{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:33:04Z","timestamp":1790742784982,"version":"4.1.0"},"reference-count":79,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>JOURNAL\/nrgr\/04.03\/01300535-202302000-00046\/figure1\/v\/2026-05-26T054653Z\/r\/image-tiff<\/jats:p>\n                  <jats:p>High cervical spinal cord injuries induce permanent neuromotor and autonomic deficits. These injuries impact both central respiratory and cardiovascular functions through modulation of the sympathetic nervous system. So far, cardiovascular studies have focused on models of complete contusion or transection at the lower cervical and thoracic levels and diaphragm activity evaluations using invasive methods. The present study aimed to evaluate the impact of C2 hemisection on different parameters representing vital functions (i.e., respiratory function, cardiovascular, and renal filtration parameters) at the moment of injury and 7 days post-injury in rats. No ventilatory parameters evaluated by plethysmography were impacted during quiet breathing after 7 days post-injury, whereas permanent diaphragm hemiplegia was observed by ultrasound and confirmed by diaphragmatic electromyography in anesthetized rats. Interestingly, the mean arterial pressure was reduced immediately after C2 hemisection, with complete compensation at 7 days post-injury. Renal filtration was unaffected at 7 days post-injury; however, remnant systolic dysfunction characterized by a reduced left ventricular ejection fraction persisted at 7 days post-injury. Taken together, these results demonstrated that following C2 hemisection, diaphragm activity and systolic function are impacted up to 7 days post-injury, whereas the respiratory and cardiovascular systems display vast adaptation to maintain ventilatory parameters and blood pressure homeostasis, with the latter likely sustained by the remaining descending sympathetic inputs spared by the initial injury. A better broad characterization of the physiopathology of high cervical spinal cord injuries covering a longer time period post-injury could be beneficial for understanding evaluations of putative therapeutics to further increase cardiorespiratory recovery.<\/jats:p>","DOI":"10.4103\/1673-5374.346469","type":"journal-article","created":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T10:10:15Z","timestamp":1658139015000},"page":"428-433","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":13,"title":["Effects of C2 hemisection on respiratory and cardiovascular functions in rats"],"prefix":"10.4103","volume":"18","author":[{"given":"Pauline","family":"Michel-Flutot","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, UVSQ, Inserm, END-ICAP, Versailles, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Mansart","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, UVSQ, Inserm, Infection et Inflammation (2I), Versailles, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdallah","family":"Fayssoil","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, UVSQ, Inserm, END-ICAP, Versailles, France"},{"name":"Raymond Poincar\u00e9 Hospital, AP-HP, Garches, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7013-1741","authenticated-orcid":false,"given":"St\u00e9phane","family":"Vinit","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, UVSQ, Inserm, END-ICAP, Versailles, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,6,2]]},"reference":[{"key":"R1-20260526","doi-asserted-by":"crossref","first-page":"17018","DOI":"10.1038\/nrdp.2017.18","article-title":"Traumatic spinal cord injury","volume":"3","author":"Ahuja","year":"2017","journal-title":"Nat Rev Dis Primers"},{"key":"R2-20260526","doi-asserted-by":"crossref","first-page":"R135","DOI":"10.1186\/cc10253","article-title":"Relation between mean arterial pressure and renal function in the early phase of shock:a prospective, explorative cohort study","volume":"15","author":"Badin","year":"2011","journal-title":"Crit Care"},{"key":"R3-20260526","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1002\/j.2040-4603.2011.tb00375.x","article-title":"Neuronal control of breathing:sex and stress hormones","volume":"1","author":"Behan","year":"2011","journal-title":"Compr Physiol"},{"key":"R4-20260526","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1179\/2045772314Y.0000000220","article-title":"Ipsilateral inspiratory intercostal muscle activity after C2 spinal cord hemisection in rats","volume":"38","author":"Beth Zimmer","year":"2015","journal-title":"J Spinal Cord