{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T12:08:09Z","timestamp":1791461289095,"version":"4.3.4"},"reference-count":68,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neural Regen Res"],"published-print":{"date-parts":[[2022]]},"DOI":"10.4103\/1673-5374.335691","type":"journal-article","created":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T20:13:46Z","timestamp":1644437626000},"page":"1875","source":"Crossref","is-referenced-by-count":14,"title":["Emerging roles of circular RNAs in retinal diseases"],"prefix":"10.4103","volume":"17","author":[{"given":"SarahX","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aneliya","family":"Hanineva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KarenSophia","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JoshuaJ","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MargaretM","family":"DeAngelis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MichaelH","family":"Farkas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"key-10.4103\/1673-5374.335691-1","doi-asserted-by":"crossref","unstructured":"Almasieh M, Wilson AM, Morquette B, Cueva Vargas JL, Di Polo A (2012) The molecular basis of retinal ganglion cell death in glaucoma. Prog Retin Eye Res 31:152-181.","DOI":"10.1016\/j.preteyeres.2011.11.002"},{"key":"key-10.4103\/1673-5374.335691-2","doi-asserted-by":"crossref","unstructured":"Cao M, Zhang L, Wang JH, Zeng H, Peng Y, Zou J, Shi J, Zhang L, Li Y, Yoshida S, Tang L, Zhou Y (2019) Identifying circRNA-associated-ceRNA networks in retinal neovascularization in mice. Int J Med Sci 16:1356-1365.","DOI":"10.7150\/ijms.35149"},{"key":"key-10.4103\/1673-5374.335691-3","doi-asserted-by":"crossref","unstructured":"Charteris DG, Sethi CS, Lewis GP, Fisher SK (2002) Proliferative vitreoretinopathy\u2014developments in adjunctive treatment and retinal pathology. Eye 16:369-374.","DOI":"10.1038\/sj.eye.6700194"},{"key":"key-10.4103\/1673-5374.335691-4","doi-asserted-by":"crossref","unstructured":"Chen LL (2020) The expanding regulatory mechanisms and cellular functions of circular RNAs. Nat Rev Mol Cell Biol 21:475-490.","DOI":"10.1038\/s41580-020-0243-y"},{"key":"key-10.4103\/1673-5374.335691-5","doi-asserted-by":"crossref","unstructured":"Chen X, Jiang C, Sun R, Yang D, Liu Q (2020a) Circular noncoding RNA NR3C1 acts as a miR-382-5p sponge to protect RPE functions via regulating PTEN\/AKT\/mTOR signaling pathway. Mol Ther 28:929-945.","DOI":"10.1016\/j.ymthe.2020.01.010"},{"key":"key-10.4103\/1673-5374.335691-6","doi-asserted-by":"crossref","unstructured":"Chen XJ, Zhang ZC, Wang XY, Zhao HQ, Li ML, Ma Y, Ji YY, Zhang CJ, Wu KC, Xiang L, Sun LF, Zhou M, Jin ZB (2020b) The circular RNome of developmental retina in mice. Mol Ther Nucleic Acids 19:339-349.","DOI":"10.1016\/j.omtn.2019.11.016"},{"key":"key-10.4103\/1673-5374.335691-7","doi-asserted-by":"crossref","unstructured":"Cheng J, Metge F, Dieterich C (2016) Specific identification and quantification of circular RNAs from sequencing data. Bioinformatics 32:1094-1096.","DOI":"10.1093\/bioinformatics\/btv656"},{"key":"key-10.4103\/1673-5374.335691-8","doi-asserted-by":"crossref","unstructured":"Conn SJ, Pillman KA, Toubia J, Conn VM, Salmanidis M, Phillips CA, Roslan