{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T20:04:18Z","timestamp":1786737858722,"version":"build-2736575974"},"reference-count":87,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neural Regen Res"],"published-print":{"date-parts":[[2022]]},"DOI":"10.4103\/1673-5374.320967","type":"journal-article","created":{"date-parts":[[2021,8,20]],"date-time":"2021-08-20T02:44:04Z","timestamp":1629427444000},"page":"488","source":"Crossref","is-referenced-by-count":13,"title":["The short form of the SUR1 and its functional implications in the damaged brain"],"prefix":"10.4103","volume":"17","author":[{"given":"Pen\u00e9lope","family":"Aguilera","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iv\u00e1n","family":"Alquisiras-Burgos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Franco-P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mois\u00e9s","family":"Rubio-Osornio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"key-10.4103\/1673-5374.320967-1","doi-asserted-by":"crossref","unstructured":"Aggarwal NT, Shi NQ, Makielski JC (2013) ATP-sensitive potassium currents from channels formed by Kir6 and a modified cardiac mitochondrial SUR2 variant. Channels (Austin) 7:493-502.","DOI":"10.4161\/chan.26181"},{"key":"key-10.4103\/1673-5374.320967-2","doi-asserted-by":"crossref","unstructured":"Aguilar-Bryan L, Iii AEB, Nelson A (1990) Photoaffinity labeling and partial purification of the beta cell sulfonylurea receptor using a novel, biologically active glyburide analog. J Biol Chem 265:8218-8224.","DOI":"10.1016\/S0021-9258(19)39060-X"},{"key":"key-10.4103\/1673-5374.320967-3","doi-asserted-by":"crossref","unstructured":"Aguilar-Bryan L, Nichols CG, Wechsler SW, Iv JPC, Ill AEB, Gonzalez G, Herrera-sosa H, Nguy K, Bryan J, Nelsont DA (1995) Cloning of the P cell high-affinity sulfonylurea receptor: a regulator of insulin secretion. Science 268:423-426.","DOI":"10.1126\/science.7716547"},{"key":"key-10.4103\/1673-5374.320967-4","doi-asserted-by":"crossref","unstructured":"Alquisiras-Burgos I, Ortiz-Plata A, Franco-P\u00e9rez J, Mill\u00e1n A, Aguilera P (2020) Resveratrol reduces cerebral edema through inhibition of de novo SUR1 expression induced after focal ischemia. Exp Neurol 330:113353.","DOI":"10.1016\/j.expneurol.2020.113353"},{"key":"key-10.4103\/1673-5374.320967-5","doi-asserted-by":"crossref","unstructured":"Amarouch MY, El Hilaly J (2020) Inherited cardiac arrhythmia syndromes: focus on molecular mechanisms underlying TRPM4 channelopathies. Cardiovasc Ther 2020:6615038.","DOI":"10.1155\/2020\/6615038"},{"key":"key-10.4103\/1673-5374.320967-6","doi-asserted-by":"crossref","unstructured":"Arikan F, Mart\u00ednez-Valverde T, S\u00e1nchez-Guerrero A, Campos M, Esteves M, Gandara D, Torn\u00e9 R, Castro L, Dalmau A, Tibau J, Sahuquillo J (2017) Malignant infarction of the middle cerebral artery in a porcine model. A pilot study. PLoS One 12:e0172637.","DOI":"10.1371\/journal.pone.0172637"},{"key":"key-10.4103\/1673-5374.320967-7","doi-asserted-by":"crossref","unstructured":"Ashfield R, Ashcroft SJ (1998) Cloning of the promoters for the beta-cell ATP-sensitive K-channel subunits Kir6.2 and SUR1. Diabetes 7:1274-1280.","DOI":"10.2337\/diabetes.47.8.1274"},{"key":"key-10.4103\/1673-5374.320967-8","doi-asserted-by":"crossref","unstructured":"Bal R, Ozturk G, Etem EO, Him A, Cengiz N, Kuloglu T, Tuzcu M, Yildirim C, Tektemur A (2018) Modulation of excitability of stellate neurons in the ventral cochlear nucleus of mice by ATP-sensitive potassium channels. J Membr Biol 251:163-178.","DOI":"10.1007\/s00232-017-0011-x"},{"key":"key-10.4103\/1673-5374.320967-9","doi-asserted-by":"crossref","unstructured":"Berdugo M, Delaunay K, Naud MC, Guegan J, Moulin A, Savoldelli M, Picard E, Radet L, Jonet