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In addition to its canonical nuclear functions in DNA damage response circuits, ataxia-telangiectasia mutated functions in various cytoplasmic and mitochondrial processes that are critically important for cellular homeostasis. We discuss these functions with a focus on the role of ataxia-telangiectasia mutated in maintaining the homeostatic redox state. Finally, we describe the unique functions of ataxia-telangiectasia mutated in various types of neuronal and glial cells including cerebellar granule neurons, astrocytes, and microglial cells.<\/jats:p>","DOI":"10.4103\/1673-5374.350194","type":"journal-article","created":{"date-parts":[[2022,8,22]],"date-time":"2022-08-22T04:59:16Z","timestamp":1661144356000},"page":"497-502","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":18,"title":["Ataxia-telangiectasia mutated plays an important role in cerebellar integrity and functionality"],"prefix":"10.4103","volume":"18","author":[{"given":"Yulia","family":"Mitiagin","sequence":"first","affiliation":[{"name":"Department of Neurobiology, the School of Neurobiology, Biophysics, Molecular Biology and Biochemistry, George S. 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