{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T15:46:14Z","timestamp":1790178374156,"version":"4.1.0"},"reference-count":68,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>JOURNAL\/nrgr\/04.03\/01300535-202309000-00023\/figure1\/v\/2026-05-25T155815Z\/r\/image-tiff<\/jats:p>\n                  <jats:p>Patients with age-related hearing loss face hearing difficulties in daily life. The causes of age-related hearing loss are complex and include changes in peripheral hearing, central processing, and cognitive-related abilities. Furthermore, the factors by which aging relates to hearing loss via changes in auditory processing ability are still unclear. In this cross-sectional study, we evaluated 27 older adults (over 60 years old) with age-related hearing loss, 21 older adults (over 60 years old) with normal hearing, and 30 younger subjects (18\u201330 years old) with normal hearing. We used the outcome of the upper-threshold test, including the time-compressed threshold and the speech recognition threshold in noisy conditions, as a behavioral indicator of auditory processing ability. We also used electroencephalography to identify presbycusis-related abnormalities in the brain while the participants were in a spontaneous resting state. The time-compressed threshold and speech recognition threshold data indicated significant differences among the groups. In patients with age-related hearing loss, information masking (babble noise) had a greater effect than energy masking (speech-shaped noise) on processing difficulties. In terms of resting-state electroencephalography signals, we observed enhanced frontal lobe (Brodmann\u2019s area, BA11) activation in the older adults with normal hearing compared with the younger participants with normal hearing, and greater activation in the parietal (BA7) and occipital (BA19) lobes in the individuals with age-related hearing loss compared with the younger adults. Our functional connection analysis suggested that compared with younger people, the older adults with normal hearing exhibited enhanced connections among networks, including the default mode network, sensorimotor network, cingulo-opercular network, occipital network, and frontoparietal network. These results suggest that both normal aging and the development of age-related hearing loss have a negative effect on advanced auditory processing capabilities and that hearing loss accelerates the decline in speech comprehension, especially in speech competition situations. Older adults with normal hearing may have increased compensatory attentional resource recruitment represented by the top-down active listening mechanism, while those with age-related hearing loss exhibit decompensation of network connections involving multisensory integration.<\/jats:p>","DOI":"10.4103\/1673-5374.361530","type":"journal-article","created":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T10:19:25Z","timestamp":1668766765000},"page":"1968-1975","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":14,"title":["Age-related hearing loss accelerates the decline in fast speech comprehension and the decompensation of cortical network connections"],"prefix":"10.4103","volume":"18","author":[{"given":"He-Mei","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, China"},{"name":"Institute of Hearing and Speech-Language Science, Sun Yat-sen University, Guangzhou, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gui-Sheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, China"},{"name":"Institute of Hearing and Speech-Language Science, Sun Yat-sen University, Guangzhou, Guangdong Province, China"},{"name":"Department of Otolaryngology, Shenzhen-Shanwei Central Hospital, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Shanwei, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong-Yi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Guangdong Provincial Work Injury Rehabilitation Hospital, Guangzhou, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-Lin","family":"Meng","sequence":"additional","affiliation":[{"name":"Acoustics Lab of School of Physics and Optoelectronics and State Key Laboratory of Subtropical Building Science, South China University of Technology, Guangzhou, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Hong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, China"},{"name":"Institute of Hearing and Speech-Language Science, Sun Yat-sen University, Guangzhou, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han-Wen","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, China"},{"name":"Institute of Hearing and Speech-Language Science, Sun Yat-sen University, Guangzhou, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Chen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Speech and Language Therapy and Hearing Science, Cardiff Metropolitan University, Cardiff, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Wu","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, China"},{"name":"Institute of Hearing and Speech-Language Science, Sun Yat-sen University, Guangzhou, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Liang","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Shenzhen Baoan Maternal and Child Health Hospital, Shenzhen, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi-Ming","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Shenzhen