Med"},{"key":"R5-20260526","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.expneurol.2018.03.014","article-title":"Spontaneous respiratory plasticity following unilateral high cervical spinal cord injury in behaving rats","volume":"305","author":"Bezdudnaya","year":"2018","journal-title":"Exp Neurol"},{"key":"R6-20260526","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.autneu.2017.02.004","article-title":"Alterations in cardiac autonomic control in spinal cord injury","volume":"209","author":"Biering-S\u00f8rensen","year":"2018","journal-title":"Auton Neurosci"},{"key":"R7-20260526","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0304-3940(01)02557-5","article-title":"Sympathetic blockade significantly improves cardiovascular alterations immediately after spinal cord injury in rats","volume":"319","author":"Bravo","year":"2002","journal-title":"Neurosci Lett"},{"key":"R8-20260526","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.pmr.2020.03.003","article-title":"Predicting outcomes after spinal cord injury","volume":"31","author":"Chay","year":"2020","journal-title":"Phys Med Rehabil Clin N Am"},{"key":"R9-20260526","doi-asserted-by":"crossref","first-page":"105389","DOI":"10.1016\/j.nbd.2021.105389","article-title":"Respiratory axon regeneration in the chronically injured spinal cord","volume":"155","author":"Cheng","year":"2021","journal-title":"Neurobiol Dis"},{"key":"R10-20260526","doi-asserted-by":"crossref","first-page":"105153","DOI":"10.1016\/j.nbd.2020.105153","article-title":"LAR inhibitory peptide promotes recovery of diaphragm function and multiple forms of respiratory neural circuit plasticity after cervical spinal cord injury","volume":"147","author":"Cheng","year":"2021","journal-title":"Neurobiol Dis"},{"key":"R11-20260526","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1172\/JCI110516","article-title":"Increased numbers of alpha receptors in sympathetic denervation supersensitivity in man","volume":"69","author":"Davies","year":"1982","journal-title":"J Clin Investig"},{"key":"R12-20260526","doi-asserted-by":"crossref","first-page":"H861","DOI":"10.1152\/ajpheart.00046.2017","article-title":"A comparison of passive hindlimb cycling and active upper-limb exercise provides new insights into systolic dysfunction after spinal cord injury","volume":"313","author":"DeVeau","year":"2017","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"R13-20260526","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.autneu.2016.12.005","article-title":"Challenging cardiac function post-spinal cord injury with dobutamine","volume":"209","author":"DeVeau","year":"2018","journal-title":"Auton Neurosci"},{"key":"R14-20260526","doi-asserted-by":"crossref","first-page":"e0236490","DOI":"10.1371\/journal.pone.0236490","article-title":"Systolic and diastolic function in chronic spinal cord injury","volume":"15","author":"Ditterline","year":"2020","journal-title":"PLoS One"},{"key":"R15-20260526","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1179\/2045772313Y.0000000161","article-title":"Structural and functional left ventricular impairment in subjects with chronic spinal cord injury and no overt cardiovascular disease","volume":"37","author":"Driussi","year":"2014","journal-title":"J Spinal Cord Med"},{"key":"R16-20260526","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.suc.2017.06.008","article-title":"Trauma:spinal cord injury","volume":"97","author":"Eckert","year":"2017","journal-title":"Surg Clin North Am"},{"key":"R17-20260526","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.ncl.2021.02.004","article-title":"Acute traumatic spinal cord injury","volume":"39","author":"Eli","year":"2021","journal-title":"Neurol Clin"},{"key":"R18-20260526","doi-asserted-by":"crossref","first-page":"103596","DOI":"10.1016\/j.resp.2020.103596","article-title":"Analysis of inspiratory and expiratory muscles using ultrasound in rats:A reproducible and non-invasive tool to study respiratory function","volume":"285","author":"Fayssoil","year":"2021","journal-title":"Respir Physiol Neurobiol"},{"key":"R19-20260526","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3233\/JND-170276","article-title":"Diaphragm:pathophysiology and ultrasound imaging in neuromuscular disorders","volume":"5","author":"Fayssoil","year":"2018","journal-title":"J Neuromuscul Dis"},{"key":"R20-20260526","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1523\/JNEUROSCI.05-08-01993.1985","article-title":"Projections from the ventral respiratory group to phrenic and intercostal motoneurons in cat:an