S, Schreiber AW, Gregory PA, Goodall GJ (2015) The RNA binding protein quaking regulates formation of circRNAs. Cell 160:1125-1134.","DOI":"10.1016\/j.cell.2015.02.014"},{"key":"key-10.4103\/1673-5374.335691-9","doi-asserted-by":"crossref","unstructured":"D\u2019Orazi FD, Suzuki SC, Wong RO (2014) Neuronal remodeling in retinal circuit assembly, disassembly, and reassembly. Trends Neurosci 37:594-603.","DOI":"10.1016\/j.tins.2014.07.009"},{"key":"key-10.4103\/1673-5374.335691-10","doi-asserted-by":"crossref","unstructured":"DeAngelis MM, Owen LA, Morrison MA, Morgan DJ, Li M, Shakoor A, Vitale A, Iyengar S, Stambolian D, Kim IK, Farrer LA (2017) Genetics of age-related macular degeneration (AMD). Hum Mol Genet 26:R45-R50.","DOI":"10.1093\/hmg\/ddx228"},{"key":"key-10.4103\/1673-5374.335691-11","doi-asserted-by":"crossref","unstructured":"Dong R, Ma XK, Chen LL, Yang L (2017) Increased complexity of circRNA expression during species evolution. RNA Biol 14:1064-1074.","DOI":"10.1080\/15476286.2016.1269999"},{"key":"key-10.4103\/1673-5374.335691-12","doi-asserted-by":"crossref","unstructured":"Ebbesen KK, Kjems J, Hansen TB (2016) Circular RNAs: identification, biogenesis and function. Biochim Biophys Acta 1859:163-168.","DOI":"10.1016\/j.bbagrm.2015.07.007"},{"key":"key-10.4103\/1673-5374.335691-13","doi-asserted-by":"crossref","unstructured":"Enuka Y, Lauriola M, Feldman ME, Sas-Chen A, Ulitsky I, Yarden Y (2016) Circular RNAs are long-lived and display only minimal early alterations in response to a growth factor. Nucleic Acids Res 44:1370-1383.","DOI":"10.1093\/nar\/gkv1367"},{"key":"key-10.4103\/1673-5374.335691-14","doi-asserted-by":"crossref","unstructured":"Fleckenstein M, Keenan TDL, Guymer RH, Chakravarthy U, Schmitz-Valckenberg S, Klaver CC, Wong WT, Chew EY (2021) Age-related macular degeneration. Nat Rev Dis Primers 7:31.","DOI":"10.1038\/s41572-021-00265-2"},{"key":"key-10.4103\/1673-5374.335691-15","doi-asserted-by":"crossref","unstructured":"Friedman DS, O\u2019Colmain BJ, Munoz B, Tomany SC, McCarty C, de Jong PT, Nemesure B, Mitchell P, Kempen J, Eye Diseases Prevalence Research G (2004) Prevalence of age-related macular degeneration in the United States. Arch Ophthalmol 122:564-572.","DOI":"10.1001\/archopht.122.4.564"},{"key":"key-10.4103\/1673-5374.335691-16","doi-asserted-by":"crossref","unstructured":"Gao Y, Wang J, Zhao F (2015) CIRI: an efficient and unbiased algorithm for de novo circular RNA identification. Genome Biol 16:4.","DOI":"10.1186\/s13059-014-0571-3"},{"key":"key-10.4103\/1673-5374.335691-17","doi-asserted-by":"crossref","unstructured":"Hammes HP, Lin J, Renner O, Shani M, Lundqvist A, Betsholtz C, Brownlee M, Deutsch U (2002) Pericytes and the pathogenesis of diabetic retinopathy. Diabetes 51:3107-3112.","DOI":"10.2337\/diabetes.51.10.3107"},{"key":"key-10.4103\/1673-5374.335691-18","doi-asserted-by":"crossref","unstructured":"Han B, Chao J, Yao H (2018) Circular RNA and its mechanisms in disease: from the bench to the clinic. Pharmacol Ther 187:31-44.","DOI":"10.1016\/j.pharmthera.2018.01.010"},{"key":"key-10.4103\/1673-5374.335691-19","doi-asserted-by":"crossref","unstructured":"Hansen TB, Jensen TI, Clausen BH, Bramsen JB, Finsen B, Damgaard CK, Kjems J (2013) Natural