L, Djerada L, Gozalo C, Daruich A, Beltrand J, Jeanny JC, Kermorvant-Duchemin E, Crisanti P, Polak M, Behar-Cohen F (2021) The antidiabetic drug glibenclamide exerts direct retinal neuroprotection. Transl Res 229:83-99.","DOI":"10.1016\/j.trsl.2020.10.003"},{"key":"key-10.4103\/1673-5374.320967-10","doi-asserted-by":"crossref","unstructured":"Bianchi B, Smith PA, Abriel H (2018) The ion channel TRPM4 in murine experimental autoimmune encephalomyelitis and in a model of glutamate-induced neuronal degeneration. Mol Brain 11:41.","DOI":"10.1186\/s13041-018-0385-4"},{"key":"key-10.4103\/1673-5374.320967-11","doi-asserted-by":"crossref","unstructured":"Braun M, Anderie I, The F (1997) Evidence for a 65 kDa sulfonylurea receptor in rat pancreatic zymogen granule membranes. FEBS Lett 411:255-259.","DOI":"10.1016\/S0014-5793(97)00711-4"},{"key":"key-10.4103\/1673-5374.320967-12","doi-asserted-by":"crossref","unstructured":"Brustovetsky T, Shalbuyeva N, Brustovetsky N (2005) Lack of manifestations of diazoxide\/5-hydroxydecanoate-sensitive KATP channel in rat brain nonsynaptosomal mitochondria. J Physiol 568:47-59.","DOI":"10.1113\/jphysiol.2005.091199"},{"key":"key-10.4103\/1673-5374.320967-13","doi-asserted-by":"crossref","unstructured":"Caffes N, Kurland DB, Gerzanich V, Simard JM (2015) Glibenclamide for the treatment of ischemic and hemorrhagic stroke. Int J Mol Sci 16:4973-4984.","DOI":"10.3390\/ijms16034973"},{"key":"key-10.4103\/1673-5374.320967-14","doi-asserted-by":"crossref","unstructured":"Chan KW, Wheeler A, Csan\u00e1dy L (2008) Sulfonylurea receptors type 1 and 2A randomly assemble to form heteromeric KATP channels of mixed subunit composition. J Gen Physiol 131:43-58.","DOI":"10.1085\/jgp.200709894"},{"key":"key-10.4103\/1673-5374.320967-15","doi-asserted-by":"crossref","unstructured":"Chen B, Ng G, Gao Y, Low SW, Sandanaraj E, Ramasamy B, Sekar S, Bhakoo K, Soong TW, Nilius B, Tang C, Robins EG, Goggi J, Liao P (2019a) Non-invasive multimodality imaging directly shows TRPM4 inhibition ameliorates stroke reperfusion injury. Transl Stroke Res 10:91-103.","DOI":"10.1007\/s12975-018-0621-3"},{"key":"key-10.4103\/1673-5374.320967-16","doi-asserted-by":"crossref","unstructured":"Chen B, Gao Y, Wei S, Low SW, Ng G, Yu D, Tu TM, Soong TW, Nilius B, Liao P (2019b) TRPM4-specific blocking antibody attenuates reperfusion injury in a rat model of stroke. Pflugers Arch 471:1455-1466.","DOI":"10.1007\/s00424-019-02326-8"},{"key":"key-10.4103\/1673-5374.320967-17","doi-asserted-by":"crossref","unstructured":"Chen X, Liu K, Lin Z, Huang K, Pan S (2020) Knockout of transient receptor potential melastatin 4 channel mitigates cerebral edema and neuronal injury after status epilepticus in mice. J Neuropathol Exp Neurol 79:1354-1364.","DOI":"10.1093\/jnen\/nlaa134"},{"key":"key-10.4103\/1673-5374.320967-18","doi-asserted-by":"crossref","unstructured":"de Wet H, Proks P (2015) Molecular action of sulphonylureas on KATP channels: a real partnership between drugs and nucleotides. Biochem Soc Trans 43:901-907.","DOI":"10.1042\/BST20150096"},{"key":"key-10.4103\/1673-5374.320967-19","doi-asserted-by":"crossref","unstructured":"Duda J, P\u00f6tschke C, Liss B (2016) Converging roles of ion channels, calcium, metabolic stress, and activity pattern of Substantia nigra dopaminergic neurons in health and Parkinson\u2019s disease. J Neurochem 139 Suppl 1:156-178.","DOI":"10.1111\/jnc.13572"},{"key":"key-10.4103\/1673-5374.320967-20","doi-asserted-by":"crossref","unstructured":"Dundar TT, Abdallah A, Yurtsever I, Guler EM, Ozer OF, Uysal O (2020) Serum SUR1 and TRPM4 in patients with subarachnoid hemorrhage. Neurosurg Rev 43:1595-1603.","DOI":"10.1007\/s10143-019-01200-6"},{"key":"key-10.4103\/1673-5374.320967-21","doi-asserted-by":"crossref","unstructured":"Fang