Baoan Maternal and Child Health Hospital, Shenzhen, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2434-9747","authenticated-orcid":false,"given":"Yue-Xin","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, China"},{"name":"Institute of Hearing and Speech-Language Science, Sun Yat-sen University, Guangzhou, Guangdong Province, China"},{"name":"Department of Otolaryngology, Shenzhen-Shanwei Central Hospital, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Shanwei, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3641-1640","authenticated-orcid":false,"given":"Yi-Qing","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, China"},{"name":"Institute of Hearing and Speech-Language Science, Sun Yat-sen University, Guangzhou, Guangdong Province, China"},{"name":"Department of Otolaryngology, Shenzhen-Shanwei Central Hospital, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Shanwei, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,11,25]]},"reference":[{"key":"R1-20260525","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1007\/s40520-019-01233-3","article-title":"Effects of aging on spatial hearing","volume":"32","author":"Adel","year":"2020","journal-title":"Aging Clin Exp Res"},{"key":"R2-20260525","doi-asserted-by":"crossref","first-page":"10503","DOI":"10.1523\/JNEUROSCI.1103-13.2013","article-title":"The autonomic brain:an activation likelihood estimation meta-analysis for central processing of autonomic function","volume":"33","author":"Beissner","year":"2013","journal-title":"J Neurosci"},{"key":"R3-20260525","doi-asserted-by":"crossref","first-page":"5739","DOI":"10.1523\/JNEUROSCI.3382-17.2018","article-title":"Cortical oscillatory mechanisms supporting the control of human social-emotional actions","volume":"38","author":"Bramson","year":"2018","journal-title":"J Neurosci"},{"key":"R4-20260525","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.neurobiolaging.2013.08.033","article-title":"Age-related deterioration of the representation of space in human auditory cortex","volume":"35","author":"Briley","year":"2014","journal-title":"Neurobiol Aging"},{"key":"R5-20260525","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1196\/annals.1440.011","article-title":"The brain's default network:anatomy, function, and relevance to disease","volume":"1124","author":"Buckner","year":"2008","journal-title":"Ann N Y Acad Sci"},{"key":"R6-20260525","doi-asserted-by":"crossref","first-page":"e13314","DOI":"10.1111\/psyp.13314","article-title":"Electrophysiology as a theoretical and methodological hub for the neural sciences","volume":"56","author":"Cavanagh","year":"2019","journal-title":"Psychophysiology"},{"key":"R7-20260525","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1093\/brain\/awl004","article-title":"The precuneus:a review of its functional anatomy and behavioural correlates","volume":"129","author":"Cavanna","year":"2006","journal-title":"Brain"},{"key":"R8-20260525","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1016\/j.neuroimage.2008.01.020","article-title":"Human secondary somatosensory cortex is involved in the processing of somatosensory rare stimuli:an fMRI study","volume":"40","author":"Chen","year":"2008","journal-title":"Neuroimage"},{"key":"R9-20260525","doi-asserted-by":"crossref","first-page":"e0157443","DOI":"10.1371\/journal.pone.0157443","article-title":"Investigating default mode and sensorimotor network connectivity in amyotrophic lateral sclerosis","volume":"11","author":"Chenji","year":"2016","journal-title":"PLoS One"},{"key":"R10-20260525","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1007\/s00415-020-10331-6","article-title":"Effect of cognitive reserve on structural and functional MRI measures in healthy subjects:a multiparametric assessment","volume":"268","author":"Conti","year":"2021","journal-title":"J Neurol"},{"key":"R11-20260525","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1523\/JNEUROSCI.3341-08.2009","article-title":"Abnormal neural filtering of irrelevant visual information in depression","volume":"29","author":"Desseilles","year":"2009","journal-title":"J Neurosci"},{"key":"R12-20260525","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s10162-018-00703-1","article-title":"Time-compressed speech identification is predicted by auditory neural processing, perceptuomotor speed, and executive functioning in younger and older listeners","volume":"20","author":"Dias","year":"2019","journal-title":"J Assoc Res Otolaryngol"},{"key":"R13-20260525","doi-asserted-by":"crossref","first-page":"E1598","DOI":"10.1073\/pnas.1715766115","article-title":"Heterogeneity within the frontoparietal control network and its relationship to the default and dorsal attention networks","volume":"115","author":"Dixon","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R14-20260525","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1152\/jn.00951.2010","article-title":"Influence of aging on human sound localization","volume":"105","author":"Dobreva","year":"2011","journal-title":"J Neurophysiol"},{"key":"R15-20260525","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1002\/hbm.21276","article-title":"sLORETA allows reliable distributed source reconstruction based on subdural strip and grid recordings","volume":"33","author":"D\u00fcmpelmann","year":"2012","journal-title":"Hum