autoradiographic study","volume":"5","author":"Feldman","year":"1985","journal-title":"J Neurosci"},{"key":"R21-20260526","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1146\/annurev-physiol-040510-130049","article-title":"Understanding the rhythm of breathing:so near, yet so far","volume":"75","author":"Feldman","year":"2013","journal-title":"Annu Rev Physiol"},{"key":"R22-20260526","doi-asserted-by":"crossref","first-page":"2993","DOI":"10.1523\/JNEUROSCI.23-07-02993.2003","article-title":"Synaptic pathways to phrenic motoneurons are enhanced by chronic intermittent hypoxia after cervical spinal cord injury","volume":"23","author":"Fuller","year":"2003","journal-title":"J Neurosci"},{"key":"R23-20260526","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.expneurol.2008.01.013","article-title":"Modest spontaneous recovery of ventilation following chronic high cervical hemisection in rats","volume":"211","author":"Fuller","year":"2008","journal-title":"Exp Neurol"},{"key":"R24-20260526","doi-asserted-by":"crossref","first-page":"845","DOI":"10.4103\/1673-5374.208539","article-title":"The crossed phrenic phenomenon","volume":"12","author":"Ghali","year":"2017","journal-title":"Neural Regen Res"},{"key":"R25-20260526","doi-asserted-by":"crossref","first-page":"8680","DOI":"10.1523\/JNEUROSCI.21-21-08680.2001","article-title":"Altered respiratory motor drive after spinal cord injury:Supraspinal and bilateral effects of a unilateral lesion","volume":"21","author":"Golder","year":"2001","journal-title":"J Neurosci"},{"key":"R26-20260526","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1152\/jappl.2001.91.6.2451","article-title":"Cervical spinal cord injury alters the pattern of breathing in anesthetized rats","volume":"91","author":"Golder","year":"2001","journal-title":"J Appl Physiol"},{"key":"R27-20260526","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/0014-4886(79)90201-2","article-title":"Developmental plasticity in the respiratory pathway of the adult rat","volume":"66","author":"Goshgarian","year":"1979","journal-title":"Exp Neurol"},{"key":"R28-20260526","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1152\/japplphysiol.00847.2002","article-title":"The crossed phrenic phenomenon:a model for plasticity in the respiratory pathways following spinal cord injury","volume":"94","author":"Goshgarian","year":"2003","journal-title":"J Appl Physiol (1985)"},{"key":"R29-20260526","doi-asserted-by":"crossref","first-page":"e13634","DOI":"10.14814\/phy2.13634","article-title":"Temporal analysis of cardiovascular control and function following incomplete T3 and T10 spinal cord injury in rodents","volume":"6","author":"Harman","year":"2018","journal-title":"Physiol Rep"},{"key":"R30-20260526","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1002\/j.2040-4603.2014.tb00584.x","article-title":"Autonomic consequences of spinal cord injury","volume":"4","author":"Hou","year":"2014","journal-title":"Compr Physiol"},{"key":"R31-20260526","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1590\/S0102-865020160040000003","article-title":"Evaluation of diaphragmatic mobility following intra-abdominal sub-diaphragmatic fixation of a double-layered mesh in rats","volume":"31","author":"Ioannis","year":"2016","journal-title":"Acta Cir Bras"},{"key":"R32-20260526","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s00210-008-0368-6","article-title":"Ten commercial antibodies for alpha-1-adrenergic receptor subtypes are nonspecific","volume":"379","author":"Jensen","year":"2009","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"R33-20260526","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/s41598-020-80478-9","article-title":"Effects of aerobic exercise training on muscle plasticity in a mouse model of cervical spinal cord injury","volume":"11","author":"Jesus","year":"2021","journal-title":"Sci Rep"},{"key":"R34-20260526","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1152\/jappl.1994.77.4.1972","article-title":"Respiratory muscle compensation for unilateral or bilateral hemidiaphragm paralysis in awake canines","volume":"77","author":"Katagiri","year":"1994","journal-title":"J Appl Physiol"},{"key":"R35-20260526","first-page":"e51235","article-title":"A murine model of cervical spinal cord injury to study post-lesional respiratory neuroplasticity","volume":"87","author":"Keomani","year":"2014","journal-title":"J Vis Exp"},{"key":"R36-20260526","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/0002-9149(86)90027-5","article-title":"Cardiovascular findings in