainresbull.2009.06.007"},{"key":"key-10.4103\/1673-5374.313016-18","doi-asserted-by":"crossref","unstructured":"Escamilla-Ayala A, Wouters R, Sannerud R, Annaert W (2020) Contribution of the Presenilins in the cell biology, structure and function of \u03b3-secretase. Semin Cell Dev Biol 105:12-26.","DOI":"10.1016\/j.semcdb.2020.02.005"},{"key":"key-10.4103\/1673-5374.313016-19","doi-asserted-by":"crossref","unstructured":"Francis YI, Stephanou A, Latchman DS (2006) CREB-binding protein activation by presenilin 1 but not by its M146L mutant. Neuroreport 17:917-921.","DOI":"10.1097\/01.wnr.0000220137.06542.a0"},{"key":"key-10.4103\/1673-5374.313016-20","doi-asserted-by":"crossref","unstructured":"Gadadhar A, Marr R, Lazarov O (2011) Presenilin-1 regulates neural progenitor cell differentiation in the adult brain. J Neurosci 31:2615.","DOI":"10.1523\/JNEUROSCI.4767-10.2011"},{"key":"key-10.4103\/1673-5374.313016-21","doi-asserted-by":"crossref","unstructured":"G\u00fcner G, Lichtenthaler SF (2020) The substrate repertoire of \u03b3-secretase\/presenilin. Semin Cell Dev Biol 105:27-42.","DOI":"10.1016\/j.semcdb.2020.05.019"},{"key":"key-10.4103\/1673-5374.313016-22","doi-asserted-by":"crossref","unstructured":"Handler M, Yang X, Shen J (2000) Presenilin-1 regulates neuronal differentiation during neurogenesis. Development 127:2593-2606.","DOI":"10.1242\/dev.127.12.2593"},{"key":"key-10.4103\/1673-5374.313016-23","doi-asserted-by":"crossref","unstructured":"Hern\u00e1ndez-Sapi\u00e9ns MA, Reza-Zald\u00edvar EE, Cevallos RR, M\u00e1rquez-Aguirre AL, Gazarian K, Canales-Aguirre AA (2020) A three-dimensional Alzheimer\u2019s disease cell culture model using iPSC-derived neurons carrying A246E mutation in PSEN1. Front Cell Neurosci 14:151.","DOI":"10.3389\/fncel.2020.00151"},{"key":"key-10.4103\/1673-5374.313016-24","doi-asserted-by":"crossref","unstructured":"Kabir MT, Uddin MS, Setu JR, Ashraf GM, Bin-Jumah MN, Abdel-Daim MM (2020) Exploring the role of PSEN mutations in the pathogenesis of Alzheimer\u2019s disease. Neurotox Res 38:833-849.","DOI":"10.1007\/s12640-020-00232-x"},{"key":"key-10.4103\/1673-5374.313016-25","doi-asserted-by":"crossref","unstructured":"Kawamura Y, Kikuchi A, Takada R, Takada S, Sudoh S, Shibamoto S, Yanagisawa K, Komano H (2001) Inhibitory effect of a presenilin 1 mutation on the Wnt signalling pathway by enhancement of beta-catenin phosphorylation. Eur J Biochem 268:3036-3041.","DOI":"10.1046\/j.1432-1327.2001.02197.x"},{"key":"key-10.4103\/1673-5374.313016-26","doi-asserted-by":"crossref","unstructured":"Killick R, Pollard CC, Asuni AA, Mudher AK, Richardson JC, Rupniak HT, Sheppard PW, Varndell IM, Brion JP, Levey AI, Levy OA, Vestling M, Cowburn R, Lovestone S, Anderton BH (2001) Presenilin 1 independently regulates beta-catenin stability and transcriptional activity. J Biol Chem 276:48554-48561.","DOI":"10.1074\/jbc.M108332200"},{"key":"key-10.4103\/1673-5374.313016-27","doi-asserted-by":"crossref","unstructured":"Kopan R, Ilagan MX (2004) Gamma-secretase: proteasome of the membrane? Nat Rev Mol Cell Biol 5:499-504.","DOI":"10.1038\/nrm1406"},{"key":"key-10.4103\/1673-5374.313016-28","doi-asserted-by":"crossref","unstructured":"Landeira BS, Santana TTdS, Ara\u00fajo JAdM, Tabet EI, Tannous BA, Schroeder T, Costa MR (2016) Activity-independent effects of CREB on neuronal survival and differentiation during mouse cerebral cortex development. Cereb Cortex 