{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T20:03:49Z","timestamp":1786737829680,"version":"build-2736575974"},"reference-count":46,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neural Regen Res"],"published-print":{"date-parts":[[2022]]},"DOI":"10.4103\/1673-5374.320991","type":"journal-article","created":{"date-parts":[[2021,8,20]],"date-time":"2021-08-20T02:44:04Z","timestamp":1629427444000},"page":"661","source":"Crossref","is-referenced-by-count":19,"title":["Kr\u00fcppel-like factor 7 attenuates hippocampal neuronal injury after traumatic brain injury"],"prefix":"10.4103","volume":"17","author":[{"given":"Xiao-Feng","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Yuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu-Mei","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-Dong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Gang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duo","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gui-Bo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"key-10.4103\/1673-5374.320991-1","doi-asserted-by":"crossref","unstructured":"Andreoli V, Gehrau RC, Bocco JL (2010) Biology of Kr\u00fcppel-like factor 6 transcriptional regulator in cell life and death. IUBMB Life 62:896-905.","DOI":"10.1002\/iub.396"},{"key":"key-10.4103\/1673-5374.320991-2","doi-asserted-by":"crossref","unstructured":"Blackmore MG, Wang Z, Lerch JK, Motti D, Zhang YP, Shields CB, Lee JK, Goldberg JL, Lemmon VP, Bixby JL (2012) Kr\u00fcppel-like Factor 7 engineered for transcriptional activation promotes axon regeneration in the adult corticospinal tract. Proc Natl Acad Sci U S A 109:7517-7522.","DOI":"10.1073\/pnas.1120684109"},{"key":"key-10.4103\/1673-5374.320991-3","doi-asserted-by":"crossref","unstructured":"Chen L, Gao X, Zhao S, Hu W, Chen J (2015) The small-molecule TrkB agonist 7, 8-dihydroxyflavone decreases hippocampal newborn neuron death after traumatic brain injury. J Neuropathol Exp Neurol 74:557-567.","DOI":"10.1097\/NEN.0000000000000199"},{"key":"key-10.4103\/1673-5374.320991-4","doi-asserted-by":"crossref","unstructured":"Coggeshall RE (1992) A consideration of neural counting methods. Trends Neurosci 15:9-13.","DOI":"10.1016\/0166-2236(92)90339-A"},{"key":"key-10.4103\/1673-5374.320991-5","doi-asserted-by":"crossref","unstructured":"Cui DM, Zeng T, Ren J, Wang K, Jin Y, Zhou L, Gao L (2017) KLF4 knockdown attenuates TBI-induced neuronal damage through p53 and JAK-STAT3 signaling. CNS Neurosci Ther 23:106-118.","DOI":"10.1111\/cns.12633"},{"key":"key-10.4103\/1673-5374.320991-6","doi-asserted-by":"crossref","unstructured":"Faden AI, Movsesyan VA, Knoblach SM, Ahmed F, Cernak I (2005) Neuroprotective effects of novel small peptides in vitro and after brain injury. Neuropharmacology 49:410-424.","DOI":"10.1016\/j.neuropharm.2005.04.001"},{"key":"key-10.4103\/1673-5374.320991-7","doi-asserted-by":"crossref","unstructured":"Falnikar A, Stratton J, Lin R, Andrews CE, Tyburski A, Trovillion VA, Gottschalk C, Ghosh B, Iacovitti L, Elliott MB, Lepore AC (2018) Differential response in novel stem cell niches of the brain after cervical spinal cord injury and traumatic brain injury. J Neurotrauma 35:2195-2207.","DOI":"10.1089\/neu.2017.5497"},{"key":"key-10.4103\/1673-5374.320991-8","doi-asserted-by":"crossref","unstructured":"Fang