{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T20:35:38Z","timestamp":1786739738401,"version":"build-2736575974"},"reference-count":41,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>JOURNAL\/nrgr\/04.03\/01300535-202302000-00050\/figure1\/v\/2026-05-26T054653Z\/r\/image-tiff<\/jats:p>\n                  <jats:p>Methylprednisolone pulse treatment is currently used for optic neuritis. It can speed visual recovery, but does not improve the ultimate visual outcomes. Recent studies have reported that miR-125a-5p has immunomodulatory effects on autoimmune diseases. However, it remains unclear whether miR-125a-5p has effects on optic neuritis. In this study, we used adeno-associated virus to overexpress or silence miR-125a-5p in mice. We found that silencing miR-125a-5p increased the latency of visual evoked potential and aggravated inflammation of the optic nerve. Overexpression of miR-125a-5p suppressed inflammation of the optic nerve, protected retinal ganglion cells, and increased the percentage of Treg cells. Our findings show that miR-125a-5p exhibits anti-inflammatory effects through promoting the differentiation of Treg cells.<\/jats:p>","DOI":"10.4103\/1673-5374.346462","type":"journal-article","created":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T10:10:15Z","timestamp":1658139015000},"page":"451-455","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":8,"title":["Anti-inflammatory effect of miR-125a-5p on experimental optic neuritis by promoting the differentiation of Treg cells"],"prefix":"10.4103","volume":"18","author":[{"given":"Jia-Lin","family":"Zhan","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, the First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Ling","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, the First 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