Y, Shi H, Ren R, Huang L, Okada T, Lenahan C, Gamdzyk M, Travis ZD, Lu Q, Tang L, Huang Y, Zhou K, Tang J, Zhang J, Zhang JH (2020) Pituitary adenylate cyclase-activating polypeptide attenuates brain edema by protecting blood-brain barrier and glymphatic system after subarachnoid hemorrhage in rats. Neurotherapeutics 17:1954-1972.","DOI":"10.1007\/s13311-020-00925-3"},{"key":"key-10.4103\/1673-5374.320967-22","doi-asserted-by":"crossref","unstructured":"Felix L, Delekate A, Petzold GC, Rose CR (2020) Sodium fluctuations in astroglia and their potential impact on astrocyte function. Front Physiol 11:871.","DOI":"10.3389\/fphys.2020.00871"},{"key":"key-10.4103\/1673-5374.320967-23","unstructured":"Filipets N, Filipets \u041e, Slobodian K, Gabunia L, Gvishiani M, Maxaradze T (2019) Pharmaceutical activators of atp-dependent potassium channels as potential nephroprotectors against glomerular and tubular damage to the nephron. Georgian Med News:163-166."},{"key":"key-10.4103\/1673-5374.320967-24","doi-asserted-by":"crossref","unstructured":"Flagg TP, Kurata HT, Masia R, Caputa G, Nichols CG (2009) Differential structure of atrial and ventricular KATP: atrial KATP channels require SUR1. Circ Res 103:1458-1465.","DOI":"10.1161\/CIRCRESAHA.108.178186"},{"key":"key-10.4103\/1673-5374.320967-25","doi-asserted-by":"crossref","unstructured":"Gerzanich V, Makar KT, Reddy GP, Kwon S, Stokum JA, Kyoon SW, Ivanova S, Ivanov A, Mehta RI, Brooke AM, Bryan J, Bever CT, Simard JM (2017) Salutary effects of glibenclamide during the chronic phase of murine experimental autoimmune encephalomyelitis. J Neuroinflammation 14:177.","DOI":"10.1186\/s12974-017-0953-z"},{"key":"key-10.4103\/1673-5374.320967-26","doi-asserted-by":"crossref","unstructured":"Gerzanich V, Seong MK, Kyoon SW, Ivanov A, Simard JM (2018) SUR1-TRPM4 channel activation and phasic secretion of MMP-9 induced by tPA in brain endothelial cells. PLoS One 13:e0195526.","DOI":"10.1371\/journal.pone.0195526"},{"key":"key-10.4103\/1673-5374.320967-27","doi-asserted-by":"crossref","unstructured":"Gerzanich V, Stokum JA, Ivanova S, Woo SK, Tsymbalyuk O, Sharma A, Akkentli F, Imran Z, Aarabi B, Sahuquillo J, Simard JM (2019) Sulfonylurea receptor 1, transient receptor potential cation channel subfamily M member 4, and KIR6.2: role in hemorrhagic progression of contusion. J Neurotrauma 36:1060-1079.","DOI":"10.1089\/neu.2018.5986"},{"key":"key-10.4103\/1673-5374.320967-28","doi-asserted-by":"crossref","unstructured":"Gong XG, Sun HM, Zhang Y, Zhang SJ, Gao YS, Feng J, Hu JH, Gai C, Guo ZY, Xu H, Ma L (2014) Da-bu-yin-wan and qian-zheng-san to neuroprotect the mouse model of Parkinson\u2019s disease. Evid Based Complement Alternat Med 2014:729195.","DOI":"10.1155\/2014\/729195"},{"key":"key-10.4103\/1673-5374.320967-29","doi-asserted-by":"crossref","unstructured":"Gros L, Trapp S, Dabrowski M, Ashcroft FM, Bataille D, Blache P (2002) Characterization of two novel forms of the rat sulphonylurea receptor SUR1A2 and SUR1B D 31. Br J Pharmacol 137:98-106.","DOI":"10.1038\/sj.bjp.0704836"},{"key":"key-10.4103\/1673-5374.320967-30","doi-asserted-by":"crossref","unstructured":"Hambrock A, Preisig-mu R, Russ U, Daut R, Piehl A, Hanley PJ, Ray J, Quast U, Derst C, Preisig-mu R, Piehl A, Hanley PJ, Ray J, Quast U, Derst C (2002) Four novel splice variants of sulfonylurea receptor 1. Am J Physiol Cell Physiol 283:C587-598.","DOI":"10.1152\/ajpcell.00083.2002"},{"key":"key-10.4103\/1673-5374.320967-31","doi-asserted-by":"crossref","unstructured":"Herbst KJ, Coltharp C, Amzel LM, Zhang J (2011) Direct activation of Epac by sulfonylurea is isoform selective. Chem Biol 