X, Zhang C, Yu Z, Li W, Huang Z, Zhang W (2019) GDNF pretreatment overcomes Schwann cell phenotype mismatch to promote motor axon regeneration via sensory graft. Exp Neurol 318:258-266.","DOI":"10.1016\/j.expneurol.2019.05.011"},{"key":"key-10.4103\/1673-5374.320991-9","doi-asserted-by":"crossref","unstructured":"Gao S, Zheng Y, Cai Q, Deng Z, Yao W, Wang J, Wang X, Zhang P (2014) Combination of acellular nerve graft and Schwann cells-like cells for rat sciatic nerve regeneration. Neural Plast 2014:139085.","DOI":"10.1155\/2014\/139085"},{"key":"key-10.4103\/1673-5374.320991-10","doi-asserted-by":"crossref","unstructured":"Kochanek PM, Jackson TC, Ferguson NM, Carlson SW, Simon DW, Brockman EC, Ji J, Bay\u0131r H, Poloyac SM, Wagner AK, Kline AE, Empey PE, Clark RS, Jackson EK, Dixon CE (2015) Emerging therapies in traumatic brain injury. Semin Neurol 35:83-100.","DOI":"10.1055\/s-0035-1544237"},{"key":"key-10.4103\/1673-5374.320991-11","doi-asserted-by":"crossref","unstructured":"Laub F, Aldabe R, Friedrich V, Jr., Ohnishi S, Yoshida T, Ramirez F (2001) Developmental expression of mouse Kr\u00fcppel-like transcription factor KLF7 suggests a potential role in neurogenesis. Dev Biol 233:305-318.","DOI":"10.1006\/dbio.2001.0243"},{"key":"key-10.4103\/1673-5374.320991-12","doi-asserted-by":"crossref","unstructured":"Laurer HL, Bareyre FM, Lee VM, Trojanowski JQ, Longhi L, Hoover R, Saatman KE, Raghupathi R, Hoshino S, Grady MS, McIntosh TK (2001) Mild head injury increasing the brain\u2019s vulnerability to a second concussive impact. J Neurosurg 95:859-870.","DOI":"10.3171\/jns.2001.95.5.0859"},{"key":"key-10.4103\/1673-5374.320991-13","doi-asserted-by":"crossref","unstructured":"Li D, Huang S, Zhu J, Hu T, Han Z, Zhang S, Zhao J, Chen F, Lei P (2019a) Exosomes from MiR-21-5p-increased neurons play a role in neuroprotection by suppressing Rab11a-mediated neuronal autophagy in vitro after traumatic brain injury. Med Sci Monit 25:1871-1885.","DOI":"10.12659\/MSM.915727"},{"key":"key-10.4103\/1673-5374.320991-14","doi-asserted-by":"crossref","unstructured":"Li WY, Jia H, Wang ZD, Zhai FG, Sun GD, Ma D, Liu GB, Li CM, Wang Y (2020) Combinatory transplantation of mesenchymal stem cells with flavonoid small molecule in acellular nerve graft promotes sciatic nerve regeneration. J Tissue Eng 11:2041731420980136.","DOI":"10.1177\/2041731420980136"},{"key":"key-10.4103\/1673-5374.320991-15","doi-asserted-by":"crossref","unstructured":"Li WY, Zhu GY, Yue WJ, Sun GD, Zhu XF, Wang Y (2019b) KLF7 overexpression in bone marrow stromal stem cells graft transplantation promotes sciatic nerve regeneration. J Neural Eng 16:056011.","DOI":"10.1088\/1741-2552\/ab3188"},{"key":"key-10.4103\/1673-5374.320991-16","doi-asserted-by":"crossref","unstructured":"Li WY, Wang Y, Zhai FG, Sun P, Cheng YX, Deng LX, Wang ZY (2017a) AAV-KLF7 promotes descending propriospinal neuron axonal plasticity after spinal cord injury. Neural Plast 2017:1621629.","DOI":"10.1155\/2017\/1621629"},{"key":"key-10.4103\/1673-5374.320991-17","doi-asserted-by":"crossref","unstructured":"Li Y, Shi X, Li J, Zhang M, Yu B (2017b) Knockdown of KLF11 attenuates hypoxia\/reoxygenation injury via JAK2\/STAT3 signaling in H9c2. Apoptosis 