RNA circles function as efficient microRNA sponges. Nature 495:384-388.","DOI":"10.1038\/nature11993"},{"key":"key-10.4103\/1673-5374.335691-20","doi-asserted-by":"crossref","unstructured":"He M, Zhou R, Liu S, Cheng W, Wang W (2021) Circular RNAs: potential star molecules involved in diabetic retinopathy. Curr Eye Res 46:277-283.","DOI":"10.1080\/02713683.2020.1812086"},{"key":"key-10.4103\/1673-5374.335691-21","doi-asserted-by":"crossref","unstructured":"Hoffmann S, Otto C, Doose G, Tanzer A, Langenberger D, Christ S, Kunz M, Holdt LM, Teupser D, Hackerm\u00fcller J, Stadler PF (2014) A multi-split mapping algorithm for circular RNA, splicing, trans-splicing and fusion detection. Genome Biol 15:R34.","DOI":"10.1186\/gb-2014-15-2-r34"},{"key":"key-10.4103\/1673-5374.335691-22","doi-asserted-by":"crossref","unstructured":"Hong H, Sun Y, Deng H, Yuan K, Chen J, Liu W, Cui Z (2019) Dysregulation of cPWWP2A-miR-579 axis mediates dexamethasone-induced cytotoxicity in human osteoblasts. Biochem Biophys Res Commun 517:491-498.","DOI":"10.1016\/j.bbrc.2019.07.095"},{"key":"key-10.4103\/1673-5374.335691-23","doi-asserted-by":"crossref","unstructured":"Ivanov A, Memczak S, Wyler E, Torti F, Porath HT, Orejuela MR, Piechotta M, Levanon EY, Landthaler M, Dieterich C, Rajewsky N (2015) Analysis of intron sequences reveals hallmarks of circular RNA biogenesis in animals. Cell Rep 10:170-177.","DOI":"10.1016\/j.celrep.2014.12.019"},{"key":"key-10.4103\/1673-5374.335691-24","doi-asserted-by":"crossref","unstructured":"Jeck WR, Sharpless NE (2014) Detecting and characterizing circular RNAs. Nat Biotechnol 32:453-461.","DOI":"10.1038\/nbt.2890"},{"key":"key-10.4103\/1673-5374.335691-25","doi-asserted-by":"crossref","unstructured":"Jeck WR, Sorrentino JA, Wang K, Slevin MK, Burd CE, Liu J, Marzluff WF, Sharpless NE (2013) Circular RNAs are abundant, conserved, and associated with ALU repeats. RNA 19:141-157.","DOI":"10.1261\/rna.035667.112"},{"key":"key-10.4103\/1673-5374.335691-26","doi-asserted-by":"crossref","unstructured":"Jiang Q, Liu C, Li CP, Xu SS, Yao MD, Ge HM, Sun YN, Li XM, Zhang SJ, Shan K, Liu BH, Yao J, Zhao C, Yan B (2020) Circular RNA-ZNF532 regulates diabetes-induced retinal pericyte degeneration and vascular dysfunction. J Clin Invest 130:3833-3847.","DOI":"10.1172\/JCI123353"},{"key":"key-10.4103\/1673-5374.335691-27","doi-asserted-by":"crossref","unstructured":"Konkel MK, Walker JA, Hotard AB, Ranck MC, Fontenot CC, Storer J, Stewart C, Marth GT, Batzer MA (2015) Sequence analysis and characterization of active human Alu subfamilies based on the 1000 genomes pilot project. Genome Biol Evol 7:2608-2622.","DOI":"10.1093\/gbe\/evv167"},{"key":"key-10.4103\/1673-5374.335691-28","doi-asserted-by":"crossref","unstructured":"Kristensen LS, Andersen MS, Stagsted LVW, Ebbesen KK, Hansen TB, Kjems J (2019) The biogenesis, biology and characterization of circular RNAs. Nat Rev Genet 20:675-691.","DOI":"10.1038\/s41576-019-0158-7"},{"key":"key-10.4103\/1673-5374.335691-29","doi-asserted-by":"crossref","unstructured":"Kulcheski FR, Christoff AP, Margis R (2016) Circular RNAs are miRNA sponges and can be used as a new class of biomarker. J Biotechnol 