18:243-251.","DOI":"10.1016\/j.chembiol.2010.12.007"},{"key":"key-10.4103\/1673-5374.320967-32","doi-asserted-by":"crossref","unstructured":"Hern\u00e1ndez-S\u00e1nchez C, Wood TL, LeRoith D (1997) Developmental and tissue-specific sulfonylurea receptor gene expression. Endocrinology 138:705-711.","DOI":"10.1210\/endo.138.2.4954"},{"key":"key-10.4103\/1673-5374.320967-33","doi-asserted-by":"crossref","unstructured":"Hu ZL, Sun T, Lu M, Ding JH, Du RH, Hu G (2019) Kir6.1\/K-ATP channel on astrocytes protects against dopaminergic neurodegeneration in the MPTP mouse model of Parkinson\u2019s disease via promoting mitophagy. Brain Behav Immun 81:509-522.","DOI":"10.1016\/j.bbi.2019.07.009"},{"key":"key-10.4103\/1673-5374.320967-34","doi-asserted-by":"crossref","unstructured":"Huang K, Wang Z, Gu Y, Hu Y, Ji Z, Wang S, Lin Z, Li X, Xie Z, Pan S (2016) Glibenclamide is comparable to target temperature management in improving survival and neurological outcome after asphyxial cardiac arrest in rats. J Am Heart Assoc 5:e003465.","DOI":"10.1161\/JAHA.116.003465"},{"key":"key-10.4103\/1673-5374.320967-35","doi-asserted-by":"crossref","unstructured":"Huang Y, Hu D, Huang C, Nichols CG (2019) Genetic discovery of ATP-sensitive K+ channels in cardiovascular diseases. Circ Arrhythm Electrophysiol 12:e007322.","DOI":"10.1161\/CIRCEP.119.007322"},{"key":"key-10.4103\/1673-5374.320967-36","doi-asserted-by":"crossref","unstructured":"Jha RM, Puccio AM, Chou SH, Chang CH, Wallisch JS, Molyneaux BJ, Zusman BE, Shutter LA, Poloyac SM, Janesko-Feldman KL, Okonkwo DO, Kochanek PM (2017) Sulfonylurea receptor-1: a novel biomarker for cerebral edema in severe traumatic brain injury. Crit Care Med 45:e255-264.","DOI":"10.1097\/CCM.0000000000002079"},{"key":"key-10.4103\/1673-5374.320967-37","doi-asserted-by":"crossref","unstructured":"Jha RM, Bell J, Citerio G, Hemphill JC, Kimberly WT, Narayan RK, Sahuquillo J, Sheth KN, Simard JM (2020) Role of sulfonylurea receptor 1 and glibenclamide in traumatic brain injury: a review of the evidence. Int J Mol Sci 21:409.","DOI":"10.3390\/ijms21020409"},{"key":"key-10.4103\/1673-5374.320967-38","doi-asserted-by":"crossref","unstructured":"Jiang B, Li L, Chen Q, Tao Y, Yang L, Zhang B, Zhang JH, Feng H, Chen Z, Tang J, Zhu G (2017) Role of glibenclamide in brain injury after intracerebral hemorrhage. Transl Stroke Res 8:183-193.","DOI":"10.1007\/s12975-016-0506-2"},{"key":"key-10.4103\/1673-5374.320967-39","doi-asserted-by":"crossref","unstructured":"Kaya ST, Bozdogan O, Ozarslan TO, Taskin E, Eksioglu D, Erim F, Firat T, Yasar S (2019) The protection of resveratrol and its combination with glibenclamide, but not berberine on the diabetic hearts against reperfusion-induced arrhythmias: the role of myocardial KATP channel. Arch Physiol Biochem 125:114-121.","DOI":"10.1080\/13813455.2018.1440409"},{"key":"key-10.4103\/1673-5374.320967-40","doi-asserted-by":"crossref","unstructured":"Kim JW, Seghers V, Cho JH, Kang Y, Kim S, Ryu Y, Baek K, Aguilar-Bryan L, Lee YD, Bryan J, Suh-Kim H (2002) Transactivation of the mouse sulfonylurea receptor I gene by BETA2\/NeuroD. Mol Endocrinol 16:1097-1107.","DOI":"10.1210\/mend.16.5.0934"},{"key":"key-10.4103\/1673-5374.320967-41","doi-asserted-by":"crossref","unstructured":"Kim JM, Song KS, Xu B, Wang T (2020) Role of potassium channels in female reproductive system. Obstet Gynecol Sci 63:565-576.","DOI":"10.5468\/ogs.20064"},{"key":"key-10.4103\/1673-5374.320967-42","doi-asserted-by":"crossref","unstructured":"Knowlton C, Kutterer S, Roeper J, Canavier CC (2018) Calcium dynamics control K-ATP channel-mediated bursting in substantia nigra dopamine neurons: a combined experimental and modeling study. J Neurophysiol 119:84-95.","DOI":"10.1152\/jn.00351.2017"},{"key":"key-10.4103\/1673-5374.320967-43","doi-asserted-by":"crossref","unstructured":"K\u00f6hling