{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T03:20:40Z","timestamp":1793330440166,"version":"4.5.0"},"reference-count":62,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>JOURNAL\/nrgr\/04.03\/01300535-202303000-00032\/figure1\/v\/2026-05-25T154646Z\/r\/image-tiff<\/jats:p>\n                  <jats:p>\n                    Our previous studies showed that miR-23b was downregulated in patients with intracerebral hemorrhage (ICH). This indicates that miR-23b may be closely related to the patho-physiological mechanism of ICH, but this hypothesis lacks direct evidence. In this study, we established rat models of ICH by injecting collagenase VII into the right basal ganglia and treating them with an injection of bone marrow mesenchymal stem cell (BMSC)-derived exosomal miR-23b via the tail vein. We found that edema in the rat brain was markedly reduced and rat behaviors were improved after BMSC exosomal miR-23b injection compared with those in the ICH groups. Additionally, exosomal miR-23b was transported to the microglia\/macrophages, thereby reducing oxidative stress and pyroptosis after ICH. We also used hemin to mimic ICH conditions\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    . We found that phosphatase and tensin homolog deleted on chromosome 10 (PTEN) was the downstream target gene of miR-23b, and exosomal miR-23b exhibited antioxidant effects by regulating the PTEN\/Nrf2 pathway. Moreover, miR-23b reduced PTEN binding to NOD-like receptor family pyrin domain containing 3 (NLRP3) and NLRP3 inflammasome activation, thereby decreasing the NLRP3-dependent pyroptosis level. These findings suggest that BMSC-derived exosomal miR-23b exhibits antioxidant effects through inhibiting PTEN and alleviating NLRP3 inflammasome-mediated pyroptosis, thereby promoting neurologic function recovery in rats with ICH.\n                  <\/jats:p>","DOI":"10.4103\/1673-5374.346551","type":"journal-article","created":{"date-parts":[[2022,8,22]],"date-time":"2022-08-22T04:59:16Z","timestamp":1661144356000},"page":"560-567","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":60,"title":["Exosomal miR-23b from bone marrow mesenchymal stem cells alleviates oxidative stress and pyroptosis after intracerebral hemorrhage"],"prefix":"10.4103","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3415-4975","authenticated-orcid":false,"given":"Liu-Ting","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong Province, China"},{"name":"Department of Neurology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing-Yang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1172-1490","authenticated-orcid":false,"given":"Yu-Hua","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0995-0294","authenticated-orcid":false,"given":"Zhi-Yi","family":"He","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1518-1030","authenticated-orcid":false,"given":"Wen-Xu","family":"Zheng","sequence":"additional","affiliation":[{"name":"Geriatric Department of Dalian Friendship Hospital, Dalian, Liaoning Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,8,2]]},"reference":[{"key":"R1-20260525","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1146\/annurev.cellbio.23.090506.123406","article-title":"microRNA functions","volume":"23","author":"Bushati","year":"2007","journal-title":"Annu Rev Cell Dev Biol"},{"key":"R2-20260525","doi-asserted-by":"crossref","first-page":"4484","DOI":"10.1038\/s41467-021-24831-0","article-title":"A connexin\/ifi30 pathway bridges HSCs with their niche to dampen oxidative stress","volume":"12","author":"Cacialli","year":"2021","journal-title":"Nat Commun"},{"key":"R3-20260525","doi-asserted-by":"crossref","first-page":"615451","DOI":"10.3389\/fnagi.2020.615451","article-title":"Mitochondria:novel mechanisms and therapeutic targets for secondary brain injury after intracerebral hemorrhage","volume":"12","author":"Chen","year":"2020","journal-title":"Front Aging Neurosci"},{"key":"R4-20260525","doi-asserted-by":"crossref","first-page":"105122","DOI":"10.1016\/j.phrs.2020.105122","article-title":"MitoQ attenuates brain damage by polarizing microglia towards the M2 phenotype through inhibition of the NLRP3 inflammasome after ICH","volume":"161","author":"Chen","year":"2020","journal-title":"Pharmacol Res"},{"key":"R5-20260525","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1007\/s10753-021-01569-x","article-title":"Mechanism of baicalein in brain injury after intracerebral hemorrhage by inhibiting the ROS\/NLRP3 inflammasome