{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T13:19:47Z","timestamp":1790169587570,"version":"4.1.0"},"reference-count":98,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:p>\n                    The inability of damaged neurons to regenerate within the mature central nervous system (CNS) is a significant neuroscientific challenge. Astrocytes are an essential component of the CNS and participate in many physiological processes including blood-brain barrier formation, axon growth regulation, neuronal support, and higher cognitive functions such as memory. Recent reprogramming studies have confirmed that astrocytes in the mature CNS can be transformed into functional neurons. Building on\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    work, many studies have demonstrated that astrocytes can be transformed into neurons in different disease models to replace damaged or lost cells. However, many findings in this field are controversial, as the source of new neurons has been questioned. This review summarizes progress in reprogramming astrocytes into neurons\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    in animal models of spinal cord injury, brain injury, Huntington\u2019s disease, Parkinson\u2019s disease, Alzheimer\u2019s disease, and other neurodegenerative conditions.\n                  <\/jats:p>","DOI":"10.4103\/1673-5374.353482","type":"journal-article","created":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T07:48:01Z","timestamp":1663746481000},"page":"750-755","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":49,"title":["In vivo astrocyte-to-neuron reprogramming for central nervous system regeneration: a narrative review"],"prefix":"10.4103","volume":"18","author":[{"given":"Zuliyaer","family":"Talifu","sequence":"first","affiliation":[{"name":"School of Rehabilitation, Capital Medical University, Beijing, China"},{"name":"Department of Spinal 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Zhu","family":"Pan","sequence":"additional","affiliation":[{"name":"School of Rehabilitation, Capital Medical University, Beijing, China"},{"name":"Department of Spinal and Neural Functional Reconstruction, China Rehabilitation Research Center, Beijing, China;"},{"name":"Chinese Institute of Rehabilitation Science, Beijing, China"},{"name":"Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, China"},{"name":"Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Ke","sequence":"additional","affiliation":[{"name":"School of Rehabilitation, Capital Medical University, Beijing, China"},{"name":"Department of Spinal and Neural Functional Reconstruction, China Rehabilitation Research Center, Beijing, China;"},{"name":"Chinese Institute of Rehabilitation Science, Beijing, China"},{"name":"Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, China"},{"name":"Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Jia","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Rehabilitation, Capital Medical University, Beijing, China"},{"name":"Department of Spinal and Neural Functional Reconstruction, China Rehabilitation Research Center, Beijing, China;"},{"name":"Chinese Institute of Rehabilitation Science, Beijing, China"},{"name":"Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, China"},{"name":"Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Rehabilitation, Capital Medical University, Beijing, 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