R, Wolfart J (2016) Potassium channels in epilepsy. Cold Spring Harb Perspect Med 6:a022871.","DOI":"10.1101\/cshperspect.a022871"},{"key":"key-10.4103\/1673-5374.320967-44","doi-asserted-by":"crossref","unstructured":"Kramer W, Oekonomopulos R, P\u00fcnter J, Summ HD (1988) Direct photoaffinity labeling of the putative sulfonylurea receptor in rat beta-cell tumor membranes by [3H]glibenclamide. FEBS Lett 229:355-359.","DOI":"10.1016\/0014-5793(88)81155-4"},{"key":"key-10.4103\/1673-5374.320967-45","first-page":"278","article-title":"Photoaffinity labeling of a 65 kDa protein by [3H]glimepiride","author":"Kramer","year":"1191","journal-title":"Biochim Biophys Acta"},{"key":"key-10.4103\/1673-5374.320967-46","doi-asserted-by":"crossref","unstructured":"Kundap UP, Paudel YN, Shaikh MF (2020) Animal models of metabolic epilepsy and epilepsy associated metabolic dysfunction: a systematic review. Pharmaceuticals (Basel) 13:106.","DOI":"10.3390\/ph13060106"},{"key":"key-10.4103\/1673-5374.320967-47","doi-asserted-by":"crossref","unstructured":"Lee JY, Choi HY, Na WH, Ju BG, Yune TY (2014) Ghrelin inhibits BSCB disruption\/hemorrhage by attenuating MMP-9 and SUR1\/TrpM4 expression and activation after spinal cord injury. Biochim Biophys Acta 1842:2403-2412.","DOI":"10.1016\/j.bbadis.2014.09.006"},{"key":"key-10.4103\/1673-5374.320967-48","doi-asserted-by":"crossref","unstructured":"Li N, Wu JX, Ding D, Cheng J, Gao N, Chen L (2017) Structure of a pancreatic ATP-sensitive potassium channel. Cell 168:101-110.","DOI":"10.1016\/j.cell.2016.12.028"},{"key":"key-10.4103\/1673-5374.320967-49","doi-asserted-by":"crossref","unstructured":"Li Y, Ba M, Du Y, Xia C, Tan S, Ng KP, Ma G (2019) A\u03b21-42 increases the expression of neural KATP subunits Kir6.2\/SUR1 via the NF-\u03baB, p38 MAPK and PKC signal pathways in rat primary cholinergic neurons. Hum Exp Toxicol 38:665-674.","DOI":"10.1177\/0960327119833742"},{"key":"key-10.4103\/1673-5374.320967-50","doi-asserted-by":"crossref","unstructured":"Li Y, Feng Y, Liu L, Li X, Li XY, Sun X, Li KX, Zha RR, Wang HD, Zhang MD, Fan XX, Wu D, Fan Y, Zhang HC, Qiao GF, Li BY (2020) The baroreflex afferent pathway plays a critical role in H2S-mediated autonomic control of blood pressure regulation under physiological and hypertensive conditions. Acta Pharmacol Sin doi: 10.1038\/s41401-020-00549-5.","DOI":"10.1038\/s41401-020-00549-5"},{"key":"key-10.4103\/1673-5374.320967-51","doi-asserted-by":"crossref","unstructured":"Lin Z, Huang H, Gu Y, Huang K, Hu Y, Ji Z, Wu Y, Wang S, Yang T, Pan S (2017) Glibenclamide ameliorates cerebral edema and improves outcomes in a rat model of status epilepticus. Neuropharmacology 121:1-11.","DOI":"10.1016\/j.neuropharm.2017.04.016"},{"key":"key-10.4103\/1673-5374.320967-52","doi-asserted-by":"crossref","unstructured":"Luo ZW, Ovcjak A, Wong R, Yang BX, Feng ZP, Sun HS (2020) Drug development in targeting ion channels for brain edema. Acta Pharmacol Sin 41:1272-1288.","DOI":"10.1038\/s41401-020-00503-5"},{"key":"key-10.4103\/1673-5374.320967-53","doi-asserted-by":"crossref","unstructured":"Martin GM, Yoshioka C, Rex EA, Fay JF, Xie Q, Whorton MR, Chen JZ, Shyng SL (2017) Cryo-EM structure of the ATP-sensitive potassium channel illuminates mechanisms of assembly and gating. eLife 6:e24149.","DOI":"10.7554\/eLife.24149"},{"key":"key-10.4103\/1673-5374.320967-54","doi-asserted-by":"crossref","unstructured":"Matsuo M, Tanabe K, Kioka N, Amachi T, Ueda K (2000) Different binding properties and affinities for ATP and ADP among sulfonylurea receptor subtypes, SUR1, SUR2A, and SUR2B. J Biol Chem 275:28757-28763.","DOI":"10.1074\/jbc.M004818200"},{"key":"key-10.4103\/1673-5374.320967-55","doi-asserted-by":"crossref","unstructured":"Menigoz