pathway","volume":"45","author":"Chen","year":"2022","journal-title":"Inflammation"},{"key":"R6-20260525","doi-asserted-by":"crossref","first-page":"113214","DOI":"10.1016\/j.expneurol.2020.113214","article-title":"l-lysine confers neuroprotection by suppressing inflammatory response via microRNA-575\/PTEN signaling after mouse intracerebral hemorrhage injury","volume":"327","author":"Cheng","year":"2020","journal-title":"Exp Neurol"},{"key":"R8-20260525","doi-asserted-by":"crossref","first-page":"e55375","DOI":"10.1371\/journal.pone.0055375","article-title":"Triggering of inflammasome by aggregated \u03b1-synuclein, an inflammatory response in synucleinopathies","volume":"8","author":"Codolo","year":"2013","journal-title":"PLoS One"},{"key":"R9-20260525","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.4103\/1673-5374.303036","article-title":"P2X7 receptor activation aggravates NADPH oxidase 2-induced oxidative stress after intracerebral hemorrhage","volume":"16","author":"Deng","year":"2021","journal-title":"Neural Regen Res"},{"key":"R10-20260525","first-page":"2992","article-title":"EGF released from human placental mesenchymal stem cells improves premature ovarian insufficiency via NRF2\/HO-1 activation","volume":"12","author":"Ding","year":"2020","journal-title":"Aging (Albany N Y)"},{"key":"R11-20260525","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.neuroscience.2015.03.065","article-title":"Peroxynitrite decomposition catalyst prevents matrix metalloproteinase-9 activation and neurovascular injury after hemoglobin injection into the caudate nucleus of rats","volume":"297","author":"Ding","year":"2015","journal-title":"Neuroscience"},{"key":"R12-20260525","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.2147\/DDDT.S255828","article-title":"Exosomes derived from microRNA-146a-5p-enriched bone marrow mesenchymal stem cells alleviate intracerebral hemorrhage by inhibiting neuronal apoptosis and microglial M1 polarization","volume":"14","author":"Duan","year":"2020","journal-title":"Drug Des Devel Ther"},{"key":"R13-20260525","doi-asserted-by":"crossref","first-page":"68","DOI":"10.3389\/fncel.2020.00068","article-title":"Programmed cell deaths and potential crosstalk with blood-brain barrier dysfunction after hemorrhagic stroke","volume":"14","author":"Fang","year":"2020","journal-title":"Front Cell Neurosci"},{"key":"R14-20260525","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3758\/BF03193146","article-title":"G*Power 3:a flexible statistical power analysis program for the social, behavioral, and biomedical sciences","volume":"39","author":"Faul","year":"2007","journal-title":"Behav Res Methods"},{"key":"R15-20260525","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.3390\/cells9051074","article-title":"Biomaterials to neuroprotect the stroke brain:a large opportunity for narrow time windows","volume":"9","author":"Gonz\u00e1lez-Nieto","year":"2020","journal-title":"Cells"},{"key":"R16-20260525","doi-asserted-by":"crossref","first-page":"174439","DOI":"10.1016\/j.ejphar.2021.174439","article-title":"The neuroprotective effect of phillyrin in intracerebral hemorrhagic mice is produced by activation of the Nrf2 signaling pathway","volume":"909","author":"Guo","year":"2021","journal-title":"Eur J Pharmacol"},{"key":"R17-20260525","doi-asserted-by":"crossref","first-page":"106141","DOI":"10.1016\/j.intimp.2019.106141","article-title":"MicroRNA-152 attenuates neuroinflammation in intracerebral hemorrhage by inhibiting thioredoxin interacting protein (TXNIP)-mediated NLRP3 inflammasome activation","volume":"80","author":"Hu","year":"2020","journal-title":"Int Immunopharmacol"},{"key":"R18-20260525","doi-asserted-by":"crossref","first-page":"105887","DOI":"10.1016\/j.intimp.2019.105887","article-title":"MicroRNA-23b alleviates neuroinflammation and brain injury in intracerebral hemorrhage by targeting inositol polyphosphate multikinase","volume":"76","author":"Hu","year":"2019","journal-title":"Int Immunopharmacol"},{"key":"R19-20260525","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1161\/STROKEAHA.112.659656","article-title":"Microglia\/macrophage polarization dynamics reveal novel mechanism of injury expansion after focal cerebral ischemia","volume":"43","author":"Hu","year":"2012","journal-title":"Stroke"},{"key":"R20-20260525","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1038\/s41556-020-0510-3","article-title":"Myeloid PTEN promotes chemotherapy-induced NLRP3-inflammasome activation and antitumour immunity","volume":"22","author":"Huang","year":"2020","journal-title":"Nat Cell Biol"},{"key":"R21-20260525","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1002\/ana.25356","article-title":"N-acetylcysteine