{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T07:58:48Z","timestamp":1790409528391,"version":"4.1.0"},"reference-count":179,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    In recent years, the pharmacological benefits of herbal extracts have been revisited for their potential neuroprotective effects in glaucoma. The polysaccharides extracted from the fruits of\n                    <jats:italic toggle=\"yes\">Lycium barbarum<\/jats:italic>\n                    L., or\n                    <jats:italic toggle=\"yes\">Lycium barbarum<\/jats:italic>\n                    polysaccharides, exert their anti-aging effect through reducing oxidative stress, modulating the immune response, enhancing neuronal responses, and promoting cytoprotection. The therapeutic efficacy of\n                    <jats:italic toggle=\"yes\">Lycium barbarum<\/jats:italic>\n                    polysaccharides in preserving retinal ganglion cells and their functions was demonstrated in a range of experimental models of optic neuropathies. These include the acute and chronic ocular hypertension models, the partial optic nerve transection model, and the ischemic-reperfusion injuries model. Based on these findings,\n                    <jats:italic toggle=\"yes\">Lycium barbarum<\/jats:italic>\n                    polysaccharides appear to be a good candidate to be developed as a neuroprotective agent for treating multifactorial diseases. This review aims to present a comprehensive review on the latest preclinical evidence on the pre- and post-treatment benefits of\n                    <jats:italic toggle=\"yes\">Lycium barbarum<\/jats:italic>\n                    polysaccharides in retinal ganglion cell neuroprotection. The possible mechanisms of\n                    <jats:italic toggle=\"yes\">Lycium barbarum<\/jats:italic>\n                    polysaccharides mediating retinal ganglion cell neuroprotection will also be described. Moreover, the potential research gaps in the effective translation of\n                    <jats:italic toggle=\"yes\">Lycium barbarum<\/jats:italic>\n                    polysaccharides treatment into clinical glaucoma management will be discussed.\n                  <\/jats:p>","DOI":"10.4103\/1673-5374.355977","type":"journal-article","created":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T10:19:25Z","timestamp":1668766765000},"page":"2623-2632","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":18,"title":["Potential role of Lycium barbarum polysaccharides in glaucoma management: evidence from preclinical in vivo studies"],"prefix":"10.4103","volume":"18","author":[{"given":"Yamunadevi","family":"Lakshmanan","sequence":"first","affiliation":[{"name":"Centre for Eye and Vision Research (CEVR), 17W Hong Kong Science Park, Hong Kong Special Administrative Region, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisca Siu Yin","family":"Wong","sequence":"additional","affiliation":[{"name":"Centre for Eye and Vision Research (CEVR), 17W Hong Kong Science Park, Hong Kong Special Administrative Region, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwok-Fai","family":"So","sequence":"additional","affiliation":[{"name":"Guangdong-Hongkong-Macau (GHM) Institute of CNS Regeneration, Jinan University, Guangzhou, Guangdong Province, China"},{"name":"Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8516-4711","authenticated-orcid":false,"given":"Henry Ho-Lung","family":"Chan","sequence":"additional","affiliation":[{"name":"Centre for Eye and Vision Research (CEVR), 17W Hong Kong Science Park, Hong Kong Special Administrative Region, China"},{"name":"Laboratory of Experimental Optometry (Neuroscience), School of Optometry, The Hong Kong Polytechnic University, Hong Kong Special Administrative Region, China"},{"name":"Research Centre for SHARP Vision (RCSV), The Hong Kong Polytechnic University, Hong Kong Special Administrative Region, China"},{"name":"University Research Facilities in Behavioral and Systems Neuroscience (UBSN), The Hong Kong Polytechnic University, Hong Kong Special Administrative Region, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,5,12]]},"reference":[{"key":"R2-20260525","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.1167\/iovs.05-1639","article-title":"Mitochondrial abnormalities in patients with primary open-angle glaucoma","volume":"47","author":"Abu-Amero","year":"2006","journal-title":"Invest Ophthalmol Vis 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