A, Ahmed T, Sabanov V, Philippaert K, Pinto S, Kerselaers S, Segal A, Freichel M, Voets T, Nilius B, Vennekens R, Balschun D (2016) TRPM4-dependent post-synaptic depolarization is essential for the induction of NMDA receptor-dependent LTP in CA1 hippocampal neurons. Pflugers Arch 468:593-607.","DOI":"10.1007\/s00424-015-1764-7"},{"key":"key-10.4103\/1673-5374.320967-56","doi-asserted-by":"crossref","unstructured":"Nelson DA, Aguilar-Bryan L, Bryan J (1992) Specificity of photolabeling of beta-cell membrane proteins with an 125I-labeled glyburide analog. J Biol Chem 267:14928-14933.","DOI":"10.1016\/S0021-9258(18)42129-1"},{"key":"key-10.4103\/1673-5374.320967-57","doi-asserted-by":"crossref","unstructured":"Nelson DA, Bryan J, Wechsler S, Clement JP 4th, Aguilar-Bryan L (1996) The high-affinity sulfonylurea receptor: distribution, glycosylation, purification, and immunoprecipitation of two forms from endocrine and neuroendocrine cell lines. Biochemistry 35:14793-14799.","DOI":"10.1021\/bi960777y"},{"key":"key-10.4103\/1673-5374.320967-58","doi-asserted-by":"crossref","unstructured":"Niki I, Welsh M, Berggren PO, Hubbrard P, Ashcroft SJH (1991) Characterization of the solubilized glibenclamide receptor in hamster pancreatic fl-cell line, HIT T15. Biochem J 277:619-624.","DOI":"10.1042\/bj2770619"},{"key":"key-10.4103\/1673-5374.320967-59","doi-asserted-by":"crossref","unstructured":"Pergakis M, Badjatia N, Chaturvedi S, Cronin CA, Kimberly WT, Sheth KN, Simard JM (2019) BIIB093 (IV glibenclamide): an investigational compound for the prevention and treatment of severe cerebral edema. Expert Opin Investig Drugs 28:1031-1040.","DOI":"10.1080\/13543784.2019.1681967"},{"key":"key-10.4103\/1673-5374.320967-60","doi-asserted-by":"crossref","unstructured":"Pu JL, Ye B, Kroboth SL, McNally E, Makielski JC, Shi NQ (2009) Cardiac sulfonylurea receptor short form-based channels confer a glibenclamide-insensitive KATP activity. J Mol Cell Cardiol 44:188-200.","DOI":"10.1016\/j.yjmcc.2007.09.010"},{"key":"key-10.4103\/1673-5374.320967-61","doi-asserted-by":"crossref","unstructured":"Puljung MC (2018) Cryo-electron microscopy structures and progress toward a dynamic understanding of KATP channels. J Gen Physiol 150:653-669.","DOI":"10.1085\/jgp.201711978"},{"key":"key-10.4103\/1673-5374.320967-62","doi-asserted-by":"crossref","unstructured":"Puljung M, Vedovato N, Usher S, Ashcroft F (2019) Activation mechanism of ATP-sensitive K+ channels explored with real-time nucleotide binding. Elife 8:e41103.","DOI":"10.7554\/eLife.41103"},{"key":"key-10.4103\/1673-5374.320967-63","doi-asserted-by":"crossref","unstructured":"Rabalet B, Mmell CJ, Johnson DG, Levinz SR (1996) Sulfonylurea binding to a low-affinity site inhibits the Na\/K-ATPase and the KATP channel in insulin-secreting cells. J Gen Physiol 107:231-241.","DOI":"10.1085\/jgp.107.2.231"},{"key":"key-10.4103\/1673-5374.320967-64","doi-asserted-by":"crossref","unstructured":"Robichaux WG 3rd, Cheng X (2018) Intracellular cAMP sensor EPAC: physiology, pathophysiology, and therapeutics development. Physiol Rev 98:919-1053.","DOI":"10.1152\/physrev.00025.2017"},{"key":"key-10.4103\/1673-5374.320967-65","doi-asserted-by":"crossref","unstructured":"Rubio C, Luna R, Rosiles A, Rubio-Osornio M (2020) Caloric restriction and ketogenic diet therapy for epilepsy: a molecular approach involving Wnt pathway and KATP channels. Front Neurol 11:584298.","DOI":"10.3389\/fneur.2020.584298"},{"key":"key-10.4103\/1673-5374.320967-66","doi-asserted-by":"crossref","unstructured":"Sakura H, Trapp S, Liss B, Ashcroft FM (1999) Altered functional properties of KATP channel conferred by a novel splice variant of SUR1. J Physiol 