{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T07:19:05Z","timestamp":1792653545393,"version":"4.5.0"},"reference-count":42,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>JOURNAL\/nrgr\/04.03\/01300535-202302000-00042\/figure1\/v\/2026-05-26T054653Z\/r\/image-tiff<\/jats:p>\n                  <jats:p>\n                    Our previous study demonstrated the potential therapeutic role of human neural stem cell-derived exosomes (hNSC-Exo) in ischemic stroke. Here, we loaded brain-derived neurotrophic factor (BDNF) into exosomes derived from NSCs to construct engineered exosomes (BDNF-hNSC-Exo) and compared their effects with those of hNSC-Exo on ischemic stroke both\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    . In a model of H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    -induced oxidative stress in NSCs, BDNF-hNSC-Exo markedly enhanced cell survival. In a rat middle cerebral artery occlusion model, BDNF-hNSC-Exo not only inhibited the activation of microglia, but also promoted the differentiation of endogenous NSCs into neurons. These results suggest that BDNF can improve the function of NSC-derived exosomes in the treatment of ischemic stroke. Our research may support the clinical use of other neurotrophic factors for central nervous system diseases.\n                  <\/jats:p>","DOI":"10.4103\/1673-5374.346466","type":"journal-article","created":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T10:10:15Z","timestamp":1658139015000},"page":"404-409","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":132,"title":["Neural stem cell-derived exosome as a nano-sized carrier for BDNF delivery to a rat model of ischemic stroke"],"prefix":"10.4103","volume":"18","author":[{"given":"Zhi-Han","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, School of Medicine, Southeast University, Nanjing, Jiangsu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Neuroscience Center, Cancer Center, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waqas","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, School of Medicine, Southeast University, Nanjing, Jiangsu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gui-Long","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, School of Medicine, Southeast University, Nanjing, Jiangsu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao-Qun","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, School of Medicine, Southeast University, Nanjing, Jiangsu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang-Hao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8075-8369","authenticated-orcid":false,"given":"Lu-Kui","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, School of Medicine, Southeast University, Nanjing, Jiangsu Province, China"},{"name":"Department of Neurosurgery, Neuroscience Center, Cancer Center, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong Province, 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