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The hematoma-induced brain injury was associated with albumin extravasation, oxidative stress, reactive astrogliosis and microglial activation in the ipsilateral hemisphere. Further proteins and injury markers were validated to be used for immunohistochemistry of porcine brain tissue. The cerebral expression patterns of oxytocin, oxytocin receptor, cystathionine-\u03b3-lyase and cystathionine-\u03b2-synthase were particularly interesting: these four proteins all co-localized at the base of the sulci, where pressure-induced brain injury elicits maximum stress. In this context, the pig is a very relevant translational model in contrast to the rodent brain. The structure of the porcine brain is very similar to the human: the presence of gyri and sulci (gyrencephalic brain), white matter to grey matter proportion and tentorium cerebelli. Thus, pressure-induced injury in the porcine brain, unlike in the rodent brain, is reflective of the human pathophysiology.<\/jats:p>","DOI":"10.4103\/1673-5374.313018","type":"journal-article","created":{"date-parts":[[2021,4,25]],"date-time":"2021-04-25T11:35:03Z","timestamp":1619350503000},"page":"2376-2382","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":9,"title":["Localization of the hydrogen sulfide and oxytocin systems at the depth of the sulci in a porcine model of acute subdural hematoma"],"prefix":"10.4103","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7879-7695","authenticated-orcid":false,"given":"Oscar","family":"McCook","sequence":"first","affiliation":[{"name":"Institute for Anesthesiological Pathophysiology and Process Engineering, Ulm University Medical Center, Ulm, 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