quadriplegic and paraplegic patients and in normal subjects","volume":"58","author":"Kessler","year":"1986","journal-title":"Am J Cardiol"},{"key":"R37-20260526","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0079-6123(05)52014-4","article-title":"The clinical problems in cardiovascular control following spinal cord injury:an overview","volume":"152","author":"Krassioukov","year":"2006","journal-title":"Prog Brain Res"},{"key":"R38-20260526","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0306-4522(95)00294-S","article-title":"Morphological changes in sympathetic preganglionic neurons after spinal cord injury in rats","volume":"70","author":"Krassioukov","year":"1996","journal-title":"Neuroscience"},{"key":"R39-20260526","doi-asserted-by":"crossref","first-page":"R363","DOI":"10.1186\/cc3540","article-title":"Renal blood flow in sepsis","volume":"9","author":"Langenberg","year":"2005","journal-title":"Crit Care"},{"key":"R40-20260526","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.spinee.2015.09.030","article-title":"Spinal cord injury enhances arterial expression and reactivity of \u03b11-adrenergic receptors-mechanistic investigation into autonomic dysreflexia","volume":"16","author":"Lee","year":"2016","journal-title":"Spine J"},{"key":"R41-20260526","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.expneurol.2013.08.003","article-title":"Phrenic motoneuron discharge patterns following chronic cervical spinal cord injury","volume":"249","author":"Lee","year":"2013","journal-title":"Exp Neurol"},{"key":"R42-20260526","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1152\/japplphysiol.01001.2013","article-title":"Respiratory motor outputs following unilateral midcervical spinal cord injury in the adult rat","volume":"116","author":"Lee","year":"2014","journal-title":"J Appl Physiol"},{"key":"R43-20260526","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.expneurol.2014.10.002","article-title":"Hypoxia triggers short term potentiation of phrenic motoneuron discharge after chronic cervical spinal cord injury","volume":"263","author":"Lee","year":"2015","journal-title":"Exp Neurol"},{"key":"R44-20260526","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.resp.2017.07.003","article-title":"Contribution of 5-HT2A receptors on diaphragmatic recovery after chronic cervical spinal cord injury","volume":"244","author":"Lee","year":"2017","journal-title":"Respir Physiol Neurobiol"},{"key":"R45-20260526","doi-asserted-by":"crossref","first-page":"e30555","DOI":"10.1371\/journal.pone.0030555","article-title":"Effect of canagliflozin on renal threshold for glucose, glycemia, and body weight in normal and diabetic animal models","volume":"7","author":"Liang","year":"2012","journal-title":"PLoS One"},{"key":"R46-20260526","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1007\/BF00239518","article-title":"Short latency inputs to phrenic motoneurones from the sensorimotor cortex in the cat","volume":"61","author":"Lipski","year":"1986","journal-title":"Exp Brain Res"},{"key":"R47-20260526","doi-asserted-by":"crossref","first-page":"3591","DOI":"10.1523\/JNEUROSCI.2908-11.2012","article-title":"Repetitive intermittent hypoxia induces respiratory and somatic motor recovery after chronic cervical spinal injury","volume":"32","author":"Lovett-Barr","year":"2012","journal-title":"J Neurosci"},{"key":"R48-20260526","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1152\/japplphysiol.00721.2019","article-title":"Direct comparison of cervical and high thoracic spinal cord injury reveals distinct autonomic and cardiovascular consequences","volume":"128","author":"Lujan","year":"2020","journal-title":"J Appl Physiol"},{"key":"R49-20260526","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1152\/japplphysiol.01104.2017","article-title":"Chronic, complete cervical(6-7) cord transection:distinct autonomic and cardiac deficits","volume":"124","author":"Lujan","year":"2018","journal-title":"J Appl Physiol"},{"key":"R50-20260526","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1152\/jn.00345.2017","article-title":"Impact of glutamatergic and serotonergic neurotransmission on diaphragm muscle activity after cervical spinal hemisection","volume":"118","author":"Mantilla","year":"2017","journal-title":"J Neurophysiol"},{"key":"R51-20260526","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1007\/s00134-013-2823-1","article-title":"Sonographic evaluation of the diaphragm in critically ill patients. Technique and clinical