22:510-518.","DOI":"10.1007\/s10495-016-1327-1"},{"key":"key-10.4103\/1673-5374.320991-18","doi-asserted-by":"crossref","unstructured":"Li Z, Peng J, Wang G, Yang Q, Yu H, Guo Q, Wang A, Zhao B, Lu S (2008) Effects of local release of hepatocyte growth factor on peripheral nerve regeneration in acellular nerve grafts. Exp Neurol 214:47-54.","DOI":"10.1016\/j.expneurol.2008.07.007"},{"key":"key-10.4103\/1673-5374.320991-19","doi-asserted-by":"crossref","unstructured":"Liu NK, Zhang YP, Zou J, Verhovshek T, Chen C, Lu QB, Walker CL, Shields CB, Xu XM (2014) A semicircular controlled cortical impact produces long-term motor and cognitive dysfunction that correlates well with damage to both the sensorimotor cortex and hippocampus. Brain Res 1576:18-26.","DOI":"10.1016\/j.brainres.2014.05.042"},{"key":"key-10.4103\/1673-5374.320991-20","doi-asserted-by":"crossref","unstructured":"Lv JX, Zhou J, Tong RQ, Wang B, Chen XL, Zhuang YY, Xia F, Wei XD (2019) Hypoxia induced miR 210 contributes to apoptosis of mouse spermatocyte GC 2 cells by targeting Kruppel like factor 7. Mol Med Rep 19:271-279.","DOI":"10.3892\/mmr.2018.9644"},{"key":"key-10.4103\/1673-5374.320991-21","doi-asserted-by":"crossref","unstructured":"Moore DL, Apara A, Goldberg JL (2011) Kr\u00fcppel-like transcription factors in the nervous system: novel players in neurite outgrowth and axon regeneration. Mol Cell Neurosci 47:233-243.","DOI":"10.1016\/j.mcn.2011.05.005"},{"key":"key-10.4103\/1673-5374.320991-22","doi-asserted-by":"crossref","unstructured":"Moore DL, Blackmore MG, Hu Y, Kaestner KH, Bixby JL, Lemmon VP, Goldberg JL (2009) KLF family members regulate intrinsic axon regeneration ability. Science 326:298-301.","DOI":"10.1126\/science.1175737"},{"key":"key-10.4103\/1673-5374.320991-23","doi-asserted-by":"crossref","unstructured":"Morrison B, 3rd, Elkin BS, Doll\u00e9 JP, Yarmush ML (2011) In vitro models of traumatic brain injury. Annu Rev Biomed Eng 13:91-126.","DOI":"10.1146\/annurev-bioeng-071910-124706"},{"key":"key-10.4103\/1673-5374.320991-24","doi-asserted-by":"crossref","unstructured":"Nagata K, Hama I, Kiryu-Seo S, Kiyama H (2014) microRNA-124 is down regulated in nerve-injured motor neurons and it potentially targets mRNAs for KLF6 and STAT3. Neuroscience 256:426-432.","DOI":"10.1016\/j.neuroscience.2013.10.055"},{"key":"key-10.4103\/1673-5374.320991-25","unstructured":"Paxinos G, Watson C (2007) The Rat Brain in Stereotaxic Coordinates. 6th ed. Academic Press\/Elsevier."},{"key":"key-10.4103\/1673-5374.320991-26","doi-asserted-by":"crossref","unstructured":"Puigdecanet E, Espinet B, Lozano JJ, Sumoy L, Bellosillo B, Arenillas L, Alvarez-Larr\u00e1n A, Sol\u00e9 F, Serrano S, Besses C, Florensa L (2008) Gene expression profiling distinguishes JAK2V617F-negative from JAK2V617F-positive patients in essential thrombocythemia. Leukemia 22:1368-1376.","DOI":"10.1038\/leu.2008.112"},{"key":"key-10.4103\/1673-5374.320991-27","doi-asserted-by":"crossref","unstructured":"Qu W, Liu NK, Wu X, Wang Y, Xia Y, Sun Y, Lai Y, Li R, Shekhar A, Xu XM (2020) Disrupting nNOS-PSD95 interaction improves neurological and cognitive recoveries after traumatic brain injury. Cereb Cortex 30:3859-3871.","DOI":"10.1093\/cercor\/bhaa002"},{"key":"key-10.4103\/1673-5374.320991-28","doi-asserted-by":"crossref","unstructured":"Rizk