{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:23:22Z","timestamp":1792801402751,"version":"4.5.0"},"reference-count":115,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Parkinson\u2019s disease is a neurodegenerative condition characterized by motor impairments caused by the selective loss of dopaminergic neurons in the substantia nigra. Levodopa is an effective and well-tolerated dopamine replacement agent. However, levodopa provides only symptomatic improvements, without affecting the underlying pathology, and is associated with side effects after long-term use. Cell-based replacement is a promising strategy that offers the possibility to replace lost neurons in Parkinson\u2019s disease treatment. Clinical studies of transplantation of human fetal ventral mesencephalic tissue have provided evidence that the grafted dopaminergic neurons can reinnervate the striatum, release dopamine, integrate into the host neural circuits, and improve motor functions. One of the limiting factors for cell therapy in Parkinson\u2019s disease is the low survival rate of grafted dopaminergic cells. Different factors could cause cell death of dopaminergic neurons after grafting such as mechanical trauma, growth factor deprivation, hypoxia, and neuroinflammation. Neurotrophic factors play an essential role in the survival of grafted cells. However, direct, timely, and controllable delivery of neurotrophic factors into the brain faces important limitations. Different types of cells secrete neurotrophic factors constitutively and co-transplantation of these cells with dopaminergic neurons represents a feasible strategy to increase neuronal survival. In this review, we provide a general overview of the pioneering studies on cell transplantation developed in patients and animal models of Parkinson\u2019s disease, with a focus on neurotrophic factor-secreting cells, with a particular interest in mesenchymal stromal cells; that co-implanted with dopaminergic neurons would serve as a strategy to increase cell survival and improve graft outcomes.<\/jats:p>","DOI":"10.4103\/1673-5374.350193","type":"journal-article","created":{"date-parts":[[2022,8,22]],"date-time":"2022-08-22T04:59:16Z","timestamp":1661144356000},"page":"478-484","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":37,"title":["Combined cell-based therapy strategies for the treatment of Parkinson\u2019s disease: focus on mesenchymal stromal cells"],"prefix":"10.4103","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6865-2433","authenticated-orcid":false,"given":"Jannette","family":"Rodr\u00edguez-Pallares","sequence":"first","affiliation":[{"name":"Laboratory of Cellular and Molecular Neurobiology of Parkinson\u00b4s Disease, Research Center for Molecular Medicine and Chronic Diseases (CiMUS), IDIS, Department of Morphological Sciences, University of Santiago de Compostela, Santiago de Compostela, Spain"},{"name":"Networking Research Center on Neurodegenerative Diseases (CIBERNED), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7155-7234","authenticated-orcid":false,"given":"Mar\u00eda","family":"Garc\u00eda-Garrote","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular and Molecular Neurobiology of Parkinson\u00b4s Disease, Research Center for Molecular Medicine and Chronic Diseases (CiMUS), IDIS, Department of Morphological Sciences, University of Santiago de Compostela, Santiago de Compostela, Spain"},{"name":"Networking Research Center on Neurodegenerative Diseases (CIBERNED), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2072-5642","authenticated-orcid":false,"given":"Juan A.","family":"Parga","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular and Molecular Neurobiology of Parkinson\u00b4s Disease, Research Center for Molecular Medicine and Chronic Diseases (CiMUS), IDIS, Department of Morphological Sciences, University of Santiago de Compostela, Santiago de Compostela, Spain"},{"name":"Networking Research Center on Neurodegenerative Diseases (CIBERNED), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8243-9791","authenticated-orcid":false,"given":"Jos\u00e9 Luis","family":"Labandeira-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular and Molecular Neurobiology of Parkinson\u00b4s Disease, Research Center for Molecular Medicine and Chronic Diseases (CiMUS), IDIS, Department of Morphological Sciences, University of Santiago de Compostela, Santiago de Compostela, Spain"},{"name":"Networking Research Center on Neurodegenerative Diseases (CIBERNED), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,8,2]]},"reference":[{"key":"R2-20260525","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.nbd.2004.04.014","article-title":"Olfactory ensheathing cell transplantation restores functional deficits in a rat model of Parkinson's disease:a cotransplantation approach with fetal ventral mesencephalic cells","volume":"16","author":"Agrawal","year":"2004","journal-title":"Neurobiol Dis"},{"key":"R3-20260525","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0304-3940(84)90328-8","article-title":"Fetal mesencephalic 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