238:42-51.","DOI":"10.1016\/j.jbiotec.2016.09.011"},{"key":"key-10.4103\/1673-5374.335691-30","doi-asserted-by":"crossref","unstructured":"Lander ES, Linton LM, Birren B, Nusbaum C, Zody MC, Baldwin J, Devon K, Dewar K, Doyle M, FitzHugh W, Funke R, Gage D, Harris K, Heaford A, Howland J, Kann L, Lehoczky J, LeVine R, McEwan P, McKernan K, et al. (2001) Initial sequencing and analysis of the human genome. Nature 409:860-921.","DOI":"10.1038\/35057062"},{"key":"key-10.4103\/1673-5374.335691-31","doi-asserted-by":"crossref","unstructured":"Lee ECS, Elhassan SAM, Lim GPL, Kok WH, Tan SW, Leong EN, Tan SH, Chan EWL, Bhattamisra SK, Rajendran R, Candasamy M (2019) The roles of circular RNAs in human development and diseases. Biomed Pharmacother 111:198-208.","DOI":"10.1016\/j.biopha.2018.12.052"},{"key":"key-10.4103\/1673-5374.335691-32","doi-asserted-by":"crossref","unstructured":"Li L, Bu D, Zhao Y (2019) CircRNAwrap \u2013 a flexible pipeline for circRNA identification, transcript prediction, and abundance estimation. FEBS Letters 593:1179-1189.","DOI":"10.1002\/1873-3468.13423"},{"key":"key-10.4103\/1673-5374.335691-33","doi-asserted-by":"crossref","unstructured":"Li P, Chen S, Chen H, Mo X, Li T, Shao Y, Xiao B, Guo J (2015) Using circular RNA as a novel type of biomarker in the screening of gastric cancer. Clin Chim Acta 444:132-136.","DOI":"10.1016\/j.cca.2015.02.018"},{"key":"key-10.4103\/1673-5374.335691-34","doi-asserted-by":"crossref","unstructured":"Li X, Yang L, Chen LL (2018) The biogenesis, functions, and challenges of circular RNAs. Mol Cell 71:428-442.","DOI":"10.1016\/j.molcel.2018.06.034"},{"key":"key-10.4103\/1673-5374.335691-35","doi-asserted-by":"crossref","unstructured":"Li X, Liu CX, Xue W, Zhang Y, Jiang S, Yin QF, Wei J, Yao RW, Yang L, Chen LL (2017) Coordinated circRNA biogenesis and function with NF90\/NF110 in viral infection. Mol Cell 67:214-227.","DOI":"10.1016\/j.molcel.2017.05.023"},{"key":"key-10.4103\/1673-5374.335691-36","doi-asserted-by":"crossref","unstructured":"Lima JF, Cerqueira L, Figueiredo C, Oliveira C, Azevedo NF (2018) Anti-miRNA oligonucleotides: a comprehensive guide for design. RNA Biol 15:338-352.","DOI":"10.1080\/15476286.2018.1445959"},{"key":"key-10.4103\/1673-5374.335691-37","doi-asserted-by":"crossref","unstructured":"Lin YC, Lee YC, Chang KL, Hsiao KY (2019) Analysis of common targets for circular RNAs. BMC Bioinformatics 20:372.","DOI":"10.1186\/s12859-019-2966-3"},{"key":"key-10.4103\/1673-5374.335691-38","doi-asserted-by":"crossref","unstructured":"Liu C, Yao MD, Li CP, Shan K, Yang H, Wang JJ, Liu B, Li XM, Yao J, Jiang Q, Yan B (2017) Silencing of circular RNA-ZNF609 ameliorates vascular endothelial dysfunction. Theranostics 7:2863-2877.","DOI":"10.7150\/thno.19353"},{"key":"key-10.4103\/1673-5374.335691-39","doi-asserted-by":"crossref","unstructured":"Liu C, Ge HM, Liu BH, Dong R, Shan K, Chen X, Yao MD, Li XM, Yao J, Zhou RM, Zhang SJ, Jiang Q, Zhao C, Yan B (2019) Targeting pericyte\u2013endothelial cell crosstalk by circular RNA-cPWWP2A inhibition aggravates diabetes-induced microvascular dysfunction. Proc Natl Acad Sci U S A 116:7455.","DOI":"10.1073\/pnas.1814874116"},{"key":"key-10.4103\/1673-5374.335691-40","doi-asserted-by":"crossref","unstructured":"Ma J, Chen XL, Sun Q (2019) microRNA-579 