applications","volume":"39","author":"Matamis","year":"2013","journal-title":"Intensive Care Med"},{"key":"R52-20260526","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1089\/089771501750357663","article-title":"Telemetric blood pressure monitoring in conscious rats before and after compression injury of spinal cord","volume":"18","author":"Mayorov","year":"2001","journal-title":"J Neurotrauma"},{"key":"R53-20260526","doi-asserted-by":"crossref","first-page":"103568","DOI":"10.1016\/j.resp.2020.103568","article-title":"Permanent diaphragmatic deficits and spontaneous respiratory plasticity in a mouse model of incomplete cervical spinal cord injury","volume":"284","author":"Michel-Flutot","year":"2021","journal-title":"Respir Physiol Neurobiol"},{"key":"R54-20260526","first-page":"473","article-title":"Effects of chronic high-frequency rTMS protocol on respiratory neuroplasticity following C2 spinal cord hemisection in rats","volume":"11","author":"Michel-Flutot","year":"2022","journal-title":"Biology (Basel)"},{"key":"R55-20260526","doi-asserted-by":"crossref","first-page":"R514","DOI":"10.1152\/ajpregu.00445.2013","article-title":"Apolipoprotein A-I mimetic peptide 4F attenuates kidney injury, heart injury, and endothelial dysfunction in sepsis","volume":"307","author":"Moreira","year":"2014","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"R56-20260526","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.expneurol.2015.02.007","article-title":"Daily acute intermittent hypoxia elicits functional recovery of diaphragm and inspiratory intercostal muscle activity after acute cervical spinal injury","volume":"266","author":"Navarrete-Opazo","year":"2015","journal-title":"Exp Neurol"},{"key":"R57-20260526","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.expneurol.2016.03.026","article-title":"Enhanced recovery of breathing capacity from combined adenosine 2A receptor inhibition and daily acute intermittent hypoxia after chronic cervical spinal injury","volume":"287","author":"Navarrete-Opazo","year":"2017","journal-title":"Exp Neurol"},{"key":"R58-20260526","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1038\/nprot.2008.138","article-title":"Measurement of cardiac function using pressure-volume conductance catheter technique in mice and rats","volume":"3","author":"Pacher","year":"2008","journal-title":"Nat Protoc"},{"key":"R59-20260526","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.cardfail.2015.08.001","article-title":"Echocardiography in acute heart failure:current perspectives","volume":"22","author":"Papadimitriou","year":"2016","journal-title":"J Card Fail"},{"key":"R60-20260526","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1089\/neu.2017.5624","article-title":"Experimental spinal cord injury causes left-ventricular atrophy and is associated with an upregulation of proteolytic pathways","volume":"36","author":"Poormasjedi-Meibod","year":"2019","journal-title":"J Neurotrauma"},{"key":"R61-20260526","doi-asserted-by":"crossref","first-page":"3467","DOI":"10.1089\/neu.2021.0301","article-title":"Ampakines stimulate diaphragm activity after spinal cord injury","volume":"38","author":"Rana","year":"2021","journal-title":"J Neurotrauma"},{"key":"R62-20260526","doi-asserted-by":"crossref","first-page":"E885","DOI":"10.1097\/BRS.0000000000002578","article-title":"Early systemic alterations in severe spinal cord injury:an experimental study on the impact of injury level on renal function","volume":"43","author":"Rodr\u00edguez-Romero","year":"2018","journal-title":"Spine"},{"key":"R63-20260526","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ:25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat Methods"},{"key":"R64-20260526","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1111\/echo.13838","article-title":"Clinical and echocardiographic characteristics of patients in sinus rhythm, normal left ventricular function, and indeterminate diastolic function","volume":"35","author":"Shimron","year":"2018","journal-title":"Echocardiography"},{"key":"R65-20260526","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1016\/j.jacc.2005.11.084","article-title":"Renal impairment and outcomes in heart failure:systematic review and meta-analysis","volume":"47","author":"Smith","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"R66-20260526","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1113\/EP086549","article-title":"Spinal cord injury-induced cardiomyocyte atrophy and impaired cardiac function are severity dependent","volume":"103","author":"Squair","year":"2018","journal-title":"Exp