Brain Mapp"},{"key":"R16-20260525","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.3389\/fpsyg.2019.02485","article-title":"Functional connectivity of Heschl's gyrus associated with age-related hearing loss:a resting-state fMRI study","volume":"10","author":"Fitzhugh","year":"2019","journal-title":"Front Psychol"},{"key":"R17-20260525","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1121\/1.1327578","article-title":"Recognition of time-distorted sentences by normal-hearing and cochlear-implant listeners","volume":"109","author":"Fu","year":"2001","journal-title":"J Acoust Soc Am"},{"key":"R18-20260525","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1093\/cercor\/bhu012","article-title":"A brain-wide study of age-related changes in functional connectivity","volume":"25","author":"Geerligs","year":"2015","journal-title":"Cereb Cortex"},{"key":"R19-20260525","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1121\/1.2642072","article-title":"Auditory and nonauditory factors affecting speech reception in noise by older listeners","volume":"121","author":"George","year":"2007","journal-title":"J Acoust Soc Am"},{"key":"R20-20260525","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.heares.2016.11.004","article-title":"Masked speech perception across the adult lifespan:Impact of age and hearing impairment","volume":"344","author":"Goossens","year":"2017","journal-title":"Hear Res"},{"key":"R21-20260525","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1044\/jshr.3606.1276","article-title":"Temporal factors and speech recognition performance in young and elderly listeners","volume":"36","author":"Gordon-Salant","year":"1993","journal-title":"J Speech Hear Res"},{"key":"R22-20260525","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1073\/pnas.0135058100","article-title":"Functional connectivity in the resting brain:a network analysis of the default mode hypothesis","volume":"100","author":"Greicius","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R23-20260525","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0278-2626(03)00011-3","article-title":"Central and autonomic nervous system integration in emotion","volume":"52","author":"Hagemann","year":"2003","journal-title":"Brain Cogn"},{"key":"R24-20260525","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.biopsych.2017.10.030","article-title":"The multifaceted role of the ventromedial prefrontal cortex in emotion, decision making, social cognition, and psychopathology","volume":"83","author":"Hiser","year":"2018","journal-title":"Biol Psychiatry"},{"key":"R25-20260525","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1097\/00004647-199601000-00002","article-title":"Nonparametric analysis of statistic images from functional mapping experiments","volume":"16","author":"Holmes","year":"1996","journal-title":"J Cereb Blood Flow Metab"},{"key":"R26-20260525","doi-asserted-by":"crossref","first-page":"508","DOI":"10.3758\/s13414-012-0406-9","article-title":"Are age-related changes in cognitive function driven by age-related changes in sensory processing?","volume":"75","author":"Humes","year":"2013","journal-title":"Atten Percept Psychophys"},{"key":"R27-20260525","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3389\/fnsys.2014.00010","article-title":"The effect of mild-to-moderate hearing loss on auditory and emotion processing networks","volume":"8","author":"Husain","year":"2014","journal-title":"Front Syst Neurosci"},{"key":"R28-20260525","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1212\/WNL.0b013e318233b33d","article-title":"Age-related changes in the default mode network are more advanced in Alzheimer disease","volume":"77","author":"Jones","year":"2011","journal-title":"Neurology"},{"key":"R29-20260525","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/377155a0","article-title":"Functional MRI evidence for adult motor cortex plasticity during motor skill learning","volume":"377","author":"Karni","year":"1995","journal-title":"Nature"},{"key":"R30-20260525","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.apacoust.2016.06.009","article-title":"Time-compressed speech intelligibility in different reverberant conditions","volume":"113","author":"Koci\u0144ski","year":"2016","journal-title":"Appl Acoust"},{"key":"R31-20260525","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1126\/science.1142995","article-title":"Anterior prefrontal function and the limits of human decision-making","volume":"318","author":"Koechlin","year":"2007","journal-title":"Science"},{"key":"R32-20260525","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1055\/s-0028-1094615","article-title":"Reflections on the topics:EEG frequency bands and regulation of vigilance","volume":"12","author":"Kubicki","year":"1979","journal-title":"Pharmakopsychiatr Neuropsychopharmakol"},{"key":"R33-20260525","first-page":"161","article-title":"Auditory brainstem response clinical practice-technology application to disease diagnosis","volume":"20","author":"Lan","year":"2022","journal-title":"Zhongguo Tingli Yuyan Kangfu Kexue Zazhi"},{"key":"R34-20260525","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1002\/1097-0193(200007)10:3<120::AID-HBM30>3.0.CO;2-8","article-title":"Automated Talairach atlas labels for functional brain