upregulation mediates death of human macrophages with mycobacterium tuberculosis infection. Biochem Biophys Res Commun 518:219-226.","DOI":"10.1016\/j.bbrc.2019.08.035"},{"key":"key-10.4103\/1673-5374.335691-41","doi-asserted-by":"crossref","unstructured":"McLaughlin T, Siddiqi M, Wang JJ, Zhang SX (2019) Loss of XBP1 leads to early-onset retinal neurodegeneration in a mouse model of type I diabetes. J Clin Med 8:906.","DOI":"10.3390\/jcm8060906"},{"key":"key-10.4103\/1673-5374.335691-42","doi-asserted-by":"crossref","unstructured":"Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, Maier L, Mackowiak SD, Gregersen LH, Munschauer M, Loewer A, Ziebold U, Landthaler M, Kocks C, le Noble F, Rajewsky N (2013) Circular RNAs are a large class of animal RNAs with regulatory potency. Nature 495:333-338.","DOI":"10.1038\/nature11928"},{"key":"key-10.4103\/1673-5374.335691-43","doi-asserted-by":"crossref","unstructured":"Metge F, Czaja-Hasse LF, Reinhardt R, Dieterich C (2017) FUCHS-towards full circular RNA characterization using RNAseq. PeerJ 5:e2934.","DOI":"10.7717\/peerj.2934"},{"key":"key-10.4103\/1673-5374.335691-44","doi-asserted-by":"crossref","unstructured":"Nishino J, Yamashita K, Hashiguchi H, Fujii H, Shimazaki T, Hamada H (2004) Meteorin: a secreted protein that regulates glial cell differentiation and promotes axonal extension. Embo J 23:1998-2008.","DOI":"10.1038\/sj.emboj.7600202"},{"key":"key-10.4103\/1673-5374.335691-45","doi-asserted-by":"crossref","unstructured":"Pastor JC, Rojas J, Pastor-Idoate S, Di Lauro S, Gonzalez-Buendia L, Delgado-Tirado S (2016) Proliferative vitreoretinopathy: a new concept of disease pathogenesis and practical consequences. Prog Retin Eye Res 51:125-155.","DOI":"10.1016\/j.preteyeres.2015.07.005"},{"key":"key-10.4103\/1673-5374.335691-46","doi-asserted-by":"crossref","unstructured":"Qin M, Liu G, Huo X, Tao X, Sun X, Ge Z, Yang J, Fan J, Liu L, Qin W (2016) Hsa_circ_0001649: a circular RNA and potential novel biomarker for hepatocellular carcinoma. Cancer Biomark 16:161-169.","DOI":"10.3233\/CBM-150552"},{"key":"key-10.4103\/1673-5374.335691-47","doi-asserted-by":"crossref","unstructured":"Schreiner S, Didio A, Hung LH, Bindereif A (2020) Design and application of circular RNAs with protein-sponge function. Nucleic Acids Res 48:12326-12335.","DOI":"10.1093\/nar\/gkaa1085"},{"key":"key-10.4103\/1673-5374.335691-48","doi-asserted-by":"crossref","unstructured":"Shan K, Liu C, Liu BH, Chen X, Dong R, Liu X, Zhang YY, Liu B, Zhang SJ, Wang JJ, Zhang SH, Wu JH, Zhao C, Yan B (2017) Circular noncoding RNA HIPK3 mediates retinal vascular dysfunction in diabetes mellitus. Circulation 136:1629-1642.","DOI":"10.1161\/CIRCULATIONAHA.117.029004"},{"key":"key-10.4103\/1673-5374.335691-49","doi-asserted-by":"crossref","unstructured":"Song X, Zhang N, Han P, Moon BS, Lai RK, Wang K, Lu W (2016) Circular RNA profile in gliomas revealed by identification tool UROBORUS. Nucleic Acids Res 44:e87.","DOI":"10.1093\/nar\/gkw075"},{"key":"key-10.4103\/1673-5374.335691-50","doi-asserted-by":"crossref","unstructured":"Striglia E, Caccioppo A, Castellino N, Reibaldi M, Porta M (2020) Emerging drugs for the treatment of diabetic retinopathy. Expert Opin Emerg Drugs 