Physiol"},{"key":"R67-20260526","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1089\/neu.2016.4518","article-title":"High thoracic contusion model for the investigation of cardiovascular function after spinal cord injury","volume":"34","author":"Squair","year":"2017","journal-title":"J Neurotrauma"},{"key":"R68-20260526","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1089\/neu.2017.4984","article-title":"Spinal cord injury causes systolic dysfunction and cardiomyocyte atrophy","volume":"35","author":"Squair","year":"2018","journal-title":"J Neurotrauma"},{"key":"R69-20260526","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/s11910-017-0715-4","article-title":"Systemic complications of spinal cord injury","volume":"17","author":"Sweis","year":"2017","journal-title":"Curr Neurol Neurosci Rep"},{"key":"R70-20260526","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1152\/japplphysiol.00055.2011","article-title":"Diaphragm long-term facilitation following acute intermittent hypoxia during wakefulness and sleep","volume":"110","author":"Terada","year":"2011","journal-title":"J Appl Physiol"},{"key":"R71-20260526","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0096-19.2019","article-title":"Long-distance axon regeneration promotes recovery of diaphragmatic respiratory function after spinal cord injury","volume":"6","author":"Urban","year":"2019","journal-title":"eNeuro"},{"key":"R72-20260526","first-page":"56758","article-title":"Retrograde neuroanatomical tracing of phrenic motor neurons in mice","volume":"Exp","author":"Vandeweerd","year":"2018","journal-title":"J Vis"},{"key":"R73-20260526","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1089\/neu.2006.23.1137","article-title":"High cervical lateral spinal cord injury results in long-term ipsilateral hemidiaphragm paralysis","volume":"23","author":"Vinit","year":"2006","journal-title":"J Neurotrauma"},{"key":"R74-20260526","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.resp.2009.08.004","article-title":"Descending bulbospinal pathways and recovery of respiratory motor function following spinal cord injury","volume":"169","author":"Vinit","year":"2009","journal-title":"Respir Physiol Neurobiol"},{"key":"R75-20260526","doi-asserted-by":"crossref","first-page":"e0148180","DOI":"10.1371\/journal.pone.0148180","article-title":"Reorganization of respiratory descending pathways following cervical spinal partial section investigated by transcranial magnetic stimulation in the rat","volume":"11","author":"Vinit","year":"2016","journal-title":"PLoS One"},{"key":"R76-20260526","doi-asserted-by":"crossref","first-page":"4843","DOI":"10.1038\/s41467-018-06937-0","article-title":"Rapid and robust restoration of breathing long after spinal cord injury","volume":"9","author":"Warren","year":"2018","journal-title":"Nat Commun"},{"key":"R77-20260526","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S0306-4522(97)00151-6","article-title":"Changes in immunoreactivity for growth associated protein-43 suggest reorganization of synapses on spinal sympathetic neurons after cord transection","volume":"81","author":"Weaver","year":"1997","journal-title":"Neuroscience"},{"key":"R78-20260526","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/sc.2012.17","article-title":"Influence of the neurological level of spinal cord injury on cardiovascular outcomes in humans:a meta-analysis","volume":"50","author":"West","year":"2012","journal-title":"Spinal Cord"},{"key":"R79-20260526","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1080\/10790268.2019.1669955","article-title":"Ultrasonographic evaluation of diaphragm thickness and excursion in patients with cervical spinal cord injury","volume":"44","author":"Zhu","year":"2021","journal-title":"J Spinal Cord Med"}],"container-title":["Neural Regeneration Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/1673-5374.346469","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T19:31:50Z","timestamp":1786735910000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/1673-5374.346469"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,2]]},"references-count":79,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.4103\/1673-5374.346469","relation":{},"ISSN":["1673-5374","1876-7958"],"issn-type":[{"value":"1673-5374","type":"print"},{"value":"1876-7958","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,2]]},"assertion":[{"value":"2022-01-03","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-22","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}