521:337-350.","DOI":"10.1111\/j.1469-7793.1999.00337.x"},{"key":"key-10.4103\/1673-5374.320967-67","doi-asserted-by":"crossref","unstructured":"Schmid D, Stolzlechner M, Sorgner A, Bentele C, Assinger A, Chiba P, Moeslinger T (2012) An abundant, truncated human sulfonylurea receptor 1 splice variant has prodiabetic properties and impairs sulfonylurea action. Cell Mol Life Sci 69:129-148.","DOI":"10.1007\/s00018-011-0739-x"},{"key":"key-10.4103\/1673-5374.320967-68","doi-asserted-by":"crossref","unstructured":"Schwanstecher M, Lser S, Chudziak F, Bachmann C, Panten U (1994) Photoaffinity labeling of the cerebral sulfonylurea receptor using a novel radioiodinated azidoglibenclamide analogue. J Neurochem 63:698-708.","DOI":"10.1046\/j.1471-4159.1994.63020698.x"},{"key":"key-10.4103\/1673-5374.320967-69","doi-asserted-by":"crossref","unstructured":"Shi N, He J, Guo Q, Liu T, Han J (2019) Liraglutide protects against diabetes mellitus complicated with focal cerebral ischemic injury by activating mitochondrial ATP-sensitive potassium channels. Neuroreport 30:479-484.","DOI":"10.1097\/WNR.0000000000001225"},{"key":"key-10.4103\/1673-5374.320967-70","doi-asserted-by":"crossref","unstructured":"Singh BL, Chen L, Cai H, Shi H, Wang Y, Yu Ch, Chen X, Han X, Cai X (2019) Activation of adenosine A2a receptor accelerates and A2a receptor antagonist reduces intermittent hypoxia induced PC12 cell injury via PKC-KATP pathway. Brain Res Bull 150:118-126.","DOI":"10.1016\/j.brainresbull.2019.05.015"},{"key":"key-10.4103\/1673-5374.320967-71","doi-asserted-by":"crossref","unstructured":"Skeer JM, D\u00e9gano P, Coles B, Potier M, Ashcroft FM, Ashcroft SJ (1994) Determination of the molecular mass of the native beta-cell sulfonylurea receptor. FEBS Lett 338:98-102.","DOI":"10.1016\/0014-5793(94)80124-X"},{"key":"key-10.4103\/1673-5374.320967-72","doi-asserted-by":"crossref","unstructured":"Stokum JA, Gerzanich V, Simard JM (2016) Molecular pathophysiology of cerebral edema. J Cereb Blood Flow Metab 36:513-538.","DOI":"10.1177\/0271678X15617172"},{"key":"key-10.4103\/1673-5374.320967-73","doi-asserted-by":"crossref","unstructured":"Stokum JA, Kwon MS, Woo SK, Tsymbalyuk O, Vennekens R, Volodymyr G, Simard JM (2018) SUR1-TRPM4 and AQP4 form a heteromultimeric complex that amplifies ion\/water osmotic coupling and drives astrocyte swelling. Glia 66:108-125.","DOI":"10.1002\/glia.23231"},{"key":"key-10.4103\/1673-5374.320967-74","doi-asserted-by":"crossref","unstructured":"Sun Y, He Y, Yang L, Liang D, Shi W, Zhu X, Jiang Y, Ou C (2020) Manganese induced nervous injury by \u03b1-synuclein accumulation via ATP-sensitive K(+) channels and GABA receptors. Toxicol Lett 10:164-170.","DOI":"10.1016\/j.toxlet.2020.07.008"},{"key":"key-10.4103\/1673-5374.320967-75","doi-asserted-by":"crossref","unstructured":"Thomas C, Aller SG, Beis K, Carpenter EP, Chang G, Chen L, Dassa E, Dean M, Duong Van Hoa F, Ekiert D, Ford R, Gaudet R, Gong X, Holland IB, Huang Y, Kahne DK, Kato H, Koronakis V, Koth CM, Lee Y, et al. (2020) Structural and functional diversity calls for a new classification of ABC transporters. FEBS Lett 594:3767-3775.","DOI":"10.1002\/1873-3468.13935"},{"key":"key-10.4103\/1673-5374.320967-76","doi-asserted-by":"crossref","unstructured":"Tinker A, Aziz Q, Li Y, Specterman M (2018) ATP-sensitive potassium channels and their physiological and pathophysiological roles. Compr Physiol 8:1463-1511.","DOI":"10.1002\/cphy.c170048"},{"key":"key-10.4103\/1673-5374.320967-77","doi-asserted-by":"crossref","unstructured":"Tomuschat Ch, O\u2019Donnell AM, Coyle D, Dreher N, Kelly D, Puri P (2016) Altered expression of ATP-sensitive K(+) channels in Hirschsprung\u2019s disease. J Pediatr Surg 51:948-952.","DOI":"10.1016\/j.jpedsurg.2016.02.060"},{"key":"key-10.4103\/1673-5374.320967-78","doi-asserted-by":"crossref","unstructured":"Wei