25:261-271.","DOI":"10.1080\/14728214.2020.1801631"},{"key":"key-10.4103\/1673-5374.335691-51","doi-asserted-by":"crossref","unstructured":"Syc-Mazurek SB, Libby RT (2019) Axon injury signaling and compartmentalized injury response in glaucoma. Prog Retin Eye Res 73:100769.","DOI":"10.1016\/j.preteyeres.2019.07.002"},{"key":"key-10.4103\/1673-5374.335691-52","doi-asserted-by":"crossref","unstructured":"Thomson DW, Dinger ME (2016) Endogenous microRNA sponges: evidence and controversy. Nat Rev Genet 17:272-283.","DOI":"10.1038\/nrg.2016.20"},{"key":"key-10.4103\/1673-5374.335691-53","doi-asserted-by":"crossref","unstructured":"Uhr K, Sieuwerts AM, de Weerd V, Smid M, Hammerl D, Foekens JA, Martens JWM (2018) Association of microRNA-7 and its binding partner CDR1-AS with the prognosis and prediction of 1st-line tamoxifen therapy in breast cancer. Sci Rep 8:9657.","DOI":"10.1038\/s41598-018-27987-w"},{"key":"key-10.4103\/1673-5374.335691-54","doi-asserted-by":"crossref","unstructured":"Wang JJ, Liu C, Shan K, Liu BH, Li XM, Zhang SJ, Zhou RM, Dong R, Yan B, Sun XH (2018) Circular RNA-ZNF609 regulates retinal neurodegeneration by acting as miR-615 sponge. Theranostics 8:3408-3415.","DOI":"10.7150\/thno.25156"},{"key":"key-10.4103\/1673-5374.335691-55","doi-asserted-by":"crossref","unstructured":"Wang K, Singh D, Zeng Z, Coleman SJ, Huang Y, Savich GL, He X, Mieczkowski P, Grimm SA, Perou CM, MacLeod JN, Chiang DY, Prins JF, Liu J (2010) MapSplice: accurate mapping of RNA-seq reads for splice junction discovery. Nucleic Acids Res 38:e178.","DOI":"10.1093\/nar\/gkq622"},{"key":"key-10.4103\/1673-5374.335691-56","doi-asserted-by":"crossref","unstructured":"Westholm JO, Miura P, Olson S, Shenker S, Joseph B, Sanfilippo P, Celniker SE, Graveley BR, Lai EC (2014) Genome-wide analysis of drosophila circular RNAs reveals their structural and sequence properties and age-dependent neural accumulation. Cell Rep 9:1966-1980.","DOI":"10.1016\/j.celrep.2014.10.062"},{"key":"key-10.4103\/1673-5374.335691-57","doi-asserted-by":"crossref","unstructured":"Wong TY, Mwamburi M, Klein R, Larsen M, Flynn H, Hernandez-Medina M, Ranganathan G, Wirostko B, Pleil A, Mitchell P (2009) Rates of progression in diabetic retinopathy during different time periods: a systematic review and meta-analysis. Diabetes Care 32:2307-2313.","DOI":"10.2337\/dc09-0615"},{"key":"key-10.4103\/1673-5374.335691-58","doi-asserted-by":"crossref","unstructured":"Yang L, Han B, Zhang Z, Wang S, Bai Y, Zhang Y, Tang Y, Du L, Xu L, Wu F, Zuo L, Chen X, Lin Y, Liu K, Ye Q, Chen B, Li B, Tang T, Wang Y, Shen L, et al. (2020) Extracellular vesicle-mediated delivery of circular RNA SCMH1 promotes functional recovery in rodent and nonhuman primate ischemic stroke models. Circulation 142:556-574.","DOI":"10.1161\/CIRCULATIONAHA.120.045765"},{"key":"key-10.4103\/1673-5374.335691-59","doi-asserted-by":"crossref","unstructured":"Yao J, Hu LL, Li XM, Shan K, Zhou RM, Ge HM, Yao MD, Jiang Q, Zhao C, Yan B (2019) Comprehensive circular RNA profiling of proliferative vitreoretinopathy and its clinical significance. Biomed Pharmacother 111:548-554.","DOI":"10.1016\/j.biopha.2018.12.044"},{"key":"key-10.4103\/1673-5374.335691-60","doi-asserted-by":"crossref","unstructured":"You X, Conrad