28:538-548.","DOI":"10.1093\/cercor\/bhw387"},{"key":"key-10.4103\/1673-5374.313016-29","doi-asserted-by":"crossref","unstructured":"Lanoisel\u00e9e HM, Nicolas G, Wallon D, Rovelet-Lecrux A, Lacour M, Rousseau S, Richard AC, Pasquier F, Rollin-Sillaire A, Martinaud O, Quillard-Muraine M, de la Sayette V, Boutoleau-Bretonniere C, Etcharry-Bouyx F, Chauvir\u00e9 V, Sarazin M, le Ber I, Epelbaum S, Jonveaux T, Rouaud O, et al. (2017) APP, PSEN1, and PSEN2 mutations in early-onset Alzheimer disease: A genetic screening study of familial and sporadic cases. PLoS Med 14:e1002270.","DOI":"10.1371\/journal.pmed.1002270"},{"key":"key-10.4103\/1673-5374.313016-30","doi-asserted-by":"crossref","unstructured":"Lazarov O, Marr RA (2010) Neurogenesis and Alzheimer\u2019s disease: at the crossroads. Exp Neurol 223:267-281.","DOI":"10.1016\/j.expneurol.2009.08.009"},{"key":"key-10.4103\/1673-5374.313016-31","doi-asserted-by":"crossref","unstructured":"Li L, Kim HJ, Roh JH, Kim M, Koh W, Kim Y, Heo H, Chung J, Nakanishi M, Yoon T, Hong CP, Seo SW, Na DL, Song J (2020) Pathological manifestation of the induced pluripotent stem cell-derived cortical neurons from an early-onset Alzheimer\u2019s disease patient carrying a presenilin-1 mutation (S170F). Cell Proli 53:e12798.","DOI":"10.1111\/cpr.12798"},{"key":"key-10.4103\/1673-5374.313016-32","doi-asserted-by":"crossref","unstructured":"Li P, Lin X, Zhang JR, Li Y, Lu J, Huang FC, Zheng CH, Xie JW, Wang JB, Huang CM (2016) The expression of presenilin 1 enhances carcinogenesis and metastasis in gastric cancer. Oncotarget 7:10650-10662.","DOI":"10.18632\/oncotarget.7298"},{"key":"key-10.4103\/1673-5374.313016-33","doi-asserted-by":"crossref","unstructured":"Louvi A, Sisodia SS, Grove EA (2004) Presenilin 1 in migration and morphogenesis in the central nervous system. Development 131:3093.","DOI":"10.1242\/dev.01191"},{"key":"key-10.4103\/1673-5374.313016-34","doi-asserted-by":"crossref","unstructured":"Marambaud P, Shioi J, Serban G, Georgakopoulos A, Sarner S, Nagy V, Baki L, Wen P, Efthimiopoulos S, Shao Z, Wisniewski T, Robakis NK (2002) A presenilin-1\/\u03b3-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions. EMBO J 21:1948-1956.","DOI":"10.1093\/emboj\/21.8.1948"},{"key":"key-10.4103\/1673-5374.313016-35","doi-asserted-by":"crossref","unstructured":"Marathe S, Alberi L (2015) Notch in memories: Points to remember. Hippocampus 25:1481-1488.","DOI":"10.1002\/hipo.22426"},{"key":"key-10.4103\/1673-5374.313016-36","doi-asserted-by":"crossref","unstructured":"Moore S, Evans Lewis DB, Andersson T, Portelius E, Smith J, Dias Tatyana B, Saurat N, McGlade A, Kirwan P, Blennow K, Hardy J, Zetterberg H, Livesey Frederick J (2015) APP metabolism regulates Tau proteostasis in human cerebral cortex neurons. Cell Rep 11:689-696.","DOI":"10.1016\/j.celrep.2015.03.068"},{"key":"key-10.4103\/1673-5374.313016-37","doi-asserted-by":"crossref","unstructured":"Ochalek A, Mihalik B, Avci HX, Chandrasekaran A, T\u00e9gl\u00e1si A, Bock I, Giudice ML, T\u00e1ncos Z, Moln\u00e1r K, L\u00e1szl\u00f3 L, Nielsen JE, Holst B, Freude K, Hyttel P, Kobol\u00e1k J, Dinny\u00e9s A (2017) Neurons derived from sporadic Alzheimer\u2019s disease iPSCs reveal elevated TAU hyperphosphorylation, increased amyloid levels, and GSK3B activation. Alzheimers Res Ther 9:90.","DOI":"10.1186\/s13195-017-0317-z"},{"key":"key-10.4103\/1673-5374.313016-38","doi-asserted-by":"crossref","unstructured":"Oikawa N, Walter J (2019) Presenilins and \u03b3-secretase in membrane proteostasis. Cells 8:209.","DOI":"10.3390\/cells8030209"},{"key":"key-10.4103\/1673-5374.313016-39","doi-asserted-by":"crossref","unstructured":"Otto GP, Sharma D, Williams RSB (2016) Non-catalytic roles of presenilin throughout evolution. J Alzheimers Dis 52:1177-1187.","DOI":"10.3233\/JAD-150940"},{"key":"key-10.4103\/1673-5374.313016-40","doi-asserted-by":"crossref","unstructured":"Parisiadou L, Fassa A, Fotinopoulou A, Bethani I, Efthimiopoulos S (2004) Presenilin 1 and cadherins: stabilization of cell-cell adhesion and proteolysis-dependent regulation of transcription. Neurodegener Dis 1:184-191.","DOI":"10.1159\/000080984"},{"key":"key-10.4103\/1673-5374.313016-41","doi-asserted-by":"crossref","unstructured":"Pigino G, Pelsman A, Mori H, Busciglio J (2001) Presenilin-1 mutations reduce cytoskeletal association, deregulate neurite growth, and potentiate neuronal dystrophy and tau phosphorylation. J Neurosci 21:834-842.","DOI":"10.1523\/JNEUROSCI.21-03-00834.2001"},{"key":"key-10.4103\/1673-5374.313016-42","doi-asserted-by":"crossref","unstructured":"Raja WK, Mungenast AE, Lin Y-T, Ko T, Abdurrob F, Seo J, Tsai LH (2016) Self-organizing 3D human neural tissue derived from induced pluripotent stem cells recapitulate Alzheimer\u2019s disease phenotypes. PLoS One 11:e0161969.","DOI":"10.1371\/journal.pone.0161969"},{"key":"key-10.4103\/1673-5374.313016-43","doi-asserted-by":"crossref","unstructured":"Saura CA, Choi S-Y, Beglopoulos V, Malkani S, Zhang D, Rao BSS, Chattarji S, Kelleher RJ, III, Kandel ER, Duff K, Kirkwood A, Shen J (2004) Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration. Neuron 42:23-36.","DOI":"10.1016\/S0896-6273(04)00182-5"},{"key":"key-10.4103\/1673-5374.313016-44","doi-asserted-by":"crossref","unstructured":"Siman R, Reaume AG, Savage MJ, Trusko S, Lin YG, Scott RW, Flood DG (2000) Presenilin-1 P264L knock-in mutation: differential effects on abeta production, amyloid deposition, and neuronal vulnerability. J Neurosci 20:8717-8726.","DOI":"10.1523\/JNEUROSCI.20-23-08717.2000"},{"key":"key-10.4103\/1673-5374.313016-45","doi-asserted-by":"crossref","unstructured":"Sproul AA, Jacob S, Pre D, Kim SH, Nestor MW, Navarro-Sobrino M, Santa-Maria I, Zimmer M, Aubry S, Steele JW, Kahler DJ, Dranovsky A, Arancio O, Crary JF, Gandy S, Noggle SA (2014) Characterization and molecular profiling of PSEN1 familial Alzheimer\u2019s disease iPSC-derived neural progenitors. PLoS One 9:e84547.","DOI":"10.1371\/journal.pone.0084547"},{"key":"key-10.4103\/1673-5374.313016-46","doi-asserted-by":"crossref","unstructured":"Stanga S, Vrancx C, Tasiaux B, Marinangeli C, Karlstr\u00f6m H, Kienlen-Campard P (2018) Specificity of presenilin-1- and presenilin-2-dependent \u03b3-secretases towards substrate processing. J Cell Mol Med 22:823-833.","DOI":"10.1111\/jcmm.13364"},{"key":"key-10.4103\/1673-5374.313016-47","doi-asserted-by":"crossref","unstructured":"Szklarczyk D, Gable AL, Lyon D, Junge A, Wyder S, Huerta-Cepas J, Simonovic M, Doncheva NT, Morris JH, Bork P, Jensen LJ, Mering CV (2019) STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets. Nucleic Acids Res. 47:D607-613.","DOI":"10.1093\/nar\/gky1131"},{"key":"key-10.4103\/1673-5374.313016-48","doi-asserted-by":"crossref","unstructured":"Uemura K, Kitagawa N, Kohno R, Kuzuya A, Kageyama T, Shibasaki H, Shimohama S (2003) Presenilin 1 mediates retinoic acid-induced differentiation of