targets 5 lipoxygenase-derived, toxic lipids and can synergize with prostaglandin E(2) to inhibit ferroptosis and improve outcomes following hemorrhagic stroke in mice","volume":"84","author":"Karuppagounder","year":"2018","journal-title":"Ann Neurol"},{"key":"R22-20260525","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/s41580-018-0015-0","article-title":"The functions and regulation of the PTEN tumour suppressor:new modes and prospects","volume":"19","author":"Lee","year":"2018","journal-title":"Nat Rev Mol Cell Biol"},{"key":"R23-20260525","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1002\/tox.23346","article-title":"Long noncoding RNA FAM66C promotes tumor progression and glycolysis in intrahepatic cholangiocarcinoma by regulating hsa-miR-23b-3p\/KCND2 axis","volume":"36","author":"Lei","year":"2021","journal-title":"Environ Toxicol"},{"key":"R24-20260525","doi-asserted-by":"crossref","first-page":"146777","DOI":"10.1016\/j.brainres.2020.146777","article-title":"Exercise ameliorates post-stroke depression by inhibiting PTEN elevation-mediated upregulation of TLR4\/NF-\u03baB\/NLRP3 signaling in mice","author":"Li","year":"2020","journal-title":"Brain Res"},{"key":"R25-20260525","doi-asserted-by":"crossref","first-page":"112864","DOI":"10.1016\/j.yexcr.2021.112864","article-title":"Selenomethionine protects oxidative-stress-damaged bone-marrow-derived mesenchymal stem cells via an antioxidant effect and the PTEN\/PI3K\/AKT pathway","volume":"408","author":"Li","year":"2021","journal-title":"Exp Cell Res"},{"key":"R26-20260525","doi-asserted-by":"crossref","first-page":"667644","DOI":"10.3389\/fphar.2021.667644","article-title":"Total flavones of abelmoschus manihot ameliorates podocyte pyroptosis and injury in high glucose conditions by targeting METTL3-dependent m(6)A modification-mediated NLRP3-inflammasome activation and PTEN\/PI3K\/Akt signaling","volume":"12","author":"Liu","year":"2021","journal-title":"Front Pharmacol"},{"key":"R27-20260525","doi-asserted-by":"crossref","first-page":"675660","DOI":"10.3389\/fimmu.2021.675660","article-title":"Microglia:a double-edged sword in intracerebral hemorrhage from basic mechanisms to clinical research","volume":"12","author":"Liu","year":"2021","journal-title":"Front Immunol"},{"key":"R28-20260525","doi-asserted-by":"crossref","first-page":"582","DOI":"10.2174\/1570159X17666181227170053","article-title":"NLRP3 Inflammasome in the Pathophysiology of Hemorrhagic Stroke:A Review","volume":"17","author":"Luo","year":"2019","journal-title":"Curr Neuropharmacol"},{"key":"R29-20260525","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.tins.2019.11.005","article-title":"Fiery cell death:pyroptosis in the central nervous system","volume":"43","author":"McKenzie","year":"2020","journal-title":"Trends Neurosci"},{"key":"R30-20260525","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/978-1-4939-6728-5_3","article-title":"Immuno-characterization of exosomes using nanoparticle tracking analysis","volume":"1545","author":"McNicholas","year":"2017","journal-title":"Methods Mol Biol"},{"key":"R31-20260525","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1111\/j.1476-5381.2011.01389.x","article-title":"Kaempferol acts through mitogen-activated protein kinases and protein kinase B\/AKT to elicit protection in a model of neuroinflammation in BV2 microglial cells","volume":"164","author":"Park","year":"2011","journal-title":"Br J Pharmacol"},{"key":"R32-20260525","doi-asserted-by":"crossref","first-page":"e3000410","DOI":"10.1371\/journal.pbio.3000410","article-title":"The ARRIVE guidelines 2.0:Updated guidelines for reporting animal research","volume":"18","author":"Percie","year":"2020","journal-title":"PLoS Biol"},{"key":"R33-20260525","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1177\/0271678X20923551","article-title":"Potential therapeutic targets for intracerebral hemorrhage-associated inflammation:An update","volume":"40","author":"Ren","year":"2020","journal-title":"J Cereb Blood Flow Metab"},{"key":"R34-20260525","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1089\/ars.2014.5843","article-title":"The PTEN\/NRF2 axis promotes human carcinogenesis","volume":"21","author":"Rojo","year":"2014","journal-title":"Antioxid Redox Signal"},{"key":"R35-20260525","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1212\/WNL.0000000000002792","article-title":"Sex-related differences in primary intracerebral