M, Vu J, Zhang Z (2021) Impact of pediatric traumatic brain injury on hippocampal neurogenesis. Neural Regen Res 16:926-933.","DOI":"10.4103\/1673-5374.297057"},{"key":"key-10.4103\/1673-5374.320991-29","doi-asserted-by":"crossref","unstructured":"Salvador E, Burek M, F\u00f6rster CY (2015) Stretch and\/or oxygen glucose deprivation (OGD) in an in vitro traumatic brain injury (TBI) model induces calcium alteration and inflammatory cascade. Front Cell Neurosci 9:323.","DOI":"10.3389\/fncel.2015.00323"},{"key":"key-10.4103\/1673-5374.320991-30","doi-asserted-by":"crossref","unstructured":"Salvador E, Burek M, F\u00f6rster CY (2018) An in vitro model of traumatic brain injury. Methods Mol Biol 1717:219-227.","DOI":"10.1007\/978-1-4939-7526-6_17"},{"key":"key-10.4103\/1673-5374.320991-31","doi-asserted-by":"crossref","unstructured":"S\u00eerbulescu RF, Zupanc GK (2010) Inhibition of caspase-3-mediated apoptosis improves spinal cord repair in a regeneration-competent vertebrate system. Neuroscience 171:599-612.","DOI":"10.1016\/j.neuroscience.2010.09.002"},{"key":"key-10.4103\/1673-5374.320991-32","doi-asserted-by":"crossref","unstructured":"Song Y, Li T, Liu Z, Xu Z, Zhang Z, Chi L, Liu Y (2019) Inhibition of Drp1 after traumatic brain injury provides brain protection and improves behavioral performance in rats. Chem Biol Interact 304:173-185.","DOI":"10.1016\/j.cbi.2019.03.013"},{"key":"key-10.4103\/1673-5374.320991-33","unstructured":"Sun TJ, Liu SJ, Xie FK, Huang XF, Zhang J, Jiang XH, Feng H, Yu AY (2021) Role and hotspots of stem cell-derived exosome in the repair of traumatic brain injury. Zhongguo Zuzhi Gongcheng Yanjiu 25:123-127."},{"key":"key-10.4103\/1673-5374.320991-34","doi-asserted-by":"crossref","unstructured":"Tao J, Shen C, Sun Y, Chen W, Yan G (2018) Neuroprotective effects of pinocembrin on ischemia\/reperfusion-induced brain injury by inhibiting autophagy. Biomed Pharmacother 106:1003-1010.","DOI":"10.1016\/j.biopha.2018.07.026"},{"key":"key-10.4103\/1673-5374.320991-35","doi-asserted-by":"crossref","unstructured":"Tetreault MP, Alrabaa R, McGeehan M, Katz JP (2012) Kr\u00fcppel-like factor 5 protects against murine colitis and activates JAK-STAT signaling in vivo. PLoS One 7:e38338.","DOI":"10.1371\/journal.pone.0038338"},{"key":"key-10.4103\/1673-5374.320991-36","doi-asserted-by":"crossref","unstructured":"Torrente D, Avila MF, Cabezas R, Morales L, Gonzalez J, Samudio I, Barreto GE (2014) Paracrine factors of human mesenchymal stem cells increase wound closure and reduce reactive oxygen species production in a traumatic brain injury in vitro model. Hum Exp Toxicol 33:673-684.","DOI":"10.1177\/0960327113509659"},{"key":"key-10.4103\/1673-5374.320991-37","doi-asserted-by":"crossref","unstructured":"Veldman MB, Bemben MA, Thompson RC, Goldman D (2007) Gene expression analysis of zebrafish retinal ganglion cells during optic nerve regeneration identifies KLF6a and KLF7a as important regulators of axon regeneration. Dev Biol 312:596-612.","DOI":"10.1016\/j.ydbio.2007.09.019"},{"key":"key-10.4103\/1673-5374.320991-38","doi-asserted-by":"crossref","unstructured":"V\u00f6lkening B, Sch\u00f6nig K, Kronenberg G, Bartsch D, Weber T (2017) Deletion of psychiatric risk