TO (2016) Acfs: accurate circRNA identification and quantification from RNA-Seq data. Sci Rep 6:38820.","DOI":"10.1038\/srep38820"},{"key":"key-10.4103\/1673-5374.335691-61","doi-asserted-by":"crossref","unstructured":"Yu CY, Kuo HC (2019) The emerging roles and functions of circular RNAs and their generation. J Biomed Sci 26:29.","DOI":"10.1186\/s12929-019-0523-z"},{"key":"key-10.4103\/1673-5374.335691-62","doi-asserted-by":"crossref","unstructured":"Zhang SJ, Chen X, Li CP, Li XM, Liu C, Liu BH, Shan K, Jiang Q, Zhao C, Yan B (2017) Identification and characterization of circular RNAs as a new class of putative biomarkers in diabetes retinopathy. Invest Ophthalmol Vis Sci 58:6500-6509.","DOI":"10.1167\/iovs.17-22698"},{"key":"key-10.4103\/1673-5374.335691-63","doi-asserted-by":"crossref","unstructured":"Zhang SX, Ma JH, Bhatta M, Fliesler SJ, Wang JJ (2015) The unfolded protein response in retinal vascular diseases: Implications and therapeutic potential beyond protein folding. Prog Retin Eye Res 45:111-131.","DOI":"10.1016\/j.preteyeres.2014.12.001"},{"key":"key-10.4103\/1673-5374.335691-64","doi-asserted-by":"crossref","unstructured":"Zhang XO, Wang HB, Zhang Y, Lu X, Chen LL, Yang L (2014) Complementary sequence-mediated exon circularization. Cell 159:134-147.","DOI":"10.1016\/j.cell.2014.09.001"},{"key":"key-10.4103\/1673-5374.335691-65","doi-asserted-by":"crossref","unstructured":"Zhang XO, Dong R, Zhang Y, Zhang JL, Luo Z, Zhang J, Chen LL, Yang L (2016) Diverse alternative back-splicing and alternative splicing landscape of circular RNAs. Genome Res 26:1277-1287.","DOI":"10.1101\/gr.202895.115"},{"key":"key-10.4103\/1673-5374.335691-66","doi-asserted-by":"crossref","unstructured":"Zhao C, Yasumura D, Li X, Matthes M, Lloyd M, Nielsen G, Ahern K, Snyder M, Bok D, Dunaief JL, LaVail MM, Vollrath D (2011) mTOR-mediated dedifferentiation of the retinal pigment epithelium initiates photoreceptor degeneration in mice. J Clin Invest 121:369-383.","DOI":"10.1172\/JCI44303"},{"key":"key-10.4103\/1673-5374.335691-67","doi-asserted-by":"crossref","unstructured":"Zhou RM, Wang XQ, Yao J, Shen Y, Chen SN, Yang H, Jiang Q, Yan B (2015) Identification and characterization of proliferative retinopathy-related long noncoding RNAs. Biochem Biophys Res Commun 465:324-330.","DOI":"10.1016\/j.bbrc.2015.07.120"},{"key":"key-10.4103\/1673-5374.335691-68","doi-asserted-by":"crossref","unstructured":"Zhu K, Hu X, Chen H, Li F, Yin N, Liu AL, Shan K, Qin YW, Huang X, Chang Q, Xu GZ, Wang Z (2019) Downregulation of circRNA DMNT3B contributes to diabetic retinal vascular dysfunction through targeting miR-20b-5p and BAMBI. EBioMedicine 49:341-353.","DOI":"10.1016\/j.ebiom.2019.10.004"}],"container-title":["Neural Regeneration Research"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:27:12Z","timestamp":1787164032000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/1673-5374.335691"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":68,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022]]}},"alternative-id":["335691"],"URL":"https:\/\/doi.org\/10.4103\/1673-5374.335691","relation":{},"ISSN":["1673-5374"],"issn-type":[{"value":"1673-5374","type":"print"}],"subject":[],"published":{"date-parts":[[2022]]}}}