hemorrhage","volume":"87","author":"Roquer","year":"2016","journal-title":"Neurology"},{"key":"R36-20260525","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.taap.2018.09.014","article-title":"Regulatory crosstalk between the oxidative stress-related transcription factor Nfe2l2\/Nrf2 and mitochondria","volume":"359","author":"Ryoo","year":"2018","journal-title":"Toxicol Appl Pharmacol"},{"key":"R37-20260525","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.tibs.2016.10.004","article-title":"Pyroptosis:gasdermin-mediated programmed necrotic cell death","volume":"42","author":"Shi","year":"2017","journal-title":"Trends Biochem Sci"},{"key":"R38-20260525","first-page":"5040","article-title":"Mesenchymal stem cell-derived exosomes carrying miRNAs in tissue repair and treatment of related diseases:application and advantages","volume":"25","author":"Shi","year":"2021","journal-title":"Zhongguo Zuzhi Gongcheng Yanjiu"},{"key":"R39-20260525","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1007\/s10753-020-01270-5","article-title":"Melatonin attenuates thrombin-induced inflammation in BV2 cells and then protects HT22 cells from apoptosis","volume":"43","author":"Tang","year":"2020","journal-title":"Inflammation"},{"key":"R40-20260525","doi-asserted-by":"crossref","first-page":"29","DOI":"10.5853\/jos.2019.02236","article-title":"Neuroinflammation after intracerebral hemorrhage and potential therapeutic targets","volume":"22","author":"Tschoe","year":"2020","journal-title":"J Stroke"},{"key":"R41-20260525","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/s41418-019-0351-4","article-title":"LncRNA H19 initiates microglial pyroptosis and neuronal death in retinal ischemia\/reperfusion injury","volume":"27","author":"Wan","year":"2020","journal-title":"Cell Death Differ"},{"key":"R42-20260525","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1177\/0300060516630852","article-title":"Differential expression of circulating microRNAs in blood and haematoma samples from patients with intracerebral haemorrhage","volume":"44","author":"Wang","year":"2016","journal-title":"J Int Med Res"},{"key":"R43-20260525","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.freeradbiomed.2018.12.014","article-title":"Melatonin receptor activation provides cerebral protection after traumatic brain injury by mitigating oxidative stress and inflammation via the Nrf2 signaling pathway","volume":"131","author":"Wang","year":"2019","journal-title":"Free Radic Biol Med"},{"key":"R44-20260525","first-page":"652034","article-title":"Safety of mesenchymal stem cells for clinical application","author":"Wang","year":"2012","journal-title":"Stem Cells Int"},{"key":"R45-20260525","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1161\/STROKEAHA.116.014416","article-title":"Natural history of perihematomal edema and impact on outcome after intracerebral hemorrhage","volume":"48","author":"Wu","year":"2017","journal-title":"Stroke"},{"key":"R46-20260525","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S1474-4422(05)70283-0","article-title":"Mechanisms of brain injury after intracerebral haemorrhage","volume":"5","author":"Xi","year":"2006","journal-title":"Lancet Neurol"},{"key":"R47-20260525","doi-asserted-by":"crossref","first-page":"20041","DOI":"10.1074\/jbc.RA118.001858","article-title":"miR-27a-3p protects against blood-brain barrier disruption and brain injury after intracerebral hemorrhage by targeting endothelial aquaporin-11","volume":"293","author":"Xi","year":"2018","journal-title":"J Biol Chem"},{"key":"R48-20260525","doi-asserted-by":"crossref","first-page":"5130","DOI":"10.1007\/s12035-020-02082-2","article-title":"Neuroinflammation mediated by NLRP3 inflammasome after intracerebral hemorrhage and potential therapeutic targets","volume":"57","author":"Xiao","year":"2020","journal-title":"Mol Neurobiol"},{"key":"R49-20260525","doi-asserted-by":"crossref","first-page":"578060","DOI":"10.3389\/fncel.2020.578060","article-title":"Inhibition of NOX4\/ROS suppresses neuronal and blood-brain barrier injury by attenuating oxidative stress after intracerebral hemorrhage","volume":"14","author":"Xie","year":"2020","journal-title":"Front Cell Neurosci"},{"key":"R50-20260525","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1038\/jcbfm.2013.152","article-title":"Systemic administration of exosomes released from mesenchymal stromal cells promote functional recovery and neurovascular plasticity after stroke in rats","volume":"33","author":"Xin","year":"2013","journal-title":"J Cereb Blood Flow Metab"},{"key":"R51-20260525","doi-asserted-by":"crossref","first-page":"5574130","DOI":"10.1155\/2021\/5574130","article-title":"Elevated