S, Low SW, Poore CP, Chen B, Gao Y, Nilius B, Liao P (2020) Comparison of anti-oncotic effect of TRPM4 blocking antibody in neuron, astrocyte and vascular endothelial cell under hypoxia. Front Cell Dev Biol 8:562584.","DOI":"10.3389\/fcell.2020.562584"},{"key":"key-10.4103\/1673-5374.320967-79","doi-asserted-by":"crossref","unstructured":"Woo SK, Tsymbalyuk N, Tsymbalyuk O, Ivanova S, Gerzanich V, Simard JM (2020) SUR1-TRPM4 channels, not K(ATP), mediate brain swelling following cerebral ischemia. Neurosci Lett 718:134729.","DOI":"10.1016\/j.neulet.2019.134729"},{"key":"key-10.4103\/1673-5374.320967-80","doi-asserted-by":"crossref","unstructured":"Wu Z, Zhu SZ, Hu YF, Gu Y, Wang SN, Lin ZZ, Xie ZS, Pan SY (2016) Glibenclamide enhances the effects of delayed hypothermia after experimental stroke in rats. Brain Res 15:113-122.","DOI":"10.1016\/j.brainres.2016.04.067"},{"key":"key-10.4103\/1673-5374.320967-81","doi-asserted-by":"crossref","unstructured":"Yamada M, Kurachi Y (2005) Focused issue on K ATP channels A functional role of the C-terminal 42 amino acids of SUR2A and SUR2B in the physiology and pharmacology of cardiovascular ATP-sensitive K+ channels. J Mol Cell Cardiol 39:1-6.","DOI":"10.1016\/j.yjmcc.2004.11.022"},{"key":"key-10.4103\/1673-5374.320967-82","doi-asserted-by":"crossref","unstructured":"Yan J, Bengtson CP, Buchthal B, Hagenston AM, Bading H (2020) Coupling of NMDA receptors and TRPM4 guides discovery of unconventional neuroprotectants. Science 370:eaay3302.","DOI":"10.1126\/science.aay3302"},{"key":"key-10.4103\/1673-5374.320967-83","doi-asserted-by":"crossref","unstructured":"Zhang Q, Li C, Zhang T, Ge Y, Han X, Sun S, Ding J, Lu M, Hu G (2018) Deletion of Kir6.2\/SUR1 potassium channels rescues diminishing of DA neurons via decreasing iron accumulation in PD. Mol Cell Neurosci 92:164-176.","DOI":"10.1016\/j.mcn.2018.08.006"},{"key":"key-10.4103\/1673-5374.320967-84","doi-asserted-by":"crossref","unstructured":"Zhang S, Guo Z, Yang S, Ma H, Fu C, Wang S, Zhang Y, Liu Y, Hu J (2016) Chronic intermittent hybobaric hypoxia protects against cerebral ischemia via modulation of mitoK ATP. Neurosci Lett 2:8-16.","DOI":"10.1016\/j.neulet.2016.10.025"},{"key":"key-10.4103\/1673-5374.320967-85","doi-asserted-by":"crossref","unstructured":"Zhao K, Wen R, Wang X, Pei L, Yang Y, Shang Y, Bazan N, Zhu LQ, Tian Q, Lu Y (2013) EPAC inhibition of SUR1 receptor increases glutamate release and seizure vulnerability. J Neurosci 33:8861-8865.","DOI":"10.1523\/JNEUROSCI.5686-12.2013"},{"key":"key-10.4103\/1673-5374.320967-86","doi-asserted-by":"crossref","unstructured":"Zhong CJ, Chen MM, Lu M, Ding JH, Du RH, Hu G (2019) Astrocyte-specific deletion of Kir6.1\/K-ATP channel aggravates cerebral ischemia\/reperfusion injury through endoplasmic reticulum stress in mice. Exp Neurol 311:225-233.","DOI":"10.1016\/j.expneurol.2018.10.005"},{"key":"key-10.4103\/1673-5374.320967-87","doi-asserted-by":"crossref","unstructured":"Zhou F, Liu Y, Yang B, Hu Z (2018) Neuroprotective potential of glibenclamide is mediated by antioxidant and anti-apoptotic pathways in intracerebral hemorrhage. Brain Res Bull 142:18-24.","DOI":"10.1016\/j.brainresbull.2018.06.006"}],"container-title":["Neural Regeneration Research"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T19:00:38Z","timestamp":1786734038000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/1673-5374.320967"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":87,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022]]}},"alternative-id":["320967"],"URL":"https:\/\/doi.org\/10.4103\/1673-5374.320967","relation":{},"ISSN":["1673-5374"],"issn-type":[{"value":"1673-5374","type":"print"}],"subject":[],"published":{"date-parts":[[2022]]}}}