gene Cacna1c impairs hippocampal neurogenesis in cell-autonomous fashion. Glia 65:817-827.","DOI":"10.1002\/glia.23128"},{"key":"key-10.4103\/1673-5374.320991-39","doi-asserted-by":"crossref","unstructured":"Wang Y, Li WY, Jia H, Zhai FG, Qu WR, Cheng YX, Liu YC, Deng LX, Guo SF, Jin ZS (2017) KLF7-transfected Schwann cell graft transplantation promotes sciatic nerve regeneration. Neuroscience 340:319-332.","DOI":"10.1016\/j.neuroscience.2016.10.069"},{"key":"key-10.4103\/1673-5374.320991-40","doi-asserted-by":"crossref","unstructured":"Wang Z, Mehra V, Simpson MT, Maunze B, Chakraborty A, Holan L, Eastwood E, Blackmore MG, Venkatesh I (2018) KLF6 and STAT3 co-occupy regulatory DNA and functionally synergize to promote axon growth in CNS neurons. Sci Rep 8:12565.","DOI":"10.1038\/s41598-018-31101-5"},{"key":"key-10.4103\/1673-5374.320991-41","doi-asserted-by":"crossref","unstructured":"Xu JH, Qin XZ, Zhang HN, Ma YX, Qi SB, Zhang HC, Ma JJ, Fu XY, Xie JL, Saijilafu (2021) Deletion of Kr\u00fcppel-like factor-4 promotes axonal regeneration in mammals. Neural Regen Res 16:166-171.","DOI":"10.4103\/1673-5374.286978"},{"key":"key-10.4103\/1673-5374.320991-42","doi-asserted-by":"crossref","unstructured":"Yamauchi K, Osuka K, Takayasu M, Usuda N, Nakazawa A, Nakahara N, Yoshida M, Aoshima C, Hara M, Yoshida J (2006) Activation of JAK\/STAT signalling in neurons following spinal cord injury in mice. J Neurochem 96:1060-1070.","DOI":"10.1111\/j.1471-4159.2005.03559.x"},{"key":"key-10.4103\/1673-5374.320991-43","doi-asserted-by":"crossref","unstructured":"Zhang Q, Zhang M, Huang X, Liu X, Li W (2016) Inhibition of cytoskeletal protein carbonylation may protect against oxidative damage in traumatic brain injury. Exp Ther Med 12:4107-4112.","DOI":"10.3892\/etm.2016.3889"},{"key":"key-10.4103\/1673-5374.320991-44","doi-asserted-by":"crossref","unstructured":"Zhao J, Li G, Zhang Y, Su X, Hang C (2011a) The potential role of JAK2\/STAT3 pathway on the anti-apoptotic effect of recombinant human erythropoietin (rhEPO) after experimental traumatic brain injury of rats. Cytokine 56:343-350.","DOI":"10.1016\/j.cyto.2011.07.018"},{"key":"key-10.4103\/1673-5374.320991-45","doi-asserted-by":"crossref","unstructured":"Zhao JB, Zhang Y, Li GZ, Su XF, Hang CH (2011b) Activation of JAK2\/STAT pathway in cerebral cortex after experimental traumatic brain injury of rats. Neurosci Lett 498:147-152.","DOI":"10.1016\/j.neulet.2011.05.001"},{"key":"key-10.4103\/1673-5374.320991-46","doi-asserted-by":"crossref","unstructured":"Zheng J, Bizzozero OA (2010) Accumulation of protein carbonyls within cerebellar astrocytes in murine experimental autoimmune encephalomyelitis. J Neurosci Res 88:3376-3385.","DOI":"10.1002\/jnr.22488"}],"container-title":["Neural Regeneration Research"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T19:00:16Z","timestamp":1786734016000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/1673-5374.320991"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":46,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022]]}},"alternative-id":["320991"],"URL":"https:\/\/doi.org\/10.4103\/1673-5374.320991","relation":{},"ISSN":["1673-5374"],"issn-type":[{"value":"1673-5374","type":"print"}],"subject":[],"published":{"date-parts":[[2022]]}}}