LINC00909 promotes tumor progression of ovarian cancer via regulating the miR-23b-3p\/MRC2 axis","author":"Yang","year":"2021","journal-title":"Oxid Med Cell Longev"},{"key":"R52-20260525","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s12031-016-0874-9","article-title":"NLRP3 is required for complement-mediated caspase-1 and IL-1beta activation in ICH","volume":"61","author":"Yao","year":"2017","journal-title":"J Mol Neurosci"},{"key":"R53-20260525","doi-asserted-by":"crossref","first-page":"8815441","DOI":"10.1155\/2021\/8815441","article-title":"Mechanisms of oxidative stress and therapeutic targets following intracerebral hemorrhage","author":"Yao","year":"2021","journal-title":"Oxid Med Cell Longev"},{"key":"R54-20260525","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s12974-017-0895-5","article-title":"Isoliquiritigenin alleviates early brain injury after experimental intracerebral hemorrhage via suppressing ROS- and\/or NF-\u03baB-mediated NLRP3 inflammasome activation by promoting Nrf2 antioxidant pathway","volume":"14","author":"Zeng","year":"2017","journal-title":"J Neuroinflammation"},{"key":"R55-20260525","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.gpb.2015.02.001","article-title":"Exosome and exosomal microRNA:trafficking, sorting, and function","volume":"13","author":"Zhang","year":"2015","journal-title":"Genomics Proteomics Bioinformatics"},{"key":"R56-20260525","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.ymthe.2017.11.013","article-title":"miR-23b suppresses leukocyte migration and pathogenesis of experimental autoimmune encephalomyelitis by targeting CCL7","volume":"26","author":"Zhang","year":"2018","journal-title":"Mol Ther"},{"key":"R57-20260525","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/imr.12909","article-title":"The regulation of the ZBP1-NLRP3 inflammasome and its implications in pyroptosis, apoptosis, and necroptosis (PANoptosis)","volume":"297","author":"Zheng","year":"2020","journal-title":"Immunol Rev"},{"key":"R58-20260525","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1177\/0271678X16648712","article-title":"Regulatory T cells ameliorate intracerebral hemorrhage-induced inflammatory injury by modulating microglia\/macrophage polarization through the IL-10\/GSK3\u03b2\/PTEN axis","volume":"37","author":"Zhou","year":"2017","journal-title":"J Cereb Blood Flow Metab"},{"key":"R59-20260525","doi-asserted-by":"crossref","first-page":"9729","DOI":"10.1021\/acsami.1c00491","article-title":"Efficient iron and ROS nanoscavengers for brain protection after intracerebral hemorrhage","volume":"13","author":"Zhu","year":"2021","journal-title":"ACS Appl Mater Interfaces"},{"key":"R60-20260525","doi-asserted-by":"crossref","first-page":"101610","DOI":"10.1016\/j.pneurobio.2019.03.003","article-title":"Role and mechanisms of cytokines in the secondary brain injury after intracerebral hemorrhage","volume":"178","author":"Zhu","year":"2019","journal-title":"Prog Neurobiol"},{"key":"R61-20260525","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1038\/nm.2815","article-title":"The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-\u03b1","volume":"18","author":"Zhu","year":"2012","journal-title":"Nat Med"},{"key":"R62-20260525","doi-asserted-by":"crossref","first-page":"e0133783","DOI":"10.1371\/journal.pone.0133783","article-title":"Association of altered serum microRNAs with perihematomal edema after acute intracerebral hemorrhage","volume":"10","author":"Zhu","year":"2015","journal-title":"PLoS One"},{"key":"R63-20260525","doi-asserted-by":"crossref","first-page":"210","DOI":"10.4103\/1673-5374.314320","article-title":"Intranasal insulin ameliorates neurological impairment after intracerebral hemorrhage in mice","volume":"17","author":"Zhu","year":"2022","journal-title":"Neural Regen Res"}],"container-title":["Neural Regeneration Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/1673-5374.346551","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T19:30:56Z","timestamp":1786735856000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/1673-5374.346551"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,2]]},"references-count":62,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.4103\/1673-5374.346551","relation":{},"ISSN":["1673-5374","1876-7958"],"issn-type":[{"value":"1673-5374","type":"print"},{"value":"1876-7958","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,2]]},"assertion":[{"value":"2022-01-16","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-24","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}