SH-SY5Y cells through facilitation of Wnt signaling. J Neurosci Res 73:166-175.","DOI":"10.1002\/jnr.10641"},{"key":"key-10.4103\/1673-5374.313016-49","doi-asserted-by":"crossref","unstructured":"Uhl\u00e9n M, Fagerberg L, Hallstr\u00f6m BM, Lindskog C, Oksvold P, Mardinoglu A, Sivertsson \u00c5, Kampf C, Sj\u00f6stedt E, Asplund A, Olsson I, Edlund K, Lundberg E, Navani S, Szigyarto CA, Odeberg J, Djureinovic D, Takanen JO, Hober S, Alm T, et al. (2015) Tissue-based map of the human proteome. Science 347:1260419.","DOI":"10.1126\/science.1260419"},{"key":"key-10.4103\/1673-5374.313016-50","doi-asserted-by":"crossref","unstructured":"Veeraraghavalu K, Sisodia SS (2013) Mutant presenilin 1 expression in excitatory neurons impairs enrichment-mediated phenotypes of adult hippocampal progenitor cells. Proc Natl Acad Sci U S A 110:9148.","DOI":"10.1073\/pnas.1302106110"},{"key":"key-10.4103\/1673-5374.313016-51","doi-asserted-by":"crossref","unstructured":"Veeraraghavalu K, Choi SH, Zhang X, Sisodia SS (2010) Presenilin 1 mutants impair the self-renewal and differentiation of adult murine subventricular zone-neuronal progenitors via cell-autonomous mechanisms involving Notch signaling. J Neurosci 30:6903-6915.","DOI":"10.1523\/JNEUROSCI.0527-10.2010"},{"key":"key-10.4103\/1673-5374.313016-52","doi-asserted-by":"crossref","unstructured":"Walton MR, Dragunow M (2000) Is CREB a key to neuronal survival? Trends Neurosci 23:48-53.","DOI":"10.1016\/S0166-2236(99)01500-3"},{"key":"key-10.4103\/1673-5374.313016-53","doi-asserted-by":"crossref","unstructured":"Wang R, Dineley KT, Sweatt JD, Zheng H (2004) Presenilin 1 familial Alzheimer\u2019s disease mutation leads to defective associative learning and impaired adult neurogenesis. Neuroscience 126:305-312.","DOI":"10.1016\/j.neuroscience.2004.03.048"},{"key":"key-10.4103\/1673-5374.313016-54","doi-asserted-by":"crossref","unstructured":"Wang W, Moerman-Herzog AM, Slaton A, Barger SW (2017) Presenilin 1 mutations influence processing and trafficking of the ApoE receptor apoER2. Neurobiol Aging 49:145-153.","DOI":"10.1016\/j.neurobiolaging.2016.10.005"},{"key":"key-10.4103\/1673-5374.313016-55","doi-asserted-by":"crossref","unstructured":"Watanabe H, Shen J (2017) Dominant negative mechanism of Presenilin-1 mutations in FAD. Proc Natl Acad Sci U S A 114:12635-12637.","DOI":"10.1073\/pnas.1717180114"},{"key":"key-10.4103\/1673-5374.313016-56","doi-asserted-by":"crossref","unstructured":"Weihl CC, Ghadge GD, Kennedy SG, Hay N, Miller RJ, Roos RP (1999) Mutant presenilin-1 induces apoptosis and downregulates Akt\/PKB. J Neurosci 19:5360-5369.","DOI":"10.1523\/JNEUROSCI.19-13-05360.1999"},{"key":"key-10.4103\/1673-5374.313016-57","doi-asserted-by":"crossref","unstructured":"Wen PH, Shao X, Shao Z, Hof PR, Wisniewski T, Kelley K, Friedrich VL, Ho L, Pasinetti GM, Shioi J, Robakis NK, Elder GA (2002) Overexpression of wild type but not an FAD mutant presenilin-1 promotes neurogenesis in the hippocampus of adult mice. Neurobiol Dis 10:8-19.","DOI":"10.1006\/nbdi.2002.0490"},{"key":"key-10.4103\/1673-5374.313016-58","doi-asserted-by":"crossref","unstructured":"Wen PH, Hof PR, Chen X, Gluck K, Austin G, Younkin SG, Younkin LH, DeGasperi R, Gama Sosa MA, Robakis NK, Haroutunian V, Elder GA (2004) The presenilin-1 familial Alzheimer disease mutant P117L impairs neurogenesis in the hippocampus of adult mice. Exp Neurol 