mapping","volume":"10","author":"Lancaster","year":"2000","journal-title":"Hum Brain Mapp"},{"key":"R35-20260525","doi-asserted-by":"crossref","first-page":"487","DOI":"10.3233\/JAD-160119","article-title":"Mini-mental state examination in elderly Chinese:a population-based normative study","volume":"53","author":"Li","year":"2016","journal-title":"J Alzheimers Dis"},{"key":"R36-20260525","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/S0896-6273(02)00612-8","article-title":"Under-recruitment and nonselective recruitment:dissociable neural mechanisms associated with aging","volume":"33","author":"Logan","year":"2002","journal-title":"Neuron"},{"key":"R37-20260525","doi-asserted-by":"crossref","first-page":"6574178","DOI":"10.1155\/2018\/6574178","article-title":"Effects of time-compressed speech training on multiple functional and structural neural mechanisms involving the left superior temporal gyrus","volume":"2018","author":"Maruyama","year":"2018","journal-title":"Neural Plast"},{"key":"R38-20260525","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.heares.2019.01.011","article-title":"Time-compression thresholds for Mandarin sentences in normal-hearing and cochlear implant listeners","volume":"374","author":"Meng","year":"2019","journal-title":"Hear Res"},{"key":"R39-20260525","doi-asserted-by":"crossref","first-page":"2980","DOI":"10.1093\/brain\/awp223","article-title":"Impaired visual processing preceding image recognition in Parkinson's disease patients with visual hallucinations","volume":"132","author":"Meppelink","year":"2009","journal-title":"Brain"},{"key":"R40-20260525","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.neuroscience.2019.08.038","article-title":"Characterization of young and old adult brains:an EEG functional connectivity analysis","volume":"422","author":"Moezzi","year":"2019","journal-title":"Neuroscience"},{"key":"R41-20260525","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1097\/AUD.0b013e3181fc98bd","article-title":"Five-year incidence and progression of hearing impairment in an older population","volume":"32","author":"Mitchell","year":"2011","journal-title":"Ear Hear"},{"key":"R42-20260525","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.bjorl.2018.10.010","article-title":"Relative contributions of auditory and cognitive functions on speech recognition in quiet and in noise among older adults","volume":"86","author":"Mukari","year":"2020","journal-title":"Braz J Otorhinolaryngol"},{"key":"R44-20260525","first-page":"E1","article-title":"Functional imaging studies of emotion regulation:a synthetic review and evolving model of the cognitive control of emotion","author":"Ochsner","year":"2012","journal-title":"Ann N Y Acad Sci"},{"key":"R45-20260525","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1162\/jocn_a_00269","article-title":"Decreased functional connectivity by aging is associated with cognitive decline","volume":"24","author":"Onoda","year":"2012","journal-title":"J Cogn Neurosci"},{"key":"R46-20260525","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s10162-012-0367-7","article-title":"Age-related hearing loss and ear morphology affect vertical but not horizontal sound-localization performance","volume":"14","author":"Otte","year":"2013","journal-title":"J Assoc Res Otolaryngol"},{"key":"R47-20260525","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s00441-014-2107-2","article-title":"Age-related changes in the central auditory system","volume":"361","author":"Ouda","year":"2015","journal-title":"Cell Tissue Res"},{"key":"R48-20260525","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/j.neuroimage.2006.12.044","article-title":"Where the brain grows old:decline in anterior cingulate and medial prefrontal function with normal aging","volume":"35","author":"Pardo","year":"2007","journal-title":"Neuroimage"},{"key":"R49-20260525","doi-asserted-by":"crossref","first-page":"e51419","DOI":"10.7554\/eLife.51419","article-title":"Bottom-up and top-down neural signatures of disordered multi-talker speech perception in adults with normal hearing","volume":"9","author":"Parthasarathy","year":"2020","journal-title":"Elife"},{"key":"R50-20260525","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1097\/AUD.0000000000000567","article-title":"Development of a test battery for evaluating speech perception in complex listening environments:effects of sensorineural hearing loss","volume":"39","author":"Phatak","year":"2018","journal-title":"Ear Hear"},{"key":"R51-20260525","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1098\/rstb.1998.0344","article-title":"Attention, self-regulation and consciousness","volume":"353","author":"Posner","year":"1998","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"R52-20260525","doi-asserted-by":"crossref","first-page":"e0116692","DOI":"10.1371\/journal.pone.0116692","article-title":"Functional changes in the human auditory cortex in ageing","volume":"10","author":"Profant","year":"2014","journal-title":"PLoS One"},{"key":"R53-20260525","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/nrn1343","article-title":"Anterior prefrontal cortex:insights into function from anatomy and neuroimaging","volume":"5","author":"Ramnani","year":"2004","journal-title":"Nat Rev Neurosci"},{"key":"R54-20260525","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1038\/s41598-019-38816-z","article-title":"The