{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T14:53:14Z","timestamp":1791816794105,"version":"4.3.4"},"reference-count":83,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T00:00:00Z","timestamp":1631836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:p>\n                    At present, treatments for Alzheimer's disease can temporarily relieve symptoms but cannot prevent the decline of cognitive ability and other neurodegenerative changes.\n                    <jats:italic toggle=\"yes\">Dendrobium<\/jats:italic>\n                    nobile Lindl alkaloid is the main active component of\n                    <jats:italic toggle=\"yes\">Dendrobium<\/jats:italic>\n                    nobile Lindl.\n                    <jats:italic toggle=\"yes\">Dendrobium<\/jats:italic>\n                    nobile Lindl alkaloid has been shown to resist aging, prolong life span, and exhibit immunomodulatory effects in animals. This review summarizes the mechanisms behind the neuroprotective effects reported in Alzheimer's disease animal models. The neuroprotective effects of\n                    <jats:italic toggle=\"yes\">Dendrobium<\/jats:italic>\n                    nobile Lindl alkaloid have not been studied in patients. The mechanisms by which\n                    <jats:italic toggle=\"yes\">Dendrobium<\/jats:italic>\n                    nobile Lindl alkaloid has been reported to improve cognitive dysfunction in Alzheimer's disease animal models may be associated with extracellular amyloid plaque production, regulation of tau protein hyperphosphorylation, inhibition of neuroinflammation and neuronal apoptosis, activation of autophagy, and enhanced synaptic connections.\n                  <\/jats:p>","DOI":"10.4103\/1673-5374.324824","type":"journal-article","created":{"date-parts":[[2021,9,19]],"date-time":"2021-09-19T08:52:33Z","timestamp":1632041553000},"page":"972-977","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":57,"title":["Potential neuroprotection by Dendrobium nobile Lindl alkaloid in Alzheimer's disease models"],"prefix":"10.4103","volume":"17","author":[{"given":"Dai-Di","family":"Li","sequence":"first","affiliation":[{"name":"Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Lab of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, Guizhou Province, China"},{"name":"School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Qing","family":"Zheng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Lab of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, Guizhou Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1122-3640","authenticated-orcid":false,"given":"Feng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Lab of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, Guizhou Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0968-7094","authenticated-orcid":false,"given":"Jing-Shan","family":"Shi","sequence":"additional","affiliation":[{"name":"Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Lab of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, Guizhou Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2021,9,17]]},"reference":[{"key":"R1-20260525","doi-asserted-by":"crossref","first-page":"103892","DOI":"10.1016\/j.micpath.2019.103892","article-title":"The role of Bax in the apoptosis of Leishmania-infected macrophages","volume":"139","author":"Aghaei","year":"2020","journal-title":"Microb 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