188:224-237.","DOI":"10.1016\/j.expneurol.2004.04.002"},{"key":"key-10.4103\/1673-5374.313016-59","doi-asserted-by":"crossref","unstructured":"Xia D, Watanabe H, Wu B, Lee SH, Li Y, Tsvetkov E, Bolshakov VY, Shen J, Kelleher RJ, 3rd (2015) Presenilin-1 knockin mice reveal loss-of-function mechanism for familial Alzheimer\u2019s disease. Neuron 85:967-981.","DOI":"10.1016\/j.neuron.2015.02.010"},{"key":"key-10.4103\/1673-5374.313016-60","doi-asserted-by":"crossref","unstructured":"Xia X, Qian S, Soriano S, Wu Y, Fletcher AM, Wang XJ, Koo EH, Wu X, Zheng H (2001) Loss of presenilin 1 is associated with enhanced \u03b2-catenin signaling and skin tumorigenesis. Proc Natl Acad Sci U S A 98:10863-10868.","DOI":"10.1073\/pnas.191284198"},{"key":"key-10.4103\/1673-5374.313016-61","doi-asserted-by":"crossref","unstructured":"Yagi T, Ito D, Okada Y, Akamatsu W, Nihei Y, Yoshizaki T, Yamanaka S, Okano H, Suzuki N (2011) Modeling familial Alzheimer\u2019s disease with induced pluripotent stem cells. Hum Mol Genet 20:4530-4539.","DOI":"10.1093\/hmg\/ddr394"},{"key":"key-10.4103\/1673-5374.313016-62","doi-asserted-by":"crossref","unstructured":"Yang J, Zhao H, Ma Y, Shi G, Song J, Tang Y, Li S, Li T, Liu N, Tang F, Gu J, Zhang L, Zhang Z, Zhang X, Jin Y, Le W (2017) Early pathogenic event of Alzheimer\u2019s disease documented in iPSCs from patients with PSEN1 mutations. Oncotarget 8:7900-7913.","DOI":"10.18632\/oncotarget.13776"},{"key":"key-10.4103\/1673-5374.313016-63","doi-asserted-by":"crossref","unstructured":"Yonemura Y, Futai E, Yagishita S, Kaether C, Ishiura S (2016) Specific combinations of presenilins and Aph1s affect the substrate specificity and activity of \u03b3-secretase. Biochem Biophys Res Commun 478:1751-1757.","DOI":"10.1016\/j.bbrc.2016.09.018"},{"key":"key-10.4103\/1673-5374.313016-64","doi-asserted-by":"crossref","unstructured":"Zhang L, Yang X, Yang S, Zhang J (2011) The Wnt\/\u03b2-catenin signaling pathway in the adult neurogenesis. Eur J Neurosci 33:1-8.","DOI":"10.1111\/j.1460-9568.2010.7483.x"},{"key":"key-10.4103\/1673-5374.313016-65","doi-asserted-by":"crossref","unstructured":"Zhang W, Han SW, McKeel DW, Goate A, Wu JY (1998a) Interaction of presenilins with the filamin family of actin-binding proteins. J Neurosci 18:914.","DOI":"10.1523\/JNEUROSCI.18-03-00914.1998"},{"key":"key-10.4103\/1673-5374.313016-66","doi-asserted-by":"crossref","unstructured":"Zhang Z, Hartmann H, Do VM, Abramowski D, Sturchler-Pierrat C, Staufenbiel M, Sommer B, van de Wetering M, Clevers H, Saftig P, De Strooper B, He X, Yankner BA (1998b) Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis. Nature 395:698-702.","DOI":"10.1038\/27208"},{"key":"key-10.4103\/1673-5374.313016-67","doi-asserted-by":"crossref","unstructured":"Zoltowska KM, Berezovska O (2018) Dynamic nature of presenilin1\/\u03b3-secretase: implication for Alzheimer\u2019s disease Pathogenesis. Mol Neurobiol 55:2275-2284.","DOI":"10.1007\/s12035-017-0487-5"}],"container-title":["Neural Regeneration Research"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T18:57:12Z","timestamp":1786733832000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/1673-5374.313016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":67,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022]]}},"alternative-id":["313016"],"URL":"https:\/\/doi.org\/10.4103\/1673-5374.313016","relation":{},"ISSN":["1673-5374"],"issn-type":[{"value":"1673-5374","type":"print"}],"subject":[],"published":{"date-parts":[[2022]]}}}