effect of age-related hearing loss and listening effort on resting state connectivity","volume":"9","author":"Rosemann","year":"2019","journal-title":"Sci Rep"},{"key":"R55-20260525","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.tics.2012.01.005","article-title":"Ventromedial prefrontal-subcortical systems and the generation of affective meaning","volume":"16","author":"Roy","year":"2012","journal-title":"Trends Cogn Sci"},{"key":"R56-20260525","doi-asserted-by":"crossref","first-page":"3320","DOI":"10.1121\/1.4934629","article-title":"Speech perception at positive signal-to-noise ratios using adaptive adjustment of time compression","volume":"138","author":"Schlueter","year":"2015","journal-title":"J Acoust Soc Am"},{"key":"R57-20260525","doi-asserted-by":"crossref","first-page":"e76488","DOI":"10.1371\/journal.pone.0076488","article-title":"Default mode, dorsal attention and auditory resting state networks exhibit differential functional connectivity in tinnitus and hearing loss","volume":"8","author":"Schmidt","year":"2013","journal-title":"PLoS One"},{"key":"R58-20260525","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1523\/JNEUROSCI.5587-06.2007","article-title":"Dissociable intrinsic connectivity networks for salience processing and executive control","volume":"27","author":"Seeley","year":"2007","journal-title":"J Neurosci"},{"key":"R59-20260525","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1089\/brain.2014.0327","article-title":"Functional connectivity in multiple cortical networks is associated with performance across cognitive domains in older adults","volume":"5","author":"Shaw","year":"2015","journal-title":"Brain Connect"},{"key":"R60-20260525","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.tins.2020.07.005","article-title":"The effects of age-related hearing loss on the brain and cognitive function","volume":"43","author":"Slade","year":"2020","journal-title":"Trends Neurosci"},{"key":"R61-20260525","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1121\/1.1426376","article-title":"The relationship between the intelligibility of time-compressed speech and speech in noise in young and elderly listeners","volume":"111","author":"Versfeld","year":"2002","journal-title":"J Acoust Soc Am"},{"key":"R62-20260525","doi-asserted-by":"crossref","first-page":"3328","DOI":"10.1152\/jn.90355.2008","article-title":"Evidence for a frontoparietal control system revealed by intrinsic functional connectivity","volume":"100","author":"Vincent","year":"2008","journal-title":"J Neurophysiol"},{"key":"R63-20260525","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1093\/cercor\/bhr295","article-title":"The left occipitotemporal cortex does not show preferential activity for words","volume":"22","author":"Vogel","year":"2012","journal-title":"Cereb Cortex"},{"key":"R65-20260525","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.neuroscience.2005.09.028","article-title":"Under the curve:critical issues for elucidating D1 receptor function in working memory","volume":"139","author":"Williams","year":"2006","journal-title":"Neuroscience"},{"key":"R66-20260525","doi-asserted-by":"crossref","first-page":"70s","DOI":"10.1097\/AUD.0b013e31803154d0","article-title":"Development of the Mandarin Hearing in Noise Test (MHINT)","volume":"28","author":"Wong","year":"2007","journal-title":"Ear Hear"},{"key":"R68-20260525","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.heares.2013.01.021","article-title":"Current concepts in age-related hearing loss:epidemiology and mechanistic pathways","volume":"303","author":"Yamasoba","year":"2013","journal-title":"Hear Res"},{"key":"R69-20260525","first-page":"298","article-title":"Study of ceiling efect of commonly used Chinese recognition materials in post-lingual deafened patients with cochlear implant","volume":"29","author":"Ye","year":"2015","journal-title":"Zhonghua Erbiyanhou Toujing Waike Zazhi"},{"key":"R70-20260525","doi-asserted-by":"crossref","first-page":"628","DOI":"10.2174\/1567205013666161201201000","article-title":"Directed functional connectivity of posterior cingulate cortex and whole brain in Alzheimer's disease and mild cognitive impairment","volume":"14","author":"Yu","year":"2017","journal-title":"Curr Alzheimer Res"},{"key":"R71-20260525","doi-asserted-by":"crossref","first-page":"e01758","DOI":"10.1002\/brb3.1758","article-title":"Diffusion tensor imaging study of brain precentral gyrus and postcentral gyrus during normal brain aging process","volume":"10","author":"Zhou","year":"2020","journal-title":"Brain Behav"}],"container-title":["Neural Regeneration Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/1673-5374.361530","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T19:30:57Z","timestamp":1786735857000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/1673-5374.361530"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,25]]},"references-count":68,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.4103\/1673-5374.361530","relation":{},"ISSN":["1673-5374","1876-7958"],"issn-type":[{"value":"1673-5374","type":"print"},{"value":"1876-7958","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,25]]},"assertion":[{"value":"2022-06-03","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-08","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}